HUT66379A - Calcium, trace mineral, vitamin d and drug therapy combinations - Google Patents

Calcium, trace mineral, vitamin d and drug therapy combinations Download PDF

Info

Publication number: HUT66379A
Authority: HU; Hungary
Prior art keywords: calcium; bone; diphosphonic acid; manganese; zinc
Prior art date: 1991-05-28

Application number

HU9303364A

Other languages

English (en)

Hungarian (hu)

Other versions

HU9303364D0 (en

Inventor

Mark Benson Andon

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-28

Filing date

1992-05-15

Publication date

1994-11-28

1992-05-15 Application filed by Procter & Gamble filed Critical Procter & Gamble

1994-03-28 Publication of HU9303364D0 publication Critical patent/HU9303364D0/hu

1994-11-28 Publication of HUT66379A publication Critical patent/HUT66379A/hu

Links

OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims description 76
239000011575 calcium Substances 0.000 title claims description 71
229910052791 calcium Inorganic materials 0.000 title claims description 71
229940046008 vitamin d Drugs 0.000 title claims description 39
235000001465 calcium Nutrition 0.000 title description 68
239000011573 trace mineral Substances 0.000 title description 28
235000013619 trace mineral Nutrition 0.000 title description 28
238000002651 drug therapy Methods 0.000 title 1
239000000203 mixture Substances 0.000 claims description 65
235000013361 beverage Nutrition 0.000 claims description 46
238000000034 method Methods 0.000 claims description 41
229940092124 calcium citrate malate Drugs 0.000 claims description 40
QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 39
MPCMQXRREZMSPJ-UHFFFAOYSA-L calcium;2-hydroxybutanedioate;2-hydroxypropane-1,2,3-tricarboxylic acid;pentahydrate Chemical compound O.O.O.O.O.[Ca+2].[O-]C(=O)C(O)CC([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O MPCMQXRREZMSPJ-UHFFFAOYSA-L 0.000 claims description 39
229910052500 inorganic mineral Inorganic materials 0.000 claims description 39
239000011707 mineral Substances 0.000 claims description 39
235000010755 mineral Nutrition 0.000 claims description 38
239000011710 vitamin D Substances 0.000 claims description 38
229930003316 Vitamin D Natural products 0.000 claims description 37
235000019166 vitamin D Nutrition 0.000 claims description 37
150000003710 vitamin D derivatives Chemical class 0.000 claims description 36
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 33
208000001132 Osteoporosis Diseases 0.000 claims description 33
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 33
239000010949 copper Substances 0.000 claims description 33
229910052802 copper Inorganic materials 0.000 claims description 33
239000011701 zinc Substances 0.000 claims description 32
229910052725 zinc Inorganic materials 0.000 claims description 32
PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 26
229910052748 manganese Inorganic materials 0.000 claims description 26
239000011572 manganese Substances 0.000 claims description 26
150000003839 salts Chemical class 0.000 claims description 25
150000001875 compounds Chemical class 0.000 claims description 24
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 21
BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 21
102000055006 Calcitonin Human genes 0.000 claims description 17
108060001064 Calcitonin Proteins 0.000 claims description 17
230000037176 bone building Effects 0.000 claims description 17
239000002552 dosage form Substances 0.000 claims description 16
239000000262 estrogen Substances 0.000 claims description 16
229940011871 estrogen Drugs 0.000 claims description 16
229940088594 vitamin Drugs 0.000 claims description 16
229930003231 vitamin Natural products 0.000 claims description 16
239000011782 vitamin Substances 0.000 claims description 16
BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 15
229960004015 calcitonin Drugs 0.000 claims description 15
235000013343 vitamin Nutrition 0.000 claims description 15
DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims description 13
229940049920 malate Drugs 0.000 claims description 12
230000009469 supplementation Effects 0.000 claims description 12
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims description 11
241000282414 Homo sapiens Species 0.000 claims description 10
230000011164 ossification Effects 0.000 claims description 10
230000008569 process Effects 0.000 claims description 10
239000000126 substance Substances 0.000 claims description 9
230000008468 bone growth Effects 0.000 claims description 6
