HRP20040109A2 - Screening method for inhibitors of folate synthesis pathway enzimes - Google Patents

Screening method for inhibitors of folate synthesis pathway enzimes Download PDF

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Publication number
HRP20040109A2
HRP20040109A2 HR20040109A HRP20040109A HRP20040109A2 HR P20040109 A2 HRP20040109 A2 HR P20040109A2 HR 20040109 A HR20040109 A HR 20040109A HR P20040109 A HRP20040109 A HR P20040109A HR P20040109 A2 HRP20040109 A2 HR P20040109A2
Authority
HR
Croatia
Prior art keywords
dhps
activity
determining
inhibitory activity
accordance
Prior art date
Application number
HR20040109A
Other languages
English (en)
Croatian (hr)
Inventor
Thur Se Stachyra
Jacques Biton
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of HRP20040109A2 publication Critical patent/HRP20040109A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/527—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving lyase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
HR20040109A 2001-08-01 2002-07-30 Screening method for inhibitors of folate synthesis pathway enzimes HRP20040109A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01402085A EP1281769A1 (fr) 2001-08-01 2001-08-01 Procédé de criblage des inhibiteurs de la voie de synthèse de l'acide folique
PCT/EP2002/009421 WO2003012132A2 (fr) 2001-08-01 2002-07-30 Technique permettant de determiner l'activite inhibitrice d'un compose sur une des enzymes du mecanisme de synthese du folate

Publications (1)

Publication Number Publication Date
HRP20040109A2 true HRP20040109A2 (en) 2004-06-30

Family

ID=8182836

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040109A HRP20040109A2 (en) 2001-08-01 2002-07-30 Screening method for inhibitors of folate synthesis pathway enzimes

Country Status (6)

Country Link
US (1) US20060088900A1 (fr)
EP (2) EP1281769A1 (fr)
JP (1) JP2005508620A (fr)
AU (1) AU2002327846A1 (fr)
HR (1) HRP20040109A2 (fr)
WO (1) WO2003012132A2 (fr)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH670709A5 (fr) * 1986-04-24 1989-06-30 Univ Moskovsk
EP0999284A1 (fr) * 1998-09-11 2000-05-10 Hoechst Marion Roussel Procédé de triage pour des substances antimycotiques utilisant des gènes dérivant de C.albicans, et les gènes eux-mêmes
WO2000036152A1 (fr) * 1998-12-14 2000-06-22 Li-Cor, Inc. Systeme et procede de sequençage d'acides nucleiques mono-moleculaires par synthese de polymerase
WO2000042214A1 (fr) * 1999-01-15 2000-07-20 Pantherix Ltd. Dosage enzymatique par liberation de phosphate
US7202023B2 (en) * 2000-08-11 2007-04-10 Millennium Pharmaceuticals, Inc. High throughput screen for inhibitors of the folate biosynthetic pathway in bacteria

Also Published As

Publication number Publication date
WO2003012132A3 (fr) 2003-08-28
WO2003012132A2 (fr) 2003-02-13
US20060088900A1 (en) 2006-04-27
AU2002327846A1 (en) 2003-02-17
EP1281769A1 (fr) 2003-02-05
EP1414993A2 (fr) 2004-05-06
JP2005508620A (ja) 2005-04-07

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ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
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