HRP20090160T1 - Amino-tropane derivatives, preparation thereof and therapeutic use thereof - Google Patents

Amino-tropane derivatives, preparation thereof and therapeutic use thereof

Info

Publication number
HRP20090160T1
HRP20090160T1 HR20090160T HRP20090160T HRP20090160T1 HR P20090160 T1 HRP20090160 T1 HR P20090160T1 HR 20090160 T HR20090160 T HR 20090160T HR P20090160 T HRP20090160 T HR P20090160T HR P20090160 T1 HRP20090160 T1 HR P20090160T1
Authority
HR
Croatia
Prior art keywords
cycloalkyl
alkyl
group
hydrogen atom
aryl
Prior art date
Application number
HR20090160T
Other languages
English (en)
Croatian (hr)
Inventor
Braun Alain
Cornet Bruno
Courtemanche Gilles
Crespin Olivier
Pascal C�cile
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of HRP20090160T1 publication Critical patent/HRP20090160T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Addiction (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HR20090160T 2004-07-29 2005-07-20 Amino-tropane derivatives, preparation thereof and therapeutic use thereof HRP20090160T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0408372A FR2873693B1 (fr) 2004-07-29 2004-07-29 Derives d'amino-tropane, leur preparation et leur application en therapeutique
PCT/FR2005/001856 WO2006021657A1 (fr) 2004-07-29 2005-07-20 Derives d'amino-tropane, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
HRP20090160T1 true HRP20090160T1 (en) 2009-05-31

Family

ID=34947491

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090160T HRP20090160T1 (en) 2004-07-29 2005-07-20 Amino-tropane derivatives, preparation thereof and therapeutic use thereof

Country Status (26)

Country Link
US (1) US7569582B2 (pl)
EP (1) EP1773829B1 (pl)
JP (1) JP2008508242A (pl)
KR (1) KR20070047803A (pl)
CN (1) CN101010320B (pl)
AR (1) AR050019A1 (pl)
AT (1) ATE417846T1 (pl)
AU (1) AU2005276355B2 (pl)
BR (1) BRPI0513923A (pl)
CA (1) CA2574517A1 (pl)
CY (1) CY1108878T1 (pl)
DE (1) DE602005011818D1 (pl)
DK (1) DK1773829T3 (pl)
ES (1) ES2319918T3 (pl)
FR (1) FR2873693B1 (pl)
HR (1) HRP20090160T1 (pl)
IL (1) IL180797A (pl)
MX (1) MX2007001023A (pl)
PE (1) PE20060575A1 (pl)
PL (1) PL1773829T3 (pl)
PT (1) PT1773829E (pl)
RU (1) RU2389727C2 (pl)
SI (1) SI1773829T1 (pl)
TW (1) TW200617005A (pl)
UY (1) UY29040A1 (pl)
WO (1) WO2006021657A1 (pl)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873691B1 (fr) * 2004-07-29 2006-10-06 Sanofi Synthelabo Derives d'amino-piperidine, leur preparation et leur application en therapeutique
FR2873690B1 (fr) * 2004-07-29 2006-10-13 Sanofi Synthelabo Derives d'oxopiperidine, leur preparation et leur application en therapeutique
WO2007028770A1 (en) * 2005-09-05 2007-03-15 Neurosearch A/S Monoamine neurotransmitter re-uptake inhibitors for neuroprotection in patients suffering from an advanced stage of a mental disease
PL2305263T3 (pl) * 2007-06-07 2012-12-31 Novartis Ag Stabilizowane amorficzne formy mesylanu imatinibu
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
SI2074120T1 (sl) * 2007-10-25 2010-06-30 Exelixis Inc Tropan spojine
US8153653B2 (en) * 2010-06-22 2012-04-10 Hoffmann-La Roche Inc. Amido-tropane derivatives
EP2683703B1 (de) 2011-03-08 2015-05-27 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8846666B2 (en) 2011-03-08 2014-09-30 Sanofi Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683698B1 (de) 2011-03-08 2017-10-04 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968929A (en) * 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
AU733454B2 (en) * 1996-10-30 2001-05-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
FR2762316B1 (fr) * 1997-04-18 1999-12-17 Sanofi Synthelabo Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
EP1358163A1 (en) * 2001-01-23 2003-11-05 Eli Lilly And Company Melanocortin receptor agonists
WO2003007949A1 (en) * 2001-07-18 2003-01-30 Merck & Co., Inc. Bridged piperidine derivatives as melanocortin receptor agonists
EP1469851B1 (en) * 2002-01-23 2006-10-11 Eli Lilly And Company Melanocortin receptor agonists

