ID16974A - Komposisi dan metoda pembuatan antibiotik karbapenem - Google Patents

Komposisi dan metoda pembuatan antibiotik karbapenem

Info

Publication number
ID16974A
ID16974A IDP971736A ID971736A ID16974A ID 16974 A ID16974 A ID 16974A ID P971736 A IDP971736 A ID P971736A ID 971736 A ID971736 A ID 971736A ID 16974 A ID16974 A ID 16974A
Authority
ID
Indonesia
Prior art keywords
compibition
carbapenems
making antibiotic
making
antibiotic carbapenems
Prior art date
Application number
IDP971736A
Other languages
English (en)
Indonesian (id)
Inventor
Jeffrey A Zimmermann
John M Williams
Paul A Bergquist
Lisa M Dimichele
David C Dubost
Michael J Kaufman
Daniel R Sidler
William A Hunke
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9612668.5A external-priority patent/GB9612668D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ID16974A publication Critical patent/ID16974A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/887—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero atom or a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IDP971736A 1996-05-28 1997-05-26 Komposisi dan metoda pembuatan antibiotik karbapenem ID16974A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1851896P 1996-05-28 1996-05-28
GBGB9612668.5A GB9612668D0 (en) 1996-06-18 1996-06-18 Carbapenem antibiotic composition and method of preparation

Publications (1)

Publication Number Publication Date
ID16974A true ID16974A (id) 1997-11-27

Family

ID=26309530

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP971736A ID16974A (id) 1996-05-28 1997-05-26 Komposisi dan metoda pembuatan antibiotik karbapenem

Country Status (33)

Country Link
EP (1) EP0863901B1 (fr)
JP (2) JPH11509871A (fr)
KR (2) KR100403497B1 (fr)
CN (1) CN1067074C (fr)
AT (1) ATE252584T1 (fr)
AU (1) AU710102B2 (fr)
BG (1) BG63821B1 (fr)
CA (1) CA2227994C (fr)
CO (1) CO4940412A1 (fr)
CY (1) CY2437B1 (fr)
CZ (1) CZ296381B6 (fr)
DE (1) DE69725696T2 (fr)
DK (1) DK0863901T3 (fr)
DZ (1) DZ2242A1 (fr)
EA (1) EA000534B1 (fr)
EE (1) EE04678B1 (fr)
ES (1) ES2208907T3 (fr)
HR (1) HRP970281B1 (fr)
HU (1) HU229426B1 (fr)
ID (1) ID16974A (fr)
IL (1) IL123078A (fr)
IS (1) IS2353B (fr)
MX (1) MX9800808A (fr)
NO (1) NO323815B1 (fr)
NZ (1) NZ329649A (fr)
PL (1) PL188917B1 (fr)
PT (1) PT863901E (fr)
RS (1) RS49583B (fr)
SI (1) SI0863901T1 (fr)
SK (1) SK284359B6 (fr)
TR (1) TR199800146T1 (fr)
TW (1) TW434014B (fr)
WO (1) WO1997045430A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU725298B2 (en) * 1996-10-28 2000-10-12 Merck & Co., Inc. Stabilized carbapenem antibiotic compositions and method of making
US6180783B1 (en) * 1997-06-16 2001-01-30 Merck & Co., Inc. Stabilized carbapenem intermediates and improved process for carbapenem synthesis
JP3245427B2 (ja) * 1997-06-16 2002-01-15 メルク エンド カンパニー インコーポレーテッド 安定化されたカルバペネム中間体および合成における使用
US6504027B1 (en) 1998-03-02 2003-01-07 Merck & Co., Inc. Decarboxylation process for synthesizing carbapenem antibiotics
CA2388163C (fr) * 1999-10-29 2009-08-25 Merck & Co., Inc. Procede de preparation de compositions antibiotiques a base de carbapenem
AR035728A1 (es) 2001-01-16 2004-07-07 Merck & Co Inc Proceso perfeccionado para la sintesis de carbapenem
CN101357918B (zh) * 2007-06-22 2011-05-18 山东轩竹医药科技有限公司 含有异硫脲基巯基吡咯烷的培南衍生物
CN101367815B (zh) * 2007-06-28 2012-07-04 山东轩竹医药科技有限公司 六元环甲酰胺取代的巯基吡咯烷碳青霉烯化合物
JPWO2009075309A1 (ja) 2007-12-12 2011-04-28 大日本住友製薬株式会社 製剤組成物
CN101550138B (zh) * 2008-04-03 2011-05-18 山东轩竹医药科技有限公司 巯基氮杂环烷酰胺醇取代的培南衍生物
EP2303225B1 (fr) * 2008-06-11 2013-11-20 Ranbaxy Laboratories Limited Compositions D'Adduit de Dioxide de Carbone D'Ertapénem et Formes Polymorphiques du Sel Monosodium d'Ertapénem
KR101316971B1 (ko) 2009-03-31 2013-10-11 미쓰비시마테리알덴시카세이가부시키가이샤 함불소 ｎ-알킬술포닐이미드 화합물 및 그 제조 방법, 그리고 이온성 화합물의 제조 방법
BRPI1014338B1 (pt) 2009-06-25 2019-12-24 Shell Int Research método para injetar água em uma formação contendo hidrocarbonetos, e, método para preparar uma água com salinidade elevada
WO2012047832A2 (fr) 2010-10-07 2012-04-12 Shell Oil Company Procédé de production d'alcools à partir de biomasse
WO2012061596A1 (fr) 2010-11-05 2012-05-10 Shell Oil Company Traitement de biomasse pour produire des matières utiles pour des biocarburants
US8609379B2 (en) 2010-12-20 2013-12-17 Shell Oil Company Process for the production of alcohols from biomass
PL2791344T3 (pl) 2011-12-15 2016-08-31 Shell Int Research Sposób obróbki produktów ubocznych z wytwarzania etanolu
AU2013262758B9 (en) 2012-05-17 2015-11-12 Shell Internationale Research Maatschappij B.V. Process for producing volatile organic compounds from biomass material
CN103860485A (zh) * 2012-12-18 2014-06-18 深圳市海滨制药有限公司 一种厄他培南钠冻干制剂及其制备方法
US20150299739A1 (en) 2014-04-17 2015-10-22 Shell Oil Company Processes for producing fermentation products
WO2016025678A1 (fr) 2014-08-14 2016-02-18 Shell Oil Company Procédé permettant de préparer du furfural à partir d'une biomasse

