ID21881A - NEW PIRAZOL SUBSTITUTED PURAZOLS - Google Patents

NEW PIRAZOL SUBSTITUTED PURAZOLS

Info

Publication number
ID21881A
ID21881A IDW990388A ID990388A ID21881A ID 21881 A ID21881 A ID 21881A ID W990388 A IDW990388 A ID W990388A ID 990388 A ID990388 A ID 990388A ID 21881 A ID21881 A ID 21881A
Authority
ID
Indonesia
Prior art keywords
purazols
pirazol
substituted
new
substituted purazols
Prior art date
Application number
IDW990388A
Other languages
Indonesian (id)
Inventor
Alexander Straub
Chantal Furstner
Thomas Jaetsch
Achim Feurer
Raimund Kast
Johannes Peter Stasch
Elisabeth Perzborn
Joachim Hutter
Klaus Dembowsky
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ID21881A publication Critical patent/ID21881A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IDW990388A 1996-11-26 1997-11-14 NEW PIRAZOL SUBSTITUTED PURAZOLS ID21881A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19649460A DE19649460A1 (en) 1996-11-26 1996-11-26 New substituted pyrazole derivatives

Publications (1)

Publication Number Publication Date
ID21881A true ID21881A (en) 1999-08-05

Family

ID=7813100

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW990388A ID21881A (en) 1996-11-26 1997-11-14 NEW PIRAZOL SUBSTITUTED PURAZOLS

Country Status (25)

Country Link
EP (1) EP0944631B1 (en)
JP (2) JP4422800B2 (en)
CN (1) CN1122032C (en)
AR (1) AR010310A1 (en)
AT (1) ATE259812T1 (en)
AU (1) AU729642B2 (en)
BR (1) BR9714363A (en)
CA (1) CA2272584C (en)
CZ (1) CZ185099A3 (en)
DE (2) DE19649460A1 (en)
DK (1) DK0944631T3 (en)
EE (1) EE9900211A (en)
ES (1) ES2214646T3 (en)
HU (1) HUP0000562A3 (en)
ID (1) ID21881A (en)
IL (1) IL129998A0 (en)
MX (1) MXPA99004826A (en)
NO (1) NO992400L (en)
NZ (1) NZ335890A (en)
PT (1) PT944631E (en)
SK (1) SK67699A3 (en)
TR (1) TR199901172T2 (en)
TW (1) TW403746B (en)
WO (1) WO1998023619A1 (en)
ZA (1) ZA9710573B (en)

