HUT42485A - Improved process for producing 2,4,7-thiamino-6-phenyl-pteridine - Google Patents
Improved process for producing 2,4,7-thiamino-6-phenyl-pteridineInfo
- Publication number
- HUT42485A HUT42485A HU316385A HU316385A HUT42485A HU T42485 A HUT42485 A HU T42485A HU 316385 A HU316385 A HU 316385A HU 316385 A HU316385 A HU 316385A HU T42485 A HUT42485 A HU T42485A
- Authority
- HU
- Hungary
- Prior art keywords
- pteridine
- phenyl
- thiamino
- producing
- improved process
- Prior art date
Links
- ABNZXLFWDCIEMI-UHFFFAOYSA-N 4-(7-aminopteridin-2-yl)benzene-1,3-diamine Chemical compound NC1=C(C=CC(=C1)N)C1=NC2=NC(=CN=C2C=N1)N ABNZXLFWDCIEMI-UHFFFAOYSA-N 0.000 abstract 2
- XLQQJSWJHHKLOK-UHFFFAOYSA-N 5-nitrosopyrimidine-2,4,6-triamine Chemical compound NC1=NC(N)=C(N=O)C(N)=N1 XLQQJSWJHHKLOK-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 150000002357 guanidines Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- SUSQOBVLVYHIEX-UHFFFAOYSA-N phenylacetonitrile Chemical compound N#CCC1=CC=CC=C1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000007039 two-step reaction Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Improved prepn. of 2,4,7-triamino- phenyl-pteridine (VII) consists of a two step reaction carried out in the same reaction mix at 50-130 deg.C in the presence of a base. Solvents used are of alcohol, alcohol-ether or amide type. The first step consists of heating iso-nitroso-malonic-dinitride (V) guanidine salt to form 2,4,6-triamino -5-nitroso-pyrimidine (IV). Benzylcyanide reacts with (IV) in the second step to obtain (VII).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU316385A HU195817B (en) | 1985-08-16 | 1985-08-16 | Process for producing 2,4,7-thiamino-6-phenyl-pteridine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU316385A HU195817B (en) | 1985-08-16 | 1985-08-16 | Process for producing 2,4,7-thiamino-6-phenyl-pteridine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUT42485A true HUT42485A (en) | 1987-07-28 |
| HU195817B HU195817B (en) | 1988-07-28 |
Family
ID=10962890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU316385A HU195817B (en) | 1985-08-16 | 1985-08-16 | Process for producing 2,4,7-thiamino-6-phenyl-pteridine |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HU195817B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106967069A (en) * | 2017-03-22 | 2017-07-21 | 盐城市麦迪科化学品制造有限公司 | A kind of preparation method of triamterene |
-
1985
- 1985-08-16 HU HU316385A patent/HU195817B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU195817B (en) | 1988-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HU90 | Patent valid on 900628 | ||
| HMM4 | Cancellation of final prot. due to non-payment of fee |