235000015203 fruit juice Nutrition 0.000 claims description 6
XQRLCLUYWUNEEH-UHFFFAOYSA-L diphosphonate(2-) Chemical compound [O-]P(=O)OP([O-])=O XQRLCLUYWUNEEH-UHFFFAOYSA-L 0.000 claims description 5
235000011389 fruit/vegetable juice Nutrition 0.000 claims description 5
239000002243 precursor Substances 0.000 claims description 5
OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 4
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims description 4
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 4
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
239000002775 capsule Substances 0.000 claims description 4
229940108925 copper gluconate Drugs 0.000 claims description 4
239000011683 manganese gluconate Substances 0.000 claims description 4
235000014012 manganese gluconate Nutrition 0.000 claims description 4
229940072543 manganese gluconate Drugs 0.000 claims description 4
OXHQNTSSPHKCPB-IYEMJOQQSA-L manganese(2+);(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Mn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OXHQNTSSPHKCPB-IYEMJOQQSA-L 0.000 claims description 4
239000000463 material Substances 0.000 claims description 4
235000015205 orange juice Nutrition 0.000 claims description 4
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
229910002651 NO3 Inorganic materials 0.000 claims description 3
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 3
150000001450 anions Chemical class 0.000 claims description 3
150000007942 carboxylates Chemical class 0.000 claims description 3
229940050410 gluconate Drugs 0.000 claims description 3
239000008297 liquid dosage form Substances 0.000 claims description 3
150000002696 manganese Chemical class 0.000 claims description 3
229940029985 mineral supplement Drugs 0.000 claims description 3
235000020786 mineral supplement Nutrition 0.000 claims description 3
239000007909 solid dosage form Substances 0.000 claims description 3
238000006467 substitution reaction Methods 0.000 claims description 3
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 3
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 claims description 3
229960001763 zinc sulfate Drugs 0.000 claims description 3
229910000368 zinc sulfate Inorganic materials 0.000 claims description 3
235000005979 Citrus limon Nutrition 0.000 claims description 2
244000131522 Citrus pyriformis Species 0.000 claims description 2
ISZIECUHZQGAPV-UHFFFAOYSA-N NP(O)(=O)OP(O)=O Chemical compound NP(O)(=O)OP(O)=O ISZIECUHZQGAPV-UHFFFAOYSA-N 0.000 claims description 2
235000014443 Pyrus communis Nutrition 0.000 claims description 2
240000001987 Pyrus communis Species 0.000 claims description 2
240000001717 Vaccinium macrocarpon Species 0.000 claims description 2
235000012545 Vaccinium macrocarpon Nutrition 0.000 claims description 2
235000002118 Vaccinium oxycoccus Nutrition 0.000 claims description 2
150000001879 copper Chemical class 0.000 claims description 2
235000004634 cranberry Nutrition 0.000 claims description 2
229940088597 hormone Drugs 0.000 claims description 2
239000005556 hormone Substances 0.000 claims description 2
239000002207 metabolite Substances 0.000 claims description 2
229940095064 tartrate Drugs 0.000 claims description 2
235000005282 vitamin D3 Nutrition 0.000 claims description 2
239000011647 vitamin D3 Substances 0.000 claims description 2
229940021056 vitamin d3 Drugs 0.000 claims description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 3
235000015197 apple juice Nutrition 0.000 claims 1
235000019674 grape juice Nutrition 0.000 claims 1
-1 invert sugar Substances 0.000 description 68
229960005069 calcium Drugs 0.000 description 67
239000000796 flavoring agent Substances 0.000 description 34
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 33
210000000988 bone and bone Anatomy 0.000 description 32
235000019634 flavors Nutrition 0.000 description 32
229940108928 copper Drugs 0.000 description 25
235000002639 sodium chloride Nutrition 0.000 description 25
235000013305 food Nutrition 0.000 description 22
238000002360 preparation method Methods 0.000 description 20
206010065687 Bone loss Diseases 0.000 description 16
235000003599 food sweetener Nutrition 0.000 description 16
239000003765 sweetening agent Substances 0.000 description 16
239000003826 tablet Substances 0.000 description 15
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 14
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 14
238000009472 formulation Methods 0.000 description 14
235000005911 diet Nutrition 0.000 description 13
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 12
235000016709 nutrition Nutrition 0.000 description 12
235000000346 sugar Nutrition 0.000 description 12
238000011282 treatment Methods 0.000 description 12
159000000007 calcium salts Chemical class 0.000 description 11
235000015165 citric acid Nutrition 0.000 description 11
239000004615 ingredient Substances 0.000 description 11
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 10
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 10
235000008504 concentrate Nutrition 0.000 description 10
239000001630 malic acid Substances 0.000 description 10
235000011090 malic acid Nutrition 0.000 description 10
239000000243 solution Substances 0.000 description 10
239000013589 supplement Substances 0.000 description 10
239000004480 active ingredient Substances 0.000 description 9
230000037213 diet Effects 0.000 description 9
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
239000007787 solid Substances 0.000 description 9
239000006188 syrup Substances 0.000 description 9
235000020357 syrup Nutrition 0.000 description 9
244000299461 Theobroma cacao Species 0.000 description 8
239000002253 acid Substances 0.000 description 8
239000003086 colorant Substances 0.000 description 8
230000000694 effects Effects 0.000 description 8
230000035764 nutrition Effects 0.000 description 8
241001465754 Metazoa Species 0.000 description 7
229910000019 calcium carbonate Inorganic materials 0.000 description 7
235000014171 carbonated beverage Nutrition 0.000 description 7
235000013399 edible fruits Nutrition 0.000 description 7
229910052742 iron Inorganic materials 0.000 description 7
150000003722 vitamin derivatives Chemical class 0.000 description 7
208000006386 Bone Resorption Diseases 0.000 description 6
150000007513 acids Chemical class 0.000 description 6
230000024279 bone resorption Effects 0.000 description 6
FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 6
239000001354 calcium citrate Substances 0.000 description 6
239000001569 carbon dioxide Substances 0.000 description 6
229910002092 carbon dioxide Inorganic materials 0.000 description 6
238000006243 chemical reaction Methods 0.000 description 6
201000010099 disease Diseases 0.000 description 6
239000007788 liquid Substances 0.000 description 6
235000013337 tricalcium citrate Nutrition 0.000 description 6
235000009470 Theobroma cacao Nutrition 0.000 description 5
230000009102 absorption Effects 0.000 description 5
238000010521 absorption reaction Methods 0.000 description 5
150000001412 amines Chemical class 0.000 description 5
235000010323 ascorbic acid Nutrition 0.000 description 5
239000011668 ascorbic acid Substances 0.000 description 5
229960004256 calcium citrate Drugs 0.000 description 5
210000004027 cell Anatomy 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 5
239000012141 concentrate Substances 0.000 description 5
239000003814 drug Substances 0.000 description 5
239000003995 emulsifying agent Substances 0.000 description 5
230000003993 interaction Effects 0.000 description 5
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 5
239000000047 product Substances 0.000 description 5
150000008163 sugars Chemical class 0.000 description 5
108090000445 Parathyroid hormone Proteins 0.000 description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
229930006000 Sucrose Natural products 0.000 description 4
230000002411 adverse Effects 0.000 description 4
230000000378 dietary effect Effects 0.000 description 4
239000003937 drug carrier Substances 0.000 description 4
230000012010 growth Effects 0.000 description 4
235000012907 honey Nutrition 0.000 description 4
150000002500 ions Chemical class 0.000 description 4
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
235000013336 milk Nutrition 0.000 description 4
239000008267 milk Substances 0.000 description 4
210000004080 milk Anatomy 0.000 description 4
238000002156 mixing Methods 0.000 description 4
235000013615 non-nutritive sweetener Nutrition 0.000 description 4
235000015097 nutrients Nutrition 0.000 description 4
239000003755 preservative agent Substances 0.000 description 4
239000005720 sucrose Substances 0.000 description 4
239000000725 suspension Substances 0.000 description 4
235000013311 vegetables Nutrition 0.000 description 4
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
241000196324 Embryophyta Species 0.000 description 3
239000005715 Fructose Substances 0.000 description 3
229910019142 PO4 Inorganic materials 0.000 description 3
102000003982 Parathyroid hormone Human genes 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
230000032683 aging Effects 0.000 description 3
229940024606 amino acid Drugs 0.000 description 3
150000001413 amino acids Chemical class 0.000 description 3
239000008122 artificial sweetener Substances 0.000 description 3
235000021311 artificial sweeteners Nutrition 0.000 description 3
229960005070 ascorbic acid Drugs 0.000 description 3
230000009286 beneficial effect Effects 0.000 description 3
230000008901 benefit Effects 0.000 description 3
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 3
239000000920 calcium hydroxide Substances 0.000 description 3
229910001861 calcium hydroxide Inorganic materials 0.000 description 3
239000001506 calcium phosphate Substances 0.000 description 3
229910000389 calcium phosphate Inorganic materials 0.000 description 3
235000011010 calcium phosphates Nutrition 0.000 description 3
150000001720 carbohydrates Chemical class 0.000 description 3
235000014633 carbohydrates Nutrition 0.000 description 3
235000019219 chocolate Nutrition 0.000 description 3
229910000365 copper sulfate Inorganic materials 0.000 description 3
ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 3
230000034994 death Effects 0.000 description 3
238000011161 development Methods 0.000 description 3
230000018109 developmental process Effects 0.000 description 3
235000018823 dietary intake Nutrition 0.000 description 3
235000015872 dietary supplement Nutrition 0.000 description 3
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 3
208000035475 disorder Diseases 0.000 description 3
239000000839 emulsion Substances 0.000 description 3
150000002148 esters Chemical class 0.000 description 3
239000008187 granular material Substances 0.000 description 3
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210000002997 osteoclast Anatomy 0.000 description 3
239000000199 parathyroid hormone Substances 0.000 description 3
229960001319 parathyroid hormone Drugs 0.000 description 3
239000008194 pharmaceutical composition Substances 0.000 description 3
230000000144 pharmacologic effect Effects 0.000 description 3
239000010452 phosphate Substances 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
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239000002904 solvent Substances 0.000 description 3
230000004936 stimulating effect Effects 0.000 description 3
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QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 3
GKUBJNUBGKBXKR-UHFFFAOYSA-N (1-hydroxy-1-phosphono-2-piperidin-2-ylethyl)phosphonic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1CCCCN1 GKUBJNUBGKBXKR-UHFFFAOYSA-N 0.000 description 2
QEICZTZQRCHYHZ-UHFFFAOYSA-N (1-hydroxy-1-phosphono-2-piperidin-3-ylethyl)phosphonic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1CCCNC1 QEICZTZQRCHYHZ-UHFFFAOYSA-N 0.000 description 2
TXRLEBBHLXZUOJ-UHFFFAOYSA-N (1-phosphono-2-piperidin-2-ylethyl)phosphonic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)CC1CCCCN1 TXRLEBBHLXZUOJ-UHFFFAOYSA-N 0.000 description 2
UKAZEFXPLHNKOY-UHFFFAOYSA-N (1-phosphono-2-piperidin-3-ylethyl)phosphonic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)CC1CCCNC1 UKAZEFXPLHNKOY-UHFFFAOYSA-N 0.000 description 2
MXYOPVWZZKEAGX-UHFFFAOYSA-N 1-phosphonoethylphosphonic acid Chemical compound OP(=O)(O)C(C)P(O)(O)=O MXYOPVWZZKEAGX-UHFFFAOYSA-N 0.000 description 2
ITQTTZVARXURQS-UHFFFAOYSA-N 3-methylpyridine Chemical compound CC1=CC=CN=C1 ITQTTZVARXURQS-UHFFFAOYSA-N 0.000 description 2
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RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
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RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
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CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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230000014860 sensory perception of taste Effects 0.000 description 1
239000010703 silicon Substances 0.000 description 1
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239000011780 sodium chloride Substances 0.000 description 1
239000002689 soil Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
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MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/32—Manganese; Compounds thereof
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Inorganic Chemistry (AREA)
Engineering & Computer Science (AREA)
Mycology (AREA)
Nutrition Science (AREA)
Polymers & Plastics (AREA)
Food Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Non-Alcoholic Beverages (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)

