HUT68802A - N,n'-substituted imidocarbonimidic diamides, pharmaceutical compositions containing them and use of these compounds against infection - Google Patents

N,n'-substituted imidocarbonimidic diamides, pharmaceutical compositions containing them and use of these compounds against infection

Info

Publication number
HUT68802A
HUT68802A HU9401976A HU9401976A HUT68802A HU T68802 A HUT68802 A HU T68802A HU 9401976 A HU9401976 A HU 9401976A HU 9401976 A HU9401976 A HU 9401976A HU T68802 A HUT68802 A HU T68802A
Authority
HU
Hungary
Prior art keywords
group
carbon atoms
mono
substituted
infection
Prior art date
Application number
HU9401976A
Other languages
English (en)
Other versions
HU9401976D0 (en
HU220389B (hu
Inventor
Craig Canfield
David Jacobus
Neil Lewis
Original Assignee
Jacobus Pharma Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jacobus Pharma Co Inc filed Critical Jacobus Pharma Co Inc
Publication of HU9401976D0 publication Critical patent/HU9401976D0/hu
Publication of HUT68802A publication Critical patent/HUT68802A/hu
Publication of HU220389B publication Critical patent/HU220389B/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/24Y being a hetero atom
    • C07C279/26X and Y being nitrogen atoms, i.e. biguanides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/13Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Paints Or Removers (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Luminescent Compositions (AREA)
  • Detergent Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Seasonings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
HU9401976A 1992-02-14 1993-01-19 N1,N5-Diszubsztituált imido-dikarboximid-diamidok, ezen vegyületeket tartalmazó gyógyászati készítmények, valamint eljárás e készítmények előállítására HU220389B (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/837,258 US5322858A (en) 1992-02-14 1992-02-14 N,N'-substituted imidodicarbonimidic diamides derived from hydroxylamines
PCT/US1993/000395 WO1993016037A1 (en) 1992-02-14 1993-01-19 N,n'-substituted imidocarbonimidic diamides derived from hydroxylamines

Publications (3)

Publication Number Publication Date
HU9401976D0 HU9401976D0 (en) 1994-09-28
HUT68802A true HUT68802A (en) 1995-07-28
HU220389B HU220389B (hu) 2002-01-28

Family

ID=25273975

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9401976A HU220389B (hu) 1992-02-14 1993-01-19 N1,N5-Diszubsztituált imido-dikarboximid-diamidok, ezen vegyületeket tartalmazó gyógyászati készítmények, valamint eljárás e készítmények előállítására

Country Status (25)

