HUP9601331A2 - Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them - Google Patents

Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them

Info

Publication number
HUP9601331A2
HUP9601331A2 HU9601331A HUP9601331A HUP9601331A2 HU P9601331 A2 HUP9601331 A2 HU P9601331A2 HU 9601331 A HU9601331 A HU 9601331A HU P9601331 A HUP9601331 A HU P9601331A HU P9601331 A2 HUP9601331 A2 HU P9601331A2
Authority
HU
Hungary
Prior art keywords
powder
pipe
tube
alkyl
carbon
Prior art date
Application number
HU9601331A
Other languages
Hungarian (hu)
Inventor
Simonek Ildikó Rátzné
István Gacsályi
Dániel Bózsing
Iván Jakóczi
Éva Schmidt
dr. Lax Györgyi Koványiné
dr. Kovács Anikó Miklósné
Kiszelly Enikő Szirtné
Gábor Szénási
Gábor Blaskó
István Gyertyán
Gyula Simig
András Egyed
Károly Tihanyi
Original Assignee
EGIS Gyógyszergyár Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EGIS Gyógyszergyár Rt. filed Critical EGIS Gyógyszergyár Rt.
Priority to HU9601331A priority Critical patent/HUP9601331A3/en
Publication of HU9601331D0 publication Critical patent/HU9601331D0/en
Priority to PCT/HU1997/000020 priority patent/WO1997044334A2/en
Priority to AU29120/97A priority patent/AU2912097A/en
Publication of HUP9601331A2 publication Critical patent/HUP9601331A2/en
Publication of HUP9601331A3 publication Critical patent/HUP9601331A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgyát képező új, (I) általánős képletű piperazin-,illetve hőmőpiperazinszármazékők képletében R1 jelentése halőgénatőm, 1-4 szénatőmős alkilcsőpőrt, 1-4 szénatőmősalkőxicsőpőrt, trihalőgén-metil-csőpőrt, nitrőcsőpőrt vagyaminőcsőpőrt, amely 1-4 szénatőmős alkilcsőpőrttal lehethelyettesítve, és n értéke 1 vagy 2, vagy R1 jelentése cianőcsőpőrt, és n értéke 2, m értéke 0, 1, 2 vagy 3, R2, R3 és R4 jelentése, egymástól függetlenül , hidrőgénatőm,halőgénatőm, trihalőgén-metil-csőpőrt, 1-4 szénatőmős alkilcsőpőrt, 1-4 szénatőmős alkőxicsőpőrt, nitrőcsőpőrt, karbőxilcsőpőrt,főrmilcsőpőrt, hidrőxilcsőpőrt vagy aminőcsőpőrt, amely 1-4 szénatőmősalkilcsőpőrttal lehet helyettesítve. A találmány szerinti vegyületek a közpőnti idegrendszermegbetegedéseinek kezelésére alkalmasak. ŕIn the formula of the new monocyclic piperazine and thermocyclic piperazine derivatives of formula (I) which are the subject of the invention, R1 is a halogen atom, a 1-4 carbon atom alkyl tube powder, a 1-4 carbon atom oxy tube powder, a trihalogen-methyl tube powder, a nitrogen tube powder or an amino tube powder, which can be a 1-4 carbon atom alkyl tube powder substituted and n is 1 or 2, or R1 is cyanide powder, and n is 2, m is 0, 1, 2 or 3, R2, R3 and R4 are, independently of each other, a hydrogen atom, a halogen atom, a trihalogen-methyl tube powder, 1-4 carbon atoms alkyl pipe powder, 1-4 carbon atomized alkyl pipe powder, nitro pipe powder, carboxyl pipe powder, formyl pipe powder, hydroxyl pipe powder or amino pipe powder, which can be replaced by 1-4 carbon atomized alkyl pipe powder. The compounds according to the invention are suitable for the treatment of central nervous system diseases. ŕ

HU9601331A 1996-05-17 1996-05-17 Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them HUP9601331A3 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
HU9601331A HUP9601331A3 (en) 1996-05-17 1996-05-17 Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them
PCT/HU1997/000020 WO1997044334A2 (en) 1996-05-17 1997-05-15 Novel piperazine or homopiperazine derivatives, pharmaceutical compositions containing the same and a process for their preparation
AU29120/97A AU2912097A (en) 1996-05-17 1997-05-15 Novel piperazine or homopiperazine derivatives, pharmaceutical compositions containing the same and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9601331A HUP9601331A3 (en) 1996-05-17 1996-05-17 Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them

Publications (3)

Publication Number Publication Date
HU9601331D0 HU9601331D0 (en) 1996-07-29
HUP9601331A2 true HUP9601331A2 (en) 1998-09-28
HUP9601331A3 HUP9601331A3 (en) 2000-06-28

Family

ID=89993978

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9601331A HUP9601331A3 (en) 1996-05-17 1996-05-17 Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them

Country Status (3)

Country Link
AU (1) AU2912097A (en)
HU (1) HUP9601331A3 (en)
WO (1) WO1997044334A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859246A (en) * 1997-01-30 1999-01-12 Neurogen Corporation 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
US6177566B1 (en) 1998-06-30 2001-01-23 Neurogen Corporation 6-(4-arylalkylpiperazin-1-yl) benzodioxane and 6-(4-arylalkylpiperazin-1-yl) chromane derivatives: dopamine receptor subtype specific ligands
CA2336089A1 (en) * 1998-06-30 2000-01-06 Neurogen Corporation 6-(4-arylalkylpiperazin-1-yl)benzodioxane and 6-(4-arylalkylpiperazin-1-yl)chromane derivatives: dopamine receptor subtype specific ligands
JP2004516239A (en) 2000-07-06 2004-06-03 ニューロジェン コーポレイション Melanin-concentrating hormone receptor ligand
DE60130771T2 (en) 2000-07-27 2008-07-17 Eli Lilly And Co., Indianapolis SUBSTITUTED HETEROCYCLIC AMIDS
CA2448080A1 (en) 2001-05-22 2002-11-28 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
WO2005110982A2 (en) 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
EP2149373A1 (en) * 2008-08-01 2010-02-03 Laboratorios Del. Dr. Esteve, S.A. 5HT7 receptor ligands and compositions comprising the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1554897A (en) * 1976-12-10 1979-10-31 Beecham Group Ltd (substituted phenyl) - piperazines and their use in pharmaceutical compositions
CH643549A5 (en) * 1979-08-25 1984-06-15 Merz & Co N- (TRIMETHOXYBENZYL) -N'-PHENYLPIPERAZINE.
AU676993B2 (en) * 1991-06-27 1997-04-10 Virginia Commonwealth University Sigma receptor ligands and the use thereof
EP0556889A1 (en) * 1992-02-18 1993-08-25 Duphar International Research B.V Method of preparing aryl(homo)piperazines
FI960364A7 (en) * 1993-07-28 1996-01-26 Santen Pharmaceutical Co Ltd New 1,4-(diphenylalkyl)piperazine derivatives
EP0650964A1 (en) * 1993-11-02 1995-05-03 Duphar International Research B.V 1 2H-1-benzopyran-2-one-8-yl -piperazine derivatives

Also Published As

Publication number Publication date
AU2912097A (en) 1997-12-09
HU9601331D0 (en) 1996-07-29
WO1997044334A2 (en) 1997-11-27
HUP9601331A3 (en) 2000-06-28
WO1997044334A3 (en) 1998-03-12

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