HRP20161674T1 - 4-(8-METOKSI-1-((1-METOKSIPROPAN-2-IL)-2-(TETRAHIDRO-2H-PIRAN-4-IL)-1H-IMIDAZO[4,5-c]KINOLIN-7-IL)-3,5-DIMETILIZOKSAZOL I NJEGOVA UPOTREBA KAO INHIBITORA BROMODOMENE - Google Patents

4-(8-METOKSI-1-((1-METOKSIPROPAN-2-IL)-2-(TETRAHIDRO-2H-PIRAN-4-IL)-1H-IMIDAZO[4,5-c]KINOLIN-7-IL)-3,5-DIMETILIZOKSAZOL I NJEGOVA UPOTREBA KAO INHIBITORA BROMODOMENE Download PDF

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Publication number
HRP20161674T1
HRP20161674T1 HRP20161674TT HRP20161674T HRP20161674T1 HR P20161674 T1 HRP20161674 T1 HR P20161674T1 HR P20161674T T HRP20161674T T HR P20161674TT HR P20161674 T HRP20161674 T HR P20161674T HR P20161674 T1 HRP20161674 T1 HR P20161674T1
Authority
HR
Croatia
Prior art keywords
compound
pharmaceutically acceptable
cancer
acceptable salt
dimethylisoxazole
Prior art date
Application number
HRP20161674TT
Other languages
English (en)
Croatian (hr)
Inventor
Emmanuel Hubert Demont
Katherine Louise Jones
Robert J WATSON
Original Assignee
Glaxosmithkline Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc filed Critical Glaxosmithkline Llc
Publication of HRP20161674T1 publication Critical patent/HRP20161674T1/hr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HRP20161674TT 2011-08-17 2012-08-15 4-(8-METOKSI-1-((1-METOKSIPROPAN-2-IL)-2-(TETRAHIDRO-2H-PIRAN-4-IL)-1H-IMIDAZO[4,5-c]KINOLIN-7-IL)-3,5-DIMETILIZOKSAZOL I NJEGOVA UPOTREBA KAO INHIBITORA BROMODOMENE HRP20161674T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1114103.3A GB201114103D0 (en) 2011-08-17 2011-08-17 Novel compounds
PCT/EP2012/065918 WO2013024104A1 (en) 2011-08-17 2012-08-15 4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2h-pyran-4-yl)-1 h-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor
EP12748028.3A EP2744809B1 (en) 2011-08-17 2012-08-15 4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2h-pyran-4-yl)-1 h-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor

Publications (1)

Publication Number Publication Date
HRP20161674T1 true HRP20161674T1 (hr) 2017-01-27

Family

ID=44764570

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20161674TT HRP20161674T1 (hr) 2011-08-17 2012-08-15 4-(8-METOKSI-1-((1-METOKSIPROPAN-2-IL)-2-(TETRAHIDRO-2H-PIRAN-4-IL)-1H-IMIDAZO[4,5-c]KINOLIN-7-IL)-3,5-DIMETILIZOKSAZOL I NJEGOVA UPOTREBA KAO INHIBITORA BROMODOMENE

Country Status (38)

Country Link
US (4) US9067936B2 (2)
EP (2) EP3150601A1 (2)
JP (1) JP6059723B2 (2)
KR (1) KR20140064878A (2)
CN (1) CN103889984B (2)
AR (1) AR087545A1 (2)
AU (1) AU2012296914B2 (2)
BR (1) BR112014003681A8 (2)
CA (1) CA2843537A1 (2)
CL (1) CL2014000365A1 (2)
CO (1) CO6862151A2 (2)
CR (1) CR20140076A (2)
CY (1) CY1118370T1 (2)
DK (1) DK2744809T3 (2)
DO (1) DOP2014000031A (2)
EA (1) EA023374B1 (2)
ES (1) ES2609857T3 (2)
GB (1) GB201114103D0 (2)
HR (1) HRP20161674T1 (2)
HU (1) HUE030106T2 (2)
IL (1) IL230489A (2)
IN (1) IN2014CN00568A (2)
JO (1) JO3187B1 (2)
LT (1) LT2744809T (2)
ME (1) ME02589B (2)
MX (1) MX350597B (2)
MY (1) MY170729A (2)
PE (1) PE20141406A1 (2)
PH (1) PH12014500379A1 (2)
PL (1) PL2744809T3 (2)
PT (1) PT2744809T (2)
RS (1) RS55560B1 (2)
SI (1) SI2744809T1 (2)
SM (2) SMT201700005T1 (2)
TW (1) TWI558704B (2)
UA (1) UA110838C2 (2)
UY (1) UY34264A (2)
WO (1) WO2013024104A1 (2)

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Publication number Publication date
JO3187B1 (ar) 2018-03-08
CN103889984A (zh) 2014-06-25
US9861627B2 (en) 2018-01-09
CY1118370T1 (el) 2017-06-28
PH12014500379A1 (en) 2021-07-12
DOP2014000031A (es) 2014-06-01
KR20140064878A (ko) 2014-05-28
AU2012296914B2 (en) 2016-03-03
CA2843537A1 (en) 2013-02-21
PL2744809T3 (pl) 2017-08-31
MY170729A (en) 2019-08-27
IL230489A0 (en) 2014-03-31
US20170157113A1 (en) 2017-06-08
RS55560B1 (sr) 2017-05-31
MX2014001834A (es) 2014-02-27
US20150315184A1 (en) 2015-11-05
PE20141406A1 (es) 2014-10-25
ES2609857T3 (es) 2017-04-24
CR20140076A (es) 2014-03-19
TWI558704B (zh) 2016-11-21
DK2744809T3 (en) 2017-01-23
BR112014003681A2 (pt) 2017-03-01
CO6862151A2 (es) 2014-02-10
SI2744809T1 (sl) 2017-01-31
SMT201700005B (it) 2017-03-08
US9610284B2 (en) 2017-04-04
EA023374B1 (ru) 2016-05-31
TW201323424A (zh) 2013-06-16
CN103889984B (zh) 2016-01-13
NZ620263A (en) 2016-04-29
MX350597B (es) 2017-09-11
EP2744809A1 (en) 2014-06-25
SMT201700005T1 (it) 2017-03-08
LT2744809T (lt) 2016-12-27
BR112014003681A8 (pt) 2018-01-23
HUE030106T2 (en) 2017-04-28
UY34264A (es) 2013-04-05
IL230489A (en) 2016-07-31
EP2744809B1 (en) 2016-10-12
JP2014521735A (ja) 2014-08-28
CL2014000365A1 (es) 2014-07-11
EA201490200A1 (ru) 2014-07-30
ME02589B (me) 2017-06-20
UA110838C2 (uk) 2016-02-25
EP3150601A1 (en) 2017-04-05
AU2012296914A1 (en) 2014-02-13
US20140171462A1 (en) 2014-06-19
PT2744809T (pt) 2017-01-06
US20160317529A1 (en) 2016-11-03
AR087545A1 (es) 2014-04-03
JP6059723B2 (ja) 2017-01-11
IN2014CN00568A (2) 2015-04-03
WO2013024104A1 (en) 2013-02-21
GB201114103D0 (en) 2011-09-28
US9067936B2 (en) 2015-06-30
US9416130B2 (en) 2016-08-16

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