HUP0002242A2 - Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékok - Google Patents

Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékok

Info

Publication number: HUP0002242A2
Authority: HU; Hungary
Prior art keywords: alpha; alkyl; hydrogen; alkenyl; imidazolinylamino
Prior art date: 1997-04-15

Application number

HU0002242A

Other languages

English (en)

Hungarian (hu)

Inventor

Sophie Eva Bogdan

Thomas Lee Cupps

Raymond Todd Henry

Glen Edward Mieling

Nick Nikolaides

Russell James Sheldon

Original Assignee

The Procter & Gamble Co.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-15

Filing date

1998-04-09

Publication date

2001-04-28

1998-04-09 Application filed by The Procter & Gamble Co. filed Critical The Procter & Gamble Co.

2001-04-28 Publication of HUP0002242A2 publication Critical patent/HUP0002242A2/hu

Links

239000000556 agonist Substances 0.000 title 1
102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 title 1
108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 title 1
JYQSIEABODGLIB-UHFFFAOYSA-N n-(4,5-dihydroimidazol-1-yl)-3h-benzimidazol-5-amine Chemical class C1=NCCN1NC1=CC=C(N=CN2)C2=C1 JYQSIEABODGLIB-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
-1 hydroxy, mercapto Chemical group 0.000 abstract 2
108060003345 Adrenergic Receptor Proteins 0.000 abstract 1
102000017910 Adrenergic receptor Human genes 0.000 abstract 1
239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000002889 sympathetic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

HU0002242A 1997-04-15 1998-04-09 Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékok HUP0002242A2 (hu)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US4231697P	1997-04-15	1997-04-15
PCT/IB1998/000540 WO1998046595A1 (en)	1997-04-15	1998-04-09	5-(2-imidazolinylamino)benzimidazole compounds useful as alpha-2 adrenoceptor agonists

Publications (1)

Publication Number	Publication Date
HUP0002242A2 true HUP0002242A2 (hu)	2001-04-28

Family

ID=21921202

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0002242A HUP0002242A2 (hu)	1997-04-15	1998-04-09	Alfa-2 adrenoceptor agonistaként alkalmazható 5-[(imidazolinil)-amino]-benzoimidazol-származékok

Country Status (12)

Country	Link
EP (1)	EP0975627A1 (id)
JP (1)	JP2001519828A (id)
KR (1)	KR20010006440A (id)
CN (1)	CN1256691A (id)
AU (1)	AU6514498A (id)
BR (1)	BR9808904A (id)
CA (1)	CA2285610A1 (id)
HU (1)	HUP0002242A2 (id)
ID (1)	ID24081A (id)
IL (1)	IL132384A0 (id)
NO (1)	NO995030L (id)
WO (1)	WO1998046595A1 (id)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU704972B2 (en)	1994-08-04	1999-05-13	H. Lundbeck A/S	Novel benzimidazole derivatives
US6495583B1 (en)	1997-03-25	2002-12-17	Synaptic Pharmaceutical Corporation	Benzimidazole derivatives
KR20010032435A (ko) *	1997-11-24	2001-04-25	데이비드 엠 모이어	5-(2-이미다졸리닐아미노)벤즈이미다졸 유도체, 그의 제조및 대사 안정성이 개선된 알파-아드레날린수용체아고니스트로서의 그의 용도
US20040167194A1 (en)	2003-02-20	2004-08-26	Randall Jared Lynn	Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form
WO2010074753A1 (en)	2008-12-23	2010-07-01	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
CN110540523B (zh) *	2018-07-05	2021-02-19	安徽圣诺贝化学科技有限公司	一种制备磺基取代苯并咪唑及其衍生物的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5091528A (en) *	1990-09-12	1992-02-25	Allergan, Inc.	6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
US5478858A (en) *	1993-12-17	1995-12-26	The Procter & Gamble Company	5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
AU704972B2 (en) *	1994-08-04	1999-05-13	H. Lundbeck A/S	Novel benzimidazole derivatives

1998
- 1998-04-04 ID IDW991378A patent/ID24081A/id unknown
- 1998-04-09 JP JP54366398A patent/JP2001519828A/ja active Pending
- 1998-04-09 BR BR9808904-8A patent/BR9808904A/pt not_active IP Right Cessation
- 1998-04-09 IL IL13238498A patent/IL132384A0/xx unknown
- 1998-04-09 EP EP98910927A patent/EP0975627A1/en not_active Withdrawn
- 1998-04-09 AU AU65144/98A patent/AU6514498A/en not_active Abandoned
- 1998-04-09 WO PCT/IB1998/000540 patent/WO1998046595A1/en not_active Ceased
- 1998-04-09 CN CN98805130A patent/CN1256691A/zh active Pending
- 1998-04-09 CA CA002285610A patent/CA2285610A1/en not_active Abandoned
- 1998-04-09 HU HU0002242A patent/HUP0002242A2/hu unknown
- 1998-04-09 KR KR1019997009530A patent/KR20010006440A/ko not_active Ceased
1999
- 1999-10-15 NO NO995030A patent/NO995030L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0975627A1 (en)	2000-02-02
WO1998046595A1 (en)	1998-10-22
CN1256691A (zh)	2000-06-14
AU6514498A (en)	1998-11-11
BR9808904A (pt)	2005-02-22
CA2285610A1 (en)	1998-10-22
KR20010006440A (ko)	2001-01-26
NO995030D0 (no)	1999-10-15
ID24081A (id)	2000-07-06
IL132384A0 (en)	2001-03-19
JP2001519828A (ja)	2001-10-23
NO995030L (no)	1999-12-15

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