HU197584B - Process for producing 2,3-diamino-2,3-dideoxy-hexose derivatives and pharmaceuticals comprising same as active ingredient - Google Patents

Process for producing 2,3-diamino-2,3-dideoxy-hexose derivatives and pharmaceuticals comprising same as active ingredient Download PDF

Info

Publication number
HU197584B
HU197584B HU852162A HU216285A HU197584B HU 197584 B HU197584 B HU 197584B HU 852162 A HU852162 A HU 852162A HU 216285 A HU216285 A HU 216285A HU 197584 B HU197584 B HU 197584B
Authority
HU
Hungary
Prior art keywords
hydrogen
phosphate
dideoxy
diamino
compound
Prior art date
Application number
HU852162A
Other languages
English (en)
Hungarian (hu)
Other versions
HUT42099A (en
Inventor
Ingolf Macher
Frank M Unger
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19843415100 external-priority patent/DE3415100A1/de
Priority claimed from DE19843415102 external-priority patent/DE3415102A1/de
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of HUT42099A publication Critical patent/HUT42099A/hu
Publication of HU197584B publication Critical patent/HU197584B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • C07H11/04—Phosphates; Phosphites; Polyphosphates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
HU852162A 1984-04-21 1985-04-17 Process for producing 2,3-diamino-2,3-dideoxy-hexose derivatives and pharmaceuticals comprising same as active ingredient HU197584B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19843415100 DE3415100A1 (de) 1984-04-21 1984-04-21 Neue 2,3-diamino-2,3-didesoxyhexosederivate, verfahren zu ihrer herstellung und ihre verwendung
DE19843415102 DE3415102A1 (de) 1984-04-21 1984-04-21 Neue 2,3-diamino-2,3-didesoxyhexosederivate, verfahren zu ihrer herstellung und ihre verwendung
PCT/EP1985/000171 WO1985004881A1 (en) 1984-04-21 1985-04-17 2,3-dinamo-2,3-didesoxyhexose derivatives, processes for their preparation and their use

Publications (2)

Publication Number Publication Date
HUT42099A HUT42099A (en) 1987-06-29
HU197584B true HU197584B (en) 1989-04-28

Family

ID=25820628

Family Applications (1)

Application Number Title Priority Date Filing Date
HU852162A HU197584B (en) 1984-04-21 1985-04-17 Process for producing 2,3-diamino-2,3-dideoxy-hexose derivatives and pharmaceuticals comprising same as active ingredient

Country Status (16)

Country Link
US (1) US4698331A (2)
EP (1) EP0180608B1 (2)
AT (1) ATE54920T1 (2)
AU (1) AU580061B2 (2)
CA (1) CA1264739A (2)
DE (1) DE3578866D1 (2)
DK (1) DK600585D0 (2)
ES (1) ES8605531A1 (2)
FI (1) FI81807C (2)
GR (1) GR850955B (2)
HU (1) HU197584B (2)
IL (1) IL75042A (2)
NZ (1) NZ211846A (2)
PH (1) PH23127A (2)
PT (1) PT80320B (2)
WO (1) WO1985004881A1 (2)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU199494B (en) * 1985-06-28 1990-02-28 Sandoz Ag Process for producing new saccharides and pharmaceutical compositions comprising same
DE3731953A1 (de) 1987-09-23 1989-04-06 Sandoz Ag Neue saccharide, verfahren zu ihrer herstellung und ihre verwendung
US5219843A (en) * 1987-09-23 1993-06-15 Sandoz Ltd. Saccharide derivatives
ATE397001T1 (de) * 2000-02-10 2008-06-15 Mitsui Chemicals Inc Verfahren zur selektiven herstellung eines 1- phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78246B (2) * 1981-01-23 1984-09-26 Ciba Geigy Ag
US4384998A (en) * 1981-03-30 1983-05-24 Merck & Co., Inc. Synthesis of thienamycin from D-glucose
DE3220426A1 (de) * 1982-05-29 1983-12-01 Behringwerke Ag, 3550 Marburg Chemische verbindung, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung der malaria
JPS60501259A (ja) * 1983-05-06 1985-08-08 ウイスコンシン・アルムニ・リサ−チ・フアンデ−シヨン 免疫刺激活性をもつ単糖類化合物
US4481196A (en) * 1983-08-31 1984-11-06 Fujisawa Pharmaceutical Co., Ltd. Glycoside phosphate derivatives, pharmaceutical composition of the same and method of use
DE3347163A1 (de) * 1983-12-27 1985-07-04 Behringwerke Ag, 3550 Marburg Verwendung von oligosacchariden zur chemotherapie oder chemoprophylaxe der malaria
US4481198A (en) * 1984-02-13 1984-11-06 Wisconsin Alumni Research Foundation Vitamin D metabolism inhibitor

Also Published As

Publication number Publication date
ES542416A0 (es) 1986-03-16
US4698331A (en) 1987-10-06
PT80320A (en) 1985-05-01
FI81807C (fi) 1990-12-10
HUT42099A (en) 1987-06-29
EP0180608B1 (en) 1990-07-25
WO1985004881A1 (en) 1985-11-07
ES8605531A1 (es) 1986-03-16
DK600585A (da) 1985-12-20
DE3578866D1 (de) 1990-08-30
EP0180608A1 (en) 1986-05-14
ATE54920T1 (de) 1990-08-15
AU4238085A (en) 1985-11-15
NZ211846A (en) 1989-07-27
DK600585D0 (da) 1985-12-20
GR850955B (2) 1985-11-25
FI81807B (fi) 1990-08-31
FI855132L (fi) 1985-12-20
PT80320B (en) 1987-02-16
CA1264739A (en) 1990-01-23
AU580061B2 (en) 1988-12-22
IL75042A0 (en) 1985-08-30
FI855132A0 (fi) 1985-12-20
IL75042A (en) 1989-05-15
PH23127A (en) 1989-05-05

Similar Documents

Publication Publication Date Title
JP3723227B2 (ja) ジ（ウリジン５’）−テトラホスフェート及びその塩の大規模生産のための方法
JP2590248B2 (ja) 抗ウイルス・抗腫瘍・抗転移・免疫系増強ヌクレオシド類およびヌクレオチド類
CS205027B2 (en) Method of producing glucosamine derivatives
JPH11506419A (ja) 化学的化合物
US7091334B2 (en) Method for large-scale production of di(uridine 5′)-tetraphosphate and salts thereof
US4548923A (en) Muramyl peptides and processes for their manufacture
AU596800B2 (en) Improvements in or relating to organic compounds
FI89494C (fi) Foerfarande foer framstaellning av nya sackaridderivat
US3920630A (en) 2,2{40 -Anhydro-ara-cytidine compounds and process of preparation
EP0267297B1 (en) Sialosylcholesterol, process for its preparation, and drug for treating diseases of nervous system
EP0014159B1 (en) Immunologically active dipeptidyl saccharides and methods of preparation
EP0180608B1 (en) 2,3-diamino-2,3-didesoxyhexose derivatives, processes for their preparation and their use
US4866035A (en) Dipeptidyl saccharides as host resistance enhancers in AIDS-immuno-compromised hosts and methods of use
AZUMA et al. Polyoxin analogs. III. Synthesis and biological activity of aminoacyl derivatives of polyoxins C and L
KR890004136B1 (ko) 시 알로실 콜레스테롤 및 그의 제조 방법 및 시알로실 콜레스테롤로 이루어지는 신경성 질환 치료제
JPS61501919A (ja) ３−ジアミノ−２，３−ジデスオキシヘキソ−ス誘導体、その製造方法およびその使用
JPH08837B2 (ja) サイクリツクａｍｐ誘導体
JPS624297A (ja) 新規糖類、その製法および医薬組成物
HU199861B (en) Process for producing 1-0-phosphono-d-glycopyranose derivatives substituted by tetradecanoyl group and pharmaceutical compositions comprising same
HU176636B (hu) Eljárás N4 acil-1β-D-arabinofuranozil-citozin-foszfát-származékok előállítására
Rajabalee Approaches to the Synthesis of Polyamino Monosaccharides
KR830002059B1 (ko) 멀아밀-펲타이드형태인 신규 화합물의 제조방법
GB2195338A (en) 4-O-phosphono-glycosides
MXPA99011769A (en) Method for large-scale production of di(uridine 5'-tetraphosphate) and salts thereof
HK1028613B (en) Method for large-scale production of di(uridine 5')-tetraphosphate and salts thereof

Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee