HRP20040207A2 - Ascorbic acid derivatives, methods of synthesis and pharmaceutical use thereof - Google Patents

Ascorbic acid derivatives, methods of synthesis and pharmaceutical use thereof Download PDF

Info

Publication number
HRP20040207A2
HRP20040207A2 HR20040207A HRP20040207A HRP20040207A2 HR P20040207 A2 HRP20040207 A2 HR P20040207A2 HR 20040207 A HR20040207 A HR 20040207A HR P20040207 A HRP20040207 A HR P20040207A HR P20040207 A2 HRP20040207 A2 HR P20040207A2
Authority
HR
Croatia
Prior art keywords
lysine
proline
ascorbyl
ascorbic acid
polylysine
Prior art date
Application number
HR20040207A
Other languages
English (en)
Croatian (hr)
Inventor
Rath Matthias
Niedzwiecki Aleksandra
Ivanov Vanim
Netke Shrirang
Waheed Roomi M.
Original Assignee
Rath Matthias
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rath Matthias filed Critical Rath Matthias
Publication of HRP20040207A2 publication Critical patent/HRP20040207A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/62—Three oxygen atoms, e.g. ascorbic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
HR20040207A 2001-08-24 2002-08-23 Ascorbic acid derivatives, methods of synthesis and pharmaceutical use thereof HRP20040207A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31485701P 2001-08-24 2001-08-24
PCT/EP2002/009451 WO2003018568A2 (en) 2001-08-24 2002-08-23 Ascorbic acid derivatives, methods of synthesis and pharmaceutical use thereof

Publications (1)

Publication Number Publication Date
HRP20040207A2 true HRP20040207A2 (en) 2005-02-28

Family

ID=23221754

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040207A HRP20040207A2 (en) 2001-08-24 2002-08-23 Ascorbic acid derivatives, methods of synthesis and pharmaceutical use thereof

Country Status (19)

Country Link
US (2) US6864284B2 (de)
EP (3) EP2241559A3 (de)
JP (1) JP4162593B2 (de)
KR (1) KR20040044472A (de)
CN (3) CN100361987C (de)
BR (1) BR0205944A (de)
CA (1) CA2458344A1 (de)
HR (1) HRP20040207A2 (de)
HU (1) HUP0600084A2 (de)
IL (4) IL155578A0 (de)
MX (1) MXPA04001655A (de)
NO (1) NO20031844L (de)
NZ (3) NZ531430A (de)
PL (1) PL373522A1 (de)
RU (1) RU2309152C2 (de)
UA (1) UA78223C2 (de)
WO (2) WO2003018000A1 (de)
YU (1) YU38103A (de)
ZA (1) ZA200304712B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040067890A1 (en) * 2002-10-04 2004-04-08 Gupta Shyam K. Ascorbic acid salts of organic bases with enhanced bioavailability for synergictic anti-aging and skin protective cosmetic compositions
CN1805948A (zh) * 2003-04-21 2006-07-19 塔格拉生物科技有限公司 抗坏血酸的稳定衍生物
CN100346782C (zh) * 2004-05-21 2007-11-07 北京京卫信康医药科技发展有限公司 一种含氨基酸的维生素c组合物
KR100544159B1 (ko) * 2004-07-14 2006-01-24 센양 뉴라이프 인더스트리알 코 엘티디 아스코르빌 테트라이소팔미테이트와 디팔미토일하이드록시프롤린을 함유한 나노 에멀젼 및 이를함유하는 화장료 조성물
US20070002866A1 (en) * 2005-06-29 2007-01-04 Denso Corporation Receive power priority flooding in mobile ad hoc networks
KR20090010160A (ko) 2006-02-21 2009-01-29 마리 케이 인코포레이티드 안정적인 비타민 ｃ 조성물
US20080188553A1 (en) * 2007-02-06 2008-08-07 Waheed M Roomi Novel ascorbic acid compounds, methods of synthesis and application use thereof
FR2913686B1 (fr) * 2007-03-14 2009-05-01 Oreal Nouveaux composes carbamates de vitamine c, compositions les comprenant, et utilisations
US8828960B2 (en) * 2007-07-17 2014-09-09 Idexx Laboratories, Inc. Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
WO2018005762A2 (en) * 2016-06-29 2018-01-04 Orasis Medical, Inc. Ascorbic acid-amino acid conjugates and their use in regulation of fluid outflow
EP3682892A4 (de) * 2017-09-15 2021-10-27 Kine Sciences Co., Ltd. Verwendung von peptiden als therapeutisches mittel für autoimmunerkrankungen und knochenerkrankungen

