HRP20100543T1 - Glp-1 pegilirani spojevi - Google Patents

Glp-1 pegilirani spojevi Download PDF

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Publication number
HRP20100543T1
HRP20100543T1 HR20100543T HRP20100543T HRP20100543T1 HR P20100543 T1 HRP20100543 T1 HR P20100543T1 HR 20100543 T HR20100543 T HR 20100543T HR P20100543 T HRP20100543 T HR P20100543T HR P20100543 T1 HRP20100543 T1 HR P20100543T1
Authority
HR
Croatia
Prior art keywords
compound according
pegylated glp
glp
val
cys46
Prior art date
Application number
HR20100543T
Other languages
English (en)
Croatian (hr)
Inventor
Zhang Lianshan
Mark Vick Andrew
Lee Junior Millican Rohn
Philip Mayer John
Glaesner Wolfgang
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of HRP20100543T1 publication Critical patent/HRP20100543T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
HR20100543T 2005-05-13 2006-05-11 Glp-1 pegilirani spojevi HRP20100543T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68068805P 2005-05-13 2005-05-13
PCT/US2006/018284 WO2006124529A1 (en) 2005-05-13 2006-05-11 Glp-1 pegylated compounds

Publications (1)

Publication Number Publication Date
HRP20100543T1 true HRP20100543T1 (hr) 2010-11-30

Family

ID=36926842

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20100543T HRP20100543T1 (hr) 2005-05-13 2006-05-11 Glp-1 pegilirani spojevi

Country Status (25)

Country Link
US (1) US8183340B2 (2)
EP (1) EP1881850B1 (2)
JP (2) JP5225074B2 (2)
KR (1) KR101011081B1 (2)
CN (1) CN101166545B (2)
AT (1) ATE482724T1 (2)
AU (1) AU2006247734B2 (2)
BR (1) BRPI0609676A2 (2)
CA (1) CA2608311C (2)
CY (1) CY1110853T1 (2)
DE (1) DE602006017202D1 (2)
DK (1) DK1881850T3 (2)
EA (1) EA012442B1 (2)
ES (1) ES2350852T3 (2)
HR (1) HRP20100543T1 (2)
IL (1) IL186772A0 (2)
ME (1) ME02786B (2)
MX (1) MX2007014052A (2)
NO (1) NO20076415L (2)
PL (1) PL1881850T3 (2)
PT (1) PT1881850E (2)
RS (1) RS51637B (2)
SI (1) SI1881850T1 (2)
UA (1) UA90896C2 (2)
WO (1) WO2006124529A1 (2)

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US20090215981A1 (en) 2009-08-27
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CN101166545A (zh) 2008-04-23
NO20076415L (no) 2007-12-12
EP1881850B1 (en) 2010-09-29
AU2006247734A1 (en) 2006-11-23
CA2608311A1 (en) 2006-11-23
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PL1881850T3 (pl) 2011-03-31
US8183340B2 (en) 2012-05-22
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CA2608311C (en) 2012-11-27
UA90896C2 (en) 2010-06-10
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DE602006017202D1 (de) 2010-11-11
IL186772A0 (en) 2008-02-09
WO2006124529A1 (en) 2006-11-23
JP2008540565A (ja) 2008-11-20
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CN101166545B (zh) 2011-06-15
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DK1881850T3 (da) 2011-01-03
BRPI0609676A2 (pt) 2011-10-18

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