HRP970510A2 - A method and a composition against parasites of small mammals - Google Patents

A method and a composition against parasites of small mammals

Info

Publication number: HRP970510A2
Authority: HR; Croatia
Prior art keywords: alkyl; haloalkyl; compound; radical; mixture according
Prior art date: 1996-09-19

Application number

HR9611446A

Other languages

English (en)

Croatian (hr)

Inventor

Philippe Jeannin

Original Assignee

Philippe Jeannin

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-19

Filing date

1997-09-19

Publication date

1998-08-31

1997-09-19 Application filed by Philippe Jeannin filed Critical Philippe Jeannin

1998-08-31 Publication of HRP970510A2 publication Critical patent/HRP970510A2/hr

Links

239000000203 mixture Substances 0.000 title claims description 72
244000045947 parasite Species 0.000 title claims description 49
238000000034 method Methods 0.000 title claims description 22
241000124008 Mammalia Species 0.000 title claims description 11
150000001875 compounds Chemical class 0.000 claims description 71
241001465754 Metazoa Species 0.000 claims description 35
125000000217 alkyl group Chemical group 0.000 claims description 28
125000001188 haloalkyl group Chemical group 0.000 claims description 28
125000005843 halogen group Chemical group 0.000 claims description 26
239000003795 chemical substances by application Substances 0.000 claims description 21
AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 20
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 20
229960002418 ivermectin Drugs 0.000 claims description 20
239000000243 solution Substances 0.000 claims description 20
241000282472 Canis lupus familiaris Species 0.000 claims description 18
SPBDXSGPUHCETR-JFUDTMANSA-N 8883yp2r6d Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O[C@@H]([C@@H](C)CC4)C(C)C)O3)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 SPBDXSGPUHCETR-JFUDTMANSA-N 0.000 claims description 17
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 16
239000005660 Abamectin Substances 0.000 claims description 15
238000002425 crystallisation Methods 0.000 claims description 15
238000009472 formulation Methods 0.000 claims description 15
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-1 4,5-dicyanoimidazol-2-yl Chemical group 0.000 claims description 12
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FXWHFKOXMBTCMP-WMEDONTMSA-N milbemycin Natural products COC1C2OCC3=C/C=C/C(C)CC(=CCC4CC(CC5(O4)OC(C)C(C)C(OC(=O)C(C)CC(C)C)C5O)OC(=O)C(C=C1C)C23O)C FXWHFKOXMBTCMP-WMEDONTMSA-N 0.000 claims description 10
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
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238000013270 controlled release Methods 0.000 claims description 4
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QLFZZSKTJWDQOS-YDBLARSUSA-N doramectin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C3CCCCC3)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C QLFZZSKTJWDQOS-YDBLARSUSA-N 0.000 claims description 4
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CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
229940043253 butylated hydroxyanisole Drugs 0.000 description 1
235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
229940095259 butylated hydroxytoluene Drugs 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
229940078456 calcium stearate Drugs 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
239000004359 castor oil Substances 0.000 description 1
235000019438 castor oil Nutrition 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
235000019864 coconut oil Nutrition 0.000 description 1
239000003240 coconut oil Substances 0.000 description 1
239000012050 conventional carrier Substances 0.000 description 1
239000006071 cream Substances 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000003814 drug Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
229940100242 glycol stearate Drugs 0.000 description 1
150000004820 halides Chemical class 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
RNYJXPUAFDFIQJ-UHFFFAOYSA-N hydron;octadecan-1-amine;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[NH3+] RNYJXPUAFDFIQJ-UHFFFAOYSA-N 0.000 description 1
239000007943 implant Substances 0.000 description 1
230000006872 improvement Effects 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000003993 interaction Effects 0.000 description 1
244000000053 intestinal parasite Species 0.000 description 1
SYJRVVFAAIUVDH-UHFFFAOYSA-N ipa isopropanol Chemical compound CC(C)O.CC(C)O SYJRVVFAAIUVDH-UHFFFAOYSA-N 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
239000000787 lecithin Substances 0.000 description 1
235000010445 lecithin Nutrition 0.000 description 1
229940067606 lecithin Drugs 0.000 description 1
239000012669 liquid formulation Substances 0.000 description 1
230000005923 long-lasting effect Effects 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000005259 measurement Methods 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
ZHALDANPYXAMJF-UHFFFAOYSA-N octadecanoate;tris(2-hydroxyethyl)azanium Chemical compound OCC[NH+](CCO)CCO.CCCCCCCCCCCCCCCCCC([O-])=O ZHALDANPYXAMJF-UHFFFAOYSA-N 0.000 description 1
239000002674 ointment Substances 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
230000003647 oxidation Effects 0.000 description 1
238000007254 oxidation reaction Methods 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
229920000223 polyglycerol Polymers 0.000 description 1
229940104257 polyglyceryl-6-dioleate Drugs 0.000 description 1
239000004626 polylactic acid Substances 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229950008882 polysorbate Drugs 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
229940114930 potassium stearate Drugs 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
229910002059 quaternary alloy Inorganic materials 0.000 description 1
208000005687 scabies Diseases 0.000 description 1
230000028327 secretion Effects 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
229940083542 sodium Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229940080236 sodium cetyl sulfate Drugs 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229940001584 sodium metabisulfite Drugs 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
229940001474 sodium thiosulfate Drugs 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
ITCAUAYQCALGGV-XTICBAGASA-M sodium;(1r,4ar,4br,10ar)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylate Chemical compound [Na+].C([C@@H]12)CC(C(C)C)=CC1=CC[C@@H]1[C@]2(C)CCC[C@@]1(C)C([O-])=O ITCAUAYQCALGGV-XTICBAGASA-M 0.000 description 1
GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
JNYAEWCLZODPBN-CTQIIAAMSA-N sorbitan Polymers OCC(O)C1OCC(O)[C@@H]1O JNYAEWCLZODPBN-CTQIIAAMSA-N 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
241000894007 species Species 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000003892 spreading Methods 0.000 description 1
230000007480 spreading Effects 0.000 description 1
230000001629 suppression Effects 0.000 description 1
238000012385 systemic delivery Methods 0.000 description 1
208000009920 trichuriasis Diseases 0.000 description 1
229940029614 triethanolamine stearate Drugs 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
239000002699 waste material Substances 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Pest Control & Pesticides (AREA)
Agronomy & Crop Science (AREA)
Wood Science & Technology (AREA)
Plant Pathology (AREA)
Dentistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

