HUP9800521A2 - Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or propylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis - Google Patents

Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or propylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis

Info

Publication number
HUP9800521A2
HUP9800521A2 HU9800521A HUP9800521A HUP9800521A2 HU P9800521 A2 HUP9800521 A2 HU P9800521A2 HU 9800521 A HU9800521 A HU 9800521A HU P9800521 A HUP9800521 A HU P9800521A HU P9800521 A2 HUP9800521 A2 HU P9800521A2
Authority
HU
Hungary
Prior art keywords
treatment
propylaxis
hyperlipoproteinaemia
hypertriglyceridaemia
hypercholesterolaemia
Prior art date
Application number
HU9800521A
Other languages
Hungarian (hu)
Inventor
Steven Bain
Birgitte Hjort Guldhammer
Charles E. Hart
Niels Korsgaard
Michael Shalmi
Jan Ulrik Weis
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of HUP9800521A2 publication Critical patent/HUP9800521A2/en
Publication of HUP9800521A3 publication Critical patent/HUP9800521A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

A találmány tárgya az (I) általánős képletű -, ahől R1, R4 és R5jelentése egymástól függetlenül hidrőgénatőm, hidrőxilcsőpőrt,halőgénatőm, triflűőr-metil-, rövid szénláncú alkil-, rövid szénláncúalkőxi- vagy tercier-minő-(rövid szénláncú)-alkőxi-csőpőrt, és R2 ésR3 jelentése egymástól függetlenül hidrőgénatőm vagy rövid szénláncúalkilcsőpőrt - vegyületnek vagy gyógyászati szempőntból alkalmazhatósóinak felhasználása hiperlipőprőteinémia, hipertrigliceridémia,hiperlipidémia vagy hiperkőleszterinémia kezelésére vagy megelőzéséreszőlgáló gyógyszerkészítmény ipari előállítására gyógyászatiszempőntból alkalmazható vivőanyag kíséretében, azzal a feltétellel,hőgy az adőtt vegyület vagy gyógyászati szempőntból alkalmazható sójanem a d-centkrőmán őptikai izőmer. ŕThe subject of the invention is the general formula (I) -, where R1, R4 and R5 are independently hydrogen atom, hydroxyl group, halogen atom, trifluoromethyl, lower alkyl, lower alkyl or tertiary lower (lower) alkyl pipe powder, and R2 and R3 independently represent a hydrogen atom or a short-chain alkyl pipe powder - the use of a compound or its salts that can be used from a medical point of view for the industrial production of a pharmaceutical preparation for the treatment or prevention of hyperlipoproteinemia, hypertriglyceridemia, hyperlipidemia, or hypercalceterinemia, accompanied by a carrier that can be used from a medical point of view, on the condition that the given compound or medicinal powder salt that can be used from nt d-centkröman is an optical muscle. ŕ

HU9800521A 1995-01-13 1996-01-10 Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or propylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis HUP9800521A3 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DK4195 1995-01-13
DK4395 1995-01-13
DK6995 1995-01-20
DK76795 1995-06-30
DK76695 1995-06-30
DK77795 1995-06-30

Publications (2)

Publication Number Publication Date
HUP9800521A2 true HUP9800521A2 (en) 1998-12-28
HUP9800521A3 HUP9800521A3 (en) 1999-12-28

Family

ID=27545138

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800521A HUP9800521A3 (en) 1995-01-13 1996-01-10 Use of 3,4-diphenyl chromans for the manufacture of a pharmaceutical composition for the treatment or propylaxis of hyperlipoproteinaemia, hypertriglyceridaemia, hyperlipidaemia or hypercholesterolaemia or arteriosclerosis

Country Status (11)

Country Link
EP (1) EP0804189A1 (en)
JP (1) JPH10511961A (en)
CN (1) CN1168098A (en)
AU (1) AU4329296A (en)
BR (1) BR9606890A (en)
CA (1) CA2208859A1 (en)
CZ (1) CZ212397A3 (en)
HU (1) HUP9800521A3 (en)
IL (1) IL116745A (en)
NO (1) NO973241L (en)
WO (1) WO1996021443A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407955A (en) * 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease
US6069175A (en) * 1996-11-15 2000-05-30 Pfizer Inc. Estrogen agonist/antagonists treatment of atherosclerosis
AU3023999A (en) * 1998-03-20 1999-10-18 Novo Nordisk A/S Use of 3,4-diphenylchromans for the manufacture of a pharmaceutical composition for lowering plasma levels of lp(a) in a human or sub-human primate
US6465445B1 (en) * 1998-06-11 2002-10-15 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US7005428B1 (en) 1998-06-11 2006-02-28 Endorecherche, Inc. Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors
US6613083B2 (en) 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
CA2581316C (en) 2004-09-21 2013-09-10 Novogen Research Pty Ltd Substituted chroman derivatives, medicaments and use in therapy
EP2635273B1 (en) 2010-11-01 2020-01-08 MEI Pharma, Inc. Isoflavonoid compositions and methods for the treatment of cancer
MX368063B (en) 2014-02-07 2019-09-18 Novogen ltd Functionalised benzopyran compounds and use thereof.
CN116139125A (en) 2015-02-02 2023-05-23 梅制药公司 combination therapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1543749A1 (en) * 1966-02-16 1969-12-11 Merck Ag E Process for the preparation of 3,4-cis-4-aryl-isoflavans
US5407955A (en) * 1994-02-18 1995-04-18 Eli Lilly And Company Methods for lowering serum cholesterol and inhibiting smooth muscle cell proliferation, restenosis, endometriosis, and uterine fibroid disease

Also Published As

Publication number Publication date
JPH10511961A (en) 1998-11-17
CZ212397A3 (en) 1997-11-12
BR9606890A (en) 1997-10-28
IL116745A (en) 1999-12-22
HUP9800521A3 (en) 1999-12-28
AU4329296A (en) 1996-07-31
MX9705214A (en) 1997-10-31
IL116745A0 (en) 1996-05-14
EP0804189A1 (en) 1997-11-05
NO973241D0 (en) 1997-07-11
CA2208859A1 (en) 1996-07-18
NO973241L (en) 1997-07-11
WO1996021443A1 (en) 1996-07-18
CN1168098A (en) 1997-12-17

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