HUT77874A - Módosított humán C3 fehérjék - Google Patents

Módosított humán C3 fehérjék Download PDF

Info

Publication number
HUT77874A
HUT77874A HU9800775A HU9800775A HUT77874A HU T77874 A HUT77874 A HU T77874A HU 9800775 A HU9800775 A HU 9800775A HU 9800775 A HU9800775 A HU 9800775A HU T77874 A HUT77874 A HU T77874A
Authority
HU
Hungary
Prior art keywords
protein
factor
convertase
cleavage
arg
Prior art date
Application number
HU9800775A
Other languages
English (en)
Hungarian (hu)
Inventor
Timothy Charles Farries
Richard Alexander Harrison
Original Assignee
Imutran Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9418147A external-priority patent/GB9418147D0/en
Priority claimed from GBGB9509102.1A external-priority patent/GB9509102D0/en
Application filed by Imutran Limited filed Critical Imutran Limited
Publication of HUT77874A publication Critical patent/HUT77874A/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472Complement proteins, e.g. anaphylatoxin, C3a, C5a
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HU9800775A 1994-09-08 1995-09-08 Módosított humán C3 fehérjék HUT77874A (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9418147A GB9418147D0 (en) 1994-09-08 1994-09-08 Modified proteins
GBGB9509102.1A GB9509102D0 (en) 1995-05-04 1995-05-04 Modified proteins

Publications (1)

Publication Number Publication Date
HUT77874A true HUT77874A (hu) 1998-09-28

Family

ID=26305590

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9800775A HUT77874A (hu) 1994-09-08 1995-09-08 Módosított humán C3 fehérjék

Country Status (21)

Country Link
US (1) US5849297A (no)
EP (1) EP0779922B1 (no)
JP (1) JPH10505241A (no)
CN (1) CN1104501C (no)
AT (1) ATE273388T1 (no)
AU (1) AU707004B2 (no)
BG (1) BG63606B1 (no)
BR (1) BR9509172A (no)
CA (1) CA2197888A1 (no)
CZ (1) CZ290596B6 (no)
DE (1) DE69533359T2 (no)
ES (1) ES2224133T3 (no)
FI (1) FI970979A0 (no)
HU (1) HUT77874A (no)
NO (1) NO971059L (no)
NZ (2) NZ333949A (no)
PL (1) PL319040A1 (no)
RO (1) RO117189B1 (no)
RU (1) RU2194713C2 (no)
SK (1) SK29697A3 (no)
WO (1) WO1996007738A2 (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990087571A (ko) 1996-03-07 1999-12-27 질리안 리틀 하향 조절 내성 c3 컨버타제
JP2001515589A (ja) * 1997-03-06 2001-09-18 バイオン ダイアグノスティック サイエンシーズ,インコーポレイテッド 補体レギュレーターまたはレセプタータンパク質を使用するスクリーニングおよび処置
US6221621B1 (en) 1997-03-06 2001-04-24 Bard Diagnostic Sciences, Inc. Methods of screening for colorectal cancers in which a complement Factor I or related protein is associated
WO2001092295A2 (en) * 2000-05-30 2001-12-06 University Of Toronto Ligands for cd21 and compositions thereof for modulating immune responses
US6998243B2 (en) * 2001-04-30 2006-02-14 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 1793 daltons
US7294688B2 (en) * 2001-04-30 2007-11-13 Nanogen Inc. Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons
US7314717B2 (en) * 2001-04-30 2008-01-01 Nanogen Inc. Biopolymer marker indicative of disease state having a molecular weight of 1562 daltons
US6756476B2 (en) * 2001-04-30 2004-06-29 Syn X Pharma, Inc. Biopolymer marker indicative of disease state having a molecular weight of 2021 daltons
US7179610B2 (en) * 2001-11-23 2007-02-20 Nanogen Inc. Complement C3 precursor biopolymer markers indicative of insulin resistance
US7097989B2 (en) * 2001-11-23 2006-08-29 Syn X Pharma, Inc. Complement C3 precursor biopolymer markers predictive of type II diabetes
RU2251698C1 (ru) * 2003-12-09 2005-05-10 Государственное учреждение "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского Министерства здравоохранения Российской Федерации" СПОСОБ ОПРЕДЕЛЕНИЯ ФУНКЦИОНАЛЬНОЙ АКТИВНОСТИ СУБКОМПОНЕНТОВ C1r2s2 ПЕРВОГО КОМПОНЕНТА КОМПЛЕМЕНТА ЧЕЛОВЕКА
MXPA06012321A (es) * 2004-04-30 2007-04-19 Univ Hawaii Derivados c3 del complemento humano con funcion similar al factor de veneno de cobra.
US20080199499A1 (en) * 2005-01-12 2008-08-21 Proteonova, Inc. Method for Making Targeted Therapeutic Agents
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
WO2010056399A1 (en) * 2008-11-17 2010-05-20 Incode Biopharmaceutics, Inc. Method and composition for modulating the immune system and various inflammatory conditions comprising complement depletors
RU2542401C1 (ru) * 2013-11-06 2015-02-20 Федеральное бюджетное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Способ определения функциональной активности компонента с2 комплемента человека
RU2542404C1 (ru) * 2013-11-06 2015-02-20 Федеральное бюджетное учреждение науки "Московский научно-исследовательский институт эпидемиологии и микробиологии им. Г.Н. Габричевского" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека Способ определения функциональной активности компонента с4 комплемента человека
US11903996B2 (en) * 2015-10-07 2024-02-20 David C. Fritzinger Modulators of complement function
CN113214373B (zh) * 2020-02-06 2022-08-30 深圳华大基因股份有限公司 新包虫病抗原Murinoglobulin-2蛋白
US11918624B2 (en) * 2020-06-10 2024-03-05 Kelsius Laboratories LLC Therapeutic composition for use in the treatment of COVID-19 and other cytokine storm associated disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661347A (en) * 1982-11-12 1987-04-28 Scripps Clinic Cytotoxic compositions

