HUE028070T2 - Új kollagén anyagok és eljárások ezek elõállítására - Google Patents
Új kollagén anyagok és eljárások ezek elõállítására Download PDFInfo
- Publication number
- HUE028070T2 HUE028070T2 HUE10715551A HUE10715551A HUE028070T2 HU E028070 T2 HUE028070 T2 HU E028070T2 HU E10715551 A HUE10715551 A HU E10715551A HU E10715551 A HUE10715551 A HU E10715551A HU E028070 T2 HUE028070 T2 HU E028070T2
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- HU
- Hungary
- Prior art keywords
- collagen
- cross
- solution
- linking
- collagen material
- Prior art date
Links
- 108010035532 Collagen Proteins 0.000 title claims description 204
- 102000008186 Collagen Human genes 0.000 title claims description 204
- 229920001436 collagen Polymers 0.000 title claims description 204
- 239000000463 material Substances 0.000 title claims description 96
- 238000000034 method Methods 0.000 title claims description 58
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 65
- 239000000243 solution Substances 0.000 claims description 52
- 239000012528 membrane Substances 0.000 claims description 37
- 229910021529 ammonia Inorganic materials 0.000 claims description 29
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- 239000007864 aqueous solution Substances 0.000 claims description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims description 4
- 239000000512 collagen gel Substances 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 229920000945 Amylopectin Polymers 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 1
- HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical compound CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 claims 1
- 235000002566 Capsicum Nutrition 0.000 claims 1
- 241000272201 Columbiformes Species 0.000 claims 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims 1
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- 235000015278 beef Nutrition 0.000 claims 1
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- 241000335053 Beta vulgaris Species 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 241001550206 Colla Species 0.000 description 1
- 241000448280 Elates Species 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
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- IYYIVELXUANFED-UHFFFAOYSA-N bromo(trimethyl)silane Chemical compound C[Si](C)(C)Br IYYIVELXUANFED-UHFFFAOYSA-N 0.000 description 1
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- BULVZWIRKLYCBC-UHFFFAOYSA-N phorate Chemical compound CCOP(=S)(OCC)SCSCC BULVZWIRKLYCBC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
- Y10T428/1348—Cellular material derived from plant or animal source [e.g., wood, cotton, wool, leather, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Claims (10)
- Szabadalmi Igénypontok il Eljárás kollagén anyag elMlíáására, ami leSename, hogy az. tamtaamfc#v$ta8 ládánkét: a) eiöáliíy ák egy sav tormáira» lévő natív vagy deaaturált kollagén vizes oldsstát, b| hozzáadunk egy' $ma& pH-η nem reaktiv »Mehid íérhálésMszefí, #a vizes kollagén oldatot sígtoljnk vagy Ín|SL # a vizes kollagén oldatot ammôKiagiK^yegœk: keléssel fcoagts!á§úk és iérfeáíósájafe *} az. apsnöpistolesléget eliávoláj ok, és saMíissa! kollagén anyagot kapunk.
- 2. Az 3 . igájyportt szerinti eljárás kollagén anyag előállítására, ázzál jellenrezve, hogy az. a) lépés szerinti vizes ölési 0,Öő4s tómeg% kollagént tartalmaz sas? tormábm
- 3. Az I. vagy % igénypont szerinti éfáirás kollagén anyag élMlkására, azzal jellensezve, l«^y sa a| lépés szerinti vizes oldatot sertés!?*, marha!«, feárányin és csikóin kollagénpi kézül kiválasztod sssas rostos kollagénnel állítjuk eió.
- 4. Á® i -3, igénypontok bármelyike szerinti eljárás kollagén anyag elMiíMsára, ami jellemezve, hogy a él lépésben & kollagén óidat keagulálásáS és téaháiósltását arnruániagám] legalább M óráit át Vepsjí kezeléssel végezzük.:
- 5. Az 1-4, igénypontok bármelyike szerinti eljárás koitagén stlyag élfáiláására, ami jeltotnézyé, hogy az aldehid: lérlrálositoszejl glikpgért és aldehid amilopektinek közül választgjh.
- Ó. Az 1--4. ^H^yiee szerinti eljárás kollagén anyag előállítására, azzal jellestem, hogy azgtidehiá
- 7, At. St vagy 6. igénypont szériái! epzás kollagén anyag elM! lírására, azzal jéllemézve, hogy az aide* híd térliálósitoszert f,S5-ó tímemánybs esó arányokban adagoljuk az aldehid tétoálósidszer €110 és a kollagén Mily arányára vonatkoztatva.
- I, Az: 1»7. tgénypóálik.-Í^^él5áák#:-issÉáRtí eprás kollagén anyag etoáMáásnta. azzal jellestezve, hogy a kollagén anyag egy mentberán, azzal hogy a e> lépésben a vite® kollagén oldatot: egy lapos préstortnán belyéz-zttfc el, továbbá azzal, hogy #;.#:;ï|pési^t-:ÉK-^s8!^^Ôfesfeg6t..eÂo!l^k» és szárítássá! kollagén membránt kaptunk.
- 9. Kollagén anyag, amely az 3-S. igénypontok bármelyike szerinti elíátással van előállítva, homogén tér-Midsitássaí, ahol az anyag külső telszinén végbtoő tom#ősodás és belsejében: végbemenő tétbálósötMs Mzbltt különbség 25% vagy ennél kisebb.
- 10, ¾ <>. ígénygöm matimx· kollagén anyag, ahol a denahirácxős höméAőklet emelkedés TC vagy *»nSl nagyobb a nem térhálósított kollagén anyaghoz viszonyítva, IK A & vagy K), igénypont szeAsirÄälbstet kollagén anyag, ahol a denaiorácios hőmérséklet «mel-anyaghoz viszonyllAa isgaMbs 5%. 12, A 9ΊΚ igénypontok bármelyike sneimti kollagén anyag, amely kollagén membránból, kollagén Símből, kollagéíi ssiiMly kollagén nádból, koltégéh szmesből vagy kollagén gélből ill, 33:. A SM L Igényposiek bÉAiélylke szerinti kollagén anyag, ápely olyán kollagén membránból ál. mnelynek száraz vastagságé §0 ym és 120 pm közötti, sűrSsége 12 és ló mgámr közötti, duzzadást aranya kisebb xsM ö, vamboeghiztA szilárdsága tiagyöbb mini 1 H, iblptsí határa nagyobb mist 4 MiPa és százalékos etónsÉais degraÄiila irípsatinel kevesebb: mint 35%, 14, K-Oxaipozit atipg, antely tartalmaz egy textíliát, amely egyik oldalán vagy mindegyik oldalán ógg, a fAl,: igénypontok bátmelyiko számit! anyaggal vas bevonva, előnyösen a tódba bele lebet foglalva a kollagén anyagbá,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0952768A FR2944706B1 (fr) | 2009-04-28 | 2009-04-28 | Nouveaux materiaux en collagene et procedes d'obtention. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE028070T2 true HUE028070T2 (hu) | 2016-11-28 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE10715551A HUE028070T2 (hu) | 2009-04-28 | 2010-04-28 | Új kollagén anyagok és eljárások ezek elõállítására |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9168326B2 (hu) |
| EP (1) | EP2424579B1 (hu) |
| JP (2) | JP5886187B2 (hu) |
| CN (1) | CN102458493B (hu) |
| BR (1) | BRPI1007630B1 (hu) |
| CA (1) | CA2759654C (hu) |
| DK (1) | DK2424579T3 (hu) |
| ES (1) | ES2551168T3 (hu) |
| FR (1) | FR2944706B1 (hu) |
| HU (1) | HUE028070T2 (hu) |
| PL (1) | PL2424579T3 (hu) |
| PT (1) | PT2424579E (hu) |
| WO (1) | WO2010125086A1 (hu) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2954706B1 (fr) | 2009-12-31 | 2013-01-18 | Biom Up | Matrice composite |