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES525492A0 (es) * 1982-09-10 1985-02-01 Glaxo Group Ltd Un procedimiento para la produccion de un recipiente hermeticamente cerrado que contiene al menos un antibiotico de beta-lactama.
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds
CA2091309A1 (fr) * 1992-03-26 1993-09-27 Frederic H. Jung Composes antibiotiques

Also Published As

Publication number Publication date
CN1067074C (zh) 2001-06-13
ATE252584T1 (de) 2003-11-15
HU229426B1 (en) 2013-12-30
CY2437B1 (en) 2004-11-12
HRP970281A2 (en) 1998-06-30
SK10998A3 (en) 1998-08-05
EA199800180A1 (ru) 1998-08-27
EP0863901A1 (fr) 1998-09-16
BG63821B1 (bg) 2003-02-28
JP5255983B2 (ja) 2013-08-07
AU3077597A (en) 1998-01-05
PT863901E (pt) 2004-02-27
SI0863901T1 (en) 2004-04-30
HRP970281B1 (en) 2002-04-30
NZ329649A (en) 1998-11-25
HUP9901567A3 (en) 2000-03-28
KR19990036052A (fr) 1999-05-25
DZ2242A1 (fr) 2002-12-18
TW434014B (en) 2001-05-16
AU710102B2 (en) 1999-09-16
MX9800808A (es) 1998-04-30
NO980380D0 (no) 1998-01-28
IL123078A (en) 2002-03-10
DE69725696T2 (de) 2004-07-29
PL188917B1 (pl) 2005-05-31
CN1198162A (zh) 1998-11-04
KR100403497B1 (ko) 2003-10-30
CA2227994C (fr) 2002-06-25
HK1016176A1 (en) 1999-10-29
NO323815B1 (no) 2007-07-09
CO4940412A1 (es) 2000-07-24
CA2227994A1 (fr) 1997-12-04
CZ25398A3 (cs) 1998-07-15
EP0863901B1 (fr) 2003-10-22
YU4198A (sh) 1998-12-23
IS4663A (is) 1998-01-27
EA000534B1 (ru) 1999-10-28
DE69725696D1 (de) 2003-11-27
NO980380L (no) 1998-03-16
CZ296381B6 (cs) 2006-03-15
JPH11509871A (ja) 1999-08-31
SK284359B6 (sk) 2005-02-04
RS49583B (sr) 2007-04-10
IS2353B (is) 2008-04-15
DK0863901T3 (da) 2004-02-16
ES2208907T3 (es) 2004-06-16
PL324746A1 (en) 1998-06-08
TR199800146T1 (xx) 1998-06-22
KR100344479B1 (ko) 2002-10-31
IL123078A0 (en) 1998-09-24
EE9800022A (et) 1998-08-17
EE04678B1 (et) 2006-08-15
JP2009084284A (ja) 2009-04-23
HUP9901567A2 (hu) 1999-09-28
WO1997045430A1 (fr) 1997-12-04
BG102273A (bg) 1998-09-30

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