HRP20080129T3 - Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders - Google Patents
Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disordersInfo
- Publication number
- HRP20080129T3 HRP20080129T3 HR20080129T HRP20080129T HRP20080129T3 HR P20080129 T3 HRP20080129 T3 HR P20080129T3 HR 20080129 T HR20080129 T HR 20080129T HR P20080129 T HRP20080129 T HR P20080129T HR P20080129 T3 HRP20080129 T3 HR P20080129T3
- Authority
- HR
- Croatia
- Prior art keywords
- disorders
- carbon atoms
- halogen
- alkyl
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0400955A HU0400955D0 (en) | 2004-05-11 | 2004-05-11 | Pyridine derivatives of dialkyl oxindoles |
| HU0500463A HUP0500463A3 (en) | 2005-05-05 | 2005-05-05 | Pyridine derivatives of dialkyl-oxindoles |
| PCT/HU2005/000051 WO2005108390A1 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080129T3 true HRP20080129T3 (en) | 2008-04-30 |
Family
ID=89985998
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080129T HRP20080129T3 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
| HR20060403A HRP20060403A2 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20060403A HRP20060403A2 (en) | 2004-05-11 | 2005-05-11 | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US20070232662A1 (de) |
| EP (1) | EP1751138B9 (de) |
| JP (1) | JP2007537228A (de) |
| KR (1) | KR20070014189A (de) |
| AT (1) | ATE382045T1 (de) |
| AU (1) | AU2005240844A1 (de) |
| BG (1) | BG109770A (de) |
| CA (1) | CA2566426A1 (de) |
| CZ (1) | CZ2006772A3 (de) |
| DE (1) | DE602005004024T2 (de) |
| EA (1) | EA010865B1 (de) |
| ES (1) | ES2299033T3 (de) |
| HR (2) | HRP20080129T3 (de) |
| IL (1) | IL179030A0 (de) |
| MX (1) | MXPA06013065A (de) |
| NO (1) | NO20065661L (de) |
| PL (2) | PL1751138T3 (de) |
| PT (1) | PT1751138E (de) |
| RS (1) | RS20060622A (de) |
| SK (1) | SK51062006A3 (de) |
| WO (1) | WO2005108390A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1751134A1 (de) * | 2004-05-11 | 2007-02-14 | EGIS Gyógyszergyár Nyrt | Pyridinderivate von alkyloxindolen als auf den 5-ht7-rezeptor wirkende mittel |
| MXPA06013069A (es) | 2004-05-11 | 2007-03-30 | Egis Gyogyszergyar Nyrt | Derivados de 3-(((4-fenil) -piperazin-1-il) -alquil)-3 -alquil-1, 3-dihidro-2h -indol-2 -ona y compuestos relacionados para el tratamiento de trastornos del sistema nervioso central. |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8830312D0 (en) * | 1988-12-28 | 1989-02-22 | Lundbeck & Co As H | Heterocyclic compounds |
| US6407112B1 (en) * | 1998-04-22 | 2002-06-18 | Meiji Seika Kaisha, Ltd. | Optically active tetrahydrobenzindole derivative |
| FR2779429B1 (fr) * | 1998-06-03 | 2000-07-13 | Synthelabo | Derives d'oxindole, leurs preparations et leurs applications en therapeutique |
| AR035521A1 (es) * | 2000-12-22 | 2004-06-02 | Lundbeck & Co As H | Derivados de 3-indolina y composicion farmaceutica que los comprende |
-
2005
- 2005-05-11 WO PCT/HU2005/000051 patent/WO2005108390A1/en not_active Ceased
- 2005-05-11 AT AT05745439T patent/ATE382045T1/de not_active IP Right Cessation
- 2005-05-11 RS RSP-2006/0622A patent/RS20060622A/sr unknown
- 2005-05-11 HR HR20080129T patent/HRP20080129T3/xx unknown
- 2005-05-11 PT PT05745439T patent/PT1751138E/pt unknown
- 2005-05-11 CA CA002566426A patent/CA2566426A1/en not_active Abandoned
- 2005-05-11 KR KR1020067025313A patent/KR20070014189A/ko not_active Withdrawn
- 2005-05-11 EP EP05745439A patent/EP1751138B9/de not_active Expired - Lifetime
- 2005-05-11 AU AU2005240844A patent/AU2005240844A1/en not_active Abandoned
- 2005-05-11 CZ CZ20060772A patent/CZ2006772A3/cs unknown
- 2005-05-11 PL PL05745439T patent/PL1751138T3/pl unknown
- 2005-05-11 ES ES05745439T patent/ES2299033T3/es not_active Expired - Lifetime
- 2005-05-11 MX MXPA06013065A patent/MXPA06013065A/es active IP Right Grant
- 2005-05-11 HR HR20060403A patent/HRP20060403A2/xx not_active Application Discontinuation
- 2005-05-11 JP JP2007512358A patent/JP2007537228A/ja active Pending
- 2005-05-11 SK SK5106-2006A patent/SK51062006A3/sk not_active Application Discontinuation
- 2005-05-11 EA EA200602082A patent/EA010865B1/ru not_active IP Right Cessation
- 2005-05-11 PL PL381614A patent/PL381614A1/pl not_active Application Discontinuation
