HRP20041167A2 - Hidroxy tetrahydro-naphthalenylurea derivatives - Google Patents

Hidroxy tetrahydro-naphthalenylurea derivatives

Info

Publication number
HRP20041167A2
HRP20041167A2 HR20041167A HRP20041167A HRP20041167A2 HR P20041167 A2 HRP20041167 A2 HR P20041167A2 HR 20041167 A HR20041167 A HR 20041167A HR P20041167 A HRP20041167 A HR P20041167A HR P20041167 A2 HRP20041167 A2 HR P20041167A2
Authority
HR
Croatia
Prior art keywords
tetrahydro
pain
hidroxy
useful
treatment
Prior art date
Application number
HR20041167A
Other languages
English (en)
Inventor
Yura Takeshi
Mogi Muneto
Urbahns Klaus
Fujishima Hiroshi
Masuda Tsutomu
Moriwaki Toshiya
Yoshida Nagahiro
Kokubo Toshio
Shiroo Masahiro
Tajimi Masaomi
Tsukimi Yasuhiro
Yamamoto Noriyuki
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0210512.0A external-priority patent/GB0210512D0/en
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of HRP20041167A2 publication Critical patent/HRP20041167A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HR20041167A 2002-05-08 2003-04-28 Hidroxy tetrahydro-naphthalenylurea derivatives HRP20041167A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0210512.0A GB0210512D0 (en) 2002-05-08 2002-05-08 Tetrahydro-napthalene derivatives
GBGB0227262.3A GB0227262D0 (en) 2002-05-08 2002-11-21 Tetrahydro-naphthalene derivatives
PCT/EP2003/004395 WO2003095420A1 (en) 2002-05-08 2003-04-28 Hydroxy tetrahydro-naphthalenylurea derivatives

Publications (1)

Publication Number Publication Date
HRP20041167A2 true HRP20041167A2 (en) 2005-08-31

Family

ID=29422108

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20041167A HRP20041167A2 (en) 2002-05-08 2003-04-28 Hidroxy tetrahydro-naphthalenylurea derivatives

Country Status (20)

Country Link
US (1) US7612113B2 (de)
EP (1) EP1506167B1 (de)
JP (1) JP4335131B2 (de)
CN (1) CN1307150C (de)
AT (1) ATE371641T1 (de)
AU (1) AU2003229734B2 (de)
BR (1) BR0309940A (de)
CA (1) CA2487238C (de)
DE (1) DE60315973T2 (de)
DK (1) DK1506167T3 (de)
ES (1) ES2292959T3 (de)
HR (1) HRP20041167A2 (de)
IL (1) IL165004A (de)
MX (1) MXPA04010938A (de)
NO (1) NO20045359L (de)
NZ (1) NZ536418A (de)
PL (1) PL210288B1 (de)
RU (1) RU2331635C2 (de)
TW (1) TWI271396B (de)
WO (1) WO2003095420A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004028440A2 (en) * 2002-09-24 2004-04-08 Bayer Healthcare Ag Vr1 antagonists for the treatment of urological disorders
CA2508618C (en) 2002-12-06 2012-02-21 Bayer Healthcare Ag Tetrahydro-naphthalene derivatives
AU2003288200A1 (en) * 2002-12-09 2004-06-30 Bayer Healthcare Ag Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists
EP1679296A4 (de) 2003-10-14 2007-12-26 Ajinomoto Kk Etherderivat
EP1678123A1 (de) * 2003-10-15 2006-07-12 Bayer HealthCare AG Tetrahydronaphthalin- und harnstoffderivate
WO2005044802A2 (en) * 2003-11-08 2005-05-19 Bayer Healthcare Ag Tetrahydro-quinolinylurea derivatives as vrl antagonists
WO2005095329A1 (en) * 2004-03-31 2005-10-13 Pfizer Japan Inc. Substituted benzamide compounds as vr1 receptor antagonists
EP1893189A2 (de) * 2005-03-05 2008-03-05 Bayer HealthCare AG Verwendung von hydroxytetrahydronaphthalinderivaten zur behandlung von atemwegserkrankungen
AU2006225496A1 (en) 2005-03-19 2006-09-28 Amorepacific Corporation Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same
DE102005017286B3 (de) * 2005-04-14 2006-12-28 Schering Ag Tetrahydronaphthalinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005023943A1 (de) 2005-05-20 2006-11-23 Grünenthal GmbH Pentafluorsulfanyl-substituierte Verbindung und deren Verwendung zur Herstellung von Arzneimitteln
JP2010513557A (ja) * 2006-12-20 2010-04-30 アボット・ラボラトリーズ 疼痛治療のためのtrpv1バニロイド受容体アンタゴニストとしてのn−(5,6,7,8−テトラヒドロナフタレン−1−イル)尿素誘導体および関連化合物
WO2008096755A1 (ja) * 2007-02-07 2008-08-14 Nippon Suisan Kaisha, Ltd. バニロイド受容体(vr1)阻害剤及びその用途
DE102009055915A1 (de) * 2009-11-27 2011-06-01 Beiersdorf Ag Verwendung von Zingeron zur Herstellung kosmetischer oder dermatologischer Zubereitungen, welche auf der Haut ein Prickeln hervorrufen
WO2021039023A1 (ja) 2019-08-23 2021-03-04 持田製薬株式会社 ヘテロシクリデンアセトアミド誘導体の製造方法
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9713484D0 (en) 1997-06-27 1997-09-03 Smithkline Beecham Plc Neuroprotective vanilloid compounds
GB9727532D0 (en) * 1997-12-23 1998-02-25 Rh Ne Poulenc Rorer Limited Chemical compounds
US6333337B1 (en) * 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
EP1154989B1 (de) * 1999-02-22 2005-12-14 Pacific Corporation Vanilloid-analoge die resiniferatoxin-pharmacophore enthalten als wirksame vanilloid rezeptor agonisten und analgetika, zusammensetzungen und ihre verwendung
HUP0200996A3 (en) 1999-04-07 2003-01-28 Sankyo Company Ltd Chuo Ku Amine derivatives, pharmaceutical compositions containing them and their use
US6294694B1 (en) 1999-06-04 2001-09-25 Wisconsin Alumni Research Foundation Matrix metalloproteinase inhibitors and method of using same
CA2508618C (en) * 2002-12-06 2012-02-21 Bayer Healthcare Ag Tetrahydro-naphthalene derivatives
EP1493438A1 (de) * 2003-07-03 2005-01-05 Bayer HealthCare AG Inhibitoren des Vanilloid-Rezeptors (VR1) zur Behandlung von HIV-bedingten Schmerz
EP1678123A1 (de) * 2003-10-15 2006-07-12 Bayer HealthCare AG Tetrahydronaphthalin- und harnstoffderivate
DE602004017892D1 (de) * 2003-11-08 2009-01-02 Bayer Healthcare Ag Bicyclische amid-, carbamat- oder harnstoffderivate als modulatoren des vanilloidrezeptors

