ID16660A - Senyawa-senyawa b-laktam monosiklik baru - Google Patents

Senyawa-senyawa b-laktam monosiklik baru

Info

Publication number: ID16660A
Authority: ID; Indonesia
Prior art keywords: monosiclic; laktam; compounds; new; new monosiclic
Prior art date: 1996-04-26

Application number

IDP971394A

Other languages

English (en)

Inventor

Colin Andrew Leach

Deirdre Mary Bernadette Hickey

Robert John Ife

Dashyant Dhanak

Colin Theobald

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-26

Filing date

1997-04-25

Publication date

1997-10-30

1996-04-26 Priority claimed from GBGB9608646.7A external-priority patent/GB9608646D0/en

1996-11-15 Priority claimed from GBGB9623756.5A external-priority patent/GB9623756D0/en

1996-12-03 Priority claimed from GBGB9625121.0A external-priority patent/GB9625121D0/en

1997-04-25 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1997-10-30 Publication of ID16660A publication Critical patent/ID16660A/id

Links

150000001875 compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Toxicology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IDP971394A 1996-04-26 1997-04-25 Senyawa-senyawa b-laktam monosiklik baru ID16660A (id)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9608646.7A GB9608646D0 (en)	1996-04-26	1996-04-26	Novel compounds
GBGB9623756.5A GB9623756D0 (en)	1996-11-15	1996-11-15	Novel compounds
GBGB9625121.0A GB9625121D0 (en)	1996-12-03	1996-12-03	Novel compounds

Publications (1)

Publication Number	Publication Date
ID16660A true ID16660A (id)	1997-10-30

Family

ID=27268259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDP971394A ID16660A (id)	1996-04-26	1997-04-25	Senyawa-senyawa b-laktam monosiklik baru

Country Status (17)

Country	Link
EP (1)	EP0915843A1 (id)
JP (1)	JP2000509049A (id)
AR (1)	AR006833A1 (id)
AU (1)	AU2698697A (id)
BR (1)	BR9709196A (id)
CA (1)	CA2252696A1 (id)
CZ (1)	CZ341098A3 (id)
HU (1)	HUP9901359A3 (id)
ID (1)	ID16660A (id)
IL (1)	IL126696A0 (id)
MA (1)	MA26426A1 (id)
NO (1)	NO984939L (id)
NZ (1)	NZ332476A (id)
PE (1)	PE64398A1 (id)
PL (1)	PL329530A1 (id)
TR (1)	TR199802160T2 (id)
WO (1)	WO1997041098A1 (id)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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DK1263740T3 (da)	2000-02-16	2006-11-13	Smithkline Beecham Plc	Pyrimidin-4-on-derivat som LDL-PLA2-inhibitor
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
PT1355644E (pt)	2001-01-26	2006-11-30	Schering Corp	Utilização de compostos azetidinona substituídos para o tratamento de sitosterolemia
RS20100015A (sr)	2001-01-26	2010-12-31	Schering Corporation	Kombinacija aktivatora receptora aktiviranog peroksizom- proliferatorom (ppar) fenofibrata sa inhibitorom apsorpcije sterola ezetimibom za vaskularne indikacije
IL157552A0 (en)	2001-03-28	2004-03-28	Schering Corp	Enantioselective synthesis of azetidinone intermediate compounds
DE60216275T2 (de) *	2001-05-25	2007-06-21	Schering Corp.	Verwendung von mit azetidinon substituierten derivaten bei der behandlung der alzheimer-krankheit
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
EP1429756B1 (en)	2001-09-21	2006-11-22	Schering Corporation	Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
JP2006508188A (ja)	2002-11-06	2006-03-09	シェーリング　コーポレイション	脱髄の処置のためのコレステロール吸収インヒビター
CN1756756A (zh)	2003-03-07	2006-04-05	先灵公司	取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN1756755A (zh)	2003-03-07	2006-04-05	先灵公司	取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
DE602004016123D1 (de)	2003-03-07	2008-10-09	Schering Corp	Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
CN101687009A (zh)	2007-05-11	2010-03-31	宾夕法尼亚大学理事会	治疗皮肤溃疡的方法
US8962633B2 (en)	2007-05-11	2015-02-24	Thomas Jefferson University	Methods of treatment and prevention of metabolic bone diseases and disorders
KR101730290B1 (ko)	2007-05-11	2017-04-25	토마스 제퍼슨 유니버시티	신경변성 질환 및 장애의 치료 및 예방 방법
KR101861883B1 (ko)	2010-12-06	2018-05-28	글락소 그룹 리미티드	Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물
ES2847883T3 (es)	2010-12-17	2021-08-04	Glaxo Group Ltd	Uso de inhibidores de LP-PLA2 en el tratamiento y prevención de enfermedades oculares
CN103619831B (zh)	2011-06-27	2016-05-04	中国科学院上海药物研究所	唑类杂环化合物、其制备方法、药物组合物和用途
AR087309A1 (es)	2011-07-27	2014-03-12	Glaxo Group Ltd	Compuesto heterociclico de anillos condensados sustituido, composicion farmaceutica que lo comprende y su uso para la fabricacion de un medicamento para el tratamiento de enfermedades neurogenerativas y aterosclerosis
CA2842965A1 (en)	2011-07-27	2013-01-31	Glaxo Group Limited	2,3-dihydroimidazo[1,2-c] pyrimidin-5(1h)-one compounds use as lp-pla2 inhibitors
MX2015009633A (es)	2013-01-25	2015-11-30	Glaxosmithkline Ip Dev Ltd	Inhibidores de fosfolipasa a2 asociada con lipoproteinas basados en 2,3-dihidroimidazol[1,2-c] pirimidin-5(1h)-ona.
US9296755B2 (en)	2013-01-25	2016-03-29	Glaxosmithkline Intellectual Property Development Limited	3,4-dihydro-1H-pyrimido[1,6-a]pyrimidin-6(2H)-one compounds and their therapeutic applications
EP2948456A4 (en)	2013-01-25	2016-09-14	Glaxosmithkline Ip Dev Ltd	BICYCLIC PYRIMIDONE COMPOUNDS AS LP-PLA2 INHIBITORS
WO2016012917A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
EP4056571A4 (en)	2019-11-09	2024-01-24	Shanghai Simr Biotechnology Co., Ltd.	Tricyclic dihydroimidazopyrimidone derivative, preparation method therefor, pharmaceutical composition and use thereof
CN115304620A (zh)	2021-05-07	2022-11-08	上海赛默罗生物科技有限公司	嘧啶酮衍生物、其制备方法、药物组合物和用途
WO2025015951A1 (zh)	2023-07-17	2025-01-23	上海枢境生物科技有限公司	双环[5,6]咪唑嘧啶酮类衍生物、其制备方法和应用

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US4680391A (en) *	1983-12-01	1987-07-14	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
IL89835A0 (en) *	1988-04-11	1989-12-15	Merck & Co Inc	Substituted azetidinones,their preparation and pharmaceutical compositions containing them
IL99658A0 (en) *	1990-10-15	1992-08-18	Merck & Co Inc	Substituted azetidinones and pharmaceutical compositions containing them
WO1993000332A1 (en) *	1991-06-25	1993-01-07	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
TW223059B (id) *	1991-07-23	1994-05-01	Schering Corp
CA2108584C (en) *	1992-10-27	1998-11-24	James B. Doherty	Substituted azetidinones as anti-inflammatory and antidegenerative agents
AU5802894A (en) *	1992-12-17	1994-07-04	Merck & Co., Inc.	New substituted azetidinones as anti-inflammatory and antidegenerative agents
EP0658205B1 (en) *	1993-06-25	2000-03-15	Smithkline Beecham Plc	Lipoprotein associated phospholipase a2, inhibitors thereof and use of the same in diagnosis and therapy
ATE315655T1 (de) *	1993-10-06	2006-02-15	Icos Corp	Acethylhydrolase des plättchen aktivierenden faktors
GB9421816D0 (en) *	1994-10-29	1994-12-14	Smithkline Beecham Plc	Novel compounds
HUT77089A (hu) *	1994-12-22	1998-03-02	Smithkline Beecham Plc.	Atherosclerosis kezelésére alkalmas szubsztituált 2-oxo-azetidinek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények
AU5014496A (en) *	1995-03-23	1996-10-08	Japan Tobacco Inc.	Diphenylmethyl-azetidinone compounds and elastase inhibitor
CN1197452A (zh) *	1995-07-01	1998-10-28	史密丝克莱恩比彻姆有限公司	用于治疗动脉粥样硬化的氮杂环丁烷酮衍生物
JP2000505063A (ja) *	1995-12-08	2000-04-25	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	アテローム性動脈硬化症の治療のためのアゼチジノン化合物

1997
- 1997-04-15 IL IL12669697A patent/IL126696A0/xx unknown
- 1997-04-15 HU HU9901359A patent/HUP9901359A3/hu unknown
- 1997-04-15 CA CA002252696A patent/CA2252696A1/en not_active Abandoned
- 1997-04-15 PL PL97329530A patent/PL329530A1/xx unknown
- 1997-04-15 CZ CZ983410A patent/CZ341098A3/cs unknown
- 1997-04-15 EP EP97920699A patent/EP0915843A1/en not_active Withdrawn
- 1997-04-15 AU AU26986/97A patent/AU2698697A/en not_active Abandoned
- 1997-04-15 BR BR9709196A patent/BR9709196A/pt not_active Application Discontinuation
- 1997-04-15 NZ NZ332476A patent/NZ332476A/en unknown
- 1997-04-15 WO PCT/EP1997/001898 patent/WO1997041098A1/en not_active Ceased
- 1997-04-15 JP JP9538507A patent/JP2000509049A/ja active Pending
- 1997-04-15 TR TR1998/02160T patent/TR199802160T2/xx unknown
- 1997-04-24 MA MA24565A patent/MA26426A1/fr unknown
- 1997-04-24 PE PE1997000311A patent/PE64398A1/es not_active Application Discontinuation
- 1997-04-24 AR ARP970101682A patent/AR006833A1/es unknown
- 1997-04-25 ID IDP971394A patent/ID16660A/id unknown
1998
- 1998-10-23 NO NO984939A patent/NO984939L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR9709196A (pt)	1999-05-25
WO1997041098A1 (en)	1997-11-06
PE64398A1 (es)	1999-01-06
AR006833A1 (es)	1999-09-29
TR199802160T2 (xx)	1999-04-21
AU2698697A (en)	1997-11-19
CZ341098A3 (cs)	1999-03-17
CA2252696A1 (en)	1997-11-06
HUP9901359A3 (en)	2000-03-28
PL329530A1 (en)	1999-03-29
IL126696A0 (en)	1999-08-17
JP2000509049A (ja)	2000-07-18
HUP9901359A2 (hu)	1999-08-30
NO984939D0 (no)	1998-10-23
NZ332476A (en)	2000-06-23
MA26426A1 (fr)	2004-12-20
NO984939L (no)	1998-12-23
EP0915843A1 (en)	1999-05-19

Publication	Publication Date	Title
ID21881A (id)	1999-08-05	Turunan-turunan baru pirazol tersubstitusi
ID17686A (id)	1998-01-22	Fotoinisiator alpha-aminoasetofenon baru
ID15881A (id)	1997-08-14	Oksazolidinan tersubstitusi yang baru
ID15840A (id)	1997-08-14	Turunan-turunan 19-nor-pregnena baru
ID18759A (id)	1998-05-07	Imidazole tersubstitusi sikloalkil baru
ID19609A (id)	1998-07-23	Senyawa-senyawa heterosiklik
ID19403A (id)	1998-07-09	Senyawa-senyawa heterosiklik
ID16152A (id)	1997-09-04	Senyawa-senyawa triaril
ID21850A (id)	1999-08-05	Formula senyawa baru
ID27263A (id)	2001-03-22	Dihidropirimidina baru
ID15904A (id)	1997-08-14	Senyawa-senyawa tiofenopirimidina
ID19476A (id)	1998-07-16	Senyawa piridilpirol
ID18685A (id)	1998-04-30	Senyawa trisiklik tersubstitusi
DE69716924D1 (de)	2002-12-12	Phosphonat-nukleotid-verbindungen
ID18431A (id)	1998-04-09	Senyawa-senyawa baru
BR9705635A (pt)	1999-05-18	Compostos
ID17421A (id)	1997-12-24	Senyawa senyawa baru
ID26299A (id)	2000-12-14	Herbisida baru
DK0923594T3 (da)	2003-02-10	Bromotiacumicinforbindelser
ID18262A (id)	1998-03-19	Turunan-turunan baru piranosida
ID16247A (id)	1997-09-11	Metode baru
ID19433A (id)	1998-07-09	Senyaw-senyawa baru
ID16684A (id)	1997-10-30	Senyawa-senyawa sulfonilurea baru
ID24191A (id)	2000-07-13	Komposisi baru
DE69709659D1 (de)	2002-02-21	Halopropargyl-einschlussverbindungen