Also Published As

Publication number Publication date
BG63606B1 (bg) 2002-06-28
WO1996007738A3 (en) 1996-03-28
NZ292565A (en) 1999-03-29
AU3477295A (en) 1996-03-27
CN1162335A (zh) 1997-10-15
EP0779922B1 (en) 2004-08-11
BR9509172A (pt) 1997-11-25
SK29697A3 (en) 1998-01-14
FI970979A7 (fi) 1997-03-07
CZ290596B6 (cs) 2002-08-14
ATE273388T1 (de) 2004-08-15
PL319040A1 (en) 1997-07-21
EP0779922A2 (en) 1997-06-25
DE69533359T2 (de) 2005-07-28
ES2224133T3 (es) 2005-03-01
CN1104501C (zh) 2003-04-02
MX9701783A (es) 1997-10-31
RO117189B1 (ro) 2001-11-30
AU707004B2 (en) 1999-07-01
DE69533359D1 (de) 2004-09-16
NO971059L (no) 1997-05-07
WO1996007738A2 (en) 1996-03-14
CA2197888A1 (en) 1996-03-14
FI970979L (fi) 1997-03-07
NZ333949A (en) 2000-06-23
CZ68597A3 (en) 1997-11-12
JPH10505241A (ja) 1998-05-26
NO971059D0 (no) 1997-03-07
RU2194713C2 (ru) 2002-12-20
FI970979A0 (fi) 1997-03-07
US5849297A (en) 1998-12-15
BG101295A (bg) 1997-12-30

Similar Documents

Publication Publication Date Title
HUT77874A (hu) Módosított humán C3 fehérjék
EP1432441B1 (en) Use of hmgb1 for the activation of dendritic cells
JP2009118849A (ja) アポリポタンパク質類似体
US6221657B1 (en) Modified human C3 DNA sequences and vectors
US6268485B1 (en) Down-regulation resistant C3 convertase
JPWO1999014325A1 (ja) 新規Fasリガンド誘導体
MXPA06012321A (es) Derivados c3 del complemento humano con funcion similar al factor de veneno de cobra.
JP4544715B2 (ja) ラットbcl−x遺伝子の改変型cDNAと改変型タンパク質
RU2238322C2 (ru) Протеин, обладающий способностью к образованию с3-конвертазы, днк, вектор, конъюгат и их использование
US20020169308A1 (en) Novel human membrane protein
JP2001521385A (ja) ヒト腫瘍関連膜タンパク質
MXPA97001783A (es) Proteinas c3 humanas modificadas
CN100425695C (zh) 新型人Rab GTP酶,其编码序列及用途
WO2003080662A1 (en) Protein kinase c modulators, their aminoacid and nucleotide sequences and uses thereof
WO2001040275A2 (en) Peptides that stabilize protein antigens and enhance presentation to cd8+ t cells
PT1335938E (pt) Construções de apolipoproteínas
EP1573011A1 (fr) Procede de preparation d'heterocarpine recombinante