HUT72325A - Stabile, liophylised composition containing proteins and kit applicabe for dosing - Google Patents

Stabile, liophylised composition containing proteins and kit applicabe for dosing

Info

Publication number
HUT72325A
HUT72325A HU9501276A HU9501276A HUT72325A HU T72325 A HUT72325 A HU T72325A HU 9501276 A HU9501276 A HU 9501276A HU 9501276 A HU9501276 A HU 9501276A HU T72325 A HUT72325 A HU T72325A
Authority
HU
Hungary
Prior art keywords
kit
applicabe
liophylised
stabile
dosing
Prior art date
Application number
HU9501276A
Other languages
Hungarian (hu)
Other versions
HU220220B (en
HU9501276D0 (en
Inventor
Alain Bayol
Thierry Breul
Patrice Dupin
Philippe Faure
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of HU9501276D0 publication Critical patent/HU9501276D0/en
Publication of HUT72325A publication Critical patent/HUT72325A/en
Publication of HU220220B publication Critical patent/HU220220B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Stable, freeze-dried, pharmaceutically acceptable compsns. comprises a protein a buffer, alanine and mannitol. The mannitol/alanine wt. ratio is 0.1-1. Also claimed is a test kit comprising a compsn. as above.
HU9501276A 1994-05-04 1995-05-03 A stable lyophilized formulation containing a protein and a kit for administration HU220220B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9405486A FR2719479B1 (en) 1994-05-04 1994-05-04 Stable lyophilized formulation comprising a protein: assay kit.

Publications (3)

Publication Number Publication Date
HU9501276D0 HU9501276D0 (en) 1995-06-28
HUT72325A true HUT72325A (en) 1996-04-29
HU220220B HU220220B (en) 2001-11-28

Family

ID=9462880

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9501276A HU220220B (en) 1994-05-04 1995-05-03 A stable lyophilized formulation containing a protein and a kit for administration

Country Status (25)

Country Link
US (1) US5763409A (en)
EP (1) EP0682944B1 (en)
JP (1) JP2948125B2 (en)
KR (1) KR100273053B1 (en)
CN (1) CN1088583C (en)
AT (1) ATE178484T1 (en)
AU (1) AU694763B2 (en)
CA (1) CA2148537C (en)
CZ (1) CZ286195B6 (en)
DE (1) DE69508837T2 (en)
DK (1) DK0682944T3 (en)
ES (1) ES2131781T3 (en)
FI (1) FI117321B (en)
FR (1) FR2719479B1 (en)
GR (1) GR3030146T3 (en)
HU (1) HU220220B (en)
IL (1) IL113578A (en)
MX (1) MX9502034A (en)
NO (1) NO320364B1 (en)
NZ (1) NZ272045A (en)
PL (1) PL179240B1 (en)
RU (1) RU2136306C1 (en)
SI (1) SI0682944T1 (en)
TW (1) TW397687B (en)
ZA (1) ZA953596B (en)

