ID16410A - Proses produksi lipstatin dan tetrahidrolipstatin - Google Patents

Proses produksi lipstatin dan tetrahidrolipstatin

Info

Publication number
ID16410A
ID16410A IDP970979A ID970979A ID16410A ID 16410 A ID16410 A ID 16410A ID P970979 A IDP970979 A ID P970979A ID 970979 A ID970979 A ID 970979A ID 16410 A ID16410 A ID 16410A
Authority
ID
Indonesia
Prior art keywords
tetrahidrolipstatin
lipstatin
production process
production
tetrahidrolipstatin production
Prior art date
Application number
IDP970979A
Other languages
English (en)
Indonesian (id)
Inventor
Adelbert Bacher
Peter Stohler
Wolfgang Weber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ID16410A publication Critical patent/ID16410A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IDP970979A 1996-04-26 1997-03-25 Proses produksi lipstatin dan tetrahidrolipstatin ID16410A (id)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96106598 1996-04-26

Publications (1)

Publication Number Publication Date
ID16410A true ID16410A (id) 1997-10-30

Family

ID=8222717

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP970979A ID16410A (id) 1996-04-26 1997-03-25 Proses produksi lipstatin dan tetrahidrolipstatin

Country Status (15)

Country Link
US (1) US20020110873A1 (da)
EP (1) EP0803576B1 (da)
JP (1) JP4094698B2 (da)
CN (1) CN1128224C (da)
AR (1) AR006831A1 (da)
AT (1) ATE229077T1 (da)
BR (1) BR9701953A (da)
CA (1) CA2202016C (da)
DE (1) DE69717530T2 (da)
DK (1) DK0803576T3 (da)
ES (1) ES2186818T3 (da)
ID (1) ID16410A (da)
MY (1) MY116591A (da)
PT (1) PT803576E (da)
TR (1) TR199700289A2 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE228118T1 (de) * 1999-01-29 2002-12-15 Hoffmann La Roche Reinigung von lipstatin
AU2002235885A1 (en) * 2001-02-09 2002-08-28 Unilever N.V. Process for the preparation of one or more statins by fermentation
EP1458882A2 (en) * 2001-12-04 2004-09-22 Biogal Gyogyszergyar Rt. A fermentation process for lipstatin and method of extracting lipstatin from a fermentation broth
WO2003047531A2 (en) * 2001-12-04 2003-06-12 Biogal Gyogyszergyar Rt Preparation of orlistat and orlistat crystalline forms
AU2003253254A1 (en) * 2003-07-17 2005-02-04 Biocon Limited Preparation of tetrahydrolipstatin by hydrogenation of lipstatin, solvent extraction and purification
SK22006A3 (sk) * 2006-01-03 2007-08-02 Biotika, A. S. Kmeň Streptomyces toxytricini produkujúci lipstatín a príprava lipstatínu s uvedeným kmeňom
EP1860194A1 (en) * 2006-05-22 2007-11-28 KRKA, tovarna zdravil, d.d., Novo mesto Fermentative production of lipstatin
WO2009040827A1 (en) * 2007-09-24 2009-04-02 Biocon Limited A process for obtaining tetrahydrolipstatin
ES2755736T3 (es) * 2008-03-26 2020-04-23 Biocon Ltd Proceso de fermentación mejorado para un coeficiente de rendimiento más alto de inhibidor de lipasa respecto al ácido graso consumido
CN102268466B (zh) * 2011-07-23 2013-06-12 鲁南新时代生物技术有限公司 一种发酵生产利普司他汀的方法及其培养基组份
CN103820510B (zh) * 2014-01-17 2016-01-20 浙江工业大学 一种微生物发酵生产利普司他汀的方法及培养基

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1247547A (en) * 1983-06-22 1988-12-28 Paul Hadvary Leucine derivatives
CH675966A5 (da) 1987-02-20 1990-11-30 Firmenich & Cie
CA2098167C (en) * 1992-06-24 2006-12-19 Dorothea Isler Foodstuffs and feedstuffs containing a lipase inhibitor

Also Published As

Publication number Publication date
DE69717530T2 (de) 2003-11-06
EP0803576B1 (en) 2002-12-04
DK0803576T3 (da) 2003-03-24
JPH1066592A (ja) 1998-03-10
TR199700289A3 (tr) 1997-11-21
ATE229077T1 (de) 2002-12-15
EP0803576A2 (en) 1997-10-29
AR006831A1 (es) 1999-09-29
BR9701953A (pt) 1998-09-15
CN1128224C (zh) 2003-11-19
US20020110873A1 (en) 2002-08-15
EP0803576A3 (en) 1999-04-21
PT803576E (pt) 2003-03-31
CA2202016A1 (en) 1997-10-26
JP4094698B2 (ja) 2008-06-04
ES2186818T3 (es) 2003-05-16
DE69717530D1 (de) 2003-01-16
MY116591A (en) 2004-02-28
MX9703057A (es) 1998-06-30
CA2202016C (en) 2009-12-08
CN1170761A (zh) 1998-01-21
TR199700289A2 (en) 1997-11-21

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