HUE039931T2 - Szfingozin-1-foszfát receptor agonisták, azok elkészítési eljárásai, és azokat aktív ágensként tartalmazó gyógyszerészeti készítmények - Google Patents
Szfingozin-1-foszfát receptor agonisták, azok elkészítési eljárásai, és azokat aktív ágensként tartalmazó gyógyszerészeti készítményekInfo
- Publication number
- HUE039931T2 HUE039931T2 HUE14753476A HUE14753476A HUE039931T2 HU E039931 T2 HUE039931 T2 HU E039931T2 HU E14753476 A HUE14753476 A HU E14753476A HU E14753476 A HUE14753476 A HU E14753476A HU E039931 T2 HUE039931 T2 HU E039931T2
- Authority
- HU
- Hungary
- Prior art keywords
- same
- sphingosine
- preparing
- methods
- pharmaceutical compositions
- Prior art date
Links
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 title 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 title 1
- 239000013543 active substance Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20130018293 | 2013-02-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE039931T2 true HUE039931T2 (hu) | 2019-02-28 |
Family
ID=51391525
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE14753476A HUE039931T2 (hu) | 2013-02-20 | 2014-02-19 | Szfingozin-1-foszfát receptor agonisták, azok elkészítési eljárásai, és azokat aktív ágensként tartalmazó gyógyszerészeti készítmények |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9540362B2 (fr) |
| EP (1) | EP2958913B1 (fr) |
| JP (1) | JP6294359B2 (fr) |
| KR (1) | KR101939657B1 (fr) |
| CN (1) | CN105051037B (fr) |
| AU (1) | AU2014219575B2 (fr) |
| BR (1) | BR112015019794B1 (fr) |
| DK (1) | DK2958913T3 (fr) |
| ES (1) | ES2698359T3 (fr) |
| HU (1) | HUE039931T2 (fr) |
| MX (1) | MX370032B (fr) |
| PL (1) | PL2958913T3 (fr) |
| PT (1) | PT2958913T (fr) |
| RU (1) | RU2654483C2 (fr) |
| SI (1) | SI2958913T1 (fr) |
| TW (1) | TWI582073B (fr) |
| WO (1) | WO2014129796A1 (fr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI692469B (zh) * | 2012-11-09 | 2020-05-01 | 南韓商Ｌｇ化學股份有限公司 | Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物 |
| KR102644587B1 (ko) * | 2015-12-24 | 2024-03-07 | (주)아모레퍼시픽 | 유사 세라마이드 화합물 및 그 제조방법 |
| EP3409658B9 (fr) * | 2016-01-29 | 2024-07-17 | ONO Pharmaceutical Co., Ltd. | Dérivé de tétrahydronaphtalène |
| ES2877686T3 (es) * | 2016-07-22 | 2021-11-17 | Shijiazhuang Sagacity New Drug Dev Co Ltd | Agonista S1P1 y aplicación del mismo |
| WO2018162607A1 (fr) * | 2017-03-07 | 2018-09-13 | F. Hoffmann-La Roche Ag | Oxadiazole en tant qu'inhibiteurs de canaux potentiels de récepteur transitoire |
| CN107382965A (zh) * | 2017-08-14 | 2017-11-24 | 河南科技大学第附属医院 | 具有抗肿瘤活性的新型s1p‑1受体激动剂药物分子的合成方法 |
| KR101891051B1 (ko) * | 2018-01-29 | 2018-08-31 | 주식회사 세종바이오메드 | 스핑고신-1-포스페이트 유사체 및 이의 합성 방법 |
| US10710994B2 (en) | 2018-03-19 | 2020-07-14 | Genentech, Inc. | Oxadiazole transient receptor potential channel inhibitors |