HR9611446A 1996-09-19 1997-09-19 A method and a composition against parasites of small mammals HRP970510A2 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9611446A FR2753377B1 (fr)	1996-09-19	1996-09-19	Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides

Publications (1)

Publication Number	Publication Date
HRP970510A2 true HRP970510A2 (en)	1998-08-31

Family

ID=9495897

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR9611446A HRP970510A2 (en)	1996-09-19	1997-09-19	A method and a composition against parasites of small mammals

Country Status (18)

Country	Link
US (1)	US6482425B1 (fr)
JP (2)	JP3756194B2 (fr)
AU (1)	AU733408B2 (fr)
BE (1)	BE1011370A5 (fr)
BR (1)	BR9713469B1 (fr)
CH (1)	CH693732A8 (fr)
DE (2)	DE19781981T1 (fr)
ES (1)	ES2166300B1 (fr)
FR (1)	FR2753377B1 (fr)
GB (1)	GB2334888B (fr)
HR (1)	HRP970510A2 (fr)
IE (1)	IE970675A1 (fr)
IT (1)	IT1297193B1 (fr)
MA (1)	MA24360A1 (fr)
NL (1)	NL1007088C2 (fr)
SE (1)	SE9900893L (fr)
WO (1)	WO1998011780A1 (fr)
ZA (1)	ZA978355B (fr)

