HRP20190946T1 - Sredstva za liječenje trostruko negativnog raka dojke - Google Patents

Sredstva za liječenje trostruko negativnog raka dojke Download PDF

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HRP20190946T1
HRP20190946T1 HRP20190946TT HRP20190946T HRP20190946T1 HR P20190946 T1 HRP20190946 T1 HR P20190946T1 HR P20190946T T HRP20190946T T HR P20190946TT HR P20190946 T HRP20190946 T HR P20190946T HR P20190946 T1 HRP20190946 T1 HR P20190946T1
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seq
antibody
antigen
binding fragment
variable region
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HRP20190946TT
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Gilles Bernard Trembalay
Anna N. MORAITIS
Mario Filion
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Adc Therapeutics Sa
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3015—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/565—Complementarity determining region [CDR]
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Claims (16)

1. Protutijelo ili njegov fragment koji veže antigen, naznačeno time, da je sposobno za specifično vezanje na antigen 1 povezan s bubregom (KAAG1) i konjugirano je s terapeutskim dijelom skupine za uporabu u liječenju trostruko negativnog raka dojke, pri čemu to protutijelo ili njegov fragment koji veže antigen, obuhvaća CDRH1 kao što je prikazano u SEQ ID NO:49, CDRH2 kao što je prikazano u SEQ ID NO:50 ili u SEQ ID NO:212, CDRH3 kao što je prikazano u SEQ ID NO:51, CDRL1 kao što je prikazano u SEQ ID NO:52, CDRL2 kao što je prikazano u SEQ ID NO:53, i CDRL3 kao što je prikazano u SEQ ID NO:54.
2. Protutijelo ili njegov fragment koji veže antigen za uporabu prema zahtjevu 1, naznačeno time, da se protutijelo ili njegov fragment koji veže antigen, veže na površinu od stanica raka.
3. Protutijelo ili njegov fragment koji veže antigen za uporabu prema zahtjevu 1 ili 2, naznačeno time, da protutijelo ili njegov fragment koji veže antigen, veže jedan epitop koji je obuhvaćen između aminokiselina od 30 do 84 od KAAG1.
4. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 3, naznačeno time, da je protutijelo ili njegov fragment koji veže antigen, monoklonsko protutijelo, kimerno protutijelo, ljudsko protutijelo ili humanizirano protutijelo, ili jedan njihov fragment koji veže antigen.
5. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 4, naznačeno time, da se protutijelo ili njegov fragment koji veže antigen, upotrebljava u kombinaciji s kemoterapeutskim sredstvom ili s citotoksičnim sredstvom.
6. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 5, naznačeno time, da protutijelo ili njegov fragment koji veže antigen, obuhvaća varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:48 i varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:46.
7. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 5, naznačeno time, da protutijelo ili njegov fragment koji veže antigen, obuhvaća varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:186, pri čemu najmanje jedna od aminokiselina koja je identificirana kao X jest supstitucija aminokiseline u usporedbi s odgovarajućom aminokiselinom u polipeptidu koji je prikazan u SEQ ID NO:48, te obuhvaća varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:191, pri čemu najmanje jedna od aminokiselina koja je identificirana kao X jest supstitucija aminokiseline u usporedbi s odgovarajućom aminokiselinom u polipeptidu koji je prikazan u SEQ ID NO:46.
8. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 5 ili 7, naznačeno time, da je varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:187 i pritom je varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:192.
9. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 5, 7 ili 8, naznačeno time, da je varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:188 i pritom je varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:193.
10. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 5 ili 7 do 9, naznačeno time, da protutijelo ili njegov fragment koji veže antigen, obuhvaća sljedeće: a. varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:189 ili SEQ ID NO:190 i varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:194, SEQ ID NO:195, SEQ ID NO:196 ili SEQ ID NO:197; b. varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:189 i varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:194; c. varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:189 i varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:195; d. varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:189 i varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:196; e. varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:189 i varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:197; f. varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:190 i varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:194; g. varijabilno područje lakog lanca kao što je prikazano u SEQ ID NO:190 i varijabilno područje teškog lanca kao što je prikazano u SEQ ID NO:195; ili h. laki lanac kao što je prikazan u SEQ ID NO:199 ili SEQ ID NO:200 i teški lanac kao što je prikazan u SEQ ID NO:202, SEQ ID NO:203, SEQ ID NO:204 ili SEQ ID NO:205.
11. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 5 ili 8 do 10, naznačeno time, da protutijelo ili njegov fragment koji veže antigen, obuhvaća sljedeće: a. laki lanac kao što je prikazan u SEQ ID NO:199 i teški lanac kao što je prikazan u SEQ ID NO:202; b. laki lanac kao što je prikazan u SEQ ID NO:199 i teški lanac kao što je prikazan u SEQ ID NO:203; c. laki lanac kao što je prikazan u SEQ ID NO:199 i teški lanac kao što je prikazan u SEQ ID NO:204; d. laki lanac kao što je prikazan u SEQ ID NO:199 i teški lanac kao što je prikazan u SEQ ID NO:205; e. laki lanac kao što je prikazan u SEQ ID NO:200 i teški lanac kao što je prikazan u SEQ ID NO:202; f. laki lanac kao što je prikazan u SEQ ID NO:200 i teški lanac kao što je prikazan u SEQ ID NO:203; g. laki lanac kao što je prikazan u SEQ ID NO:200 i teški lanac kao što je prikazan u SEQ ID NO:204; ili h. laki lanac kao što je prikazan u SEQ ID NO:200 i teški lanac kao što je prikazan u SEQ ID NO:205.
12. Protutijelo ili njegov fragment koji veže antigen za uporabu prema zahtjevu 1, naznačeno time, da terapeutski dio skupine je jedno citotoksično sredstvo.
13. Protutijelo ili njegov fragment koji veže antigen za uporabu prema zahtjevu 1, naznačeno time, da terapeutski dio skupine je jedan anti-mitotički spoj.
14. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 5 ili 8 do 10, naznačeno time, da protutijelo ili njegov fragment koji veže antigen, ima afinitet za KAAG1 od 1 nM ili manje ili 0,1 nM ili manje.
15. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 5 ili 8 do 10, 12 do 14, naznačeno time, da se protutijelo ili njegov fragment koji veže antigen, internalizira unutar stanice.
16. Protutijelo ili njegov fragment koji veže antigen za uporabu prema bilo kojem od zahtjeva 1 do 15, naznačeno time, da se navedeno protutijelo ili njegov fragment koji veže antigen, upotrebljava zajedno sa sredstvom protiv raka.
HRP20190946TT 2012-01-09 2013-01-09 Sredstva za liječenje trostruko negativnog raka dojke HRP20190946T1 (hr)

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US201261584629P 2012-01-09 2012-01-09
PCT/CA2013/000011 WO2013104050A2 (en) 2012-01-09 2013-01-09 Method for treating breast cancer
EP13735811.5A EP2802351B1 (en) 2012-01-09 2013-01-09 Agents for treating triple negative breast cancer

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EP (2) EP3533468A1 (hr)
JP (3) JP6282597B2 (hr)
KR (1) KR102102239B1 (hr)
CN (2) CN104955477B (hr)
AU (1) AU2013209234B2 (hr)
BR (1) BR112014016723A2 (hr)
CA (2) CA2857400A1 (hr)
CY (1) CY1121667T1 (hr)
DK (1) DK2802351T3 (hr)
EA (2) EA034414B1 (hr)
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HR (1) HRP20190946T1 (hr)
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IL (2) IL232915A0 (hr)
IN (1) IN2014CN04690A (hr)
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MX (2) MX366973B (hr)
NZ (1) NZ625758A (hr)
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PT (1) PT2802351T (hr)
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SI (1) SI2802351T1 (hr)
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