| CN113784713A (zh) * | 2019-01-11 | 2021-12-10 | 纳吉斯制药股份有限公司 | 白三烯合成抑制剂 |
| CN110240537B (zh) * | 2019-05-22 | 2022-06-21 | 成都阿奇生物医药科技有限公司 | 一种茚氧乙酸类化合物及其制备方法和用途 |
| EP4050010B1 (fr) | 2019-12-03 | 2023-10-18 | LG Chem, Ltd. | Agoniste du récepteur de sphingosine-1-phosphate, son procédé de préparation et composition pharmaceutique le comprenant en tant qu'agent actif |
| KR20210073998A (ko) | 2019-12-11 | 2021-06-21 | 주식회사 엘지화학 | 다발성 경화증 예방 또는 치료용 약제학적 조성물 |
| CA3192701A1 (fr) * | 2020-09-28 | 2022-03-31 | Ki Chan Kim | Utilisation d'un agoniste d'un recepteur de la sphingosine-1-phosphate |
| TW202220651A (zh) * | 2020-09-28 | 2022-06-01 | 南韓商Ｌｇ化學股份有限公司 | 神經鞘胺醇－１－磷酸受體促效劑的用途 |
| KR102647663B1 (ko) * | 2020-10-13 | 2024-03-14 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조 방법 |
| KR102653918B1 (ko) * | 2020-10-13 | 2024-04-02 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제 합성을 위한 중간체의 제조 방법 |
| CN117222632A (zh) * | 2021-04-14 | 2023-12-12 | 株式会社Lg化学 | 鞘氨醇-1-磷酸酯受体激动剂的结晶形式 |
| WO2022220598A1 (fr) * | 2021-04-14 | 2022-10-20 | 주식회사 엘지화학 | Forme cristalline d'un agoniste du récepteur de la sphingosine-1-phosphate |
| US20240228441A1 (en) * | 2021-04-14 | 2024-07-11 | Lg Chem, Ltd. | Method for preparing intermediate for synthesis of sphingosine-1-phosphate receptor agonist |
| CN117202893A (zh) * | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 包含鞘氨醇-1-磷酸受体激动剂的可直接压缩的药物组合物 |
| CN117120038A (zh) * | 2021-04-14 | 2023-11-24 | 株式会社Lg化学 | 包含鞘氨醇-1-磷酸受体激动剂的固体制剂的制备方法 |
| KR102806317B1 (ko) * | 2021-04-14 | 2025-05-13 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제의 결정형 |
| WO2022220610A1 (fr) | 2021-04-14 | 2022-10-20 | 주식회사 엘지화학 | Procédé de préparation d'un intermédiaire pour la synthèse d'un agoniste du récepteur de la sphingosine-1-phosphate |
| KR102815426B1 (ko) * | 2021-04-14 | 2025-05-30 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제의 약제학적으로 허용되는 염 및 이의 결정형 |
| KR20220142379A (ko) * | 2021-04-14 | 2022-10-21 | 주식회사 엘지화학 | 습식과립법에 의한 스핑고신-1-인산 수용체 효능제를 포함하는 경구용 고형 제제의 제조 방법 |
| CN117203189A (zh) * | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 制备用于合成鞘氨醇-1-磷酸酯受体激动剂的中间体的方法 |
| KR102802371B1 (ko) * | 2021-04-14 | 2025-05-07 | 주식회사 엘지화학 | 스핑고신-1-인산 수용체 효능제의 신규한 제조방법 |
| US20240207242A1 (en) * | 2021-04-14 | 2024-06-27 | Lg Chem, Ltd. | Pharmaceutical composition comprising sphingosine-1-phosphate receptor agonist with controlled particle size |
| CN117136183B (zh) * | 2021-04-14 | 2026-03-31 | 株式会社Lg化学 | 制备鞘氨醇-1-磷酸酯受体激动剂的新方法 |
| CN117120426A (zh) * | 2021-04-14 | 2023-11-24 | 株式会社Lg化学 | 鞘氨醇-1-磷酸酯受体激动剂的结晶形式 |
| KR102533409B1 (ko) | 2021-11-04 | 2023-05-26 | 주식회사 넥스트젠바이오사이언스 | 2-아미노-2-(2-(1-데실-1h-1,2,3-트라이아졸-4-일)에틸)프로판-1,3-다이올의 신규염 및 이를 포함하는 약학적 조성물 |
| CN119968367A (zh) * | 2022-08-01 | 2025-05-09 | 韩国科学技术研究院 | 新型杂环基苯基甲胺衍生物、制备方法及其预防、缓解或治疗多发性硬化症的用途 |