| RS59243B1 (sr) | 2011-04-27 | 2019-10-31 | Biomup | Hemostatski sastavi |
| FR3004333B1 (fr) | 2013-04-11 | 2019-08-23 | Biom'up | Prothese implantable de renfort, en particulier pour le renfort de la paroi abdominale |
| FR3011185B1 (fr) * | 2013-10-02 | 2016-10-28 | Univ Pierre Et Marie Curie Paris 6 | Procede de preparation d'une matrice de collagene fibrille |
| CN104399120B (zh) * | 2014-10-31 | 2016-08-17 | 陕西艾尔肤组织工程有限公司 | 一种胶原膜的制备方法及胶原膜 |
| EP3337923B2 (en) | 2015-09-21 | 2023-01-04 | Modern Meadow, Inc. | Fiber reinforced tissue composites |
| JP7109882B2 (ja) | 2016-02-15 | 2022-08-01 | モダン メドウ，インコーポレイテッド | コラーゲンフィブリルを含むバイオファブリケーテッド材料を作製するための方法 |
| HUE055368T2 (hu) | 2016-08-12 | 2021-11-29 | Biomup France Sas | Vérzéscsillapító folyadék |
| AU2018253595A1 (en) | 2017-11-13 | 2019-05-30 | Modern Meadow, Inc. | Biofabricated leather articles having zonal properties |
| EP3752211B1 (en) | 2018-02-15 | 2023-12-27 | Dilon Technologies Inc. | Multi-dimensional hemostatic product and method for producing the same |
| IL258392A (en) * | 2018-03-27 | 2018-05-31 | Datum Dental Ltd | A shaped block comprising collagen |
| AU2020209847B2 (en) | 2019-01-17 | 2024-10-17 | Modern Meadow, Inc. | Layered collagen materials and methods of making the same |
| EP4143258A4 (en) | 2020-05-01 | 2024-05-22 | Modern Meadow, Inc. | PROTEIN POLYURETHANE ALLOYS AND LAYERING MATERIALS |
| EP4271281A1 (en) * | 2020-12-30 | 2023-11-08 | Stichting Radboud universitair medisch centrum | Expandable plug |
| CN113384748B (zh) * | 2021-04-29 | 2022-04-26 | 尚诚怡美(成都)生物科技有限公司 | 一种胶原蛋白真皮植入剂及其制备方法 |
| CN116983459B (zh) * | 2023-07-14 | 2024-06-25 | 湖南贝耐特生物科技有限公司 | 一种基于海狸鼠肌腱的低免疫原性可吸收缝合线的制备方法 |
| CN118241483A (zh) * | 2024-03-27 | 2024-06-25 | 北京艾佰瑞生物技术有限公司 | 核糖交联胶原蛋白纤维及其制备和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601371B1 (fr) | 1986-07-11 | 1989-05-12 | Merieux Inst | Procede de traitement du collagene en vue, notamment, d'en faciliter la reticulation et collagene obtenu par application dudit procede |
| US5157111A (en) * | 1991-05-02 | 1992-10-20 | Pachence James M | Method of bonding collagen to fibers, particularly dacron |
| JPH06292716A (ja) * | 1993-04-09 | 1994-10-21 | Shimizu Yoshihiko | 医用材料 |
| FR2724563A1 (fr) * | 1994-09-15 | 1996-03-22 | Coletica | Utilisation de membranes collageniques comme protheses de regeneration peritoneale |
| JP3543869B2 (ja) | 1995-03-07 | 2004-07-21 | 株式会社メニコン | 培養皮膚およびその製造法 |
| FR2754268B1 (fr) | 1996-10-07 | 1998-12-24 | Dev Des Utilisations Du Collag | Composition adhesive a base de polyaldehyde macromoleculaire et procede de reticulation de collagene ou de gelatine |
| FR2766717B1 (fr) * | 1997-08-01 | 2000-06-09 | Cogent Sarl | Prothese composite pour la prevention des adherences post-chirurgicales et son procede d'obtention |
| JPH11319068A (ja) | 1998-05-12 | 1999-11-24 | Menicon Co Ltd | 人工皮膚用基材およびその製法 |
| CZ301649B6 (cs) | 2000-06-28 | 2010-05-12 | Ed. Geistlich Soehne Ag Fur Chemische Industrie Incorporated Under The Laws Of Switzerland | Trubice pro regeneraci nervu a zpusob jejich výroby |
