HRP20110058T1 - 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazin kao spoj sa kombiniranom aktivnošću vezanom za ponovno preuzimanje serotonina i i 5-ht3 i 5ht1a aktivnošću, za liječenje bolova ili rezidualnih simptoma u depresiji vezanih za san i kogniciju - Google Patents

1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazin kao spoj sa kombiniranom aktivnošću vezanom za ponovno preuzimanje serotonina i i 5-ht3 i 5ht1a aktivnošću, za liječenje bolova ili rezidualnih simptoma u depresiji vezanih za san i kogniciju Download PDF

Info

Publication number
HRP20110058T1
HRP20110058T1 HR20110058T HRP20110058T HRP20110058T1 HR P20110058 T1 HRP20110058 T1 HR P20110058T1 HR 20110058 T HR20110058 T HR 20110058T HR P20110058 T HRP20110058 T HR P20110058T HR P20110058 T1 HRP20110058 T1 HR P20110058T1
Authority
HR
Croatia
Prior art keywords
compound
dimethylphenylsulfanyl
piperazine
phenyl
pain
Prior art date
Application number
HR20110058T
Other languages
English (en)
Croatian (hr)
Inventor
Moore Nicholas
Bryan Stensbol Tine
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39564604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20110058(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/DK2007/050075 external-priority patent/WO2007144005A1/en
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of HRP20110058T1 publication Critical patent/HRP20110058T1/hr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20110058T 2007-03-20 2008-03-14 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazin kao spoj sa kombiniranom aktivnošću vezanom za ponovno preuzimanje serotonina i i 5-ht3 i 5ht1a aktivnošću, za liječenje bolova ili rezidualnih simptoma u depresiji vezanih za san i kogniciju HRP20110058T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200700427 2007-03-20
PCT/DK2007/050075 WO2007144005A1 (en) 2006-06-16 2007-06-15 1- [2- (2, 4-dimethylphenylsulfanyl) -phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
PCT/DK2008/050063 WO2008113359A2 (en) 2007-03-20 2008-03-14 1- [2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of pain or residual symptoms in depression relating to sleep and cognition

Publications (1)

Publication Number Publication Date
HRP20110058T1 true HRP20110058T1 (hr) 2011-03-31

Family

ID=39564604

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110058T HRP20110058T1 (hr) 2007-03-20 2008-03-14 1-[2-(2,4-dimetilfenilsulfanil)fenil]piperazin kao spoj sa kombiniranom aktivnošću vezanom za ponovno preuzimanje serotonina i i 5-ht3 i 5ht1a aktivnošću, za liječenje bolova ili rezidualnih simptoma u depresiji vezanih za san i kogniciju

Country Status (29)

