HRP20041202A2 - Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof - Google Patents

Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof

Info

Publication number
HRP20041202A2
HRP20041202A2 HR20041202A HRP20041202A HRP20041202A2 HR P20041202 A2 HRP20041202 A2 HR P20041202A2 HR 20041202 A HR20041202 A HR 20041202A HR P20041202 A HRP20041202 A HR P20041202A HR P20041202 A2 HRP20041202 A2 HR P20041202A2
Authority
HR
Croatia
Prior art keywords
compounds
production
medicaments containing
substituted diphenyl
cationically substituted
Prior art date
Application number
HR20041202A
Inventor
Jaehne Gerhard
Frick Wendelin
Flohr Alexander
Lindenschmidt Andreas
Glombik Heiner
Kramer Werner
Heuer Hubert
Schaefer Hans-Ludwig
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of HRP20041202A2 publication Critical patent/HRP20041202A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The invention relates to compounds of formula (I), in which R1, R2, R3, R4, R5 and R6 are defined as cited, in addition to their physiologically compatible salts. The compounds are suitable for use e.g. as hypolipidaemics.
HR20041202A 2002-06-19 2003-06-04 Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof HRP20041202A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10227507A DE10227507A1 (en) 2002-06-19 2002-06-19 Cationically substituted diphenylazetidinones, processes for their preparation, medicaments containing these compounds and their use
PCT/EP2003/005814 WO2004000803A1 (en) 2002-06-19 2003-06-04 Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof

Publications (1)

Publication Number Publication Date
HRP20041202A2 true HRP20041202A2 (en) 2005-06-30

Family

ID=29719282

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20041202A HRP20041202A2 (en) 2002-06-19 2003-06-04 Cationically substituted diphenyl azetidinones, method for their production, medicaments containing said compounds and use thereof

Country Status (26)

Country Link
EP (1) EP1517890B1 (en)
JP (1) JP2005533071A (en)
KR (1) KR20050010061A (en)
CN (1) CN1662494A (en)
AT (1) ATE401304T1 (en)
AU (1) AU2003238209B2 (en)
BR (1) BR0311984A (en)
CA (1) CA2490108A1 (en)
DE (2) DE10227507A1 (en)
DK (1) DK1517890T3 (en)
ES (1) ES2310662T3 (en)
HR (1) HRP20041202A2 (en)
IL (1) IL165790A (en)
MA (1) MA27251A1 (en)
MX (1) MXPA04012308A (en)
NO (1) NO20050088L (en)
PA (1) PA8575601A1 (en)
PL (1) PL372660A1 (en)
PT (1) PT1517890E (en)
RS (1) RS108604A (en)
RU (1) RU2315753C2 (en)
SV (1) SV2004001555A (en)
TW (1) TW200406380A (en)
UY (1) UY27852A1 (en)
WO (1) WO2004000803A1 (en)
ZA (1) ZA200409379B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
ATE485267T1 (en) 2003-12-23 2010-11-15 Astrazeneca Ab DIPHENYLAZETIDINONE DERIVATIVES WITH CHOLESTERINE ABSORPTION INHIBITING EFFECT
CN102633730A (en) 2004-12-03 2012-08-15 先灵公司 Substituted piperazines as cb1 antagonists
BRPI0609614A2 (en) 2005-04-04 2010-04-20 Univ Pontificia Catolica Chile use of ezetimibe in the prevention and treatment of biliary tree cholesterol lithiases
TW200738676A (en) 2005-06-20 2007-10-16 Schering Corp Heteroatom-linked substituted piperidines and derivatives thereof useful as histamine H3 antagonists
SA06270191B1 (en) 2005-06-22 2010-03-29 استرازينيكا ايه بي Novel 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors for the Treatment of Hyperlipidaemic Conditions
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
EP2061767B1 (en) 2006-08-08 2014-12-17 Sanofi Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
DE102007002260A1 (en) 2007-01-16 2008-07-31 Sanofi-Aventis Use of substituted pyranonic acid derivatives for the preparation of medicaments for the treatment of the metabolic syndrome
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
DE102007054497B3 (en) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh Novel crystalline diphenylazetidinone hydrates and process for their preparation
UY31968A (en) 2008-07-09 2010-01-29 Sanofi Aventis NEW HETEROCYCLIC DERIVATIVES, THEIR PROCESSES FOR THEIR PREPARATION, AND THEIR THERAPEUTIC USES
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
EP2403848A1 (en) 2009-03-06 2012-01-11 Lipideon Biotechnology AG Pharmaceutical hypocholesterolemic compositions
CN101993403B (en) 2009-08-11 2012-07-11 浙江海正药业股份有限公司 Azetidinone compound and medical applications thereof
KR20120060207A (en) 2009-08-26 2012-06-11 사노피 Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
EP2582709B1 (en) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683704B1 (en) 2011-03-08 2014-12-17 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (en) 2011-03-08 2016-06-01 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
WO2012120056A1 (en) 2011-03-08 2012-09-13 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
AU2019318209B2 (en) 2018-08-10 2025-09-25 Diapin Therapeutics, Llc Tri-peptides and treatment of metabolic, cardiovascular and inflammatory disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) * 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
DE10042447A1 (en) * 2000-08-29 2002-03-28 Aventis Pharma Gmbh Vertebrate intestinal protein that absorbs cholesterol and use of this protein to identify inhibitors of intestinal cholesterol transport
IL156552A0 (en) * 2000-12-21 2004-01-04 Aventis Pharma Gmbh Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use
MXPA03005019A (en) * 2000-12-21 2003-09-25 Avantis Pharma Deutschland Gmb Diphenyl azetidinone derivatives, method for the production thereof, medicaments containing these compounds, and their use.
EP1345895B1 (en) * 2000-12-21 2006-12-27 Sanofi-Aventis Deutschland GmbH Novel 1,2-diphenzylazetidinones, method for producing the same, medicaments containing said compounds, and the use thereof for treating disorders of the lipid metabolism

Also Published As

Publication number Publication date
BR0311984A (en) 2005-04-26
PL372660A1 (en) 2005-07-25
PT1517890E (en) 2008-10-14
IL165790A0 (en) 2006-01-15
SV2004001555A (en) 2004-03-19
DK1517890T3 (en) 2008-11-10
DE10227507A1 (en) 2004-01-08
PA8575601A1 (en) 2004-02-07
UY27852A1 (en) 2003-12-31
TW200406380A (en) 2004-05-01
ZA200409379B (en) 2006-05-31
RS108604A (en) 2007-02-05
WO2004000803A1 (en) 2003-12-31
AU2003238209A1 (en) 2004-01-06
CN1662494A (en) 2005-08-31
MXPA04012308A (en) 2005-02-25
MA27251A1 (en) 2005-03-01
AU2003238209B2 (en) 2009-01-22
KR20050010061A (en) 2005-01-26
DE50310161D1 (en) 2008-08-28
ES2310662T3 (en) 2009-01-16
ATE401304T1 (en) 2008-08-15
RU2315753C2 (en) 2008-01-27
JP2005533071A (en) 2005-11-04
IL165790A (en) 2010-04-15
RU2005101088A (en) 2005-06-27
NO20050088L (en) 2005-01-06
EP1517890A1 (en) 2005-03-30
EP1517890B1 (en) 2008-07-16
CA2490108A1 (en) 2003-12-31

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Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE

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Payment date: 20090602

Year of fee payment: 7

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