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1273989A (fr) * 1960-09-09 1961-10-20 Marbou Procédé de préparation de l'ascorbate de lysine
US4424232A (en) * 1982-05-19 1984-01-03 Parkinson Richard W Treatment of herpes simplex
US4518614A (en) * 1982-11-04 1985-05-21 Redken Laboratories, Inc. Cosmetic preparation
JPS63190882A (ja) 1987-02-03 1988-08-08 Nippon Haipotsukusu:Kk アスコルビン酸誘導体及びそれを含有する皮膚脱色剤並びにその製造法
ATE160939T1 (de) * 1988-09-19 1997-12-15 Oxycal Lab Inc Zusammensetzungen und verabreichungsverfahren für heilmittel
FR2650180B1 (fr) * 1989-07-31 1995-03-03 Chisso Corp Procede de production d'une feuille facilement soluble dans l'eau a base d'acide hyaluronique ou de hyaluronate et feuille ainsi obtenue
EP0532706B1 (de) * 1990-06-04 1995-05-10 Health Now Verminderung von kardiovaskulären gefässverschlüssen mit ascorbat und hemmstoffen der bindung von lipoprotein (a)
JPH04247011A (ja) 1991-02-04 1992-09-03 Q P Corp リン脂質系アスコルビン酸誘導体及び該誘導体を含む皮膚外用剤
US5977073A (en) * 1991-06-06 1999-11-02 Life Sciences' Technologies, Inc. Nutrient composition for treatment of immune disorders
JPH0666958A (ja) * 1991-08-29 1994-03-11 Masaki Yoshigaki 目覚し時計の目覚し設定並びに目覚し音停止機構
JPH0678560A (ja) 1992-08-26 1994-03-18 Matsushita Electric Works Ltd インバータ装置
FR2715156B1 (fr) 1994-01-20 1996-03-01 Oreal Mono-esters d'acide cinnamique ou de ses dérivés et de vitamine C, leur procédé de préparation et leur utilisation comme anti-oxydants dans des compositions cosmétiques, pharmaceutiques ou alimentaires.
US5626883A (en) * 1994-04-15 1997-05-06 Metagenics, Inc. Ascorbic acid compositions providing enhanced human immune system activity
FR2732221B1 (fr) * 1995-03-28 1997-04-25 Oreal Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue
US5951990A (en) 1995-05-15 1999-09-14 Avon Products, Inc. Ascorbyl-phosphoryl-cholesterol
US5607968A (en) 1995-06-07 1997-03-04 Avon Products, Inc. Topical alkyl-2-O-L-ascorbyl-phosphates
FR2737971B1 (fr) 1995-08-25 1997-11-14 Lvmh Rech Utilisation de la vitamine c ou de ses derives ou analogues pour stimuler la synthese de l'elastine cutanee
US6162419A (en) 1996-11-26 2000-12-19 Nicholas V. Perricone Stabilized ascorbyl compositions
US5962517A (en) * 1997-01-31 1999-10-05 Murad; Howard Pharmaceutical compositions and methods for treating acne
EP0891771A1 (de) * 1997-07-08 1999-01-20 Health Now, Inc. Lysin und Ascorbat oder ihre Derivate zur Behandlung von kardiovaskulären Erkrankungen