Country Link
US (1) US8664225B2 (da)
EP (1) EP2142193B1 (da)
JP (1) JP5371790B2 (da)
KR (1) KR101459168B1 (da)
CN (2) CN103948597A (da)
AR (1) AR065797A1 (da)
AT (1) ATE495745T1 (da)
AU (1) AU2008228638B2 (da)
BR (1) BRPI0808941A2 (da)
CA (1) CA2684571C (da)
CL (1) CL2008000795A1 (da)
CO (1) CO6220962A2 (da)
CY (1) CY1111183T1 (da)
DE (1) DE602008004643D1 (da)
DK (1) DK2142193T3 (da)
EA (1) EA017058B1 (da)
ES (1) ES2355434T3 (da)
HR (1) HRP20110058T1 (da)
IL (2) IL200956A (da)
MX (1) MX2009009672A (da)
MY (1) MY150448A (da)
NZ (1) NZ579721A (da)
PL (1) PL2142193T3 (da)
PT (1) PT2142193E (da)
RS (1) RS51560B (da)
SI (1) SI2142193T1 (da)
TW (1) TW200848411A (da)
UA (1) UA97392C2 (da)
WO (1) WO2008113359A2 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101627901B1 (ko) * 2006-06-16 2016-06-13 하. 룬트벡 아크티에 셀스카브 인지기능 장애의 치료를 위한, 세로토닌 재흡수, 5-ht3 및 5-ht1a 활성이 조합된 화합물로서의 1-[2-(2,4-디메틸페닐술파닐)-페닐]피페라진
TW200932233A (en) * 2007-11-13 2009-08-01 Lundbeck & Co As H Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1a activity
AU2014200364B2 (en) * 2007-11-13 2015-09-17 H. Lundbeck A/S Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1A activity
TW201033181A (en) * 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
WO2010121621A1 (en) 2009-04-24 2010-10-28 H. Lundbeck A/S Liquid formulations of salts of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
GEP20135950B (en) 2009-08-24 2013-10-25 H Lundbeck As New compositions containing 1-[2-(2,4-dimethyl-phenylsulfa-nyl)-phenyl]piperazine
WO2011136376A1 (ja) * 2010-04-30 2011-11-03 武田薬品工業株式会社 腸溶性錠剤
TW201212918A (en) 2010-08-23 2012-04-01 Lundbeck & Co As H Therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine
CN104797566B (zh) * 2012-09-19 2017-07-07 桑多斯股份公司 沃替西汀氢溴酸盐的新结晶形式
US20160200698A1 (en) 2013-09-12 2016-07-14 Hangzhou Pushai Pharmaceutical Technology Co., Ltd Vortioxetine salt and crystal thereof, their preparation method, pharmaceutical compositions and usage
EP2878596A1 (en) * 2013-11-29 2015-06-03 LEK Pharmaceuticals d.d. Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates
MX368870B (es) 2013-12-20 2019-10-21 H Lundbeck As Uso de un antagonista de receptores de opioides con actividad kappa y vortioxetina para el tratamiento de trastorno depresivo con características melancólicas.
EA029060B1 (ru) * 2014-01-31 2018-02-28 Эгиш Дьёдьсердьяр Зрт. Способ получения солей вортиоксетина
CN104059030B (zh) 2014-05-30 2016-05-04 镇江圣安医药有限公司 [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途
CN105198837B (zh) * 2014-06-09 2018-05-04 上海医药工业研究院 一种沃替西汀氢溴酸盐晶体及其制备方法
CN104610195B (zh) * 2015-01-30 2017-06-27 上虞京新药业有限公司 沃替西汀的天冬氨酸盐或其水合物及其制备方法和用途
CN106279066A (zh) * 2015-05-22 2017-01-04 天津药物研究院有限公司 一种氢溴酸沃替西汀晶体的纯化方法
CN106556663B (zh) * 2015-09-30 2018-05-29 成都弘达药业有限公司 一种1-[2-(2,4-二甲基苯基硫烷基)苯基]哌嗪或其盐的检测方法
US10927089B2 (en) 2016-06-16 2021-02-23 Sunshine Lake Pharma Co., Ltd. Diaryl thioether piperazine compounds, preparation methods and uses thereof
BR112018003930A2 (pt) * 2016-07-01 2018-09-25 H Lundbeck As regimes de dosagem de vortioxetina para início rápido de efeito antidepressivo
DK3615518T3 (da) * 2017-04-25 2022-02-07 H Lundbeck As Fremgangsmåde til fremstillingen af vortioxetin hbr alpha-form
KR102026337B1 (ko) 2017-07-07 2019-09-27 영진약품 주식회사 1-[2-(2,4-디메틸페닐설파닐)페닐]피페라진의 신규염 및 이의 제조방법
EP3870292A4 (en) 2018-10-26 2022-11-09 The Research Foundation for The State University of New York COMBINATION OF SEROTONIN-SPECIFIC RESUPPUT INHIBITOR AND SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA
WO2023036820A1 (en) 2021-09-10 2023-03-16 H. Lundbeck A/S Therapeutic uses of 1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA76130C2 (en) * 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
CN100457738C (zh) * 2001-12-20 2009-02-04 H·隆德贝克有限公司 芳氧基苯基和芳硫基苯基衍生物
KR101627901B1 (ko) 2006-06-16 2016-06-13 하. 룬트벡 아크티에 셀스카브 인지기능 장애의 치료를 위한, 세로토닌 재흡수, 5-ht3 및 5-ht1a 활성이 조합된 화합물로서의 1-[2-(2,4-디메틸페닐술파닐)-페닐]피페라진