- 2005-05-11 DE DE602005004024T patent/DE602005004024T2/de not_active Expired - Fee Related
- 2005-05-11 US US11/596,471 patent/US20070232662A1/en not_active Abandoned
-
2006
- 2006-11-02 IL IL179030A patent/IL179030A0/en unknown
- 2006-12-06 NO NO20065661A patent/NO20065661L/no not_active Application Discontinuation
- 2006-12-11 BG BG109770A patent/BG109770A/bg unknown
-
2009
- 2009-07-09 US US12/500,335 patent/US20090281137A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1751138B9 (de) | 2008-11-12 |
| DE602005004024D1 (de) | 2008-02-07 |
| WO2005108390A1 (en) | 2005-11-17 |
| US20090281137A1 (en) | 2009-11-12 |
| ATE382045T1 (de) | 2008-01-15 |
| EP1751138A1 (de) | 2007-02-14 |
| PL381614A1 (pl) | 2007-06-11 |
| MXPA06013065A (es) | 2007-05-04 |
| SK51062006A3 (sk) | 2007-04-05 |
| IL179030A0 (en) | 2007-03-08 |
| HRP20060403A2 (en) | 2007-04-30 |
| RS20060622A (sr) | 2008-06-05 |
| KR20070014189A (ko) | 2007-01-31 |
| PT1751138E (pt) | 2008-02-25 |
| DE602005004024T2 (de) | 2008-12-24 |
| EA010865B1 (ru) | 2008-12-30 |
| PL1751138T3 (pl) | 2008-05-30 |
| EA200602082A1 (ru) | 2007-04-27 |
| CA2566426A1 (en) | 2005-11-17 |
| JP2007537228A (ja) | 2007-12-20 |
| EP1751138B1 (de) | 2007-12-26 |
| NO20065661L (no) | 2007-02-08 |
| CZ2006772A3 (cs) | 2007-03-14 |
| US20070232662A1 (en) | 2007-10-04 |
| BG109770A (bg) | 2008-05-30 |
| AU2005240844A1 (en) | 2005-11-17 |
| ES2299033T3 (es) | 2008-05-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20040429B1 (hr) | Derivati sulfonamida, njihova priprema i upotrebakao lijekova | |
| HRP20080477T3 (en) | Aryl-pyridine derivatives as 11-beta-hsd1 inhibitors | |
| YU48714B (sh) | Derivati benzofurana, benzotiofena, indola i indolizina i postupak za njihovo dobijanje | |
| HRP20171740T1 (hr) | Derivati 5-((halofenil)-3-hidroksi-piridin-2-yl-karboksilne kiseline kao posrednici za pripravu karbonilamino alkanoinskih kiselina, njihovih estera i amida | |
| HRP20080022T3 (en) | Pyrrolopyridine derivatives and their use as crth2 antagonists | |
| PE20040512A1 (es) | Compuesto de pirazol-pirimidina anilina | |
| HRP20080186T3 (en) | Use of tricyclic compounds as glycine transport inhibitors | |
| ATE556058T1 (de) | 1-(2h)-isochinolonderivat | |
| IL161559A0 (en) | Dibenzylamine derivatives and pharmaceutical compositions containing the same | |
| NO20005357L (no) | Sulfonamidholdige indolforbindelser | |
| DK419086A (da) | Heterocykliske substituerede indoler, mellemprodukter, fremgangsmaader til fremstilling heraf og laegemidler | |
| EA200100428A1 (ru) | Производные тетрагидробензазепина, полезные в качестве модуляторов допаминовых d3 рецепторов (антипсихотические агенты) | |
| BRPI0506817A (pt) | inibidores seletivos de quinase | |
| HRP20020109B1 (en) | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | |
| KR910004760A (ko) | 부식 억제제로서 케토산의 특정 아민 염을 함유하는 도료 조성물 | |
| EA201391537A1 (ru) | ЭТИНИЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ПОЛОЖИТЕЛЬНЫХ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ mGluR5 | |
| HRP20070498T3 (en) | Indanyl-piperazine derivatives, process for their preparation and pharmaceutical compositions containing them | |
| HRP20080119T3 (en) | Benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | |
| AR072103A1 (es) | Derivados de (piperazinilo con enlaces puente)-1- alcanona, su utilizacion como inhibidores de p75 y composiciones farmaceuticas que los contienen | |
| AR023111A1 (es) | Derivados de sulfonamida utiles como antagonistas del receptor 5-ht7, un procedimiento para su preparacion y composicion farmaceutica que los comprenden | |
| HRP20080129T3 (en) | Indol-2-one derivatives for the treatment of central nervous disorders, gastrointestinal disorders and cardiovascular disorders | |
| HRP20080097T5 (en) | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | |
| EA200401077A1 (ru) | 2-оксазоламины и их применение в качестве антагонистов рецептора 5-ht2b | |
| EA200900921A1 (ru) | НОВЫЕ СОЕДИНЕНИЯ АМИНОПИРРОЛО[1,2-a]ИНДОЛА И АМИНОПИРИДАЗИНО[1,6-a]ИНДОЛА, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ | |
| AR002259A1 (es) | Derivados de 1-oxo-2-(fenilsulfonilamino)pentilpiperidina, su preparacion, compuestos intermedios y composicion que contiene a dichos derivados. |