ID20667A - Bentuk kristal dari n-(4-trifluorometilfenil0-5-metilisoksanol-4-karboksamida - Google Patents

Bentuk kristal dari n-(4-trifluorometilfenil0-5-metilisoksanol-4-karboksamida

Info

Publication number: ID20667A
Authority: ID; Indonesia
Prior art keywords: crystal modification; carboxamide; lines; intensity; trifluoromethylphenyl
Prior art date: 1997-08-08

Application number

IDP981098A

Other languages

English (en)

Inventor

Holger Dr Faasch

Udo Dr Hedtmann

Uwe Dr Westenfelder

Erich Dr Paulus

Original Assignee

Hoechst Marion Roussel De Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-08

Filing date

1998-08-06

Publication date

1999-02-11

1997-08-08 Priority claimed from DE19734438A external-priority patent/DE19734438A1/de

1997-12-17 Priority claimed from DE1997156093 external-priority patent/DE19756093A1/de

1998-08-06 Application filed by Hoechst Marion Roussel De Gmbh filed Critical Hoechst Marion Roussel De Gmbh

1999-02-11 Publication of ID20667A publication Critical patent/ID20667A/id

Links

239000013078 crystal Substances 0.000 abstract 5
238000012986 modification Methods 0.000 abstract 5
230000004048 modification Effects 0.000 abstract 5
VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 abstract 3
238000002441 X-ray diffraction Methods 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000005540 biological transmission Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000005855 radiation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IDP981098A 1997-08-08 1998-08-06 Bentuk kristal dari n-(4-trifluorometilfenil0-5-metilisoksanol-4-karboksamida ID20667A (id)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19734438A DE19734438A1 (de)	1997-08-08	1997-08-08	Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid
DE1997156093 DE19756093A1 (de)	1997-12-17	1997-12-17	Verfahren zur Herstellung einer Kristallform von N-(4-Trifluormethylphenyl)-5-methyl-isoxazole-4-carboxamid

Publications (1)

Publication Number	Publication Date
ID20667A true ID20667A (id)	1999-02-11

Family

ID=26038983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IDP981098A ID20667A (id)	1997-08-08	1998-08-06	Bentuk kristal dari n-(4-trifluorometilfenil0-5-metilisoksanol-4-karboksamida

Country Status (28)

Country	Link
US (5)	US6060494A (id)
EP (2)	EP0903345B1 (id)
JP (2)	JPH11124372A (id)
KR (2)	KR100544041B1 (id)
CN (2)	CN1181064C (id)
AR (1)	AR015418A1 (id)
AT (2)	ATE207065T1 (id)
AU (1)	AU752764B2 (id)
BR (1)	BR9806568A (id)
CA (1)	CA2245267C (id)
CZ (3)	CZ301426B6 (id)
DE (2)	DE59800287D1 (id)
DK (2)	DK0903345T3 (id)
ES (2)	ES2166205T3 (id)
GR (1)	GR3034814T3 (id)
HK (1)	HK1049481B (id)
HU (2)	HU225870B1 (id)
ID (1)	ID20667A (id)
IL (1)	IL125671A (id)
NO (1)	NO310871B1 (id)
NZ (1)	NZ331270A (id)
PL (1)	PL192126B1 (id)
PT (2)	PT987256E (id)
RU (1)	RU2224753C2 (id)
SK (2)	SK282641B6 (id)
TR (2)	TR200600582A1 (id)
TW (1)	TW593288B (id)
UA (1)	UA54411C2 (id)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE207065T1 (de) *	1997-08-08	2001-11-15	Aventis Pharma Gmbh	Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid
DE19908527C2 (de)	1999-02-26	2001-08-30	Aventis Pharma Gmbh	Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid
HUP0204069A3 (en) *	1999-12-16	2005-01-28	Teva Pharma	Novel processes for making- and a new crystalline form of- leflunomide and pharmaceutical composition containing it
EP1257270B1 (en) *	2000-02-15	2005-04-13	Teva Pharmaceutical Industries Ltd.	A method for synthesizing leflunomide
US7022725B2 (en) *	2000-11-17	2006-04-04	Takeda Pharmaceutical Company Limited	Isoxazole derivatives
GB0123571D0 (en)	2001-04-05	2001-11-21	Aventis Pharm Prod Inc	Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
US7429593B2 (en)	2001-09-14	2008-09-30	Shionogi & Co., Ltd.	Utilities of amide compounds
JPWO2003068239A1 (ja) *	2002-02-12	2005-06-02	住友製薬株式会社	新規外用剤
US20050158371A1 (en) *	2002-02-12	2005-07-21	Sumitomo Pharmaceuticals Co., Ltd.	Novel external agent
WO2004080461A2 (en) *	2003-03-12	2004-09-23	TEVA Gyógyszergyár Részvénytársaság	Stable pharmaceutical compositions of desloratadine
US20060135547A1 (en) *	2003-03-12	2006-06-22	Toth Zoltan G	Stable pharmaceutical compositions of desloratadine and processes for preparation of polymorphic forms of desloratadine
JP4223428B2 (ja) *	2004-03-31	2009-02-12	富士通メディアデバイス株式会社	フィルタおよびその製造方法
WO2007067710A1 (en) *	2005-12-08	2007-06-14	Amphora Discovery Corporation	Certain chemical entities, compositions, and methods for modulating trpv1
CN101143834B (zh) *	2006-09-15	2010-09-08	欣凯医药化工中间体（上海）有限公司	N-(4-三氟甲基苯)-2-氰基-3-羟基丁烯酰胺钠盐的多晶型及其制备方法
LT2262790T (lt) *	2008-03-10	2017-08-25	Takeda Pharmaceutical Company Limited	Benzimidazolo junginio kristalas
CA2772275A1 (en)	2009-09-18	2011-03-24	Sanofi	(z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability
CN103977594B (zh) *	2014-06-03	2016-02-17	江苏九九久科技股份有限公司	一种结晶方法
US9895370B2 (en) *	2015-11-19	2018-02-20	Pharmedix.Co., Ltd	Pharmaceutical composition for preventing or treating of cirrhosis of liver comprising G protein coupled receptor 119 ligand as an active ingredient
CN109180599A (zh) *	2018-09-03	2019-01-11	深圳市新阳唯康科技有限公司	一种来氟米特新晶型化合物及其制备方法
CN112898215B (zh) *	2021-02-04	2022-11-08	美罗药业股份有限公司	一种来氟米特晶型i的制备方法
CN114716388B (zh) *	2021-11-04	2024-02-13	江苏冠军科技集团股份有限公司	一种磺胺-银化合物及其制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2524959C2 (de) *	1975-06-05	1983-02-10	Hoechst Ag, 6000 Frankfurt	5-Methyl-isoxazol-4-carbonsäureanilide, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Mittel
NL178596C (nl) *	1975-06-05	1986-04-16	Hoechst Ag	Werkwijze voor het bereiden van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor het bereiden van daarin als geneeskrachtige verbindingen te gebruiken 5-methylisoxazool-4-carbonzuuraniliden.
NL186239B (nl) *	1975-06-05		Hoechst Ag	Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DE2525959A1 (de) *	1975-06-11	1977-02-10	Focke Pfuhl Verpack Automat	Verpackung fuer zigaretten, zigarillos etc.
DE2854439A1 (de) *	1978-12-16	1980-07-03	Hoechst Ag	Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung
IL63968A (en) *	1980-10-01	1985-10-31	Glaxo Group Ltd	Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
US4935434A (en) *	1988-01-26	1990-06-19	Bristol-Myers Company	Antiarthritic isoxazole-4-carboxamides
US5583150A (en) *	1989-08-18	1996-12-10	Alcon Laboratories, Inc.	5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases
AU649421B2 (en) *	1990-05-18	1994-05-26	Sanofi-Aventis Deutschland Gmbh	Isoxazole-4-carboxamides and hydroxyalkylidene-cyanoacetamides, drugs containing these compounds and use of such drugs
GB9115377D0 (en) *	1991-07-17	1991-09-04	Rhone Poulenc Agriculture	New compositions of matter
DE4127737A1 (de) *	1991-08-22	1993-02-25	Hoechst Ag	Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
GB9209330D0 (en) *	1992-04-30	1992-06-17	Roussel Lab Ltd	Chemical compounds
ES2124800T3 (es) *	1993-01-08	1999-02-16	Hoechst Ag	Empleo de leflunomida para la inhibicion de interleuquina 1 beta.
ATE174219T1 (de) *	1993-01-08	1998-12-15	Hoechst Ag	Verwendung von leflunomid zur hemmung von tumornekrosefaktor alpha
EP0607777B1 (de) *	1993-01-08	1998-12-09	Hoechst Aktiengesellschaft	Verwendung von Leflunomid zur Hemmung von Interleukin 8
TW314467B (id) *	1993-03-31	1997-09-01	Hoechst Ag
GB9320299D0 (en) *	1993-10-01	1993-11-17	Roussel Lab Ltd	Isoxazole derivatives
US5610173A (en) *	1994-01-07	1997-03-11	Sugen, Inc.	Formulations for lipophilic compounds
PT787491E (pt) *	1994-10-17	2000-11-30	Aventis Pharma Ltd	Composicao para a profilaxia e para o tratamento de doencas alergicas de tipo i
SK283608B6 (sk) *	1995-02-06	2003-10-07	Smithkline Beecham Plc	Bezvodý hydrochlorid paroxetínu, spôsob jeho výroby a použitie
DE19539638A1 (de) *	1995-10-25	1997-04-30	Hoechst Ag	Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
US6316479B1 (en) *	1997-05-19	2001-11-13	Sugen, Inc.	Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
HRP980291A2 (en) *	1997-06-16	1999-04-30	Lin-Hua Zhang	Crystalline roxifiban
ATE207065T1 (de) *	1997-08-08	2001-11-15	Aventis Pharma Gmbh	Kristallform von n-(4-trifluormethylphenyl)-5- methylisoxazol-4-carbonsäureamid
US6096770A (en) *	1998-08-03	2000-08-01	American Home Products Corporation	Anthranilic acid analogs
DE19908527C2 (de) *	1999-02-26	2001-08-30	Aventis Pharma Gmbh	Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid
HUP0204069A3 (en) *	1999-12-16	2005-01-28	Teva Pharma	Novel processes for making- and a new crystalline form of- leflunomide and pharmaceutical composition containing it
EP1257270B1 (en) *	2000-02-15	2005-04-13	Teva Pharmaceutical Industries Ltd.	A method for synthesizing leflunomide
US6727272B1 (en) *	2002-07-15	2004-04-27	Unitech Pharmaceuticals, Inc.	Leflunomide analogs for treating rheumatoid arthritis

