HRP940577B1 - Use of 5-thia-1,4-diazabicyclo (4.2.0) octane-3,8-dioxo compounds in antitumor therapy - Google Patents

Use of 5-thia-1,4-diazabicyclo (4.2.0) octane-3,8-dioxo compounds in antitumor therapy

Info

Publication number: HRP940577B1
Authority: HR; Croatia
Prior art keywords: thia; hydrogen; diazabicyclo; octane; dioxo
Prior art date: 1994-09-21

Application number

HR940577A

Other languages

English (en)

Inventor

Lukić Irena

Original Assignee

Lukić Irena

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-21

Filing date

1994-09-21

Publication date

1998-12-31

1994-09-21 Application filed by Lukić Irena filed Critical Lukić Irena

1994-09-21 Priority to HR940577A priority Critical patent/HRP940577B1/xx

1995-09-18 Priority to DE69501810T priority patent/DE69501810T2/de

1995-09-18 Priority to AT95114673T priority patent/ATE164069T1/de

1995-09-18 Priority to ES95114673T priority patent/ES2115303T3/es

1995-09-18 Priority to EP95114673A priority patent/EP0705606B1/de

1995-09-20 Priority to CZ952447A priority patent/CZ285621B6/cs

1995-09-20 Priority to JP7241717A priority patent/JPH08310954A/ja

1995-09-20 Priority to RU95116239A priority patent/RU2136284C1/ru

1995-09-20 Priority to CA002158678A priority patent/CA2158678C/en

1995-09-21 Priority to SI9500297A priority patent/SI9500297A/sl

1995-09-21 Priority to HU9502770A priority patent/HU218287B/hu

1995-09-21 Priority to CN95116888A priority patent/CN1127115A/zh

1995-09-21 Priority to BG100020A priority patent/BG62237B1/bg

1995-09-21 Priority to SK1170-95A priority patent/SK280815B6/sk

1997-04-30 Publication of HRP940577A2 publication Critical patent/HRP940577A2/hr

1998-12-31 Publication of HRP940577B1 publication Critical patent/HRP940577B1/xx

Links

150000001875 compounds Chemical class 0.000 title abstract 2
230000000259 anti-tumor effect Effects 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1
150000002431 hydrogen Chemical class 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
208000019065 cervical carcinoma Diseases 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 abstract 1
125000005544 phthalimido group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000001629 suppression Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

HR940577A 1994-09-21 1994-09-21 Use of 5-thia-1,4-diazabicyclo (4.2.0) octane-3,8-dioxo compounds in antitumor therapy HRP940577B1 (en)

Priority Applications (14)

Application Number	Priority Date	Filing Date	Title
HR940577A HRP940577B1 (en)	1994-09-21	1994-09-21	Use of 5-thia-1,4-diazabicyclo (4.2.0) octane-3,8-dioxo compounds in antitumor therapy
DE69501810T DE69501810T2 (de)	1994-09-21	1995-09-18	Verwendung von 5-Thia-1,4-Diazabicyclo [4.2.0] Octane-3,8-dioxo Verbindungen in der Antitumor-Therapie
AT95114673T ATE164069T1 (de)	1994-09-21	1995-09-18	Verwendung von 5-thia-1,4-diazabicyclo (4.2.0> octane-3,8-dioxo verbindungen in der antitumor- therapie
ES95114673T ES2115303T3 (es)	1994-09-21	1995-09-18	Uso de compuestos de 5-tia-1,4-diazabiciclo(4.2.0)octan-3,8-dioxo en terapia antitumoral.
EP95114673A EP0705606B1 (de)	1994-09-21	1995-09-18	Verwendung von 5-Thia-1,4-Diazabicyclo [4.2.0] Octane-3,8-dioxo Verbindungen in der Antitumor-Therapie
CZ952447A CZ285621B6 (cs)	1994-09-21	1995-09-20	Použití 5-thia-1,4-diazabicyklo[4,2,0]oktan-3,8-dioxo-sloučenin v protinádorové terapii
JP7241717A JPH08310954A (ja)	1994-09-21	1995-09-20	製薬組成物
RU95116239A RU2136284C1 (ru)	1994-09-21	1995-09-20	Применение 5-тиа-1,4-диазабицикло[4.2.0]октан-3,8-диоксопроизводных в противоопухолевой терапии
CA002158678A CA2158678C (en)	1994-09-21	1995-09-20	Use of 5-thia-1, 4-diazabicyclo/4.2.0/octane-3,8-dioxo compounds in antitumor therapy
SI9500297A SI9500297A (en)	1994-09-21	1995-09-21	Use of 5-thia-1,4-diazabicyclo/4.2.0/octane-3,8-dioxo compounds in antitumor therapy
HU9502770A HU218287B (en)	1994-09-21	1995-09-21	Use of 5-thia-1,4-diazabicyclo[4.2.0]octane-3,8-dioxo compounds in antitumor therapy
CN95116888A CN1127115A (zh)	1994-09-21	1995-09-21	3，8-二氧代-5-硫代-1，4-二氮杂二环[4.2.0]辛烷化合物在抗肿瘤治疗中的应用
BG100020A BG62237B1 (bg)	1994-09-21	1995-09-21	Използване на5-тио-1,4-диазобицикло-[4,2,0]-октан-3,8-диоксосъединения приантитуморна терапия
SK1170-95A SK280815B6 (sk)	1994-09-21	1995-09-21	Použitie 5-tia-1,4-diazabicyklo[4.2.0]oktán-3,8-dioxozlúčeniny v protinádorovej terapii