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US6685940B2 (en) * 1995-07-27 2004-02-03 Genentech, Inc. Protein formulation
DE19539574A1 (en) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Preparations and processes for stabilizing biological materials by means of drying processes without freezing
FR2740686B1 (en) 1995-11-03 1998-01-16 Sanofi Sa STABLE LYOPHILIZED PHARMACEUTICAL FORMULATION
EP0852951A1 (en) * 1996-11-19 1998-07-15 Roche Diagnostics GmbH Stable lyophilized monoclonal or polyclonal antibodies containing pharmaceuticals
FR2768341B1 (en) * 1997-09-18 2000-04-14 Lab Francais Du Fractionnement LYOPHILISABLE PLACEBO PHARMACEUTICAL COMPOSITION FOR IMITATING A MEDICAMENT, IN PARTICULAR BASED ON PROTEINS OR POLYPEPTIDES
EP0913178A1 (en) * 1997-11-03 1999-05-06 Boehringer Mannheim Gmbh Process for the manufacture of dry, amorphous products comprising biologically active material by means of convection drying and products obtainable by the process
EP0913177A1 (en) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Process for producing dry, amorphous products comprising biological active materials by means of convection drying technique, especially spray drying
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DK1820516T3 (en) 1999-02-22 2013-10-28 Univ Connecticut New albumin-free factor VIII preparations
IL149355A0 (en) * 1999-10-28 2002-11-10 Inst Neftechimicheskogo Sintez Polypeptide corporation
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US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
CA2512680A1 (en) * 2003-01-08 2004-07-29 Chiron Corporation Stabilized lyophilized compositions comprising tissue factor pathway inhibitor or tissue factor pathway inhibitor variants
GB0304636D0 (en) * 2003-02-28 2003-04-02 Britannia Pharmaceuticals Ltd Pharmaceutical composition for nasal delivery
MXPA05010555A (en) * 2003-04-04 2006-03-09 Genentech Inc High concentration antibody and protein formulations.
DE10333317A1 (en) * 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulation for protein medicines without the addition of human serum albumin (HSA)
GB0404586D0 (en) * 2004-03-01 2004-04-07 Britannia Pharmaceuticals Ltd Improvements in or relating to organic materials
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
MX2009004862A (en) * 2006-11-07 2009-07-17 Sanofi Pasteur Biologics Co Stabilization of vaccines by lyophilization.
EP2170268A2 (en) * 2007-06-25 2010-04-07 Amgen, Inc. Compositions of specific binding agents to hepatocyte growth factor
GB0715285D0 (en) * 2007-08-06 2007-09-12 Britannia Pharmaceuticals Ltd Improvements in or relating to powdered medicaments for nasal delivery
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
MX339060B (en) 2008-11-07 2016-05-09 Baxter Int Factor viii formulations.
RU2011126338A (en) * 2008-11-28 2013-01-10 Эбботт Лэборетриз STABLE COMPOSITIONS OF ANTIBODIES AND METHODS FOR THEIR STABILIZATION
AU2010315325B2 (en) * 2009-11-03 2014-11-27 Grifols Therapeutics Inc. Composition, method, and kit for alpha-1 proteinase inhibitor
RU2581020C2 (en) * 2009-12-22 2016-04-10 Селлдекс Терапьютикс, Инк. Vaccine compositions
RU2448156C1 (en) * 2011-03-17 2012-04-20 Эспосито Трейдинг Лтд Method of producing lyophilised substance
RU2448158C1 (en) * 2011-03-24 2012-04-20 Эспосито Трейдинг Лтд Method for preparing preparation fortelysin showing fibrinolytic properties, and its application for treating myocardial infraction
US10166381B2 (en) 2011-05-23 2019-01-01 Excelsior Medical Corporation Antiseptic cap
CA2841832C (en) 2011-07-12 2019-06-04 Icu Medical, Inc. Device for delivery of antimicrobial agent into a trans-dermal catheter
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US20140017318A1 (en) * 2012-07-10 2014-01-16 Kevin O'Connell Method to produce a medicinal product comprising a biologically active protein and the resulting product
US9314519B2 (en) 2012-08-21 2016-04-19 Intervet Inc. Liquid stable virus vaccines
US9393298B2 (en) 2013-03-15 2016-07-19 Intervet Inc. Liquid stable bovine virus vaccines
US9480739B2 (en) 2013-03-15 2016-11-01 Intervet Inc. Bovine virus vaccines that are liquid stable
AR097762A1 (en) 2013-09-27 2016-04-13 Intervet Int Bv DRY FORMULATIONS OF VACCINES THAT ARE STABLE AT ENVIRONMENTAL TEMPERATURE
EP3689335A1 (en) 2013-09-27 2020-08-05 Hanmi Pharm. Co., Ltd. Sustained type human growth hormone preparation
AR099470A1 (en) 2014-02-17 2016-07-27 Intervet Int Bv LIQUID CORRAL BIRD VIRUS VACCINES
TWI670085B (en) 2014-02-19 2019-09-01 荷蘭商英特威國際公司 Swine virus vaccines that are liquid stable
JP6546988B2 (en) 2014-05-02 2019-07-17 エクセルシオール・メディカル・コーポレイションＥｘｃｅｌｓｉｏｒ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ Strip package for preservative cap
DK3294404T3 (en) 2015-05-08 2025-09-08 Icu Medical Inc MEDICAL CONNECTORS CONFIGURED TO RECEIVE EMISSIONS OF THERAPEUTIC AGENTS
JP2018524067A (en) 2015-06-11 2018-08-30 アットウィル メディカル ソルーションズ インコーポレイテッド Medical devices, systems and methods utilizing antithrombin-heparin compositions
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WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
US11110063B2 (en) 2017-08-25 2021-09-07 MAIA Pharmaceuticals, Inc. Storage stable sincalide formulations
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
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Also Published As

Publication number Publication date
CN1116522A (en) 1996-02-14
ZA953596B (en) 1996-11-04
NZ272045A (en) 1996-02-27
FI117321B (en) 2006-09-15
FR2719479A1 (en) 1995-11-10
IL113578A (en) 1999-10-28
AU1777495A (en) 1995-11-16
PL179240B1 (en) 2000-08-31
NO951724L (en) 1995-11-06
CZ286195B6 (en) 2000-02-16
HU220220B (en) 2001-11-28
US5763409A (en) 1998-06-09
FR2719479B1 (en) 1996-07-26
KR950031103A (en) 1995-12-18
FI952119L (en) 1995-11-05
RU2136306C1 (en) 1999-09-10
IL113578A0 (en) 1995-08-31
EP0682944B1 (en) 1999-04-07
NO320364B1 (en) 2005-11-28
ES2131781T3 (en) 1999-08-01
DE69508837T2 (en) 1999-11-04
DK0682944T3 (en) 1999-10-18
DE69508837D1 (en) 1999-05-12
FI952119A0 (en) 1995-05-03
CA2148537C (en) 2002-07-16
CA2148537A1 (en) 1995-11-05
HU9501276D0 (en) 1995-06-28
CN1088583C (en) 2002-08-07
EP0682944A1 (en) 1995-11-22
MX9502034A (en) 1997-02-28
CZ108195A3 (en) 1996-02-14
TW397687B (en) 2000-07-11
AU694763B2 (en) 1998-07-30
ATE178484T1 (en) 1999-04-15
PL308416A1 (en) 1995-11-13
KR100273053B1 (en) 2000-12-01
JPH0853361A (en) 1996-02-27
SI0682944T1 (en) 1999-08-31
NO951724D0 (en) 1995-05-03
JP2948125B2 (en) 1999-09-13
GR3030146T3 (en) 1999-08-31

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Legal Events

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DGB9 Succession in title of applicant

Owner name: SANOFI-SYNTHELABO, FR