HRP20040558A2 - Pharmaceutically effective compounds - Google Patents
Pharmaceutically effective compounds Download PDFInfo
- Publication number
- HRP20040558A2 HRP20040558A2 HR20040558A HRP20040558A HRP20040558A2 HR P20040558 A2 HRP20040558 A2 HR P20040558A2 HR 20040558 A HR20040558 A HR 20040558A HR P20040558 A HRP20040558 A HR P20040558A HR P20040558 A2 HRP20040558 A2 HR P20040558A2
- Authority
- HR
- Croatia
- Prior art keywords
- nitrogen
- substituted
- hydroxy
- compound
- oxygen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0200109A HUP0200109D0 (en) | 2002-01-11 | 2002-01-11 | Compounds having pharmaceutical activity |
| HU0204362A HUP0204362D0 (en) | 2002-12-17 | 2002-12-17 | Compounds having pharmaceutical activity |
| PCT/HU2003/000003 WO2003057664A1 (en) | 2002-01-11 | 2003-01-10 | Carboxamidine derivatives and their use in the treatment of vascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20040558A2 true HRP20040558A2 (en) | 2004-10-31 |
Family
ID=90001534
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20040558A HRP20040558A2 (en) | 2002-01-11 | 2003-01-10 | Pharmaceutically effective compounds |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US7384936B2 (sr) |
| EP (1) | EP1492763A1 (sr) |
| JP (1) | JP2005514418A (sr) |
| KR (1) | KR20040089102A (sr) |
| CN (1) | CN1615296A (sr) |
| AU (1) | AU2003202104B8 (sr) |
| BR (1) | BR0306778A (sr) |
| CA (1) | CA2471752A1 (sr) |
| HR (1) | HRP20040558A2 (sr) |
| IL (1) | IL162941A0 (sr) |
| MX (1) | MXPA04006716A (sr) |
| NO (1) | NO20043029L (sr) |
| NZ (1) | NZ533795A (sr) |
| PL (1) | PL371251A1 (sr) |
| RS (1) | RS60604A (sr) |
| RU (1) | RU2320330C2 (sr) |
| WO (1) | WO2003057664A1 (sr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003057664A1 (en) * | 2002-01-11 | 2003-07-17 | Biorex Kutató És Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| AU2009262670B2 (en) | 2008-06-26 | 2013-06-20 | Zevra Denmark A/S | Use of Hsp70 as a regulator of enzymatic activity |
| CA2817773A1 (en) | 2010-11-30 | 2012-06-07 | Orphazyme Aps | Methods for increasing intracellular activity of hsp70 |
| WO2014036655A1 (en) * | 2012-09-06 | 2014-03-13 | Mcpharma Biotech Inc. | Treatment of diarrhea and post-weaning diarrhea with resistant potato starch |
| AU2015317447B2 (en) | 2014-09-15 | 2021-02-25 | Zevra Denmark A/S | Arimoclomol formulation |
| EP3435938B1 (en) | 2016-04-01 | 2021-09-29 | 3M Innovative Properties Company | Hearing protection device and method of forming same |
| US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| DK3782624T3 (da) | 2016-04-29 | 2025-12-15 | Zevra Denmark As | Arimoclomol til behandling af glucocerebrosidase-associerede lidelser |
| KR20230128462A (ko) | 2020-11-19 | 2023-09-05 | 제브라 덴마크 에이/에스 | 아리모클로몰 시트레이트 및 이의 중간체를 제조하기 위한 공정 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177578B (en) | 1976-08-27 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
| DE2651083A1 (de) | 1976-11-09 | 1978-05-18 | Hoechst Ag | Neue o-alkylierte hydroxylamine, verfahren zu ihrer herstellung und ihre verwendung |
| IT1110460B (it) | 1977-03-02 | 1985-12-23 | Ciba Geigy Ag | Prodotti che favoriscono la crescita delle piante e prodotti che proteggono le piante a base di eteri di ossime e di esteri di ossime loro preparazione e loro impiego |
| US4187220A (en) | 1977-08-30 | 1980-02-05 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. | New O-(3-amino-2-hydroxy-propyl)-amidoxime derivatives, process for the preparation thereof and pharmaceutical compositions containing same |
| HU207988B (en) | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| EP0369944A1 (de) | 1988-11-18 | 1990-05-23 | Ciba-Geigy Ag | Substituierte Oxadiaminobutane |
| HUT54347A (en) | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
| GB9017351D0 (en) | 1990-08-08 | 1990-09-19 | Wellcome Found | Medicaments for treatment of atherosclerosis |
| EP0495750A3 (en) | 1991-01-14 | 1992-09-16 | Ciba-Geigy Ag | Heterocyclic hydroxylamine |
| US5334600A (en) | 1991-07-30 | 1994-08-02 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
| AU691201B2 (en) * | 1993-11-01 | 1998-05-14 | Japat Ltd. | Endothelin receptor antagonists |
