HRP20080186T3 - Use of tricyclic compounds as glycine transport inhibitors - Google Patents

Use of tricyclic compounds as glycine transport inhibitors

Info

Publication number: HRP20080186T3
Authority: HR; Croatia
Prior art keywords: group; alkyl; phenyl; groups; optionally substituted
Prior art date: 2003-10-17

Application number

HR20080186T

Other languages

English (en)

Croatian (hr)

Inventor

Dargazanli Gihad

Estenne-Bouhtou Geneviève

Magat Pascale

Marabout Beno�t

Roger Pierre

Original Assignee

Sanofi-Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-17

Filing date

2004-10-15

Publication date

2008-05-31

2004-10-15 Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis

2008-05-31 Publication of HRP20080186T3 publication Critical patent/HRP20080186T3/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Anesthesiology (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HR20080186T 2003-10-17 2004-10-15 Use of tricyclic compounds as glycine transport inhibitors HRP20080186T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0312165A FR2861076B1 (fr)	2003-10-17	2003-10-17	Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
PCT/FR2004/002643 WO2005037783A2 (fr)	2003-10-17	2004-10-15	Composes tricycliques comme inhibiteurs de transport de glycine

Publications (1)

Publication Number	Publication Date
HRP20080186T3 true HRP20080186T3 (en)	2008-05-31

Family

ID=34385252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20080186T HRP20080186T3 (en)	2003-10-17	2004-10-15	Use of tricyclic compounds as glycine transport inhibitors

Country Status (32)

Country	Link
US (3)	US7288656B2 (sr)
EP (1)	EP1680421B1 (sr)
JP (1)	JP4853918B2 (sr)
KR (1)	KR101125305B1 (sr)
CN (2)	CN101684118B (sr)
AT (1)	ATE386036T1 (sr)
AU (1)	AU2004281217B2 (sr)
BR (1)	BRPI0415489A (sr)
CA (1)	CA2542647C (sr)
CR (1)	CR8342A (sr)
CY (1)	CY1108925T1 (sr)
DE (1)	DE602004011806T2 (sr)
DK (1)	DK1680421T3 (sr)
EC (1)	ECSP066511A (sr)
ES (1)	ES2300837T3 (sr)
FR (1)	FR2861076B1 (sr)
HR (1)	HRP20080186T3 (sr)
IL (1)	IL174940A (sr)
MA (1)	MA28099A1 (sr)
ME (1)	ME00111B (sr)
NO (1)	NO335462B1 (sr)
NZ (1)	NZ547163A (sr)
OA (1)	OA13317A (sr)
PL (1)	PL1680421T3 (sr)
PT (1)	PT1680421E (sr)
RS (2)	RS51587B (sr)
RU (1)	RU2346945C2 (sr)
SG (1)	SG147435A1 (sr)
TN (1)	TNSN06110A1 (sr)
UA (1)	UA81186C2 (sr)
WO (1)	WO2005037783A2 (sr)
ZA (1)	ZA200603861B (sr)

Families Citing this family (39)

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FR2842804B1 (fr)	2002-07-29	2004-09-03	Sanofi Synthelabo	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861076B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique
FR2861074B1 (fr) *	2003-10-17	2006-04-07	Sanofi Synthelabo	Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
FR2861071B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
EP1734962A4 (en) *	2004-03-30	2010-07-14	Painceptor Pharma Corp	COMPOSITIONS AND METHOD FOR MODULATING CONTROLLED ION CHANNELS
FR2906251B1 (fr) *	2006-09-22	2008-11-07	Sanofi Aventis Sa	Derives de pyrrolizine, indolizine et quinolizine, leur preparation et leur application en therapeutique
US11817637B2 (en)	2006-11-18	2023-11-14	Rfmicron, Inc.	Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
US9582981B2 (en)	2014-10-08	2017-02-28	Rfmicron, Inc.	Radio frequency identification (RFID) moisture tag(s) and sensors with extended sensing via capillaries
TW200911808A (en) *	2007-07-23	2009-03-16	Astrazeneca Ab	Novel compounds
EP2178842A2 (en)	2007-08-22	2010-04-28	Abbott GmbH & Co. KG	4-benzylaminoquinolines, pharmaceutical compositions containing them and their use
ES2397764T3 (es)	2008-04-01	2013-03-11	Abbott Gmbh & Co. Kg	Tetrahidroisoquinolinas, composiciones farmacéuticas que las contienen, y su uso en terapia
CN102256975A (zh) *	2008-12-04	2011-11-23	赛诺菲	氮杂二环-三氟甲基苯甲酰胺衍生物的新的多晶型形式
AR075182A1 (es) *	2009-01-28	2011-03-16	Astrazeneca Ab	Compuestos 2-aza-biciclo (2.2.2) octano y sus usos
UY32397A (es) *	2009-01-28	2010-08-31	Astrazeneca Ab	Compuestos de 2-aza-biciclo [2,2,1] heptano y sus usos
FR2941954B1 (fr) *	2009-02-10	2011-04-08	Sanofi Aventis	Derives de n-°(6-aza-bicyclo°3.2.1!oct-1-yl)-aryl-methyl! benzamide, leur preparation et leur application en therapeutique
FR2941953B1 (fr) *	2009-02-10	2011-04-08	Sanofi Aventis	Derives de n-°(2-aza-bicyclo°2.1.1!hex-1-yl)-benzamide, leur preparation et leur application en therapeutique
AR075442A1 (es)	2009-02-16	2011-03-30	Abbott Gmbh & Co Kg	Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
TW201038569A (en)	2009-02-16	2010-11-01	Abbott Gmbh & Co Kg	Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
CA2755526A1 (fr) *	2009-03-16	2010-09-23	Sanofi	Derives de n-[(2-aza-bicyclo[2.1.1]hex-1-yl)-aryl-methyl]-heterobenzamide, leur preparation et leur application en therapeutique
FR2943059A1 (fr) *	2009-03-16	2010-09-17	Sanofi Aventis	Derives de n-°6-aza-bicyclo°3.2.1!oct-5-yl)-aryl-methyl!- heterobenzamide,leur preparation et leur application en therapeutique
FR2943056A1 (fr) *	2009-03-16	2010-09-17	Sanofi Aventis	Derives de n-°2-aza-bicyclo°2.1.1!hex-1-yl)-aryl-methyl!- heterobenzamide, leur preparation et leur application en therapeutique
FR2944284A1 (fr) *	2009-04-14	2010-10-15	Sanofi Aventis	Derives de n-°7-aza-bicyclo°2.2.1!hept-1-yl)-aryl-methyl! -benzamide, leur preparation et leur application en therapeutique
US8153653B2 (en) *	2010-06-22	2012-04-10	Hoffmann-La Roche Inc.	Amido-tropane derivatives
US9045459B2 (en) *	2010-08-13	2015-06-02	AbbVie Deutschland GmbH & Co. KG	Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en)	2010-08-13	2014-11-11	Abbott Laboratories	Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en)	2010-08-13	2014-09-30	Abbott Laboratories	Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en)	2010-08-13	2015-06-09	AbbVie Deutschland GmbH & Co. KG	Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en)	2010-08-13	2014-11-04	Abbott Laboratories	Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en)	2011-05-12	2016-04-12	AbbVie Deutschland GmbH & Co. KG	Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
JP2014521682A (ja)	2011-08-05	2014-08-28	アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー	アミノクロマン、アミノチオクロマンおよびアミノ−１，２，３，４−テトラヒドロキノリン誘導体、これらを含有する医薬組成物、ならびに治療におけるこれらの使用
EP2780328A1 (en)	2011-11-18	2014-09-24	Abbvie Deutschland GmbH & Co. KG	N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2013081400A2 (ko) *	2011-11-29	2013-06-06	주식회사 비보존	신규한 벤즈아마이드 유도체 및 그 용도
US9365512B2 (en)	2012-02-13	2016-06-14	AbbVie Deutschland GmbH & Co. KG	Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en)	2013-03-15	2017-05-23	Abbvie Inc.	Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en)	2013-03-15	2017-05-16	Abbvie Inc.	Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2016004936A (es)	2013-10-17	2016-12-20	Abbvie Deutschland	Derivados de aminocromano, aminotiocromano y amino-1,2,3,4-tetrahi droquinilina, composiciones farmaceuticas que los contienen, y su uso en terapia.
WO2015055771A1 (en)	2013-10-17	2015-04-23	AbbVie Deutschland GmbH & Co. KG	Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9550754B2 (en)	2014-09-11	2017-01-24	AbbVie Deutschland GmbH & Co. KG	4,5-dihydropyrazole derivatives, pharmaceutical compositions containing them, and their use in therapy
JP6906227B2 (ja) *	2017-08-18	2021-07-21	国立大学法人千葉大学	ハロゲン結合ドナー／有機塩基複合型化合物及び酸塩基複合触媒