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1996
- 1996-09-19 FR FR9611446A patent/FR2753377B1/fr not_active Expired - Lifetime
1997
- 1997-09-11 IE IE970675A patent/IE970675A1/en not_active IP Right Cessation
- 1997-09-15 JP JP51433498A patent/JP3756194B2/ja not_active Expired - Lifetime
- 1997-09-15 DE DE19781981T patent/DE19781981T1/de active Pending
- 1997-09-15 ES ES009950013A patent/ES2166300B1/es not_active Expired - Fee Related
- 1997-09-15 DE DE19781981A patent/DE19781981B3/de not_active Expired - Lifetime
- 1997-09-15 BR BRPI9713469-4B1A patent/BR9713469B1/pt not_active IP Right Cessation
- 1997-09-15 GB GB9906314A patent/GB2334888B/en not_active Expired - Lifetime
- 1997-09-15 WO PCT/FR1997/001548 patent/WO1998011780A1/fr not_active Ceased
- 1997-09-15 CH CH00501/99A patent/CH693732A8/fr not_active IP Right Cessation
- 1997-09-15 AU AU42110/97A patent/AU733408B2/en not_active Expired
- 1997-09-17 ZA ZA978355A patent/ZA978355B/xx unknown
- 1997-09-17 MA MA24800A patent/MA24360A1/fr unknown
- 1997-09-18 BE BE9700759A patent/BE1011370A5/fr not_active IP Right Cessation
- 1997-09-18 IT IT97TO000823A patent/IT1297193B1/it active IP Right Grant
- 1997-09-19 NL NL1007088A patent/NL1007088C2/nl not_active IP Right Cessation
- 1997-09-19 HR HR9611446A patent/HRP970510A2/hr not_active Application Discontinuation
1999
- 1999-03-12 SE SE9900893A patent/SE9900893L/xx not_active Application Discontinuation
- 1999-03-17 US US09/271,470 patent/US6482425B1/en not_active Expired - Lifetime
2005
- 2005-09-21 JP JP2005273962A patent/JP2006056897A/ja active Pending

Also Published As

Publication number	Publication date
ES2166300A1 (es)	2002-04-01
CH693732A8 (fr)	2004-02-27
ZA978355B (en)	1999-03-17
ITTO970823A1 (it)	1999-03-18
GB9906314D0 (en)	1999-05-12
SE9900893D0 (sv)	1999-03-12
BR9713469A (pt)	2000-04-11
DE19781981T1 (de)	1999-09-23
AU733408C (en)	1998-04-14
FR2753377A1 (fr)	1998-03-20
FR2753377B1 (fr)	1999-09-24
BR9713469B1 (pt)	2013-10-29
GB2334888B (en)	2001-02-28
AU733408B2 (en)	2001-05-10
JP2006056897A (ja)	2006-03-02
BE1011370A5 (fr)	1999-08-03
CH693732A5 (fr)	2004-01-15
IE970675A1 (en)	1999-01-13
JP2001503390A (ja)	2001-03-13
IT1297193B1 (it)	1999-08-03
GB2334888A (en)	1999-09-08
JP3756194B2 (ja)	2006-03-15
AU4211097A (en)	1998-04-14
DE19781981B3 (de)	2013-05-29
US6482425B1 (en)	2002-11-19
MA24360A1 (fr)	1998-07-01
NL1007088C2 (nl)	1998-03-20
WO1998011780A1 (fr)	1998-03-26
SE9900893L (sv)	1999-04-16
ES2166300B1 (es)	2003-09-16

Legal Events

Date	Code	Title	Description
1998-08-31	A1OB	Publication of a patent application
1998-09-19	ODRP	Renewal fee for the maintenance of a patent	Payment date: 19980919 Year of fee payment: 2
1998-12-17	AIPI	Request for the grant of a patent on the basis of a substantive examination of a patent application
2003-04-15	ODBI	Application refused

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