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR940577A HRP940577B1 (en)	1994-09-21	1994-09-21	Use of 5-thia-1,4-diazabicyclo (4.2.0) octane-3,8-dioxo compounds in antitumor therapy

Publications (2)

Publication Number	Publication Date
HRP940577A2 HRP940577A2 (en)	1997-04-30
HRP940577B1 true HRP940577B1 (en)	1998-12-31

Family

ID=10946157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR940577A HRP940577B1 (en)	1994-09-21	1994-09-21	Use of 5-thia-1,4-diazabicyclo (4.2.0) octane-3,8-dioxo compounds in antitumor therapy

Country Status (14)

Country	Link
EP (1)	EP0705606B1 (de)
JP (1)	JPH08310954A (de)
CN (1)	CN1127115A (de)
AT (1)	ATE164069T1 (de)
BG (1)	BG62237B1 (de)
CA (1)	CA2158678C (de)
CZ (1)	CZ285621B6 (de)
DE (1)	DE69501810T2 (de)
ES (1)	ES2115303T3 (de)
HR (1)	HRP940577B1 (de)
HU (1)	HU218287B (de)
RU (1)	RU2136284C1 (de)
SI (1)	SI9500297A (de)
SK (1)	SK280815B6 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN101671336B (zh) *	2009-09-23	2013-11-13	辽宁利锋科技开发有限公司	芳杂环并嘧啶衍生物和类似物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5598188A (en) *	1979-01-23	1980-07-25	Mitsui Toatsu Chem Inc	Novel cephalosporin and its preparation
JPS57171994A (en) *	1981-04-15	1982-10-22	Asahi Chem Ind Co Ltd	Novel compound
HRP921292A2 (en)	1992-11-17	1994-08-31	Pliva Pharm & Chem Works	5-thia-1,4-diazabicyclo (4.2.0.)octane -3,8-dioxo analogs of beta-lactams, the process for the preparation and use thereof

1994
- 1994-09-21 HR HR940577A patent/HRP940577B1/xx not_active IP Right Cessation
1995
- 1995-09-18 DE DE69501810T patent/DE69501810T2/de not_active Expired - Fee Related
- 1995-09-18 ES ES95114673T patent/ES2115303T3/es not_active Expired - Lifetime
- 1995-09-18 EP EP95114673A patent/EP0705606B1/de not_active Expired - Lifetime
- 1995-09-18 AT AT95114673T patent/ATE164069T1/de not_active IP Right Cessation
- 1995-09-20 CA CA002158678A patent/CA2158678C/en not_active Expired - Fee Related
- 1995-09-20 JP JP7241717A patent/JPH08310954A/ja active Pending
- 1995-09-20 RU RU95116239A patent/RU2136284C1/ru active
- 1995-09-20 CZ CZ952447A patent/CZ285621B6/cs not_active IP Right Cessation
- 1995-09-21 SI SI9500297A patent/SI9500297A/sl unknown
- 1995-09-21 SK SK1170-95A patent/SK280815B6/sk unknown
- 1995-09-21 HU HU9502770A patent/HU218287B/hu not_active IP Right Cessation
- 1995-09-21 BG BG100020A patent/BG62237B1/bg unknown
- 1995-09-21 CN CN95116888A patent/CN1127115A/zh active Pending