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US4066662A (en)	1973-12-14	1978-01-03	Science Union Et Cie., Societe Francaise De Recherche Medicale	N-substituted-2-aminomethyl-3-azabicyclo(3,3,0)octane compounds
IE56226B1 (en)	1982-04-14	1991-05-22	Beecham Group Plc	Substituted azabicyclo compounds,process for their preparation and pharmaceutical compositions containing them
EP0272052B1 (en)	1986-12-16	1992-07-08	A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation)	Anxiolytic-N-(1-Azabicyclo[2.2.2]Oct-3-yl) Benzamides and Thobenzamides
GB8720805D0 (en)	1987-09-04	1987-10-14	Naylor R J	2-alkoxy-n-(1-azabicyclo(2 2 2)oct-3-yl)benzamides & thiobenzamides
SE9600683D0 (sv) *	1996-02-23	1996-02-23	Astra Ab	Azabicyclic esters of carbamic acids useful in therapy
CN1291984A (zh) *	1998-03-06	2001-04-18	詹森药业有限公司	甘氨酸传输抑制剂
FR2861076B1 (fr) *	2003-10-17	2006-01-06	Sanofi Synthelabo	Derives de n-heterocyclymethylbenzamide, leur preparation et leur application en therapeutique

2003
- 2003-10-17 FR FR0312165A patent/FR2861076B1/fr not_active Expired - Lifetime
2004
- 2004-10-15 UA UAA200605374A patent/UA81186C2/uk unknown
- 2004-10-15 JP JP2006534800A patent/JP4853918B2/ja not_active Expired - Fee Related
- 2004-10-15 NZ NZ547163A patent/NZ547163A/en not_active IP Right Cessation
- 2004-10-15 ES ES04791554T patent/ES2300837T3/es not_active Expired - Lifetime
- 2004-10-15 PT PT04791554T patent/PT1680421E/pt unknown
- 2004-10-15 AT AT04791554T patent/ATE386036T1/de active
- 2004-10-15 CA CA2542647A patent/CA2542647C/fr not_active Expired - Fee Related
- 2004-10-15 EP EP04791554A patent/EP1680421B1/fr not_active Expired - Lifetime
- 2004-10-15 ME MEP-2008-122A patent/ME00111B/me unknown
- 2004-10-15 CN CN2009101638818A patent/CN101684118B/zh not_active Expired - Fee Related
- 2004-10-15 ZA ZA200603861A patent/ZA200603861B/en unknown
- 2004-10-15 DK DK04791554T patent/DK1680421T3/da active
- 2004-10-15 WO PCT/FR2004/002643 patent/WO2005037783A2/fr not_active Ceased
- 2004-10-15 SG SG200807634-1A patent/SG147435A1/en unknown
- 2004-10-15 RU RU2006116889/04A patent/RU2346945C2/ru not_active IP Right Cessation
- 2004-10-15 RS RS20060314A patent/RS51587B/sr unknown
- 2004-10-15 DE DE602004011806T patent/DE602004011806T2/de not_active Expired - Lifetime
- 2004-10-15 OA OA1200600127A patent/OA13317A/fr unknown
- 2004-10-15 CN CN2004800335688A patent/CN1882587B/zh not_active Expired - Fee Related
- 2004-10-15 RS YUP-2006/0314A patent/RS20060314A/sr unknown
- 2004-10-15 AU AU2004281217A patent/AU2004281217B2/en not_active Ceased
- 2004-10-15 KR KR1020067007370A patent/KR101125305B1/ko not_active Expired - Fee Related
- 2004-10-15 BR BRPI0415489-4A patent/BRPI0415489A/pt not_active IP Right Cessation
- 2004-10-15 PL PL04791554T patent/PL1680421T3/pl unknown
- 2004-10-15 HR HR20080186T patent/HRP20080186T3/xx unknown
2006
- 2006-04-11 IL IL174940A patent/IL174940A/en not_active IP Right Cessation
- 2006-04-14 US US11/404,273 patent/US7288656B2/en not_active Expired - Lifetime
- 2006-04-17 TN TNP2006000110A patent/TNSN06110A1/fr unknown
- 2006-04-17 MA MA28944A patent/MA28099A1/fr unknown
- 2006-04-17 EC EC2006006511A patent/ECSP066511A/es unknown
- 2006-04-18 CR CR8342A patent/CR8342A/es unknown
- 2006-05-05 NO NO20062030A patent/NO335462B1/no not_active IP Right Cessation
2007
- 2007-09-20 US US11/858,436 patent/US7619089B2/en not_active Expired - Lifetime
2008
- 2008-05-12 CY CY20081100494T patent/CY1108925T1/el unknown
2009
- 2009-10-05 US US12/573,470 patent/US8513246B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4853918B2 (ja)	2012-01-11
NO335462B1 (no)	2014-12-15
CY1108925T1 (el)	2014-07-02
US20060264441A1 (en)	2006-11-23
ZA200603861B (en)	2007-12-27
CR8342A (es)	2006-10-04
MEP12208A (en)	2010-06-10
FR2861076B1 (fr)	2006-01-06
ATE386036T1 (de)	2008-03-15
AU2004281217A1 (en)	2005-04-28
KR20060109432A (ko)	2006-10-20
HK1098465A1 (en)	2007-07-20
DE602004011806D1 (de)	2008-03-27
US20080070941A1 (en)	2008-03-20
RU2346945C2 (ru)	2009-02-20
CN101684118B (zh)	2013-04-10
RU2006116889A (ru)	2007-11-27
HK1142887A1 (en)	2010-12-17
DE602004011806T2 (de)	2009-02-05
ES2300837T3 (es)	2008-06-16
WO2005037783A2 (fr)	2005-04-28
PT1680421E (pt)	2008-05-13
UA81186C2 (en)	2007-12-10
EP1680421A2 (fr)	2006-07-19
NO20062030L (no)	2006-07-07
CA2542647A1 (fr)	2005-04-28
FR2861076A1 (fr)	2005-04-22
DK1680421T3 (da)	2008-06-09
AU2004281217B2 (en)	2010-07-22
US8513246B2 (en)	2013-08-20
CN1882587B (zh)	2012-06-27
PL1680421T3 (pl)	2008-07-31
CA2542647C (fr)	2012-07-10
SG147435A1 (en)	2008-11-28
CN1882587A (zh)	2006-12-20
JP2007508361A (ja)	2007-04-05
EP1680421B1 (fr)	2008-02-13
ECSP066511A (es)	2006-10-10
NZ547163A (en)	2010-01-29
CN101684118A (zh)	2010-03-31
RS20060314A (sr)	2008-08-07
WO2005037783A3 (fr)	2005-07-07
US20100022548A1 (en)	2010-01-28
IL174940A (en)	2010-11-30
IL174940A0 (en)	2006-08-20
RS51587B (sr)	2011-08-31
US7619089B2 (en)	2009-11-17
US7288656B2 (en)	2007-10-30
TNSN06110A1 (fr)	2007-11-15
MA28099A1 (fr)	2006-08-01
ME00111B (me)	2010-10-10
BRPI0415489A (pt)	2006-12-26
KR101125305B1 (ko)	2012-03-27
OA13317A (fr)	2007-04-13