Country Link
US (1) US5322858A (hu)
EP (1) EP0625967B1 (hu)
JP (1) JP3207200B2 (hu)
KR (1) KR950700243A (hu)
CN (1) CN1057520C (hu)
AT (1) ATE157352T1 (hu)
AU (1) AU668709B2 (hu)
CA (1) CA2129430C (hu)
CZ (1) CZ294257B6 (hu)
DE (1) DE69313438T2 (hu)
DK (1) DK0625967T3 (hu)
EG (1) EG20476A (hu)
ES (1) ES2108862T3 (hu)
FI (1) FI943738A7 (hu)
GR (1) GR3025429T3 (hu)
HU (1) HU220389B (hu)
IL (1) IL104484A (hu)
MX (1) MX9300688A (hu)
NO (1) NO302616B1 (hu)
NZ (1) NZ245865A (hu)
OA (1) OA10094A (hu)
PL (2) PL173258B1 (hu)
RU (1) RU2133737C1 (hu)
WO (1) WO1993016037A1 (hu)
ZA (1) ZA93974B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4321444A1 (de) * 1993-06-28 1995-01-05 Bernd Prof Dr Clement Pharmazeutische Zubereitung
US6551614B2 (en) 2001-03-14 2003-04-22 Jacobus Pharmaceutical Co., Inc. Antimalarial N,N′-substituted biguanides derived from hydroxylamines
CA2477604A1 (en) 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
US7256218B2 (en) * 2002-11-22 2007-08-14 Jacobus Pharmaceutical Company, Inc. Biguanide and dihydrotriazine derivatives
CN1738794B (zh) * 2002-11-22 2010-12-22 雅各布斯制药公司 双胍和二氢三嗪衍生物
WO2006084033A1 (en) * 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
SI2194985T1 (sl) 2007-10-08 2019-04-30 Mmv Medicines For Malaria Venture Protimalarijske spojine z gibkimi stranskimi verigami
EP2200641B1 (en) * 2007-10-13 2012-07-04 Cornell University Compositions for eliciting an immune response against mycobacterium avium subspecies paratuberculosis
CN102014897B (zh) 2008-04-21 2015-08-05 西格纳姆生物科学公司 化合物、组合物和其制备方法
MX2010012261A (es) * 2008-05-09 2011-04-07 Tolmar Inc Proguanil para tratar enfermedades de la piel/mucosa.
US10829440B2 (en) 2015-06-12 2020-11-10 Brown University Antibacterial compounds and methods of making and using same
WO2018106907A1 (en) * 2016-12-08 2018-06-14 Novatarg, Inc. Fused bicyclic alkylene linked imidodicarbonimidic diamides, methods for synthesis, and uses in therary
US11555010B2 (en) 2019-07-25 2023-01-17 Brown University Diamide antimicrobial agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB603070A (en) * 1946-01-25 1948-06-08 Albert Frederick Crowther Manufacture of biguanide derivatives
GB665680A (en) * 1948-02-20 1952-01-30 Rhone Poulenc Sa Improvements in or relating to the production of n-p-chlorophenyl-n-isopropyl biguanide
DE824942C (de) * 1949-01-31 1951-12-17 Ici Ltd Verfahren zur Herstellung von Biguanidderivaten
GB667116A (en) * 1949-04-25 1952-02-27 Albert Frederick Crowther Manufacture of biguanide derivatives
GB814563A (en) * 1956-11-15 1959-06-10 Vitamins Ltd Biguanides
GB1270831A (en) * 1968-11-22 1972-04-19 Beecham Group Ltd Di-hydro triazine derivatives and processes for their manufacture
GB1250531A (hu) * 1969-01-01 1971-10-20
US3723429A (en) * 1969-11-06 1973-03-27 Beecham Group Ltd Di-hydro triazine derivatives
US3660394A (en) * 1970-01-23 1972-05-02 Vitamins Ltd 4 6-dibenzo-1 2-dihydro-aryloxy-1 3 5-triazines
GB1546937A (en) * 1976-07-29 1979-05-31 Beecham Group Ltd 2,4-diaminopyrimidine derivatives

Also Published As

Publication number Publication date
CZ294257B6 (cs) 2004-11-10
RU94039539A (ru) 1997-05-27
CZ196494A3 (en) 1995-10-18
CN1076689A (zh) 1993-09-29
KR950700243A (ko) 1995-01-16
EP0625967B1 (en) 1997-08-27
RU2133737C1 (ru) 1999-07-27
NO942988D0 (no) 1994-08-12
ES2108862T3 (es) 1998-01-01
HU9401976D0 (en) 1994-09-28
FI943738A7 (fi) 1994-10-12
OA10094A (en) 1996-12-18
DE69313438D1 (de) 1997-10-02
ATE157352T1 (de) 1997-09-15
IL104484A (en) 1998-07-15
GR3025429T3 (en) 1998-02-27
MX9300688A (es) 1993-08-01
CN1057520C (zh) 2000-10-18
DK0625967T3 (da) 1998-03-23
CA2129430C (en) 2004-04-06
DE69313438T2 (de) 1998-03-19
IL104484A0 (en) 1993-05-13
JPH07503730A (ja) 1995-04-20
EG20476A (en) 1999-05-31
FI943738A0 (fi) 1994-08-12
HU220389B (hu) 2002-01-28
CA2129430A1 (en) 1993-08-15
NZ245865A (en) 1996-02-27
NO302616B1 (no) 1998-03-30
ZA93974B (en) 1993-09-14
US5322858A (en) 1994-06-21
AU3475993A (en) 1993-09-03
PL173258B1 (pl) 1998-02-27
PL172001B1 (pl) 1997-07-31
NO942988L (no) 1994-10-05
JP3207200B2 (ja) 2001-09-10
WO1993016037A1 (en) 1993-08-19
AU668709B2 (en) 1996-05-16
EP0625967A1 (en) 1994-11-30

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees