ID19142A - Inhibitor-inhibitor sikloalkil pada protein farnesiltransferase - Google Patents

Inhibitor-inhibitor sikloalkil pada protein farnesiltransferase

Info

Publication number
ID19142A
ID19142A IDP973902A ID973902A ID19142A ID 19142 A ID19142 A ID 19142A ID P973902 A IDP973902 A ID P973902A ID 973902 A ID973902 A ID 973902A ID 19142 A ID19142 A ID 19142A
Authority
ID
Indonesia
Prior art keywords
protein
inhibitors
pherase
farnesiltrans
cyclalcyl
Prior art date
Application number
IDP973902A
Other languages
English (en)
Inventor
Annette Marian Doherty
James Stanley Kal Tenbronn
Daniele M Leornard
Dennis Joseph Mc Namara
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of ID19142A publication Critical patent/ID19142A/id

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
IDP973902A 1996-12-17 1997-12-17 Inhibitor-inhibitor sikloalkil pada protein farnesiltransferase ID19142A (id)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3366196P 1996-12-17 1996-12-17
US5683197P 1997-08-22 1997-08-22

Publications (1)

Publication Number Publication Date
ID19142A true ID19142A (id) 1998-06-18

Family

ID=26709973

Family Applications (1)

Application Number Title Priority Date Filing Date
IDP973902A ID19142A (id) 1996-12-17 1997-12-17 Inhibitor-inhibitor sikloalkil pada protein farnesiltransferase

Country Status (21)

Country Link
US (1) US6281194B1 (id)
EP (1) EP0951471B1 (id)
JP (1) JP2001506265A (id)
KR (1) KR20000057601A (id)
AT (1) ATE261987T1 (id)
AU (1) AU721786C (id)
BR (1) BR9713744A (id)
CA (1) CA2264207A1 (id)
CO (1) CO4920227A1 (id)
DE (1) DE69728165T2 (id)
DK (1) DK0951471T3 (id)
ES (1) ES2216189T3 (id)
HR (1) HRP970693B1 (id)
ID (1) ID19142A (id)
IL (1) IL128546A0 (id)
NO (1) NO992933L (id)
NZ (1) NZ334702A (id)
PE (1) PE46999A1 (id)
PT (1) PT951471E (id)
TW (1) TW552259B (id)
WO (1) WO1998027109A1 (id)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0951471B1 (en) 1996-12-17 2004-03-17 Warner-Lambert Company Llc Cycloalkyl inhibitors of protein farnesyltransferase
NZ507165A (en) 1998-04-27 2003-06-30 Warner Lambert Co Functionalized alkyl and alkenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
DE60234354D1 (de) 2001-08-24 2009-12-24 Univ Yale Piperazinon-verbindungen als antitumorale und krebsbekämpfende mittel
AU2007229363B2 (en) * 2001-08-24 2009-06-04 University Of South Florida Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment
US20070275956A1 (en) * 2003-10-14 2007-11-29 Lohray Braj B Novel Heterocyclic Compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100362338B1 (ko) 1993-11-05 2003-04-08 워너-램버트 캄파니 단백질:파르네실트랜스퍼라아제의치환디-및트리펩티드억제제
US5571792A (en) 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
EP0951471B1 (en) 1996-12-17 2004-03-17 Warner-Lambert Company Llc Cycloalkyl inhibitors of protein farnesyltransferase

Also Published As

Publication number Publication date
WO1998027109A1 (en) 1998-06-25
DE69728165D1 (de) 2004-04-22
AU5899098A (en) 1998-07-15
JP2001506265A (ja) 2001-05-15
EP0951471B1 (en) 2004-03-17
NZ334702A (en) 2000-11-24
CA2264207A1 (en) 1998-06-25
ES2216189T3 (es) 2004-10-16
DE69728165T2 (de) 2005-01-20
IL128546A0 (en) 2000-01-31
PT951471E (pt) 2004-08-31
HRP970693B1 (en) 2002-06-30
NO992933D0 (no) 1999-06-16
HRP970693A2 (en) 1998-10-31
BR9713744A (pt) 2000-03-21
US6281194B1 (en) 2001-08-28
AU721786B2 (en) 2000-07-13
EP0951471A1 (en) 1999-10-27
TW552259B (en) 2003-09-11
NO992933L (no) 1999-06-16
ATE261987T1 (de) 2004-04-15
CO4920227A1 (es) 2000-05-29
KR20000057601A (ko) 2000-09-25
PE46999A1 (es) 1999-05-20
DK0951471T3 (da) 2004-07-19
AU721786C (en) 2001-08-02

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