HUP1300680A2 - Process for preparing (11beta, 17alpha)-17-acetoxy-11-methyl-19-norpregn-4-en-3,20-dion - Google Patents

Process for preparing (11beta, 17alpha)-17-acetoxy-11-methyl-19-norpregn-4-en-3,20-dion

Info

Publication number
HUP1300680A2
HUP1300680A2 HU1300680A HUP1300680A HUP1300680A2 HU P1300680 A2 HUP1300680 A2 HU P1300680A2 HU 1300680 A HU1300680 A HU 1300680A HU P1300680 A HUP1300680 A HU P1300680A HU P1300680 A2 HUP1300680 A2 HU P1300680A2
Authority
HU
Hungary
Prior art keywords
norpregn
11beta
17alpha
dion
acetoxy
Prior art date
Application number
HU1300680A
Other languages
Hungarian (hu)
Inventor
Sandor Maho
Bela Soeroes
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Priority to HU1300680A priority Critical patent/HU230397B1/en
Priority to PCT/IB2014/066283 priority patent/WO2015075693A1/en
Priority to ARP140104409A priority patent/AR098524A1/en
Publication of HUP1300680A2 publication Critical patent/HUP1300680A2/en
Publication of HU230397B1 publication Critical patent/HU230397B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/0075—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
HU1300680A 2013-11-25 2013-11-25 Process for preparing (11b,17a)-17-acetoxy-11-methyl-19-norpregn-4-en-3,20-dion HU230397B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
HU1300680A HU230397B1 (en) 2013-11-25 2013-11-25 Process for preparing (11b,17a)-17-acetoxy-11-methyl-19-norpregn-4-en-3,20-dion
PCT/IB2014/066283 WO2015075693A1 (en) 2013-11-25 2014-11-24 Process for the synthesis of (11 beta.17alpha)-17-acetoxy-1 1 -methyl-19-norpregn-4-en-3.20-dione
ARP140104409A AR098524A1 (en) 2013-11-25 2014-11-25 PROCESS FOR THE SYNTHESIS OF (11b, 17a) -17-ACETOXI-11-METIL-3-OXO-NORPREGN-4-ENO

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1300680A HU230397B1 (en) 2013-11-25 2013-11-25 Process for preparing (11b,17a)-17-acetoxy-11-methyl-19-norpregn-4-en-3,20-dion

Publications (2)

Publication Number Publication Date
HUP1300680A2 true HUP1300680A2 (en) 2015-05-28
HU230397B1 HU230397B1 (en) 2016-04-28

Family

ID=89991338

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1300680A HU230397B1 (en) 2013-11-25 2013-11-25 Process for preparing (11b,17a)-17-acetoxy-11-methyl-19-norpregn-4-en-3,20-dion

Country Status (3)

Country Link
AR (1) AR098524A1 (en)
HU (1) HU230397B1 (en)
WO (1) WO2015075693A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109575098B (en) * 2019-01-18 2021-01-01 湖南成大生物科技有限公司 Synthetic method of norgestimate

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB912035A (en) 1960-06-22 1962-12-05 British Drug Houses Ltd 11ª--hydroxy-11ª--methyl steroids
GB912036A (en) 1960-06-23 1962-12-05 British Drug Houses Ltd 11-methylene-5ª--steroids
GB912037A (en) 1960-06-27 1962-12-05 British Drug Houses Ltd 11-methylene steroids
US3381003A (en) 1965-06-01 1968-04-30 Merck & Co Inc 3-keto-13beta-alkyl-17beta-acetyl-gona-4-ene-17alpha-ol compounds and processes of preparing them
ES361100A1 (en) * 1967-12-08 1970-10-16 Searle & Co 01beta-METHYL-19-NORPREGNENE COMPOUNDS
US3527778A (en) 1969-02-27 1970-09-08 Searle & Co 3,17 - bisoxygenated 11betamethyl - 19 - norpregn - 4 - en - 20 - ones and derivatives thereof
FR2377418A1 (en) * 1977-01-13 1978-08-11 Roussel Uclaf NEW 4,9-DIENIC 11B-SUBSTITUTE STEROID DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS MEDICINAL PRODUCTS
US6020328A (en) 1998-03-06 2000-02-01 Research Triangle Institute 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties
JP2006019516A (en) 2004-07-01 2006-01-19 Fujitsu Ltd Tunable laser and control method thereof
HU228636B1 (en) 2007-06-27 2013-04-29 Richter Gedeon Nyrt Industrial method for the synthesis of 17-acetoxy-11betha-4[-(dimethylamino)-phenyl]-21-methoxy-19-norpregna-4,9-dien-3,20-dione and the key intermediates of the process

Also Published As

Publication number Publication date
WO2015075693A1 (en) 2015-05-28
HU230397B1 (en) 2016-04-28
WO2015075693A8 (en) 2015-12-30
AR098524A1 (en) 2016-06-01

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