HRP20201230T1 - Uporaba kanabinoida u liječenju atoničkih napadaja kod lennox-gastaut sindroma - Google Patents
Uporaba kanabinoida u liječenju atoničkih napadaja kod lennox-gastaut sindroma Download PDFInfo
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- HRP20201230T1 HRP20201230T1 HRP20201230TT HRP20201230T HRP20201230T1 HR P20201230 T1 HRP20201230 T1 HR P20201230T1 HR P20201230T T HRP20201230T T HR P20201230TT HR P20201230 T HRP20201230 T HR P20201230T HR P20201230 T1 HRP20201230 T1 HR P20201230T1
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- Prior art keywords
- cbd
- use according
- concentration
- seizures
- treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/658—Medicinal preparations containing organic active ingredients o-phenolic cannabinoids, e.g. cannabidiol, cannabigerolic acid, cannabichromene or tetrahydrocannabinol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Pain & Pain Management (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Claims (14)
1. Kanabidiol (CBD) za uporabu u liječenju napadaja kod Lennox-Gastaut sindroma naznačen time što je CBD u obliku visoko pročišćenog ekstrakta kanabisa koji sadrži najmanje 98% (tež./tež.) CBD ili je prisutan kao sintetički spoj i napadaji su atonički napadaji.
2. CBD za uporabu u skladu sa patentnim zahtjevom 1, naznačen time što su atonički napadaji otporni na liječenje.
3. CBD za uporabu u skladu sa bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je CBD za uporabu u kombinaciji sa jednim ili više istovremenih anti-epileptičkih lijekova (AED).
4. CBD za uporabu u skladu sa bilo kojim od prethodnih patentnih zahtjeva, naznačen time što ekstrakt sadrži manje od 0.15% THC.
5. CBD za uporabu u skladu sa bilo kojim od prethodnih patentnih zahtjeva, naznačen time što ekstrakt dodatno sadrži do 1% CBDV.
6. CBD za uporabu u skladu sa patentnim zahtjevom 3, naznačen time što su jedan ili više AED odabrani iz grupe koja se sastoji od: klobazama; klonazepama, levetiracetama; topiramata; stiripentola; fenobarbitala; laksamida; valproinske kiseline; zonisamida; perampanela; i fosfenitoina.
7. CBD za uporabu u skladu sa bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je doza CBD od 5 do 25 mg/kg/dan.
8. CBD za uporabu u skladu sa bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je CBD dan u pripravku koji dodatno sadrži otapalo, ko-otapalo, zaslađivač, i aromu.
9. CBD za uporabu u skladu sa patentnim zahtjevom 8, naznačen time što je otapalo sezamovo ulje.
10. CBD za uporabu u skladu sa patentnim zahtjevom 8, naznačen time što je ko-otapalo etanol.
11. CBD za uporabu u skladu sa patentnim zahtjevom 8, naznačen time što je zaslađivač sukraloza.
12. CBD za uporabu u skladu sa patentnim zahtjevom 8, naznačen time što aroma je aroma jagode.
13. CBD za uporabu u skladu sa patentnim zahtjevom 8, naznačen time što je CBD prisutan u koncentraciji između 25 mg/ml i 100 mg/ml.
14. CBD za uporabu u skladu sa bilo kojim od patentnih zahtjeva 8 do 13, naznačen time što sadrži kanabidiol (CBD) u koncentraciji između 25 do 100 mg/ml, etanol u koncentraciji od 79 mg/ml, sukralozu u koncentraciji od 0.5 mg/ml, aromu jagode u koncentraciji od 0.2 mg/ml i sezam q.s. do 1.0 ml.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1418171.3A GB2531282A (en) | 2014-10-14 | 2014-10-14 | Use of cannabinoids in the treatment of epilepsy |
| EP15784111.5A EP3206716B1 (en) | 2014-10-14 | 2015-10-14 | Use of cannabinoids in the treatment of atonic seizures in lennox-gastaut syndrome |
| PCT/GB2015/053028 WO2016059403A1 (en) | 2014-10-14 | 2015-10-14 | Use of cannabinoids in the treatment of epilepsy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201230T1 true HRP20201230T1 (hr) | 2021-02-05 |
Family
ID=52001393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201230TT HRP20201230T1 (hr) | 2014-10-14 | 2015-10-14 | Uporaba kanabinoida u liječenju atoničkih napadaja kod lennox-gastaut sindroma |
Country Status (21)
| Country | Link |
|---|---|
| US (13) | US10111840B2 (hr) |
| EP (2) | EP3735964A1 (hr) |
| JP (4) | JP6656241B2 (hr) |
| AU (4) | AU2015332212B2 (hr) |
| BR (1) | BR112017007777A2 (hr) |
| CA (2) | CA3232241A1 (hr) |
| CY (1) | CY1123229T1 (hr) |
| DK (1) | DK3206716T3 (hr) |
| ES (1) | ES2811327T3 (hr) |
| GB (1) | GB2531282A (hr) |
| HR (1) | HRP20201230T1 (hr) |
| HU (1) | HUE053262T2 (hr) |
| IL (3) | IL281793B2 (hr) |
| LT (1) | LT3206716T (hr) |
| MX (3) | MX374009B (hr) |
| PL (1) | PL3206716T3 (hr) |
| PT (1) | PT3206716T (hr) |
| RS (1) | RS60767B1 (hr) |
| SI (1) | SI3206716T1 (hr) |
| SM (1) | SMT202000474T1 (hr) |
| WO (1) | WO2016059403A1 (hr) |
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