ID16660A - Senyawa-senyawa b-laktam monosiklik baru - Google Patents

Senyawa-senyawa b-laktam monosiklik baru

Info

Publication number: ID16660A
Authority: ID; Indonesia
Prior art keywords: monosiclic; laktam; compounds; new; new monosiclic
Prior art date: 1996-04-26

Application number

IDP971394A

Other languages

English (en)

Inventor

Colin Andrew Leach

Deirdre Mary Bernadette Hickey

Robert John Ife

Dashyant Dhanak

Colin Theobald

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-26

Filing date

1997-04-25

Publication date

1997-10-30

1996-04-26 Priority claimed from GBGB9608646.7A external-priority patent/GB9608646D0/en

1996-11-15 Priority claimed from GBGB9623756.5A external-priority patent/GB9623756D0/en

1996-12-03 Priority claimed from GBGB9625121.0A external-priority patent/GB9625121D0/en

1997-04-25 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1997-10-30 Publication of ID16660A publication Critical patent/ID16660A/id

Links

150000001875 compounds Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IDP971394A 1996-04-26 1997-04-25 Senyawa-senyawa b-laktam monosiklik baru ID16660A (id)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9608646.7A GB9608646D0 (en)	1996-04-26	1996-04-26	Novel compounds
GBGB9623756.5A GB9623756D0 (en)	1996-11-15	1996-11-15	Novel compounds
GBGB9625121.0A GB9625121D0 (en)	1996-12-03	1996-12-03	Novel compounds

Publications (1)

Publication Number	Publication Date
ID16660A true ID16660A (id)	1997-10-30

Family

ID=27268259

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDP971394A ID16660A (id)	1996-04-26	1997-04-25	Senyawa-senyawa b-laktam monosiklik baru

Country Status (17)

Country	Link
EP (1)	EP0915843A1 (id)
JP (1)	JP2000509049A (id)
AR (1)	AR006833A1 (id)
AU (1)	AU2698697A (id)
BR (1)	BR9709196A (id)
CA (1)	CA2252696A1 (id)
CZ (1)	CZ341098A3 (id)
HU (1)	HUP9901359A3 (id)
ID (1)	ID16660A (id)
IL (1)	IL126696A0 (id)
MA (1)	MA26426A1 (id)
NO (1)	NO984939L (id)
NZ (1)	NZ332476A (id)
PE (1)	PE64398A1 (id)
PL (1)	PL329530A1 (id)
TR (1)	TR199802160T2 (id)
WO (1)	WO1997041098A1 (id)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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NZ520752A (en)	2000-02-16	2004-03-26	Smithkline Beecham P	Pyrimidine-4-one derivatives as LDL-PLA2 inhibitors
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
DK1355644T3 (da)	2001-01-26	2006-10-23	Schering Corp	Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi
HU230253B1 (hu)	2001-01-26	2015-11-30	Merck Sharp & Dohme Corp	Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
DK1373230T3 (da)	2001-03-28	2005-11-07	Schering Corp	Enantiselektiv syntese af azetidinon mellemprodukter
JP2004532868A (ja) *	2001-05-25	2004-10-28	シェーリング　コーポレイション	アルツハイマー病の処置におけるアゼチジノン置換誘導体の使用
JP2005504091A (ja)	2001-09-21	2005-02-10	シェーリング　コーポレイション	ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en)	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
WO2004043457A1 (en)	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CA2517571C (en)	2003-03-07	2011-07-05	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP4589919B2 (ja)	2003-03-07	2010-12-01	シェーリングコーポレイション	高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
JP2006519869A (ja)	2003-03-07	2006-08-31	シェーリング　コーポレイション	置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
EP2977452A3 (en)	2007-05-11	2016-05-25	Thomas Jefferson University	Methods of treatment and prevention of neurodegenerative diseases and disorders
US8962633B2 (en)	2007-05-11	2015-02-24	Thomas Jefferson University	Methods of treatment and prevention of metabolic bone diseases and disorders
CN101687009A (zh)	2007-05-11	2010-03-31	宾夕法尼亚大学理事会	治疗皮肤溃疡的方法
KR101861883B1 (ko)	2010-12-06	2018-05-28	글락소 그룹 리미티드	Lp-PLA₂에 의해 매개되는 질환 또는 상태의 치료에 사용하기 위한 피리미디논 화합물
ES2847883T3 (es)	2010-12-17	2021-08-04	Glaxo Group Ltd	Uso de inhibidores de LP-PLA2 en el tratamiento y prevención de enfermedades oculares
EP2725024A4 (en)	2011-06-27	2014-12-03	Shanghai Inst Materia Medica	HETEROCYCLIC AZOL COMPOUND, METHOD OF MANUFACTURING THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF
EP2739627A4 (en)	2011-07-27	2015-01-21	Glaxo Group Ltd	2,3-DIHYDROIMIDAZO [1,2-C] PYRIMIDIN-5 (1H) -ONE COMPOUNDS AND USE AS INHIBITORS OF LP-PLA2
EP2736908A1 (en)	2011-07-27	2014-06-04	Glaxo Group Limited	Bicyclic pyrimidone compounds
BR112015017397A2 (pt)	2013-01-25	2017-07-11	Glaxosmithkline Ip Dev Ltd	compostos pirimidona bicíclica como inibidores de lp-pla2
UY35276A (es)	2013-01-25	2014-08-29	Glaxosmithkline Ip Dev Ltd	Nuevos compuestos que inhiben la actividad de Lp-PLA2
CA2899124A1 (en)	2013-01-25	2014-07-31	Glaxosmithkline Intellectual Property Development Limited	Compounds
WO2016012917A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012916A1 (en)	2014-07-22	2016-01-28	Glaxosmithkline Intellectual Property Development Limited	1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN114805389B (zh)	2019-11-09	2023-08-29	上海赛默罗生物科技有限公司	三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
CN115304620A (zh)	2021-05-07	2022-11-08	上海赛默罗生物科技有限公司	嘧啶酮衍生物、其制备方法、药物组合物和用途
TWI896037B (zh)	2023-07-17	2025-09-01	大陸商上海樞境生物科技有限公司	雙環[5,6]咪唑嘧啶酮類衍生物、其製備方法和應用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4680391A (en) *	1983-12-01	1987-07-14	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
NZ228600A (en) *	1988-04-11	1992-02-25	Merck & Co Inc	1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives
IL99658A0 (en) *	1990-10-15	1992-08-18	Merck & Co Inc	Substituted azetidinones and pharmaceutical compositions containing them
WO1993000332A1 (en) *	1991-06-25	1993-01-07	Merck & Co., Inc.	Substituted azetidinones as anti-inflammatory and antidegenerative agents
JP2525125B2 (ja) *	1991-07-23	1996-08-14	シェリング・コーポレーション	血清コレステロ―ル低下薬として有用な置換β−ラクタム化合物およびそれらの製法
MY128261A (en) *	1992-10-27	2007-01-31	Merck Sharp & Dohme	New substituted azetidinones as anti-inflammatory and antidegenerative agents
AU5802894A (en) *	1992-12-17	1994-07-04	Merck & Co., Inc.	New substituted azetidinones as anti-inflammatory and antidegenerative agents
DE69423436T2 (de) *	1993-06-25	2000-09-07	Smithkline Beecham P.L.C., Brentford	An lipoprotein gebundene phospholipase a2, inhibitoren davon und deren verwendung für diagnose und therapie
JP3613398B2 (ja) *	1993-10-06	2005-01-26	イコスコーポレイション	血小板活性化因子アセチルヒドロラーゼ
GB9421816D0 (en) *	1994-10-29	1994-12-14	Smithkline Beecham Plc	Novel compounds
AR002012A1 (es) *	1994-12-22	1998-01-07	Smithkline Beecham Plc	Un compuesto, una composicion farmaceutica que lo comprende, su uso, metodo de tratamiento terapeutico, metodo para la preparacion del compuesto.
AU5014496A (en) *	1995-03-23	1996-10-08	Japan Tobacco Inc.	Diphenylmethyl-azetidinone compounds and elastase inhibitor
EP0840725A1 (en) *	1995-07-01	1998-05-13	Smithkline Beecham Plc	Azetidinone derivatives for the treatment of atherosclerosis
JP2000505063A (ja) *	1995-12-08	2000-04-25	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	アテローム性動脈硬化症の治療のためのアゼチジノン化合物

1997
- 1997-04-15 HU HU9901359A patent/HUP9901359A3/hu unknown
- 1997-04-15 EP EP97920699A patent/EP0915843A1/en not_active Withdrawn
- 1997-04-15 AU AU26986/97A patent/AU2698697A/en not_active Abandoned
- 1997-04-15 BR BR9709196A patent/BR9709196A/pt not_active Application Discontinuation
- 1997-04-15 WO PCT/EP1997/001898 patent/WO1997041098A1/en not_active Ceased
- 1997-04-15 PL PL97329530A patent/PL329530A1/xx unknown
- 1997-04-15 TR TR1998/02160T patent/TR199802160T2/xx unknown
- 1997-04-15 JP JP9538507A patent/JP2000509049A/ja active Pending
- 1997-04-15 NZ NZ332476A patent/NZ332476A/en unknown
- 1997-04-15 IL IL12669697A patent/IL126696A0/xx unknown
- 1997-04-15 CZ CZ983410A patent/CZ341098A3/cs unknown
- 1997-04-15 CA CA002252696A patent/CA2252696A1/en not_active Abandoned
- 1997-04-24 MA MA24565A patent/MA26426A1/fr unknown
- 1997-04-24 PE PE1997000311A patent/PE64398A1/es not_active Application Discontinuation
- 1997-04-24 AR ARP970101682A patent/AR006833A1/es unknown
- 1997-04-25 ID IDP971394A patent/ID16660A/id unknown
1998
- 1998-10-23 NO NO984939A patent/NO984939L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP9901359A3 (en)	2000-03-28
MA26426A1 (fr)	2004-12-20
JP2000509049A (ja)	2000-07-18
BR9709196A (pt)	1999-05-25
AR006833A1 (es)	1999-09-29
CA2252696A1 (en)	1997-11-06
TR199802160T2 (xx)	1999-04-21
WO1997041098A1 (en)	1997-11-06
EP0915843A1 (en)	1999-05-19
HUP9901359A2 (hu)	1999-08-30
NO984939D0 (no)	1998-10-23
CZ341098A3 (cs)	1999-03-17
PE64398A1 (es)	1999-01-06
IL126696A0 (en)	1999-08-17
NO984939L (no)	1998-12-23
NZ332476A (en)	2000-06-23
AU2698697A (en)	1997-11-19
PL329530A1 (en)	1999-03-29

Publication	Publication Date	Title
ID21881A (id)	1999-08-05	Turunan-turunan baru pirazol tersubstitusi
ID17686A (id)	1998-01-22	Fotoinisiator alpha-aminoasetofenon baru
ID16660A (id)	1997-10-30	Senyawa-senyawa b-laktam monosiklik baru
ID15881A (id)	1997-08-14	Oksazolidinan tersubstitusi yang baru
ID15840A (id)	1997-08-14	Turunan-turunan 19-nor-pregnena baru
ID18759A (id)	1998-05-07	Imidazole tersubstitusi sikloalkil baru
ID19609A (id)	1998-07-23	Senyawa-senyawa heterosiklik
ID19403A (id)	1998-07-09	Senyawa-senyawa heterosiklik
ID16152A (id)	1997-09-04	Senyawa-senyawa triaril
ID21850A (id)	1999-08-05	Formula senyawa baru
ID27263A (id)	2001-03-22	Dihidropirimidina baru
ID15904A (id)	1997-08-14	Senyawa-senyawa tiofenopirimidina
ID19476A (id)	1998-07-16	Senyawa piridilpirol
ID18685A (id)	1998-04-30	Senyawa trisiklik tersubstitusi
DE69716924D1 (de)	2002-12-12	Phosphonat-nukleotid-verbindungen
ID18431A (id)	1998-04-09	Senyawa-senyawa baru
BR9705635A (pt)	1999-05-18	Compostos
ID17421A (id)	1997-12-24	Senyawa senyawa baru
ID26299A (id)	2000-12-14	Herbisida baru
DK0923594T3 (da)	2003-02-10	Bromotiacumicinforbindelser
ID18262A (id)	1998-03-19	Turunan-turunan baru piranosida
ID16247A (id)	1997-09-11	Metode baru
ID19433A (id)	1998-07-09	Senyaw-senyawa baru
ID16684A (id)	1997-10-30	Senyawa-senyawa sulfonilurea baru
ID24191A (id)	2000-07-13	Komposisi baru