1998
- 1998-07-31 AT AT99117098T patent/ATE207065T1/de active
- 1998-07-31 ES ES99117098T patent/ES2166205T3/es not_active Expired - Lifetime
- 1998-07-31 DE DE59800287T patent/DE59800287D1/de not_active Expired - Lifetime
- 1998-07-31 DK DK98114373T patent/DK0903345T3/da active
- 1998-07-31 AT AT98114373T patent/ATE196764T1/de active
- 1998-07-31 PT PT99117098T patent/PT987256E/pt unknown
- 1998-07-31 ES ES98114373T patent/ES2150808T3/es not_active Expired - Lifetime
- 1998-07-31 EP EP98114373A patent/EP0903345B1/de not_active Expired - Lifetime
- 1998-07-31 DK DK99117098T patent/DK0987256T3/da active
- 1998-07-31 EP EP99117098A patent/EP0987256B1/de not_active Expired - Lifetime
- 1998-07-31 PT PT98114373T patent/PT903345E/pt unknown
- 1998-07-31 DE DE59801792T patent/DE59801792D1/de not_active Expired - Lifetime
- 1998-08-05 CZ CZ20032983A patent/CZ301426B6/cs not_active IP Right Cessation
- 1998-08-05 CZ CZ20032982A patent/CZ301514B6/cs not_active IP Right Cessation
- 1998-08-05 CZ CZ19982468A patent/CZ292943B6/cs not_active IP Right Cessation
- 1998-08-05 IL IL12567198A patent/IL125671A/en not_active IP Right Cessation
- 1998-08-06 SK SK1058-98A patent/SK282641B6/sk not_active IP Right Cessation
- 1998-08-06 US US09/129,783 patent/US6060494A/en not_active Expired - Lifetime
- 1998-08-06 UA UA98084307A patent/UA54411C2/uk unknown
- 1998-08-06 AR ARP980103900A patent/AR015418A1/es active IP Right Grant
- 1998-08-06 SK SK1521-2001A patent/SK285216B6/sk not_active IP Right Cessation
- 1998-08-06 ID IDP981098A patent/ID20667A/id unknown
- 1998-08-06 NZ NZ331270A patent/NZ331270A/xx not_active IP Right Cessation
- 1998-08-06 TW TW087112927A patent/TW593288B/zh not_active IP Right Cessation
- 1998-08-06 TR TR2006/00582A patent/TR200600582A1/xx unknown
- 1998-08-06 TR TR1998/01513A patent/TR199801513A2/xx unknown
- 1998-08-07 HU HU9801844A patent/HU225870B1/hu unknown
- 1998-08-07 BR BR9806568-8A patent/BR9806568A/pt not_active Application Discontinuation
- 1998-08-07 NO NO19983632A patent/NO310871B1/no not_active IP Right Cessation
- 1998-08-07 CN CNB021045747A patent/CN1181064C/zh not_active Expired - Lifetime
- 1998-08-07 KR KR1019980032110A patent/KR100544041B1/ko not_active Expired - Lifetime
- 1998-08-07 JP JP10224015A patent/JPH11124372A/ja active Pending
- 1998-08-07 CA CA002245267A patent/CA2245267C/en not_active Expired - Lifetime
- 1998-08-07 RU RU98115390/04A patent/RU2224753C2/ru active
- 1998-08-07 AU AU78870/98A patent/AU752764B2/en not_active Expired
- 1998-08-07 HU HU0700190A patent/HU229232B1/hu unknown
- 1998-08-07 PL PL327901A patent/PL192126B1/pl unknown
- 1998-08-07 CN CN98116235A patent/CN1089759C/zh not_active Expired - Lifetime
1999
- 1999-10-28 US US09/428,499 patent/US6221891B1/en not_active Expired - Lifetime
2000
- 2000-11-10 GR GR20000402501T patent/GR3034814T3/el unknown
2001
- 2001-01-19 US US09/764,258 patent/US6552202B2/en not_active Expired - Lifetime
2002
- 2002-11-25 US US10/302,872 patent/US6900334B2/en not_active Expired - Lifetime
2003
- 2003-02-19 HK HK03101247.6A patent/HK1049481B/zh not_active IP Right Cessation
2004
- 2004-04-23 US US10/830,307 patent/US6995272B2/en not_active Expired - Lifetime
2005
- 2005-06-28 KR KR1020050056044A patent/KR100588254B1/ko not_active Expired - Lifetime
2009
- 2009-07-28 JP JP2009175137A patent/JP2009280604A/ja active Pending

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DK0903345T3 (da)	2000-10-23
RU2224753C2 (ru)	2004-02-27
CN1373126A (zh)	2002-10-09
US6552202B2 (en)	2003-04-22
TR200600582A1 (tr)	2006-08-21
CZ292943B6 (cs)	2004-01-14
KR100544041B1 (ko)	2006-09-18
PL192126B1 (pl)	2006-09-29
CN1089759C (zh)	2002-08-28
ATE207065T1 (de)	2001-11-15
NZ331270A (en)	2000-04-28
US20040204465A1 (en)	2004-10-14
DE59801792D1 (de)	2001-11-22
HU0700190D0 (en)	2007-05-02
TR199801513A3 (tr)	1999-02-22
DE59800287D1 (de)	2000-11-09
ES2150808T3 (es)	2000-12-01
HUP9801844A3 (en)	2000-04-28
AU7887098A (en)	1999-02-18
CA2245267A1 (en)	1999-02-08
HU229232B1 (en)	2013-09-30
US6900334B2 (en)	2005-05-31
HU225870B1 (en)	2007-11-28
HU9801844D0 (en)	1998-10-28
NO310871B1 (no)	2001-09-10
CZ301514B6 (cs)	2010-03-31
US20030027851A1 (en)	2003-02-06
ATE196764T1 (de)	2000-10-15
SK285216B6 (sk)	2006-09-07
CA2245267C (en)	2008-12-23
TR199801513A2 (xx)	1999-02-22
PT987256E (pt)	2002-03-28
KR100588254B1 (ko)	2006-06-12
NO983632D0 (no)	1998-08-07
US20030166945A1 (en)	2003-09-04
HUP9801844A2 (hu)	2000-02-28
KR19990023433A (ko)	1999-03-25
KR20050077498A (ko)	2005-08-02
UA54411C2 (uk)	2003-03-17
PT903345E (pt)	2001-01-31
PL327901A1 (en)	1999-02-15
EP0987256A1 (de)	2000-03-22
IL125671A0 (en)	1999-04-11
CN1181064C (zh)	2004-12-22
CZ301426B6 (cs)	2010-02-24
BR9806568A (pt)	2000-05-16
EP0987256B1 (de)	2001-10-17
DK0987256T3 (da)	2002-02-11
CZ246898A3 (cs)	1999-02-17
ES2166205T3 (es)	2002-04-01
US6995272B2 (en)	2006-02-07
HK1017681A1 (en)	1999-11-26
SK105898A3 (en)	1999-02-11
CN1208034A (zh)	1999-02-17
US6060494A (en)	2000-05-09
US6221891B1 (en)	2001-04-24
SK282641B6 (sk)	2002-10-08
JP2009280604A (ja)	2009-12-03
EP0903345A1 (de)	1999-03-24
AR015418A1 (es)	2001-05-02
AU752764B2 (en)	2002-09-26
EP0903345B1 (de)	2000-10-04
HK1049481A1 (en)	2003-05-16
JPH11124372A (ja)	1999-05-11
IL125671A (en)	2002-11-10
HK1049481B (zh)	2005-07-08
NO983632L (no)	1999-02-09
TW593288B (en)	2004-06-21
GR3034814T3 (en)	2001-02-28

Publication	Publication Date	Title
NO983632D0 (no)	1998-08-07	Krystallform av N-(4-trifluormetylfenyl)-5-metyl-isoksazol-4-karboksamid
PT977741E (pt)	2004-01-30	Derivados de fenilo substituido, sua preparacao e utilizacao
EA199900200A1 (ru)	1999-06-24	Кристаллическая форма 4-[5-метил-3-фенилизоксазол-4-ил]бензолсульфонамида
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NO902301L (no)	1990-11-26	Fremgangsmaate for fremstilling av diarylstyrylkinolin-disyrer.
DK0982988T3 (da)	2004-01-19	I det væsentlige rent zonulin, en fysiologisk modulator af mammale tight junctions
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AU7927591A (en)	1992-01-02	Substituted aminoalkylbiphenyl derivatives
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AU7610781A (en)	1982-04-22	4h-3,1-benzoxazine
DK532679A (da)	1980-06-17	Fremgangsmaade til fremstilling af 2-aryl-3,4-diaza-bicyclo (4,1,0)hepten-(2)-on-(5).
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