HUT56853A - Process for producing orally effective renin inhibiting materials - Google Patents

Process for producing orally effective renin inhibiting materials Download PDF

Info

Publication number: HUT56853A
Authority: HU; Hungary
Prior art keywords: formula; alkyl; compound; substituted; group
Prior art date: 1990-01-18

Application number

HU91134A

Other languages

English (en)

Hungarian (hu)

Other versions

HU910134D0 (en

Inventor

Dannis Jay Hoover

Bruce A Lefker

Robert Louis Rosati

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-18

Filing date

1991-01-16

Publication date

1991-10-28

1991-01-16 Application filed by Pfizer filed Critical Pfizer

1991-08-28 Publication of HU910134D0 publication Critical patent/HU910134D0/hu

1991-10-28 Publication of HUT56853A publication Critical patent/HUT56853A/hu

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Crystallography & Structural Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pyridine Compounds (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HU91134A 1990-01-18 1991-01-16 Process for producing orally effective renin inhibiting materials HUT56853A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US46706890A	1990-01-18	1990-01-18

Publications (2)

Publication Number	Publication Date
HU910134D0 HU910134D0 (en)	1991-08-28
HUT56853A true HUT56853A (en)	1991-10-28

Family

ID=23854216

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU91134A HUT56853A (en)	1990-01-18	1991-01-16	Process for producing orally effective renin inhibiting materials

Country Status (19)

Country	Link
EP (2)	EP0661292A1 (cs)
JP (1)	JPH05213873A (cs)
KR (1)	KR930007431B1 (cs)
CN (1)	CN1054071A (cs)
AU (1)	AU632894B2 (cs)
BR (1)	BR9100221A (cs)
CA (1)	CA2034315A1 (cs)
CS (1)	CS9691A2 (cs)
FI (1)	FI910254L (cs)
HU (1)	HUT56853A (cs)
IE (1)	IE910146A1 (cs)
IL (1)	IL96928A0 (cs)
NO (1)	NO910200L (cs)
NZ (1)	NZ236810A (cs)
PL (2)	PL294679A1 (cs)
PT (1)	PT96489A (cs)
TW (1)	TW209870B (cs)
YU (1)	YU7191A (cs)
ZA (1)	ZA91345B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5280122A (en) *	1992-07-01	1994-01-18	Pfizer Inc.	Resolution of 2-benzyl-4-piperidone-succinic acid
US5212185A (en) *	1992-08-14	1993-05-18	G. D. Searle & Co.	Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5422349A (en) *	1992-08-14	1995-06-06	G. D. Seale & Co.	Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
EP0656356A1 (en) *	1992-08-21	1995-06-07	Japan Tobacco Inc.	Dioxacycloalkane compound with renin-inhibiting activity
US5420283A (en) *	1993-08-02	1995-05-30	Pfizer Inc.	Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide
FR2777566B1 (fr) *	1998-04-15	2003-02-21	Synthelabo	Derives d'azacycloalcanes, leur preparation et leur application en therapeutique
AU3565999A (en) *	1999-04-16	2000-11-02	Coelacanth Chemical Corporation	Synthesis of azetidine derivatives
EA005310B1 (ru) *	2000-04-10	2004-12-30	Юити Исида	Гипотензивные средства
DE10250082A1 (de) *	2002-10-25	2004-05-13	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7595312B2 (en)	2002-10-25	2009-09-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions
DE102004015723A1 (de)	2004-03-29	2005-10-20	Boehringer Ingelheim Pharma	Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
US7491717B2 (en)	2005-03-23	2009-02-17	Boehringer Ingelheim International Gmbh	Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
TW200819457A (en)	2006-08-30	2008-05-01	Actelion Pharmaceuticals Ltd	Spiro antibiotic derivatives
CN110114676B (zh) *	2016-10-21	2022-03-25	富士瑞必欧株式会社	肾素浓度的免疫学测定方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL81234A (en) *	1986-01-16	1992-09-06	Abbott Lab	Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
MY103189A (en) *	1986-10-31	1993-05-29	Pfizer	Nor-statine and nor-cyclostatine polypeptides
DE3733296A1 (de) *	1987-10-02	1989-04-20	Merck Patent Gmbh	Aminosaeurederivate
EP0314239A3 (en) *	1987-10-28	1990-12-27	Merck & Co. Inc.	Tripeptide renin inhibitors with n-terminal ureido or sulfamido groups
DE3812328A1 (de) *	1988-04-14	1989-10-26	Merck Patent Gmbh	Aminosaeurederivate
DE3814325A1 (de) *	1988-04-28	1989-11-09	Merck Patent Gmbh	Aminosaeurederivate
DE3840289A1 (de) *	1988-11-30	1990-05-31	Merck Patent Gmbh	Aminosaeurederivate
DE3913272A1 (de) *	1989-04-22	1990-10-25	Hoechst Ag	Dipeptid-derivate mit enzym-inhibitorischer wirkung
EP0410278B1 (de) *	1989-07-25	1994-01-19	Hoechst Aktiengesellschaft	Renin-hemmende Aminooligohydroxy-Derivate

