HUT71220A - Chelate substances for targeted delivery of growth factors for bone regeneration, and pharmaceutical preparations containing them - Google Patents

Chelate substances for targeted delivery of growth factors for bone regeneration, and pharmaceutical preparations containing them

Info

Publication number
HUT71220A
HUT71220A HU9403840A HU9403840A HUT71220A HU T71220 A HUT71220 A HU T71220A HU 9403840 A HU9403840 A HU 9403840A HU 9403840 A HU9403840 A HU 9403840A HU T71220 A HUT71220 A HU T71220A
Authority
HU
Hungary
Prior art keywords
growth factors
pharmaceutical preparations
targeted delivery
preparations containing
bone regeneration
Prior art date
Application number
HU9403840A
Other languages
Hungarian (hu)
Other versions
HU9403840D0 (en
Inventor
Joseph R Garlich
Samuel E Lynch
James R Pribish
Original Assignee
Dow Chemical Co
Inst Molecular Biology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/026,800 external-priority patent/US5505931A/en
Application filed by Dow Chemical Co, Inst Molecular Biology Inc filed Critical Dow Chemical Co
Publication of HU9403840D0 publication Critical patent/HU9403840D0/en
Publication of HUT71220A publication Critical patent/HUT71220A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1858Platelet-derived growth factor [PDGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/30Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/547Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3817Acids containing the structure (RX)2P(=X)-alk-N...P (X = O, S, Se)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
HU9403840A 1992-06-30 1993-06-30 Chelate substances for targeted delivery of growth factors for bone regeneration, and pharmaceutical preparations containing them HUT71220A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90698092A 1992-06-30 1992-06-30
US08/026,800 US5505931A (en) 1993-03-04 1993-03-04 Acid cleavable compounds, their preparation and use as bifunctional acid-labile crosslinking agents

Publications (2)

Publication Number Publication Date
HU9403840D0 HU9403840D0 (en) 1995-02-28
HUT71220A true HUT71220A (en) 1995-11-28

Family

ID=26701672

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9403840A HUT71220A (en) 1992-06-30 1993-06-30 Chelate substances for targeted delivery of growth factors for bone regeneration, and pharmaceutical preparations containing them

Country Status (10)

Country Link
EP (1) EP0653941A1 (en)
JP (1) JPH07508979A (en)
CN (1) CN1092076A (en)
AU (1) AU4660093A (en)
CA (1) CA2139323A1 (en)
FI (1) FI946156A7 (en)
HU (1) HUT71220A (en)
IL (1) IL106159A0 (en)
MX (1) MX9303963A (en)
WO (1) WO1994000145A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5462725A (en) * 1993-05-06 1995-10-31 The Dow Chemical Company 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
GB9702978D0 (en) * 1997-02-13 1997-04-02 Ciba Geigy Compounds
US6794371B1 (en) * 1999-10-18 2004-09-21 The Dow Chemical Company Aminoalkylenephosphonates for treatment of bone disorders
WO2001028567A2 (en) * 1999-10-18 2001-04-26 The Dow Chemical Company Aminoalkylenephosphonates for treatment of bone disorders
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
EP1615639A2 (en) * 2003-04-03 2006-01-18 Semafore Pharmaceuticals, Inc. Targeted bone marrow protection agents
EP1932850A1 (en) 2006-12-11 2008-06-18 Thermphos Trading GmbH Phosphonate compounds
MX2017004520A (en) 2014-10-14 2018-03-15 Lynch Samuel Compositions for treating wounds.
US20180215801A1 (en) 2015-01-29 2018-08-02 Board Of Trustees Of Michigan State University Cryptic polypeptides and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011913A (en) * 1985-06-28 1991-04-30 The Procter & Gamble Company Diphosphonate-derivatized macromolecules
JPH02268190A (en) * 1989-04-07 1990-11-01 Fujisawa Pharmaceut Co Ltd Conjugate from medical compound and diphosphonic acid derivative
US5208219A (en) * 1991-02-14 1993-05-04 Celtrix Pharmaceuticals Inc. Method for inducing bone growth
AU662155B2 (en) * 1991-05-10 1995-08-24 Celtrix Pharmaceuticals, Inc. Targeted delivery of bone growth factors

Also Published As

Publication number Publication date
MX9303963A (en) 1995-01-31
EP0653941A1 (en) 1995-05-24
HU9403840D0 (en) 1995-02-28
FI946156A0 (en) 1994-12-29
CA2139323A1 (en) 1994-01-06
FI946156L (en) 1995-02-27
AU4660093A (en) 1994-01-24
JPH07508979A (en) 1995-10-05
CN1092076A (en) 1994-09-14
FI946156A7 (en) 1995-02-27
IL106159A0 (en) 1993-10-20
WO1994000145A1 (en) 1994-01-06

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Legal Events

Date Code Title Description
DFA9 Temporary protection cancelled due to abandonment