| EP0758315B1 (en) | 1994-05-06 | 1998-08-26 | Biorex Kutato Es Fejlesztö Rt. | Novel hydroximic acid derivatives, pharmaceutical compositions containing them and process for preparing same |
| HU218480B (hu) | 1995-06-15 | 2000-09-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények |
| HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| HU222994B1 (hu) * | 1995-11-02 | 2004-01-28 | BIOREX Kutató és Fejlesztő Rt. | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| UA64716C2 (en) | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
| HU220971B1 (hu) | 1997-04-03 | 2002-07-29 | BIOREX Kutató és Fejlesztő Rt. | Eljárás 0-(3-amino-2-hidroxi-propil)-hidroximsav-halogenidek előállítására |
| HUP9702365A3 (en) * | 1997-04-22 | 1999-09-28 | Biorex Kutato Fejlesztoe Kft | Application of hydroxilamin-derivatives, as well as process and composition for increase of weather extreme resistent by cultivated plants |
| HU226617B1 (en) | 1998-12-14 | 2009-04-28 | Cytrx Corp | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| HUP9900475D0 (en) | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| WO2003057664A1 (en) * | 2002-01-11 | 2003-07-17 | Biorex Kutató És Fejlesztö Rt. | Carboxamidine derivatives and their use in the treatment of vascular diseases |
| HUP0303584A3 (en) | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
-
2003
- 2003-01-10 WO PCT/HU2003/000003 patent/WO2003057664A1/en not_active Ceased
- 2003-01-10 US US10/501,029 patent/US7384936B2/en not_active Expired - Fee Related
- 2003-01-10 EP EP03700962A patent/EP1492763A1/en not_active Withdrawn
- 2003-01-10 PL PL03371251A patent/PL371251A1/xx unknown
- 2003-01-10 MX MXPA04006716A patent/MXPA04006716A/es active IP Right Grant
- 2003-01-10 IL IL16294103A patent/IL162941A0/xx unknown
- 2003-01-10 JP JP2003557981A patent/JP2005514418A/ja active Pending
- 2003-01-10 CN CNA03802151XA patent/CN1615296A/zh active Pending
- 2003-01-10 RS YU60604A patent/RS60604A/sr unknown
- 2003-01-10 BR BR0306778-5A patent/BR0306778A/pt not_active IP Right Cessation
- 2003-01-10 KR KR10-2004-7010650A patent/KR20040089102A/ko not_active Ceased
- 2003-01-10 CA CA002471752A patent/CA2471752A1/en not_active Abandoned
- 2003-01-10 AU AU2003202104A patent/AU2003202104B8/en not_active Ceased
- 2003-01-10 HR HR20040558A patent/HRP20040558A2/hr not_active Application Discontinuation
- 2003-01-10 RU RU2004124378/15A patent/RU2320330C2/ru not_active IP Right Cessation
- 2003-01-10 NZ NZ533795A patent/NZ533795A/xx not_active IP Right Cessation
-
2004
- 2004-07-12 US US10/889,966 patent/US7361655B2/en not_active Expired - Fee Related
- 2004-07-13 NO NO20043029A patent/NO20043029L/no not_active Application Discontinuation
-
2007
- 2007-10-30 US US11/981,376 patent/US7691849B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/981,422 patent/US7550457B2/en not_active Expired - Fee Related
-
2009
- 2009-06-18 US US12/487,151 patent/US20090253690A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005514418A (ja) | 2005-05-19 |
| US20090075993A1 (en) | 2009-03-19 |
| KR20040089102A (ko) | 2004-10-20 |
| RS60604A (sr) | 2006-12-15 |
| US7691849B2 (en) | 2010-04-06 |
| AU2003202104B2 (en) | 2008-09-18 |
| WO2003057664A1 (en) | 2003-07-17 |
| CA2471752A1 (en) | 2003-07-17 |
| PL371251A1 (en) | 2005-06-13 |
| NO20043029L (no) | 2004-10-11 |
| US20090253690A1 (en) | 2009-10-08 |
| US7361655B2 (en) | 2008-04-22 |
| CN1615296A (zh) | 2005-05-11 |
| EP1492763A1 (en) | 2005-01-05 |
| US7550457B2 (en) | 2009-06-23 |
| AU2003202104B8 (en) | 2008-10-02 |
| RU2320330C2 (ru) | 2008-03-27 |
| IL162941A0 (en) | 2005-11-20 |
| AU2003202104A1 (en) | 2003-07-24 |
| US20080058323A1 (en) | 2008-03-06 |
| US20060058294A1 (en) | 2006-03-16 |
| BR0306778A (pt) | 2004-12-28 |
| MXPA04006716A (es) | 2004-11-10 |
| US20050043295A1 (en) | 2005-02-24 |
| US7384936B2 (en) | 2008-06-10 |
| RU2004124378A (ru) | 2005-04-20 |
| NZ533795A (en) | 2006-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| AIPI | Request for the grant of a patent on the basis of a substantive examination of a patent application | ||
| PPPP | Transfer of rights |
Owner name: CYTRX CORPORATION, US |
|
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20091228 Year of fee payment: 8 |
|
| OBST | Application withdrawn |