HRP20110006T1 - 5-supstituirani-2-fenilaminobenzamidi kao inhibitori mek - Google Patents

5-supstituirani-2-fenilaminobenzamidi kao inhibitori mek Download PDF

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Publication number
HRP20110006T1
HRP20110006T1 HR20110006T HRP20110006T HRP20110006T1 HR P20110006 T1 HRP20110006 T1 HR P20110006T1 HR 20110006 T HR20110006 T HR 20110006T HR P20110006 T HRP20110006 T HR P20110006T HR P20110006 T1 HRP20110006 T1 HR P20110006T1
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HR
Croatia
Prior art keywords
group
hydroxyethoxy
difluoro
benzamide
alkyl group
Prior art date
Application number
HR20110006T
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English (en)
Croatian (hr)
Inventor
Isshiki Yoshiaki
Kohchi Yasunori
Mizuguchi Eisaku
Iikura Hitoshi
Matsubara Yasuaki
Tsujii Shinji
Shimma Nobuo
Miwa Masanori
Aida Satoshi
Kohchi Masami
Murata Takeshi
Aso Kosuke
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
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Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of HRP20110006T1 publication Critical patent/HRP20110006T1/hr

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    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/26—2-Pyrrolidones
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    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
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    • C07D263/18—Oxygen atoms
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    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
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  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Hematology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
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  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
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  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
HR20110006T 2004-07-26 2005-07-26 5-supstituirani-2-fenilaminobenzamidi kao inhibitori mek HRP20110006T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004218004 2004-07-26
JP2005072093 2005-03-14
PCT/JP2005/013620 WO2006011466A1 (ja) 2004-07-26 2005-07-26 Mek阻害物質としての５－置換－２－フェニルアミノ－ベンズアミド類

Publications (1)

Publication Number Publication Date
HRP20110006T1 true HRP20110006T1 (hr) 2011-02-28

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ID=35786215

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110006T HRP20110006T1 (hr) 2004-07-26 2005-07-26 5-supstituirani-2-fenilaminobenzamidi kao inhibitori mek

Country Status (26)

Country Link
US (2) US7745663B2 (sr)
EP (1) EP1780197B9 (sr)
JP (1) JP4090070B2 (sr)
KR (1) KR101153556B1 (sr)
CN (1) CN101124199B (sr)
AT (1) ATE485265T1 (sr)
AU (1) AU2005265769B2 (sr)
BR (1) BRPI0513750A (sr)
CA (1) CA2575232C (sr)
CY (1) CY1110969T1 (sr)
DE (1) DE602005024279D1 (sr)
DK (1) DK1780197T3 (sr)
ES (1) ES2354822T3 (sr)
HR (1) HRP20110006T1 (sr)
IL (1) IL179634A (sr)
MX (1) MX2007000736A (sr)
MY (1) MY144232A (sr)
NO (1) NO20071042L (sr)
NZ (1) NZ551812A (sr)
PL (1) PL1780197T3 (sr)
PT (1) PT1780197E (sr)
RS (1) RS51783B (sr)
SG (2) SG151286A1 (sr)
SI (1) SI1780197T1 (sr)
TW (1) TWI361066B (sr)
WO (1) WO2006011466A1 (sr)

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* Cited by examiner, † Cited by third party
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WO2005028426A1 (ja) 2003-09-19 2005-03-31 Chugai Seiyaku Kabushiki Kaisha 新規４−フェニルアミノ−ベンズアルドオキシム誘導体並びにそのmek阻害剤としての使用
TWI361066B (en) 2004-07-26 2012-04-01 Chugai Pharmaceutical Co Ltd 5-substituted-2-phenylamino benzamides as mek inhibitors
CN103524392B (zh) 2005-10-07 2018-06-01 埃克塞利希斯股份有限公司 作为用于治疗增生性疾病的mek 抑制剂的吖丁啶
ES2703723T3 (es) 2006-12-14 2019-03-12 Exelixis Inc Métodos para usar inhibidores de MEK
EP2370568B1 (en) 2008-12-10 2017-07-19 Dana-Farber Cancer Institute, Inc. Mek mutations conferring resistance to mek inhibitors
CN102666512B (zh) * 2009-10-13 2014-11-26 奥斯特姆医疗公司 对疾病治疗有用的mek抑制剂
EP3028699B1 (en) 2010-02-25 2018-03-21 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
EP2545187B1 (en) 2010-03-09 2018-09-05 Dana-Farber Cancer Institute, Inc. Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
WO2012018639A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
ES2575995T3 (es) * 2010-08-05 2016-07-04 Case Western Reserve University Inhibidores de ERK para trastornos del desarrollo de la conectividad neuronal
US20130123255A1 (en) * 2011-11-10 2013-05-16 Chugai Seiyaku Kabushiki Kaisha Combination of a pi3k inhibitor and a mek inhibitor
GB201201332D0 (en) 2012-01-26 2012-03-14 Imp Innovations Ltd Method
WO2013169858A1 (en) 2012-05-08 2013-11-14 The Broad Institute, Inc. Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
HRP20180670T1 (hr) 2012-10-12 2018-07-13 Exelixis Inc. Novi postupak dobivanja spojeva namijenjenih upotrebi u liječenju raka
JP2016034900A (ja) * 2012-11-26 2016-03-17 中外製薬株式会社 ５−置換−２−フェニルアミノ−ベンズアミド類の製造方法
JP2016034901A (ja) * 2012-11-26 2016-03-17 中外製薬株式会社 ３，４−ジフルオロ−２−（２−フルオロ−４−ヨード−フェニルアミノ）−ｎ−（２−ヒドロキシ−エトキシ）−５−（３−オキソ−［１，２］オキサジナン−２−イルメチル）−ベンズアミドの新規結晶形
EP3249054A1 (en) 2012-12-20 2017-11-29 Biomatrica, INC. Formulations and methods for stabilizing pcr reagents
WO2014133071A1 (ja) 2013-02-27 2014-09-04 第一三共株式会社 Ｍａｐｋシグナル伝達経路を阻害する化合物に対する応答性を予測する方法
JP6604942B2 (ja) 2013-06-13 2019-11-13 バイオマトリカ，インク． 細胞安定化
WO2015191632A1 (en) 2014-06-10 2015-12-17 Biomatrica, Inc. Stabilization of thrombocytes at ambient temperatures
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