| CN117126150A (zh) * | 2023-08-29 | 2023-11-28 | 仁合益康集团有限公司 | 一种阿齐沙坦酯钾盐杂质a的制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999011255A1 (fr) * | 1997-08-28 | 1999-03-11 | Ono Pharmaceutical Co., Ltd. | Regulateurs du recepteur active par les agents de proliferation des peroxysomes |
| AU2003261935A1 (en) | 2002-09-06 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| AU2003296405A1 (en) | 2003-01-06 | 2004-08-10 | Eli Lilly And Company | Fused heterocyclic derivatives as ppar modulators |
| US7425631B2 (en) | 2003-04-10 | 2008-09-16 | Amgen Inc. | Compounds and methods of use |
| JP5315611B2 (ja) | 2004-06-23 | 2013-10-16 | 小野薬品工業株式会社 | Ｓ１ｐ受容体結合能を有する化合物およびその用途 |
| BRPI0519012A2 (pt) | 2004-12-13 | 2008-12-23 | Ono Pharmaceutical Co | derivado do Ácido aminocarboxÍlico e seu uso medicinal |
| ATE451363T1 (de) | 2005-01-26 | 2009-12-15 | Schering Corp | 3-(indazol-5-yl)-(1,2,4)triazinderivate und verwandte verbindungen als proteinkinaseinhibitoren zur behandlung von krebs |
| JP2009528387A (ja) | 2006-03-02 | 2009-08-06 | スミスクライン・ビーチャム・コーポレイション | Ｐｉ３キナーゼ阻害剤として用いるためのチアゾロン |
| PE20080145A1 (es) | 2006-03-21 | 2008-02-11 | Janssen Pharmaceutica Nv | Tetrahidro-pirimidoazepinas como moduladores de trpv1 |
| JP2009269819A (ja) * | 2006-08-25 | 2009-11-19 | Asahi Kasei Pharma Kk | アミン化合物 |
| CA2669104A1 (fr) * | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Analogues d'hydrindane ayant une activite agoniste de recepteur de sphingosine-1-phosphate |
| US20110207704A1 (en) * | 2006-12-15 | 2011-08-25 | Abbott Laboratories | Novel Oxadiazole Compounds |
| AR064420A1 (es) | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| EP2173728A2 (fr) | 2007-07-17 | 2010-04-14 | Amgen Inc. | Modulateurs hétérocycliques de pkb |
| WO2009016460A2 (fr) | 2007-08-01 | 2009-02-05 | Pfizer Inc. | Composés pyrazoles |
| GB0725101D0 (en) | 2007-12-21 | 2008-01-30 | Glaxo Group Ltd | Compounds |
| EP3782991A1 (fr) | 2008-05-14 | 2021-02-24 | The Scripps Research Institute | Nouveaux modulateurs de récepteurs de la sphingosine phosphate |
| US8153103B2 (en) | 2008-07-01 | 2012-04-10 | Board Of Regents, The University Of Texas System | Conjugates of photo-activatable dyes |
| AU2009304596A1 (en) | 2008-10-17 | 2010-04-22 | Akaal Pharma Pty Ltd | S1P receptors modulators |
| US8741923B2 (en) | 2008-12-18 | 2014-06-03 | Merck Serono Sa | Oxadiazole fused heterocyclic derivatives useful for the treatment of multiple sclerosis |
| EP2202232A1 (fr) | 2008-12-26 | 2010-06-30 | Laboratorios Almirall, S.A. | Dérivés du 1,2,4-oxadiazole et leur application thérapeutique |
| US20100174539A1 (en) | 2009-01-06 | 2010-07-08 | Qualcomm Incorporated | Method and apparatus for vector quantization codebook search |
| KR20100092909A (ko) | 2009-02-13 | 2010-08-23 | 주식회사 엘지생명과학 | 잔틴 옥시다제 저해제로서 효과적인 신규 화합물, 그 제조방법 및 그를 함유하는 약제학적 조성물 |