HU9303364A 1991-05-28 1992-05-15 Calcium, trace mineral, vitamin d and drug therapy combinations HUT66379A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US70583291A	1991-05-28	1991-05-28

Publications (2)

Publication Number	Publication Date
HU9303364D0 HU9303364D0 (en)	1994-03-28
HUT66379A true HUT66379A (en)	1994-11-28

Family

ID=24835140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU9303364A HUT66379A (en)	1991-05-28	1992-05-15	Calcium, trace mineral, vitamin d and drug therapy combinations

Country Status (13)

Country	Link
EP (1)	EP0586521A1 (fr)
JP (1)	JPH07502012A (fr)
KR (1)	KR100244603B1 (fr)
AU (1)	AU666654B2 (fr)
BR (1)	BR9206072A (fr)
CA (1)	CA2109958C (fr)
CZ (1)	CZ281823B6 (fr)
HU (1)	HUT66379A (fr)
IE (1)	IE921701A1 (fr)
NO (1)	NO934282L (fr)
NZ (1)	NZ242920A (fr)
SK (1)	SK132693A3 (fr)
WO (1)	WO1992021355A1 (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5674844A (en) *	1991-03-11	1997-10-07	Creative Biomolecules, Inc.	Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US7056882B2 (en)	1991-03-11	2006-06-06	Curis, Inc.	Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
EP0600834A1 (fr) *	1992-11-30	1994-06-08	Ciba-Geigy Ag	Utilisation de dérivés de l'acide méthanediphosphonique pour la fabrication d'un médicament pour le traitement de fractures
AU670337B2 (en)	1992-11-30	1996-07-11	Novartis Ag	Use of certain methanebisphosphonic acid derivatives in fracture healing
FR2704393B1 (fr) *	1993-04-30	1995-06-02	Boiron	Complément nutritionnel absorbable pour optimiser la croissance et maintenir la solidité des os.
US5763429A (en)	1993-09-10	1998-06-09	Bone Care International, Inc.	Method of treating prostatic diseases using active vitamin D analogues
FR2723682B1 (fr) *	1994-08-19	1996-09-27	Boiron	Complement nutritionnel absorbable pour l'equilibre quotidien de l'enfant et l'adolescent.
IL115241A (en) *	1994-09-26	2000-08-31	American Cyanamid Co	Calcium dietary supplement
DE19503190A1 (de) *	1995-02-01	1996-08-08	Dietl Hans	Mittel zur Beeinflussung von Störungen der Knochenbildung
US6242434B1 (en)	1997-08-08	2001-06-05	Bone Care International, Inc.	24-hydroxyvitamin D, analogs and uses thereof
US5698222A (en) *	1995-04-07	1997-12-16	Abbott Laboratories	Calcium supplement
US5597595A (en) *	1995-04-07	1997-01-28	Abbott Laboratories	Low pH beverage fortified with calcium and vitamin D
US5609897A (en) *	1995-04-07	1997-03-11	Abbott Laboratories	Powdered beverage concentrate or additive fortified with calcium and vitamin D
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1992
- 1992-05-15 KR KR1019930703623A patent/KR100244603B1/ko not_active Expired - Fee Related
- 1992-05-15 BR BR9206072A patent/BR9206072A/pt not_active Application Discontinuation
- 1992-05-15 CA CA002109958A patent/CA2109958C/fr not_active Expired - Fee Related
- 1992-05-15 EP EP92912201A patent/EP0586521A1/fr not_active Withdrawn
- 1992-05-15 CZ CS932553A patent/CZ281823B6/cs unknown
- 1992-05-15 AU AU19968/92A patent/AU666654B2/en not_active Ceased
- 1992-05-15 SK SK1326-93A patent/SK132693A3/sk unknown
- 1992-05-15 WO PCT/US1992/003995 patent/WO1992021355A1/fr not_active Ceased
- 1992-05-15 JP JP5500425A patent/JPH07502012A/ja active Pending
- 1992-05-15 HU HU9303364A patent/HUT66379A/hu unknown
- 1992-05-27 NZ NZ242920A patent/NZ242920A/en unknown
- 1992-07-01 IE IE170192A patent/IE921701A1/en not_active Application Discontinuation
1993
- 1993-11-26 NO NO934282A patent/NO934282L/no unknown

Also Published As

Publication number	Publication date
BR9206072A (pt)	1994-11-15
HU9303364D0 (en)	1994-03-28
KR100244603B1 (ko)	2000-03-02
WO1992021355A1 (fr)	1992-12-10
CZ255393A3 (en)	1994-07-13
AU1996892A (en)	1993-01-08
NZ242920A (en)	1995-06-27
NO934282D0 (no)	1993-11-26
NO934282L (no)	1994-01-28
JPH07502012A (ja)	1995-03-02
AU666654B2 (en)	1996-02-22
CA2109958C (fr)	1997-06-10
EP0586521A1 (fr)	1994-03-16
IE921701A1 (en)	1992-12-02
SK132693A3 (en)	1994-06-08
CZ281823B6 (cs)	1997-02-12

Legal Events

Date	Code	Title	Description
1998-03-30	DFA9	Temporary protection cancelled due to abandonment

Publication	Publication Date	Title
HUT66379A (en)	1994-11-28	Calcium, trace mineral, vitamin d and drug therapy combinations
JP3708115B2 (ja)	2005-10-19	混合カルシウム及びビタミンｄ補給品
US5151274A (en)	1992-09-29	Calcium and trace mineral supplements
US5232709A (en)	1993-08-03	Calcium and trace mineral supplements comprising estrogen
HK1006149B (en)	1999-02-12	Calcium and trace mineral supplements
EP0304986B1 (fr)	1993-04-28	Utilisation de certains Calcium-Citrate-Malate pour l'obtention d'un médicament destiné au traitement de l'ostéoporose
US20040048925A1 (en)	2004-03-11	Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives
WO2005096846A1 (fr)	2005-10-20	Composition et procede d'amelioration de la biodisponibilite du calcium et du magnesium dans des complements alimentaires et des additifs alimentaires