| EP1370194B1 (en) * | 2001-03-23 | 2013-01-23 | Histogenics Corporation | Composition and methods fro the production of biological tissues and tissue constructs |
| US7217294B2 (en) * | 2003-08-20 | 2007-05-15 | Histogenics Corp. | Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof |
| WO2006029571A1 (en) * | 2004-09-14 | 2006-03-23 | The University Of Hong Kong | Photochemically crosslinked collagen scaffolds and methods for their preparation |
| JP2006087596A (ja) | 2004-09-22 | 2006-04-06 | Koken Co Ltd | 骨欠損部充填用コラーゲンスポンジ並びにその製造方法 |
| JP2008515848A (ja) | 2004-10-04 | 2008-05-15 | アンスティテュ、ナショナール、デ、スィアンス、アプリケ、ド、リヨン | コラーゲン上での疎水性物質の共有結合グラフト化 |
| FR2877669B1 (fr) | 2004-11-05 | 2007-01-26 | Inst Nat Sciences Appliq | Greffage covalent de substances hydrophobes sur le collagene |
| FR2902661B1 (fr) | 2006-06-22 | 2011-05-13 | Orthomed | Tubes de collagene |
| US20090054984A1 (en) * | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
-
2009
- 2009-04-28 FR FR0952768A patent/FR2944706B1/fr active Active
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2010
- 2010-04-28 WO PCT/EP2010/055681 patent/WO2010125086A1/fr not_active Ceased
- 2010-04-28 DK DK10715551.7T patent/DK2424579T3/en active
- 2010-04-28 ES ES10715551.7T patent/ES2551168T3/es active Active
- 2010-04-28 CA CA2759654A patent/CA2759654C/fr active Active
- 2010-04-28 PL PL10715551T patent/PL2424579T3/pl unknown
- 2010-04-28 HU HUE10715551A patent/HUE028070T2/hu unknown
- 2010-04-28 BR BRPI1007630A patent/BRPI1007630B1/pt active IP Right Grant
- 2010-04-28 JP JP2012507724A patent/JP5886187B2/ja active Active
- 2010-04-28 EP EP10715551.7A patent/EP2424579B1/fr active Active
- 2010-04-28 US US13/266,370 patent/US9168326B2/en active Active
- 2010-04-28 PT PT107155517T patent/PT2424579E/pt unknown
- 2010-04-28 CN CN201080028976.XA patent/CN102458493B/zh active Active
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2015
- 2015-09-21 US US14/860,363 patent/US10004825B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| DK2424579T3 (en) | 2015-10-19 |
| EP2424579B1 (fr) | 2015-09-02 |
| US10004825B2 (en) | 2018-06-26 |
| FR2944706A1 (fr) | 2010-10-29 |
| JP2012525176A (ja) | 2012-10-22 |
| PT2424579E (pt) | 2015-11-03 |
| US20120040119A1 (en) | 2012-02-16 |
| WO2010125086A1 (fr) | 2010-11-04 |
| US9168326B2 (en) | 2015-10-27 |
| CN102458493B (zh) | 2016-07-06 |
| CA2759654A1 (fr) | 2010-11-04 |
| JP5886187B2 (ja) | 2016-03-16 |
| PL2424579T3 (pl) | 2016-01-29 |
| JP2016116856A (ja) | 2016-06-30 |
| FR2944706B1 (fr) | 2012-08-24 |
| CN102458493A (zh) | 2012-05-16 |
| BRPI1007630B1 (pt) | 2018-10-09 |
| BRPI1007630A2 (pt) | 2016-02-23 |
| ES2551168T3 (es) | 2015-11-16 |
| US20160008509A1 (en) | 2016-01-14 |
| JP6316795B2 (ja) | 2018-04-25 |
| CA2759654C (fr) | 2017-08-15 |
| EP2424579A1 (fr) | 2012-03-07 |
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