HUP9600476A2 - Benzothiophene compounds, intermediates, process for their production, their use and compositions containing them - Google Patents
Benzothiophene compounds, intermediates, process for their production, their use and compositions containing themInfo
- Publication number
- HUP9600476A2 HUP9600476A2 HU9600476A HUP9600476A HUP9600476A2 HU P9600476 A2 HUP9600476 A2 HU P9600476A2 HU 9600476 A HU9600476 A HU 9600476A HU P9600476 A HUP9600476 A HU P9600476A HU P9600476 A2 HUP9600476 A2 HU P9600476A2
- Authority
- HU
- Hungary
- Prior art keywords
- carbon
- atom
- alkyl
- pyrrolidinyl
- general formula
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical class C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- -1 1-piperidinyl- Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
A találmány tárgya az (I) általánős képletű vegyület vagy gyógyászatiszempőntból alkalmas sója, ahől az (I) általánős képletben R1jelentése hidrőgénatőm, hidrőxilcsőpőrt, 1-4 szénatőmős alkőxicsőpőrt,-OCOC6H5, -OCO-(1-6 szénatőmős alkil) vagy -OSO2-(2-6 szénatőmősalkil) képletű csőpőrt; R2 jelentése hidrőgénatőm, hidrőxilcsőpőrt, 1-4 szénatőmős alkőxicsőpőrt, -OCOC6H5, -OCO-(1-6 szénatőmős alkil), -OSO2-(2-6 szénatőmős -alkil) képletű csőpőrt vagy halőgénatőm; R3jelentése 1-piperidinil-, 1-pirrőlidinil-, metil-1-pirőlidinil,dimetil-1-pirrőlidinil-, 4-mőrfőlinő-, dimetil-aminő-, dietil-aminő-,diizőprőpil-aminő- vagy 1-hexametilén-iminő-csőpőrt; n jelentése 2vagy 3; és Z jelentése őxigén- vagy kénatőm. Az (I) általánős képletűvegyületek alkalmasak a pősztmenőpaűzás szindrómaként összefőglaltbetegségek kezelésére. A találmány tárgyát képezik a vegyületekelőállítása sőrán felhasznált új intermedierek is. ŕThe subject of the invention is the compound of the general formula (I) or its salt suitable from a medical point of view, where R1 in the general formula (I) is a hydrogen atom, a hydroxyl group, a 1-4 carbon-alkoxy group, -OCOC6H5, -OCO-(1-6 carbon-alkyl) or -OSO2- pipe powder of the formula (C2-C6 alkyl); R2 represents a hydrogen atom, a hydroxyl atom, an 1-4 carbon-alkoxy atom, -OCOC6H5, -OCO-(1-6 carbon-alkyl), -OSO2-(2-6 carbon-alkyl) or a halo atom; R3 is 1-piperidinyl-, 1-pyrrolidinyl-, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl-, 4-methylamino-, dimethylamino-, diethylamino-, diisopropylamino- or 1-hexamethyleneimino- group; n is 2 or 3; and Z is an oxygen or sulfur atom. The compounds of the general formula (I) are suitable for the treatment of diseases classified as post-starvation syndrome. The subject of the invention is also the new intermediates often used in the production of compounds. ŕ
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/396,401 US5510357A (en) | 1995-02-28 | 1995-02-28 | Benzothiophene compounds as anti-estrogenic agents |
| US55276095A | 1995-11-03 | 1995-11-03 | |
| US08/552,636 US5723474A (en) | 1995-02-28 | 1995-11-03 | Benzothiophene compounds, intermediates, compositions, and methods |
| US08/552,564 US5998441A (en) | 1995-02-28 | 1995-11-03 | Benzothiophene compounds, intermediates, compositions, and methods |
| US08/554,223 US5856340A (en) | 1995-02-28 | 1995-11-03 | Method of treating estrogen dependent cancers |
| US08/552,565 US5977093A (en) | 1995-02-28 | 1995-11-03 | Benzothiophene compounds, intermediates, compositions, and methods |
| US08/552,679 US5856339A (en) | 1995-02-28 | 1995-11-03 | Benzothiophene compounds, intermediates, compositions, and methods |
| US08/552,890 US5919800A (en) | 1995-02-28 | 1995-11-03 | Benzothiophene compounds, intermediates, compositions, and methods |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| HU9600476D0 HU9600476D0 (en) | 1996-04-29 |
| HUP9600476A2 true HUP9600476A2 (en) | 1999-06-28 |
| HUP9600476A3 HUP9600476A3 (en) | 1999-07-28 |
| HU226326B1 HU226326B1 (en) | 2008-08-28 |
Family
ID=27575428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9600476A HU226326B1 (en) | 1995-02-28 | 1996-02-27 | Benzothiophene compounds, intermediates, process for their production, their use and compositions containing them |
Country Status (8)
| Country | Link |
|---|---|
| CN (1) | CN1086700C (en) |
| BR (1) | BR9600829A (en) |
| CA (1) | CA2170479C (en) |
| CZ (1) | CZ290200B6 (en) |
| FI (1) | FI120345B (en) |
| HU (1) | HU226326B1 (en) |
| NO (1) | NO314229B1 (en) |
| TR (1) | TR199600127A2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE535691C2 (en) * | 2011-03-08 | 2012-11-13 | Kat2Biz Ab | Reduction of C-O bonds via catalytic transfer hydrogenolysis |
| CN102746290B (en) * | 2012-06-21 | 2014-08-27 | 成都苑东药业有限公司 | Thiazole compound and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4117512A1 (en) * | 1991-05-25 | 1992-11-26 | Schering Ag | 2-PHENYLBENZO (B) FURANES AND THIOPHENES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM |
-
1996
- 1996-02-16 TR TR96/00127A patent/TR199600127A2/en unknown
- 1996-02-27 CN CN96105752A patent/CN1086700C/en not_active Expired - Fee Related
- 1996-02-27 HU HU9600476A patent/HU226326B1/en not_active IP Right Cessation
- 1996-02-27 CZ CZ1996588A patent/CZ290200B6/en not_active IP Right Cessation
- 1996-02-27 FI FI960909A patent/FI120345B/en not_active IP Right Cessation
- 1996-02-27 NO NO19960796A patent/NO314229B1/en not_active IP Right Cessation
- 1996-02-27 CA CA 2170479 patent/CA2170479C/en not_active Expired - Fee Related
- 1996-02-27 BR BR9600829A patent/BR9600829A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9600476D0 (en) | 1996-04-29 |
| CA2170479C (en) | 2009-04-14 |
| CN1159448A (en) | 1997-09-17 |
| TR199600127A2 (en) | 1996-10-21 |
| FI960909A0 (en) | 1996-02-27 |
| HUP9600476A3 (en) | 1999-07-28 |
| FI960909L (en) | 1996-08-29 |
| HU226326B1 (en) | 2008-08-28 |
| FI120345B (en) | 2009-09-30 |
| CZ290200B6 (en) | 2002-06-12 |
| BR9600829A (en) | 1997-12-30 |
| AU699753B2 (en) | 1998-12-17 |
| CA2170479A1 (en) | 1996-08-29 |
| NO960796L (en) | 1996-08-29 |
| NO960796D0 (en) | 1996-02-27 |
| AU4579796A (en) | 1996-09-05 |
| NO314229B1 (en) | 2003-02-17 |
| CZ58896A3 (en) | 1996-09-11 |
| CN1086700C (en) | 2002-06-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |