HRP20200091T1 - Unos rna za okidanje više imunosnih puteva - Google Patents
Unos rna za okidanje više imunosnih puteva Download PDFInfo
- Publication number
- HRP20200091T1 HRP20200091T1 HRP20200091TT HRP20200091T HRP20200091T1 HR P20200091 T1 HRP20200091 T1 HR P20200091T1 HR P20200091T T HRP20200091T T HR P20200091TT HR P20200091 T HRP20200091 T HR P20200091T HR P20200091 T1 HRP20200091 T1 HR P20200091T1
- Authority
- HR
- Croatia
- Prior art keywords
- rna
- self
- intended
- immunogens
- cap
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (7)
1. Samoreplicirajuća RNA koja kodira imunogene, naznačena time što je namijenjena upotrebi u profilaktičnom ili terapijskom postupku postizanja imunosnog odgovora kod kralježnjaka, gdje RNA ima 5’ kapu, gdje imunogen izaziva imunosni odgovor protiv bakterije, virusa, gljivice ili parazita, gdje se navedeni postupak sastoji u primjeni RNA koja kodira imunogene na kralježnjaku u kombinaciji sa submikrometarskom kationskom emulzijom ulja u vodi tako da RNA: (i) stimulira endosomski receptor TLR7 vezan uz prirođenu imunost; (ii) stimulira citoplazmatski receptor RIG-1 ili MDA5 vezan uz prirođenu imunost; i (iii) translatira se kako bi se omogućilo eksprimiranje imunogena, uz uvjet da RNA ne sadrži modificirane nukleotide osim 5’ kape.
2. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s patentnim zahtjevom 1, naznačena time što se RNA primjenjuje na skeletno mišićno tkivo.
3. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što se RNA primjenjuje injiciranjem.
4. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s patentnim zahtjevom 3, naznačena time što se injiciranje provodi iglom.
5. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što je RNA +-lančana.
6. Farmaceutski pripravak, naznačen time što sadrži samoreplicirajuću RNA koja kodira imunogene namijenjenu upotrebi u profilaktičnom ili terapijskom postupku postizanja imunosnog odgovora kod kralježnjaka, gdje RNA ima 5’ kapu, gdje imunogen izaziva imunosni odgovor protiv bakterije, virusa, gljivice ili parazita, gdje se navedeni postupak sastoji u primjeni RNA koja kodira imunogene na kralježnjaku u kombinaciji sa submikrometarskom kationskom emulzijom ulja u vodi tako da RNA: (i) stimulira endosomski receptor TLR7 vezan uz prirođenu imunost; (ii) stimulira citoplazmatski receptor RIG-1 ili MDA5 vezan uz prirođenu imunost; i (iii) translatira se kako bi se omogućilo eksprimiranje imunogena, uz uvjet da RNA ne sadrži modificirane nukleotide osim 5’ kape.
7. Samoreplicirajuća RNA koja kodira imunogene namijenjena upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-5, ili farmaceutski pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 6, naznačeni time što 5’ kapa sadrži 7-metilgvanozin.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36178910P | 2010-07-06 | 2010-07-06 | |
| EP17177123.1A EP3243526B1 (en) | 2010-07-06 | 2011-07-06 | Delivery of rna to trigger multiple immune pathways |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200091T1 true HRP20200091T1 (hr) | 2020-04-03 |
Family
ID=44629112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200091TT HRP20200091T1 (hr) | 2010-07-06 | 2020-01-20 | Unos rna za okidanje više imunosnih puteva |
Country Status (12)
| Country | Link |
|---|---|
| US (19) | US9801897B2 (hr) |
| EP (2) | EP2590670B1 (hr) |
| CY (1) | CY1122515T1 (hr) |
| DK (1) | DK3243526T3 (hr) |
| ES (2) | ES2646669T3 (hr) |
| HR (1) | HRP20200091T1 (hr) |
| HU (1) | HUE047796T2 (hr) |
| LT (1) | LT3243526T (hr) |
| PL (1) | PL3243526T3 (hr) |
| PT (1) | PT3243526T (hr) |
| SI (1) | SI3243526T1 (hr) |
| WO (1) | WO2012006377A2 (hr) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
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| SI2591114T1 (sl) | 2010-07-06 | 2016-10-28 | Glaxosmithkline Biologicals S.A. | Imunizacija velikih sesalcev z majhnimi odmerki RNA |
| US11291635B2 (en) | 2010-07-06 | 2022-04-05 | Glaxosmithkline Biological Sa | Virion-like delivery particles for self-replicating RNA molecules |
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| ES3005233T3 (en) | 2010-10-01 | 2025-03-14 | Modernatx Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
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