HUT61033A - Process for producing intermediates of lh-rh-antagonist peptides - Google Patents
Process for producing intermediates of lh-rh-antagonist peptidesInfo
- Publication number
- HUT61033A HUT61033A HU189188A HU189188A HUT61033A HU T61033 A HUT61033 A HU T61033A HU 189188 A HU189188 A HU 189188A HU 189188 A HU189188 A HU 189188A HU T61033 A HUT61033 A HU T61033A
- Authority
- HU
- Hungary
- Prior art keywords
- nal
- phe
- cit
- hci
- pro
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 239000002474 gonadorelin antagonist Substances 0.000 title 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 3
- -1 D-or L-delta 3-Pro Chemical compound 0.000 abstract 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 2
- 235000004279 alanine Nutrition 0.000 abstract 2
- DFZVZEMNPGABKO-ZETCQYMHSA-N (2s)-2-amino-3-pyridin-3-ylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=CN=C1 DFZVZEMNPGABKO-ZETCQYMHSA-N 0.000 abstract 1
- AHLPHDHHMVZTML-SCSAIBSYSA-N D-Ornithine Chemical compound NCCC[C@@H](N)C(O)=O AHLPHDHHMVZTML-SCSAIBSYSA-N 0.000 abstract 1
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 1
- 125000001711 D-phenylalanine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- AYFVYJQAPQTCCC-STHAYSLISA-N D-threonine Chemical compound C[C@H](O)[C@@H](N)C(O)=O AYFVYJQAPQTCCC-STHAYSLISA-N 0.000 abstract 1
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical group C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 abstract 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 abstract 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 abstract 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 235000013477 citrulline Nutrition 0.000 abstract 1
- 229960002173 citrulline Drugs 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 102220067365 rs143592561 Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Peptides of formula X-R1-R2-R3-Ser-Tyr -R6-Leu-Arg-Pro-R10-NH2 (I) and their acid-addn.salts are new ; where X=1-7C aliphatic or alicyclic carboxylic acyl or CONH2; R1=D-or L-Pro, D-or L-delta 3-Pro, D-Phe, D-Phe-(4-Hl), D-Ser, D-Thr, D-Ala, D-Nal(1), or D-Nal(2),where NAL(1) and Nal(2) are 3-(1-napthyl)alanine and 3-(2-napthyl)alanine respectively; R2= D-Phe or D-Phe(4-Hl); R3=D-Trp, D-Phe, D.Pal(3), D-Nal(1), or D-Nal(2), where Pal(3) is 3-(3-pyridyl)alanine; R6=D-Cit, D-Hci, D-Cit(Q), or D-Hci(Q), where Cit and Hci are citrulline and homocitrullin respectively; R10=Gly or D.Ala; H-=F, Cl or Br and Q=1-3C alkyl. - Protected intermediates of formula X1-R1-R2-R3-Ser(X4)-Tyr(X5) -R'6(X6)-Leu-Arg(X8)-Pro-R10-NHX10 (II) are also new where X1=X,H or Boc; X4,X5,X6, andX8= H or protecting gps; X10=H or a resin contg. benzhydrryl or methlybenzhydryl gps.; and R'6=D-Cit, D-Hci, D-Lys or D-Orn.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/074,126 US4800191A (en) | 1987-07-17 | 1987-07-17 | LHRH antagonists |
| HU883701A HU206376B (en) | 1987-07-17 | 1988-07-15 | Process for producing lh-rh antagonists and pharmaceutical compositions comprising same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUT61033A true HUT61033A (en) | 1992-11-30 |
Family
ID=26317678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU189188A HUT61033A (en) | 1987-07-17 | 1988-07-15 | Process for producing intermediates of lh-rh-antagonist peptides |
Country Status (1)
| Country | Link |
|---|---|
| HU (1) | HUT61033A (en) |
-
1988
- 1988-07-15 HU HU189188A patent/HUT61033A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI883388A0 (en) | A method for preparing novel therapeutically useful peptides | |
| HU885868D0 (en) | Process for producing compounds antagonizing effect of hormon releasing luteinizing hormon and pharmaceutical preparatives containing said compounds as active substance | |
| MY125555A (en) | Heptapeptide oxytocin analogues | |
| KR850001230A (en) | Method for preparing octapeptide vazopressin antagonist | |
| NO871574L (en) | PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE PEPTIDES. | |
| EP0334244A3 (en) | Bradykinin antagonist peptides | |
| AU551892B2 (en) | Gnrh antagonists | |
| IE872693L (en) | Analogs of gonadoliberin | |
| ES8504677A1 (en) | GnRH antagonists. | |
| IE810703L (en) | Peptides | |
| EP0206730A3 (en) | Vasopressin antagonists | |
| ATE59393T1 (en) | PEPTIDES. | |
| EP0307662A3 (en) | Enkephalin analogs | |
| FI933629L (en) | ANTAGONIST PEPTIDER TILL HORMON SOM FRIGOER LUTEINISERANDE HORMON (LHRH) | |
| DE3665462D1 (en) | Pharmacologically active peptides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DFC9 | Refusal of application |