Also Published As

Publication number Publication date
CN1763028A (zh) 2006-04-26
EP1423375A2 (de) 2004-06-02
HUP0600084A2 (en) 2006-06-28
EP2241559A2 (de) 2010-10-20
CN100360514C (zh) 2008-01-09
MXPA04001655A (es) 2004-05-31
UA78223C2 (uk) 2007-03-15
RU2309152C2 (ru) 2007-10-27
EP2241559A3 (de) 2014-07-09
CA2458344A1 (en) 2003-03-06
CN100361987C (zh) 2008-01-16
NO20031844D0 (no) 2003-04-24
KR20040044472A (ko) 2004-05-28
IL176523A0 (en) 2006-10-05
EP2241560A3 (de) 2014-07-09
WO2003018568A3 (en) 2003-12-04
RU2004108687A (ru) 2005-09-20
NZ531430A (en) 2006-05-26
IL155578A (en) 2006-12-10
US7230124B2 (en) 2007-06-12
US20040167077A1 (en) 2004-08-26
JP4162593B2 (ja) 2008-10-08
CN1763027A (zh) 2006-04-26
NO20031844L (no) 2003-06-12
IL176524A0 (en) 2006-10-05
IL155578A0 (en) 2003-11-23
WO2003018568A2 (en) 2003-03-06
NZ542241A (en) 2006-09-29
US6864284B2 (en) 2005-03-08
NZ542240A (en) 2006-09-29
US20030119753A1 (en) 2003-06-26
EP2241560A2 (de) 2010-10-20
CN1518545A (zh) 2004-08-04
JP2005501867A (ja) 2005-01-20
BR0205944A (pt) 2004-12-28
PL373522A1 (en) 2005-09-05
WO2003018000A1 (en) 2003-03-06
ZA200304712B (en) 2004-07-12
CN100378087C (zh) 2008-04-02
YU38103A (sh) 2006-05-25

Similar Documents

Publication Publication Date Title
RU2004124384A (ru) Обладающий питательными свойствами фармацевтический состав на основе полифенолов и его использование при лечении рака
US20030147937A1 (en) Use of compatible solutes as substances having free radical scavenging properties
Takebayashi et al. Inhibition of free radical-induced erythrocyte hemolysis by 2-O-substituted ascorbic acid derivatives
HRP20040207A2 (en) Ascorbic acid derivatives, methods of synthesis and pharmaceutical use thereof
EP1784388B8 (de) Biphenyloxyessigsäure - derivate zur behandlung von atemwegserkränkungen
DE69815750D1 (de) Verfahren zur Herstellung von Ascorbinsäurederivaten
US5863939A (en) Creatine ascorbates and a method of producing them
US20070167517A1 (en) Stabilized derivatives of ascorbic aicd
EP0545972A1 (de) Therapeutisch wirksames stoffgemisch aus glutathion- und anthocyan-verbindungen.
CA2664982C (en) Cleavable carnitine compound
US20080188553A1 (en) Novel ascorbic acid compounds, methods of synthesis and application use thereof
Du et al. The protective effect of ascorbic acid derivative on PC12 cells: Involvement of its ROS scavenging ability
KR101123366B1 (ko) 우수한 안정성을 갖는 항산화제와 키토산과의 복합체
AU2002337011A1 (en) Ascorbic acid derivatives, methods of synthesis and pharmaceutical use thereof
JP2020029529A (ja) 抗酸化剤
US20030113362A1 (en) Unique ascorbic acid derivatives with essential amino acids, nonessential amino acid and amino acids that do not occur in protein: the process for their preparation and use in research, medicine, physiology, pharmacology, nutrition, pharmaceuticals, and for cosmetic, commercial and industrial applications
WO2020146635A1 (en) Water-soluble mineral ferulates and their method of preparation
JP2004521943A (ja) ビタミンｃ組成物

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20070820

Year of fee payment: 6

OBST Application withdrawn