HUT54035A - Process for coating labile pharmaceutical active components for protecting from oxygen and humidity - Google Patents
Process for coating labile pharmaceutical active components for protecting from oxygen and humidityInfo
- Publication number
- HUT54035A HUT54035A HU318789A HU318789A HUT54035A HU T54035 A HUT54035 A HU T54035A HU 318789 A HU318789 A HU 318789A HU 318789 A HU318789 A HU 318789A HU T54035 A HUT54035 A HU T54035A
- Authority
- HU
- Hungary
- Prior art keywords
- coating
- oxygen
- humidity
- protecting
- active components
- Prior art date
Links
- 239000011248 coating agent Substances 0.000 title abstract 3
- 238000000576 coating method Methods 0.000 title abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052760 oxygen Inorganic materials 0.000 title abstract 2
- 239000001301 oxygen Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000001035 drying Methods 0.000 abstract 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 abstract 1
- 235000019441 ethanol Nutrition 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 229960004592 isopropanol Drugs 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000007921 spray Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- 229940117958 vinyl acetate Drugs 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Easily decomposed pharmaceuticals are coated for protection against moisture and oxygen. Based on 100 pts. wt. powdered pharmaceuticals, 2-20 pts. wt. of vinyl-pyrrolidone:vinyl-acetate (6:4) copolymer are dissolved in an organic solvent, pref. in dichloro-methane, ethyl-alcohol or iso-propyl-alcohol. This soln. contains 0.5-50% solids and is applied to the granules as a spray or kneaded coating using one or several layers. The coating is dried by suitable means but pref. by fluidised bed drying to 2/3-3/4 moisture content, sieving and complete drying follows to remove all traces of solvents. Coated cpds. have a long decomposition free shelf life and are suitable for diverse uses e.g. "dry" syrup
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU318789A HUT54035A (en) | 1989-06-22 | 1989-06-22 | Process for coating labile pharmaceutical active components for protecting from oxygen and humidity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU318789A HUT54035A (en) | 1989-06-22 | 1989-06-22 | Process for coating labile pharmaceutical active components for protecting from oxygen and humidity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUT54035A true HUT54035A (en) | 1991-01-28 |
Family
ID=10963013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU318789A HUT54035A (en) | 1989-06-22 | 1989-06-22 | Process for coating labile pharmaceutical active components for protecting from oxygen and humidity |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUT54035A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1334732B1 (en) * | 2000-11-17 | 2010-06-02 | Takeda Pharmaceutical Company Limited | Pharmaceutical preparation of n-[2-(1,6,7,8-tetrahydro-2h-indeno[5,4 b]furan-8-yl)ethyl]propionamide coated with a copolyvidone-containing coating free of polyethylene glycol |
-
1989
- 1989-06-22 HU HU318789A patent/HUT54035A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1334732B1 (en) * | 2000-11-17 | 2010-06-02 | Takeda Pharmaceutical Company Limited | Pharmaceutical preparation of n-[2-(1,6,7,8-tetrahydro-2h-indeno[5,4 b]furan-8-yl)ethyl]propionamide coated with a copolyvidone-containing coating free of polyethylene glycol |
| US10098866B2 (en) | 2000-11-17 | 2018-10-16 | Takeda Pharmaceutical Company Limited | Pharmaceutical preparation containing copolyvidone |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFC9 | Refusal of application |