Publication	Publication Date	Title
GB0113233D0 (en)	2001-07-25	Chemical compounds
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HRP20080064T5 (en)	2008-10-31	Prodrugs of piperazine and substituted piperidine antiviral agents
DK1178967T3 (da)	2006-06-26	Quinolinderivater som inhibitorer af MEK-enzymer
EA200401381A1 (ru)	2005-04-28	3-гетероарилзамещённые изоксазолины
AR036093A1 (es)	2004-08-11	Compuestos derivados de tiazolidinilo, pirrolidinilo, oxazolidinilo, piperidilo, morfolinilo y tiomorfolinilo, su uso, composiciones farmaceuticas que los comprenden, y compuestos intermediarios
WO2005037783A3 (fr)	2005-07-07	Composes tricycliques comme inhibiteurs de transport de glycine
WO2005037781A3 (fr)	2005-07-14	Derives de n-[heteroaryl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
CO5611139A2 (es)	2006-02-28	Pirimidinas aril sustituidas y el uso de las mismas
HRP20020317B1 (en)	2007-08-31	Pharmaceutically active compounds
EA201170096A1 (ru)	2011-08-30	Замещенные производные пиримидона
MEP24208A (en)	2010-06-10	Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics
EA200971061A1 (ru)	2010-04-30	Пиримидоновые соединения гетероариламидов
NO20015446L (no)	2001-12-12	Kinolin-derivater som inhibitorer for MEK-enzymer
AR049418A1 (es)	2006-08-02	Derivados de heteroarilaminopirazol y composiciones farmaceuticas para el tratamiento de la diabetes.
EP1961734A4 (en)	2009-03-25	AMINE CONNECTION AND ITS USE FOR MEDICAL PURPOSES
AR052915A1 (es)	2007-04-11	Derivados de pirrolidin y piperidin acetileno
HRP20070584T3 (hr)	2008-01-31	Derivati aminokinolina i njihova uporaba kao adenozin a3 liganda
ES2177275T3 (es)	2002-12-01	Derivados de oxadiazolina y su uso como insecticidas.
DK1202954T3 (da)	2004-02-09	Nye aminobenzophenoner
TW200517387A (en)	2005-06-01	Compounds exhibiting thrombopoietin receptor agonism
ATE445619T1 (de)	2009-10-15	Pyridinylpyrazolopyrimidinon-derivate als pde 7 inhibitoren
CO5650235A2 (es)	2006-06-30	Derivados de imidazol
MEP24408A (en)	2010-10-10	Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, the preparation thereof and the application of same in therapeutics
CO4700285A1 (es)	1998-12-29	Derivados de 1-oxo-2-(fenilsulfonilamino)pentilpiperidina, su preparacion y su aplciacion en la terapeutica