HUT57730A - Process for producing isomer-free4-hydroxy-7-chloroquinoline - Google Patents

Process for producing isomer-free4-hydroxy-7-chloroquinoline

Info

Publication number
HUT57730A
HUT57730A HU903314A HU331490A HUT57730A HU T57730 A HUT57730 A HU T57730A HU 903314 A HU903314 A HU 903314A HU 331490 A HU331490 A HU 331490A HU T57730 A HUT57730 A HU T57730A
Authority
HU
Hungary
Prior art keywords
chloro
tri
methyl
hydroxy
free4
Prior art date
Application number
HU903314A
Other languages
Hungarian (hu)
Other versions
HU903314D0 (en
HU205907B (en
Inventor
Tamas Mester
Gyula Koertvelyessy
Gyulane Koertvelyessi
Gyoergy Kalman
Attila Puskas
Antal Szatmari
Gabor Varga
Andras Visy
Janos Repasi
Imre Gulyas
Janos Boldog
Pal Gajdacs
Veres Agota Repasine
Original Assignee
Alkaloida Vegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alkaloida Vegyeszeti Gyar filed Critical Alkaloida Vegyeszeti Gyar
Priority to HU903314A priority Critical patent/HU205907B/en
Publication of HU903314D0 publication Critical patent/HU903314D0/en
Publication of HUT57730A publication Critical patent/HUT57730A/en
Publication of HU205907B publication Critical patent/HU205907B/en

Links

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

4-hydroxy-7-chloro-quinoline of general formula (I) is prepd. free of isomers at 60-130 deg. C temp. and 0.1-0.6 MPa pressure from di: or tri:-ethyl-malonate, tri:ethyl-or tri:methyl-o-formate and 3-chloro-aniline, in the presence of metallic magnesium or of magnesium-oxide hydroxide or carbonate and/or unsubstd. chloro-aniline-, or 1-4C alkyl gp. (identical or dissimilar) substd. ammonium-chloride as catalyst. 2-carbomethoxy-3-(3-chloro-anilino)- methyl-acrylate (VI) is obtd. and is converted to cyclic quinoline-3-carboxylic-ester (II) at 180-280 deg. C in an inert solvent R:methyl gp. in (II). The prod. is hydrolysed and is decarboxylated thermally to cpd.(I). (1pp Dwg.No.0/0)
HU903314A 1990-05-04 1990-05-04 Process for producing 4-hidroxy-7-chloro-quinoline HU205907B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
HU903314A HU205907B (en) 1990-05-04 1990-05-04 Process for producing 4-hidroxy-7-chloro-quinoline

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU903314A HU205907B (en) 1990-05-04 1990-05-04 Process for producing 4-hidroxy-7-chloro-quinoline

Publications (3)

Publication Number Publication Date
HU903314D0 HU903314D0 (en) 1990-10-28
HUT57730A true HUT57730A (en) 1991-12-30
HU205907B HU205907B (en) 1992-07-28

Family

ID=10963540

Family Applications (1)

Application Number Title Priority Date Filing Date
HU903314A HU205907B (en) 1990-05-04 1990-05-04 Process for producing 4-hidroxy-7-chloro-quinoline

Country Status (1)

Country Link
HU (1) HU205907B (en)

Also Published As

Publication number Publication date
HU903314D0 (en) 1990-10-28
HU205907B (en) 1992-07-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee