HUT55409A - New process for producing corticosteroide-21-hemisuccinates - Google Patents

New process for producing corticosteroide-21-hemisuccinates

Info

Publication number
HUT55409A
HUT55409A HU508489A HU508489A HUT55409A HU T55409 A HUT55409 A HU T55409A HU 508489 A HU508489 A HU 508489A HU 508489 A HU508489 A HU 508489A HU T55409 A HUT55409 A HU T55409A
Authority
HU
Hungary
Prior art keywords
hemisuccinates
corticosteroide
producing
new process
formula
Prior art date
Application number
HU508489A
Other languages
Hungarian (hu)
Other versions
HU204844B (en
Inventor
Gabor Ambrus
Tibor Balogh
Gyula Horvath
Gabor Kovacs
Klara Maria Kovacs
Karacsony Erzsebet Magone
Imre Moravcsik
Ernoe Orban
Istvan Pallagi
Lajos Toldy
Aniko Tegdes
Andorne Uskert
Nandor Makk
Original Assignee
Gyogyszerkutato Intezet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszerkutato Intezet filed Critical Gyogyszerkutato Intezet
Priority to HU508489A priority Critical patent/HU204844B/en
Publication of HUT55409A publication Critical patent/HUT55409A/en
Publication of HU204844B publication Critical patent/HU204844B/en

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Abstract

Corticosteroid-21-hemisuccinates and corresponding alkali salts of formula (I) where R1 = H or OH, and R2 = H or R1 and R2 together = O; R3 = H or F; R4 = R5 = H or CH3; R6 = H or alkali metal atoms and dotted line represents an opt. double bond), are prepd. by acylation of cortico-steroids of formula (II) with succinic anhydride in an aliphatic tert.-alcohol in the presence of an organic base
HU508489A 1989-09-27 1989-09-27 New process for producing corticosteroid-21-hemisuccinates HU204844B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU508489A HU204844B (en) 1989-09-27 1989-09-27 New process for producing corticosteroid-21-hemisuccinates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU508489A HU204844B (en) 1989-09-27 1989-09-27 New process for producing corticosteroid-21-hemisuccinates

Publications (2)

Publication Number Publication Date
HUT55409A true HUT55409A (en) 1991-05-28
HU204844B HU204844B (en) 1992-02-28

Family

ID=10969633

Family Applications (1)

Application Number Title Priority Date Filing Date
HU508489A HU204844B (en) 1989-09-27 1989-09-27 New process for producing corticosteroid-21-hemisuccinates

Country Status (1)

Country Link
HU (1) HU204844B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104650172A (en) * 2015-03-25 2015-05-27 浙江仙琚制药股份有限公司 Method for preparing methylprednisolone hemisuccinate
CN109180763A (en) * 2018-08-08 2019-01-11 河南利华制药有限公司 A kind of production technology of hydrocortisone monomester succinate

Also Published As

Publication number Publication date
HU204844B (en) 1992-02-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee
HMM4 Cancellation of final prot. due to non-payment of fee