Also Published As

Publication number Publication date
EP1506167A1 (de) 2005-02-16
DE60315973T2 (de) 2008-05-21
ATE371641T1 (de) 2007-09-15
PL373257A1 (en) 2005-08-22
DK1506167T3 (da) 2008-01-02
JP2005524717A (ja) 2005-08-18
CN1665778A (zh) 2005-09-07
US20060258742A1 (en) 2006-11-16
MXPA04010938A (es) 2005-02-14
IL165004A (en) 2010-12-30
CA2487238A1 (en) 2003-11-20
US7612113B2 (en) 2009-11-03
PL210288B1 (pl) 2011-12-30
ES2292959T3 (es) 2008-03-16
TWI271396B (en) 2007-01-21
NO20045359L (no) 2004-12-07
CN1307150C (zh) 2007-03-28
RU2004136281A (ru) 2005-07-10
BR0309940A (pt) 2005-02-09
EP1506167B1 (de) 2007-08-29
WO2003095420A1 (en) 2003-11-20
HK1082946A1 (en) 2006-06-23
AU2003229734A1 (en) 2003-11-11
NZ536418A (en) 2006-04-28
IL165004A0 (en) 2005-12-18
AU2003229734B2 (en) 2009-02-19
TW200404052A (en) 2004-03-16
DE60315973D1 (de) 2007-10-11
JP4335131B2 (ja) 2009-09-30
RU2331635C2 (ru) 2008-08-20
CA2487238C (en) 2011-03-22

Similar Documents

Publication Publication Date Title
AU2003294748A1 (en) Tetrahydro-naphthalene derivatives
WO2003055848A3 (en) Urea derivatives as vr1- antagonists
IL165004A0 (en) Hydroxy tetrahydro-naphthalenylurea derivatives
WO2003014064A8 (en) Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists
WO2009109618A3 (en) 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1
WO2006059234A3 (en) Bicyclic amides as kinase inhibitors
WO2005112970A3 (en) Use of gelsolin to treat infections
WO2009109616A8 (en) 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40
AU2003288200A1 (en) Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists
WO2009109654A8 (en) 1-benzyl-3-hydr0xymethylindaz0le derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, and cx3cr1
WO2006074265A3 (en) Drug combination therapy and pharmaceutical compositions for treating inflammatory disorders
WO2007053495A3 (en) Compounds useful as antagonists of ccr2
WO2011045068A3 (en) Pharmaceutical composition containing cannabinoid-receptor 2 antagonists
GB2427405A (en) Novel hydroxamates as therapeutic agents
WO2005044802A3 (en) Tetrahydro-quinolinylurea derivatives as vrl antagonists
WO2007140181A3 (en) Combination therapy comprising an adenosine uptake inhibitor and a non-selective adenosine receptor antagonist
WO2007053499A3 (en) Compounds useful as antagonists of ccr2
MY155011A (en) Hydroxy tetrahydro-naphthalenylurea derivatives
WO2007062862A3 (en) Use of calmodulin inhibitors for the treatment of neurodegenerative disorders
WO2012060594A3 (ko) 티오우레아계 화합물 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 항염증 조성물
TW200716629A (en) Pyrazolopyrimidine derivative or pharmaceutically acceptable salt thereof
WO2006090376A3 (en) Pharmaceutical compositions of the isolated d- enantiomer of the quinazolinone derivative halofuginone
UY27794A1 (es) Derivados de hidroxi tetrahidro-naftalenilurea
TH78306A (th) อนุพันธ์ไฮดรอกซีเททตราไฮโดร-แนพธาลีนิลยูเรีย
TH78306B (th) "อนุพันธ์ไฮดรอกซีเททตราไฮโดร-แนพธาลีนิลยูเรีย"

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
ODRP Renewal fee for the maintenance of a patent

Payment date: 20110426

Year of fee payment: 9

OBST Application withdrawn