Also Published As

Publication number Publication date
DK2142193T3 (da) 2011-03-28
CO6220962A2 (es) 2010-11-19
EP2142193B1 (en) 2011-01-19
ATE495745T1 (de) 2011-02-15
IL238068A0 (en) 2015-05-31
WO2008113359A2 (en) 2008-09-25
SI2142193T1 (sl) 2011-03-31
CN101636161A (zh) 2010-01-27
IL200956A0 (en) 2010-05-17
UA97392C2 (ru) 2012-02-10
JP5371790B2 (ja) 2013-12-18
EA017058B1 (ru) 2012-09-28
AU2008228638A1 (en) 2008-09-25
CA2684571C (en) 2012-08-14
DE602008004643D1 (de) 2011-03-03
EA200970870A1 (ru) 2010-04-30
KR20090125251A (ko) 2009-12-04
AU2008228638B2 (en) 2012-09-20
PL2142193T3 (pl) 2011-04-29
CA2684571A1 (en) 2008-09-25
RS51560B (sr) 2011-06-30
CY1111183T1 (el) 2015-06-11
WO2008113359A3 (en) 2008-11-13
MX2009009672A (es) 2009-12-15
CL2008000795A1 (es) 2008-09-26
US8664225B2 (en) 2014-03-04
BRPI0808941A2 (pt) 2014-08-19
EP2142193A2 (en) 2010-01-13
TW200848411A (en) 2008-12-16
PT2142193E (pt) 2011-02-02
AR065797A1 (es) 2009-07-01
MY150448A (en) 2014-01-30
ES2355434T3 (es) 2011-03-25
KR101459168B1 (ko) 2014-11-07
NZ579721A (en) 2011-07-29
JP2010521501A (ja) 2010-06-24
IL200956A (en) 2015-05-31
CN103948597A (zh) 2014-07-30
US20110009422A1 (en) 2011-01-13

Similar Documents

Publication Publication Date Title
SG151260A1 (en) 5-substituted-2-phenylamino-benzamides as mek inhibitors
EA201270221A1 (ru) Лечение болезни крона с применением лаквинимода
NO20070295L (no) Nye CIS-imidazoliner
HRP20171197T1 (hr) Bifenilsulfonamidni antagonist receptora endotelina i angiotensina ii, namijenjen liječenju glomeruloskleroze
PL2142193T3 (pl) 1-[2-(2,4-demetylofenylosulfanylo)fenylo]piperazyna jako związek z połączonym wychwytem zwrotnym serotoniny, aktywnością względem 5HT3 i 5-HT1A do leczenia bólu lub rezydualnych objawów depresji związanych ze snem i procesami poznawczymi
PH12015502628B1 (en) Pyrazolopyrrolidine derivatives and their use in the treatment of disease
NZ602510A (en) Treatment of lupus nephritis using laquinimod
NO20084853L (no) Forbindelser som er agonister av muscarinreseptorer og som kan vaere effektive i behandling av smerte, Alzheimers sykdom og/eller schizofreni
EA201592256A1 (ru) Производные имидазопирролидинона и их применение при лечении заболеваний
MA33734B1 (fr) N1-pyrazolospirocétone inhibitrices d'acétyl-coa carboxylase
EA201101671A1 (ru) Замещенные производные аминопропионовой кислоты в качестве ингибиторов неприлизина
MX2010004688A (es) Usos terapeuticos de compuestos que tienen actividad combinada de sert, 5- ht3 y 5-ht1a.
TW200738241A (en) Pyridazine derivatives
EA200971087A1 (ru) Фармацевтические композиции и способ лечения острой мании
MX2012000275A (es) Antagonista de bomba de acido para el tratamiento de enfermedades involucradas en la motilidad gastrointestinal anormal.
MX2011008910A (es) Derivados de azol sustituidos, composicion farmaceutica que comprende los derivados, y uso de los derivados para tratar enfermeda de parkinson.
MX344109B (es) Formulaciones de sal de meglumina del ácido 1-(5,6-dicloro-1h-benz o[d]imidazol-2-il)-1h-pirazol-4-carboxílico.
EA201792072A3 (ru) Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения
HRP20160327T1 (hr) Čvrsti dozirni oblici fentanila s poboljšanom bukalnom apsorpcijom
MY148257A (en) (thio)-carbamoyl-cyclohexane derivatives and method for treating schizophrenia
HRP20171824T1 (hr) (TIENO[2,3-b][1,5]BENZOKSAZEPIN-4-IL)PIPERAZIN-1-ILNI SPOJEVI S DVOJNOM AKTIVNOŠĆU INVERZNIH AGONISTA H1 I ANTAGONISTA 5-HT2A
CO6612226A2 (es) Tableta
MY143568A (en) 11b-hsd1 inhibitors for the treatment of diabetes
SG141358A1 (en) Treatment of psychiatric patients with reduced heptaic function with paliperidone
ME02674B (me) Terapeutske upotrebe 1-[2-(2,4-dimetil-fenilsulfanil)fenil]piperazina