1990
- 1990-12-26 TW TW079110882A patent/TW209870B/zh active
1991
- 1991-01-11 IL IL96928A patent/IL96928A0/xx unknown
- 1991-01-11 EP EP95200133A patent/EP0661292A1/en not_active Withdrawn
- 1991-01-11 EP EP19910300191 patent/EP0438233A3/en not_active Withdrawn
- 1991-01-16 PT PT96489A patent/PT96489A/pt not_active Application Discontinuation
- 1991-01-16 HU HU91134A patent/HUT56853A/hu unknown
- 1991-01-16 CA CA002034315A patent/CA2034315A1/en not_active Abandoned
- 1991-01-17 ZA ZA91345A patent/ZA91345B/xx unknown
- 1991-01-17 AU AU69464/91A patent/AU632894B2/en not_active Ceased
- 1991-01-17 NZ NZ236810A patent/NZ236810A/en unknown
- 1991-01-17 NO NO91910200A patent/NO910200L/no unknown
- 1991-01-17 YU YU7191A patent/YU7191A/sh unknown
- 1991-01-17 CN CN91101145A patent/CN1054071A/zh active Pending
- 1991-01-17 KR KR1019910000729A patent/KR930007431B1/ko not_active Expired - Fee Related
- 1991-01-17 FI FI910254A patent/FI910254L/fi not_active Application Discontinuation
- 1991-01-17 IE IE014691A patent/IE910146A1/en unknown
- 1991-01-17 CS CS9196A patent/CS9691A2/cs unknown
- 1991-01-18 PL PL29467991A patent/PL294679A1/xx unknown
- 1991-01-18 PL PL91288761A patent/PL166526B1/pl unknown
- 1991-01-18 BR BR919100221A patent/BR9100221A/pt not_active Application Discontinuation
- 1991-01-18 JP JP3216669A patent/JPH05213873A/ja active Pending

Also Published As

Publication number	Publication date
ZA91345B (en)	1992-08-26
FI910254A7 (fi)	1991-07-19
JPH05213873A (ja)	1993-08-24
TW209870B (cs)	1993-07-21
KR910014396A (ko)	1991-08-31
PT96489A (pt)	1991-10-15
KR930007431B1 (ko)	1993-08-10
AU6946491A (en)	1991-07-25
EP0438233A2 (en)	1991-07-24
PL294679A1 (en)	1992-10-19
CS9691A2 (en)	1991-09-15
BR9100221A (pt)	1991-10-22
EP0438233A3 (en)	1992-09-09
NZ236810A (en)	1993-11-25
IE910146A1 (en)	1991-07-31
YU7191A (sh)	1994-06-24
FI910254L (fi)	1991-07-19
HU910134D0 (en)	1991-08-28
PL166526B1 (pl)	1995-05-31
NO910200L (no)	1991-07-19
NO910200D0 (no)	1991-01-17
PL288761A1 (en)	1992-10-05
EP0661292A1 (en)	1995-07-05
IL96928A0 (en)	1992-03-29
FI910254A0 (fi)	1991-01-17
CA2034315A1 (en)	1991-07-19
CN1054071A (zh)	1991-08-28
AU632894B2 (en)	1993-01-14

Legal Events

Date	Code	Title	Description
1996-10-28	DFD9	Temporary protection cancelled due to non-payment of fee

Publication	Publication Date	Title
DE69533991T2 (de)	2006-04-13	Dipeptide, die die ausschüttung von wachstumshormonen stimulieren
US6235755B1 (en)	2001-05-22	FSH mimetics for the treatment of infertility
US5783582A (en)	1998-07-21	Piperidines and hexahydro-1H-azepines spiro substituted at the 4-position promote release of growth hormone
PL151679B1 (en)	1990-09-28	The methodof manufacture of new polypeptides containing nor-statine and nor-cyclostatine
WO1993025574A1 (en)	1993-12-23	Inhibitors of angiotensin i chymase(s) including human heart chymase
JPH04501566A (ja)	1992-03-19	複素環ペプチド系レニン阻害剤
US5164388A (en)	1992-11-17	Heterocyclic peptide renin inhibitors
CZ20033413A3 (cs)	2004-05-12	@@Fluorpyrrolidiny jako antidiabetická činidla
AU748469B2 (en)	2002-06-06	Endothelin antagonists
US5442044A (en)	1995-08-15	Orally active renin inhibitors
PL188411B1 (pl)	2005-01-31	Nowe inhibitory trombiny i ich zastosowanie
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