Also Published As

Publication number	Publication date
SK280815B6 (sk)	2000-08-14
CZ244795A3 (en)	1996-04-17
ES2115303T3 (es)	1998-06-16
HU218287B (en)	2000-07-28
HUT74422A (en)	1996-12-30
DE69501810D1 (de)	1998-04-23
EP0705606A1 (de)	1996-04-10
CZ285621B6 (cs)	1999-10-13
HU9502770D0 (en)	1995-11-28
HRP940577A2 (en)	1997-04-30
ATE164069T1 (de)	1998-04-15
EP0705606B1 (de)	1998-03-18
SK117095A3 (en)	1996-09-04
CN1127115A (zh)	1996-07-24
CA2158678A1 (en)	1996-03-22
RU2136284C1 (ru)	1999-09-10
JPH08310954A (ja)	1996-11-26
BG100020A (bg)	1996-04-30
BG62237B1 (bg)	1999-06-30
CA2158678C (en)	2000-04-18
SI9500297A (en)	1996-04-30
DE69501810T2 (de)	1998-09-24

Legal Events

Date	Code	Title	Description
1997-04-30	A1OB	Publication of a patent application
1997-06-11	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
1998-12-31	B1PR	Patent granted
2000-09-21	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20000921 Year of fee payment: 7
2001-03-22	PBON	Lapse due to non-payment of renewal fee	Effective date: 20000922

Publication	Publication Date	Title
ATE225770T1 (de)	2002-10-15	Difluoroprostaglandin-derivate und ihre anwendung
DE69817393D1 (de)	2003-09-25	Neue heterozyklische verbindungen
IL73258A0 (en)	1985-01-31	7-aminoazolo(1,5-a)pyrimidines,their preparation and their use as fungicides
ES8604128A1 (es)	1986-01-16	Un procedimiento para la preparacion de nuevos derivados de bencenosulfonamida
AU3744397A (en)	1998-02-25	Total synthesis of antitumor acylfulvenes
AU558433B2 (en)	1987-01-29	A fungicidal indanylbenzamide
YU76500A (sh)	2003-02-28	Hemijska sinzeza morfolinskih derivata
MX9701949A (es)	1997-06-28	Derivados de distamicina substituidos con bis-(2-haloetil) aminofenilo como agentes antitumorales y antivirales.
ES8504731A1 (es)	1985-04-16	Un procedimiento para preparar antra 1,9-cd-7pirazol-6(2h)-onas
PL337188A1 (en)	2000-08-14	Derivatives of 17beta - allyloxy (thio) alkyl - androstane for modulation of meiosis
HU906230D0 (en)	1991-03-28	Process for the preparation of benzanilide derivatives and medical preparations containing them
HRP940577B1 (en)	1998-12-31	Use of 5-thia-1,4-diazabicyclo (4.2.0) octane-3,8-dioxo compounds in antitumor therapy
TW224973B (de)	1994-06-11
DE3167347D1 (en)	1985-01-03	New benzothiazine derivatives, processes for preparation thereof and use thereof
GB2071098B (en)	1983-09-21	Dibenzocycloheptenylidenes and antiinflammatory compositions
ATE1506T1 (de)	1982-09-15	Derivate des dithiepinno (1,4)(2,3-c) pyrrols, ihre herstellung und sie enthaltende medikamente.
ES8402284A1 (es)	1984-01-16	Un procedimiento para la preparacion de indoles.
ATE225366T1 (de)	2002-10-15	22s-hydroxycholesta-8,14-dien derivate mit meiose regulierende aktivität
NZ216741A (en)	1988-10-28	6-oxo-1,6-dihydropyridazines and pharmaceutical compositions
EP0443474A3 (en)	1992-04-22	1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents
SE8105297L (sv)	1982-03-11	Imidazolderivat