Also Published As

Publication number Publication date
CA2574517A1 (fr) 2006-03-02
IL180797A (en) 2011-02-28
AR050019A1 (es) 2006-09-20
CN101010320B (zh) 2011-11-16
RU2389727C2 (ru) 2010-05-20
AU2005276355A1 (en) 2006-03-02
MX2007001023A (es) 2007-04-16
FR2873693A1 (fr) 2006-02-03
EP1773829A1 (fr) 2007-04-18
US7569582B2 (en) 2009-08-04
DK1773829T3 (da) 2009-04-20
RU2007107372A (ru) 2008-09-10
BRPI0513923A (pt) 2008-05-20
TW200617005A (en) 2006-06-01
FR2873693B1 (fr) 2006-09-15
US20070191361A1 (en) 2007-08-16
CN101010320A (zh) 2007-08-01
WO2006021657A1 (fr) 2006-03-02
ES2319918T3 (es) 2009-05-14
IL180797A0 (en) 2007-06-03
UY29040A1 (es) 2006-02-24
KR20070047803A (ko) 2007-05-07
DE602005011818D1 (de) 2009-01-29
CY1108878T1 (el) 2014-07-02
JP2008508242A (ja) 2008-03-21
PL1773829T3 (pl) 2009-06-30
EP1773829B1 (fr) 2008-12-17
SI1773829T1 (sl) 2009-06-30
PE20060575A1 (es) 2006-08-02
ATE417846T1 (de) 2009-01-15
PT1773829E (pt) 2009-03-26
AU2005276355B2 (en) 2011-08-25

Similar Documents

Publication Publication Date Title
HUP0300329A2 (hu) Malonaminsavak és származékai és alkalmazásuk pajzsmirigy receptor ligandumként és ezeket tartalmazó gyógyszerkészítmények előállítására
NO20065830L (no) Substituerte 2-kinolyloksazoler som er anvendbare som PDE4-inhibitorer.
AR062666A1 (es) Benzotriazoles como moduladores de quinasas
HUP0301671A2 (hu) 4-Fenil-piridin-származékok, mint neurokinin-1-receptor antagonisták, eljárás az előállításukra és alkalmazásuk
HRP20110498T1 (hr) Azetidini kao inhibitori mek za liječenje proliferativnih bolesti
MXPA04001240A (es) Analogos antitumorales.
AR045219A1 (es) Aminas ciclicas inhibidoras de base - 1 que poseen un sustiuyente heterociclico
AR035825A1 (es) Ciclobuten-1,2-dionas 3,4-di-sustituidas y sus sales como ligandos del receptor de cxc-quimiocina, composiciones farmaceuticas y el uso de las mismas para la fabricacion de un medicamento
AR036093A1 (es) Compuestos derivados de tiazolidinilo, pirrolidinilo, oxazolidinilo, piperidilo, morfolinilo y tiomorfolinilo, su uso, composiciones farmaceuticas que los comprenden, y compuestos intermediarios
AR037418A1 (es) Derivados de benzotiazol
DE69534164D1 (de) Tri-substituierte phenyl-derivate verwendbar als pde iv hemmer
ES2369837T3 (es) Compuestos triheterocíclicos como antagonistas de receptor cfr.
HUP0401211A2 (hu) Helyettesített pirazolo-pirimidinek és tiazolo-pirimidinek, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
HUP0203895A2 (hu) Szubsztituált azaindolok és ilyen vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
PE20020062A1 (es) 5-AMINO-PIRAZOLO-[4,3-e]-1,2,4-TRIAZOLO[1,5-c]PIRIMIDINA COMO ANTAGONISTAS RECEPTORES DE ADENOSINA A2a
HUP9800541A1 (hu) Hipolipémiás hatású 1,4-benzotiazepin-1,1-dioxid-származékok, eljárás előállításukra, intermedierjeik és vegyületeket tartalmazó gyógyszerkészítmények
PE20061164A1 (es) Piperazin-piperidinas sustituidas con pirazinilo con actividad antagonista de cxcr3
TW200621768A (en) Aminopiperidine derivatives, preparation thereof and therapeutic use thereof
CO5031246A1 (es) Compuestos calciliticos
AR046753A1 (es) Derivados de benzoxazina y usos de los mismos
DE60327922D1 (de) Harnstoff-linker verbindungen und ihre verwendung als ppar regulatoren
ATE182889T1 (de) Bicyclische amidinderivate als no-synthetase inhibitoren
ATE482933T1 (de) Sulfopyrrolderivate
HRP20070584T3 (hr) Derivati aminokinolina i njihova uporaba kao adenozin a3 liganda
TW200617005A (en) Aminotropane derivatives, preparation thereof and therapeutic use thereof