HUP1400543A2 - Eljárás és köztitermék apixaban elõállítására - Google Patents

Eljárás és köztitermék apixaban elõállítására

Info

Publication number
HUP1400543A2
HUP1400543A2 HU1400543A HUP1400543A HUP1400543A2 HU P1400543 A2 HUP1400543 A2 HU P1400543A2 HU 1400543 A HU1400543 A HU 1400543A HU P1400543 A HUP1400543 A HU P1400543A HU P1400543 A2 HUP1400543 A2 HU P1400543A2
Authority
HU
Hungary
Prior art keywords
apixaban
preparation
Prior art date
Application number
HU1400543A
Other languages
English (en)
Inventor
Tamas Nagy
Andras Mravik
Balazs Volk
Gabor Nemeth
Gyoezoe Csonka-Kis
Janos Farago
Peter Slegel
Zoltan Varga
Monika Mezoevari
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to HU1400543A priority Critical patent/HU230991B1/hu
Priority to PCT/HU2015/050018 priority patent/WO2016079549A1/en
Publication of HUP1400543A2 publication Critical patent/HUP1400543A2/hu
Publication of HU230991B1 publication Critical patent/HU230991B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU1400543A 2014-11-19 2014-11-19 Eljárás és köztitermék apixaban előállítására HU230991B1 (hu)

Priority Applications (2)

Application Number Priority Date Filing Date Title
HU1400543A HU230991B1 (hu) 2014-11-19 2014-11-19 Eljárás és köztitermék apixaban előállítására
PCT/HU2015/050018 WO2016079549A1 (en) 2014-11-19 2015-11-18 Process and intermediate for the preparation of apixaban

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1400543A HU230991B1 (hu) 2014-11-19 2014-11-19 Eljárás és köztitermék apixaban előállítására

Publications (2)

Publication Number Publication Date
HUP1400543A2 true HUP1400543A2 (hu) 2016-05-30
HU230991B1 HU230991B1 (hu) 2019-08-28

Family

ID=89991646

Family Applications (1)

Application Number Title Priority Date Filing Date
HU1400543A HU230991B1 (hu) 2014-11-19 2014-11-19 Eljárás és köztitermék apixaban előállítására

Country Status (2)

Country Link
HU (1) HU230991B1 (hu)
WO (1) WO2016079549A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107434806A (zh) * 2016-12-09 2017-12-05 陕西科技大学 一种阿哌沙班羧酸衍生物的γ晶型固体物质及其制备方法与用途
WO2018127936A1 (en) * 2017-01-05 2018-07-12 Hikal Limited Novel economic metal free process for apixaban
CN109400606B (zh) * 2018-12-26 2020-01-17 山东鲁抗医药股份有限公司 一种从阿哌沙班粗品中精制阿哌沙班的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1427415B1 (en) 2001-09-21 2009-08-12 Brystol-Myers Squibb Company Lactam-containing compounds and derivatives thereof as factor xa inhibitors
TW200303201A (en) 2001-12-10 2003-09-01 Bristol Myers Squibb Co Synthesis of 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
US7396932B2 (en) 2004-09-28 2008-07-08 Bristol-Myers Squibb Company Process for preparing 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones
CA2736370C (en) 2008-09-15 2016-12-13 Auspex Pharmaceuticals, Inc. Pyrazole carboxamide inhibitors of factor xa
CN101967145B (zh) 2010-09-09 2012-07-04 华东理工大学 一种抗血栓药物阿匹沙班的制备方法
JP2014516072A (ja) 2011-06-10 2014-07-07 ディフアルマ フランチス ソシエタ ア レスポンサビリタ リミタータ アピキサバン製造方法
CN104045637B (zh) * 2014-04-18 2016-04-06 河北科技大学 一种阿哌沙班的制备方法

Also Published As

Publication number Publication date
WO2016079549A1 (en) 2016-05-26
HU230991B1 (hu) 2019-08-28

Similar Documents

Publication Publication Date Title
IL279627A (en) A method for treating depression
ZA201707303B (en) Compositions and methods for the treatment of immunodeficiency
ZA201706795B (en) Process for the preparation of dicycloplatin
IL249891A0 (en) Process for the preparation of 4-Alkoxy-3-hydroxypicolinic acids
EP3189053A4 (en) An improved process for the preparation of apixaban and intermediates thereof
IL248267A0 (en) A process for preparing converted cycloserines
EP3212620A4 (en) Process for the preparation of apixaban and intermediates thereof
HUE069644T2 (hu) Eljárás és berendezés sajtolt idomok elõállítására
PT3113774T (pt) Composições de grapiprant e métodos de utilização das mesmas
EP3227298A4 (en) Process for the preparation of baricitinib and an intermediate thereof
SG11201702700UA (en) Methods for the treatment of peri-implantitis
IL251946B (en) Process for making micro particles
ZA201703336B (en) Novel products and methods
ZA201608823B (en) Processes for the preparation of azd5363 and novel intermediate used therein
IL247443B (en) Process for the preparation of 5-fluorotryptophol
PL3228619T3 (pl) Sposób wytwarzania apiksabanu
HUP1400378A2 (hu) Eljárás apixaban elõállítására
IL253077A0 (en) Process and intermediates for the preparation of Fermpanel
ZA201701973B (en) Process for the preparation of halo-substituted trifluoroacetophenones
HUE061732T2 (hu) Eljárás részecskék elõállítására
HUP1500647A2 (en) Intermediate of baricitinib and process for its preparation
IL237572A0 (en) Process and intermediates for the preparation of dastinib
IL241974A0 (en) Process for making erlotinib
HUP1400518A2 (hu) Eljárás tofacitinib elõállítására
HUE043114T2 (hu) Eljárás tetrakonazol elõállítására