| EP2241558A1 (fr) | 2009-04-03 | 2010-10-20 | Merck Serono SA | Dérivés d'oxadiazole |
| US9757368B2 (en) | 2009-04-22 | 2017-09-12 | Resverlogix Corp. | Anti-inflammatory agents |
| GB0910674D0 (en) | 2009-06-19 | 2009-08-05 | Glaxo Group Ltd | Novel compounds |
| EP2445891A4 (fr) | 2009-06-26 | 2012-11-14 | Glaxo Group Ltd | Dérivés hétéroaryliques à 5 chaînons utilisés comme agonistes de récepteurs à la sphingosine-1-phosphate |
| ES2665461T3 (es) | 2009-11-13 | 2018-04-25 | Celgene International Ii Sàrl | Moduladores del receptor esfingosina 1-fosfato y métodos de síntesis quiral |
| PH12012500940B1 (en) | 2009-11-13 | 2018-09-26 | Receptos Llc | Selective heterocyclic sphingosine 1 phosphate receptor modulators |
| MX2012006028A (es) * | 2009-11-24 | 2012-06-19 | Allergan Inc | Compuestos novedosos como moduladores de receptor con utilidad terapeutica. |
| EP2390252A1 (fr) | 2010-05-19 | 2011-11-30 | Almirall, S.A. | Nouveaux dérivés de pyrazole |
| AU2011332196A1 (en) * | 2010-11-24 | 2013-07-11 | Allergan, Inc. | Indole derivatives as modulators of S1P receptors |
| TWI692469B (zh) * | 2012-11-09 | 2020-05-01 | 南韓商Ｌｇ化學股份有限公司 | Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物 |
-
2014
- 2014-02-19 PT PT14753476T patent/PT2958913T/pt unknown
- 2014-02-19 ES ES14753476T patent/ES2698359T3/es active Active
- 2014-02-19 DK DK14753476.2T patent/DK2958913T3/en active
- 2014-02-19 EP EP14753476.2A patent/EP2958913B1/fr active Active
- 2014-02-19 AU AU2014219575A patent/AU2014219575B2/en active Active
- 2014-02-19 CN CN201480009397.9A patent/CN105051037B/zh active Active
- 2014-02-19 TW TW103105447A patent/TWI582073B/zh active
- 2014-02-19 KR KR1020140019113A patent/KR101939657B1/ko active Active
- 2014-02-19 RU RU2015139594A patent/RU2654483C2/ru active
- 2014-02-19 MX MX2015009986A patent/MX370032B/es active IP Right Grant
- 2014-02-19 WO PCT/KR2014/001336 patent/WO2014129796A1/fr not_active Ceased
- 2014-02-19 BR BR112015019794-9A patent/BR112015019794B1/pt active IP Right Grant
- 2014-02-19 SI SI201430907T patent/SI2958913T1/sl unknown
- 2014-02-19 HU HUE14753476A patent/HUE039931T2/hu unknown
- 2014-02-19 US US14/764,116 patent/US9540362B2/en active Active
- 2014-02-19 PL PL14753476T patent/PL2958913T3/pl unknown
- 2014-02-19 JP JP2015559180A patent/JP6294359B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9540362B2 (en) | 2017-01-10 |
| ES2698359T3 (es) | 2019-02-04 |
| AU2014219575B2 (en) | 2017-07-06 |
| MX2015009986A (es) | 2015-10-05 |
| DK2958913T3 (en) | 2018-11-05 |
| RU2015139594A (ru) | 2017-03-27 |
| JP2016513126A (ja) | 2016-05-12 |
| CN105051037A (zh) | 2015-11-11 |
| BR112015019794B1 (pt) | 2022-09-13 |
| EP2958913A4 (fr) | 2016-10-05 |
| AU2014219575A1 (en) | 2015-08-20 |
| PT2958913T (pt) | 2018-12-03 |
| PL2958913T3 (pl) | 2019-03-29 |
| WO2014129796A1 (fr) | 2014-08-28 |
| RU2654483C2 (ru) | 2018-05-21 |
| CN105051037B (zh) | 2018-05-18 |
| EP2958913A1 (fr) | 2015-12-30 |
| KR101939657B1 (ko) | 2019-01-17 |
| JP6294359B2 (ja) | 2018-03-14 |
| EP2958913B1 (fr) | 2018-10-03 |
| KR20140104376A (ko) | 2014-08-28 |
| TW201444794A (zh) | 2014-12-01 |
| TWI582073B (zh) | 2017-05-11 |
| US20150376173A1 (en) | 2015-12-31 |
| SI2958913T1 (sl) | 2018-12-31 |
| MX370032B (es) | 2019-11-28 |
| BR112015019794A8 (pt) | 2018-08-14 |
| BR112015019794A2 (pt) | 2017-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SI2958913T1 (sl) | Sfingozin-1-fosfat receptor agonisti, postopki za njegovo pripravo in farmacevtski sestavki, ki ga vsebujejo kot aktivno sredstvo | |
| IL277385A (en) | Combinations of decitabine derivatives and other active substances, kits and preparations containing them and their uses | |
| GB2514951C (en) | Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof | |
| IL245504A0 (en) | Preparations containing bupropion or its analogues and dextromethorphan and their uses | |
| IL242348B (en) | Arylquinazolines, their preparation and pharmaceutical preparations containing them | |
| EP2947084B8 (fr) | Composé hétérocyclique à cinq et six chaînons, procédé de préparation, composition pharmaceutique et application associés | |
| ZA201509016B (en) | Compositions, methods & systems for respiratory delivery of three or more active agents | |
| PL3409270T3 (pl) | Preparat proszkowy zawierający środek antycholinergiczny, kortykosteroid i środek beta- adrenergiczny do podawania wziewnego | |
| EP3054933A4 (fr) | Formulations topiques agonistes du récepteur de la sphingosine-1-phosphate et procédés d'utilisation de celles-ci | |
| PL2961822T3 (pl) | Preparaty, ich zastosowanie jako środków do zmywania naczyń lub do wytwarzania środków do zmywania naczyń i ich wytwarzanie | |
| IL246406A0 (en) | History of imidazopyrazinone, their preparation and pharmaceutical preparations containing them | |
| IL243223B (en) | History of imidazole, their preparation and pharmaceutical preparations containing them | |
| PL2989192T3 (pl) | Preparaty, ich zastosowanie jako środków do zmywania naczyń lub do wytwarzania środków do zmywania naczyń i ich wytwarzanie | |
| MX367773B (es) | Forma salina sólida de la alfa-6-mpeg6-o-hidroxicodona como agonistas opioides y sus usos. | |
| IL239873A0 (en) | The history of piperidinylcarbazole, their preparation and pharmaceutical preparations containing them | |
| UA88242U (ru) | Применение ралейкина (антагониста рецепторов интерлейкина-1) как средства гипогликемического действия | |
| PT3036218T (pt) | Novas formas de co-cristais de agomelatina e ácido p-toluenossulfónico, processo para a sua preparação e composições farmacêuticas que as contêm | |
| ZA201308924B (en) | Pharmaceutical composition comprising an antiviral agent and method for the preparation thereof |