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DE19827679A1 (en) * 1998-06-22 1999-12-23 Dresden Arzneimittel New pyrazolo(3,4-d)pyrimidine derivative adenosine A3 receptor antagonists, used for treating epilepsy, asthma or allergy
DE19834044A1 (en) * 1998-07-29 2000-02-03 Bayer Ag New substituted pyrazole derivatives
DE19834045A1 (en) * 1998-07-29 2000-02-03 Bayer Ag (4-Amino-5-ethylpyrimidin-2-yl) -1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridine
DE19834047A1 (en) * 1998-07-29 2000-02-03 Bayer Ag Substituted pyrazole derivatives
GB9824310D0 (en) * 1998-11-05 1998-12-30 Univ London Activators of soluble guanylate cyclase
DE19920352A1 (en) * 1999-05-04 2000-11-09 Bayer Ag Substituted pyrazole derivative
DE19943635A1 (en) 1999-09-13 2001-03-15 Bayer Ag Novel aminodicarboxylic acid derivatives with pharmaceutical properties
DE19943636A1 (en) 1999-09-13 2001-03-15 Bayer Ag Novel dicarboxylic acid derivatives with pharmaceutical properties
DE19943634A1 (en) 1999-09-13 2001-04-12 Bayer Ag Novel dicarboxylic acid derivatives with pharmaceutical properties
DE10021069A1 (en) * 2000-04-28 2001-10-31 Bayer Ag Substituted pyrazole derivative
DE10057754A1 (en) 2000-11-22 2002-05-23 Bayer Ag New cyclic sulfonamido-substituted pyrazolo (3,4-b) pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation
CA2429308C (en) 2000-11-22 2010-09-21 Bayer Aktiengesellschaft Novel lactam-substituted pyrazolopyridine derivatives
DE10057751A1 (en) 2000-11-22 2002-05-23 Bayer Ag New carbamate-substituted pyrazolo (3,4-b) pyridine derivatives, are soluble guanylate cyclase stimulants useful e.g. for treating cardiovascular or central nervous system diseases, sexual dysfunction or inflammation
AR031176A1 (en) 2000-11-22 2003-09-10 Bayer Ag NEW DERIVATIVES OF PIRAZOLPIRIDINA SUBSTITUTED WITH PIRIDINE
DE10109861A1 (en) 2001-03-01 2002-09-05 Bayer Ag Novel side chain halogenated aminodicarboxylic acid derivatives
DE10109858A1 (en) 2001-03-01 2002-09-05 Bayer Ag Novel halogen-substituted aminodicarboxylic acid derivatives
DE10110749A1 (en) * 2001-03-07 2002-09-12 Bayer Ag Substituted aminodicarboxylic acid derivatives
DE10122894A1 (en) 2001-05-11 2002-11-14 Bayer Ag New pyrazolo(3,4-b)pyridin-3-yl)-5-pyrimidinyl sulfonates, are soluble guanyl cyclase stimulants useful e.g. for treating cardiovascular, thromboembolic or central nervous system diseases
DE10132416A1 (en) * 2001-07-04 2003-01-16 Bayer Ag New morpholine-bridged pyrazolopyridine derivatives
DE10220570A1 (en) 2002-05-08 2003-11-20 Bayer Ag Carbamate-substituted pyrazolopyridines
DE10232572A1 (en) 2002-07-18 2004-02-05 Bayer Ag New 2,5-disubstituted pyrimidine derivatives
DE10244810A1 (en) 2002-09-26 2004-04-08 Bayer Ag New morpholine-bridged indazole derivatives
JP4499721B2 (en) * 2003-06-30 2010-07-07 ヒフ バイオ，インク． Compounds, compositions and methods
DE102005050497A1 (en) 2005-10-21 2007-04-26 Bayer Healthcare Ag Difluorophenol derivatives and their use
DE102005050375A1 (en) 2005-10-21 2007-04-26 Bayer Healthcare Ag Tetrazole derivatives and their use
DE102005050377A1 (en) 2005-10-21 2007-04-26 Bayer Healthcare Ag Heterocyclic compounds and their use
DE102005050498A1 (en) 2005-10-21 2007-06-06 Bayer Healthcare Aktiengesellschaft Cyclopropylacetic acid derivatives and their use
DE102005050376A1 (en) 2005-10-21 2007-05-31 Bayer Healthcare Ag Dicarboxylic acid derivatives and their use
DE102006020327A1 (en) * 2006-04-27 2007-12-27 Bayer Healthcare Ag Heterocyclic substituted, fused pyrazole derivatives and their use
DE102006043443A1 (en) 2006-09-15 2008-03-27 Bayer Healthcare Ag Novel aza-bicyclic compounds and their use
DE102007015035A1 (en) 2007-03-29 2008-10-02 Bayer Healthcare Ag Substituted dibenzoic acid derivatives and their use
DE102007015034A1 (en) 2007-03-29 2008-10-02 Bayer Healthcare Ag Lactam-substituted dicarboxylic acids and their use
DE102007026392A1 (en) 2007-06-06 2008-12-11 Bayer Healthcare Ag Solutions for the perfusion and preservation of organs and tissues
DE102007028320A1 (en) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituted oxazolidinones and their use
DE102007028406A1 (en) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituted oxazolidinones and their use
DE102007028319A1 (en) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituted oxazolidinones and their use
DE102007028407A1 (en) 2007-06-20 2008-12-24 Bayer Healthcare Ag Substituted oxazolidinones and their use
US8759345B2 (en) 2008-04-28 2014-06-24 Janssen Pharmaceutica Nv Benzoimidazoles as prolyl hydroxylase inhibitors
EP2138178A1 (en) 2008-06-28 2009-12-30 Bayer Schering Pharma Aktiengesellschaft Oxazolidninones for the treatment fo chronic obstructive pulmonary disease (COPD) and/or asthma
DE102008063992A1 (en) 2008-12-19 2010-09-02 Lerner, Zinoviy, Dipl.-Ing. New aliphatic substituted pyrazolopyridines and their use
DE102009004245A1 (en) 2009-01-09 2010-07-15 Bayer Schering Pharma Aktiengesellschaft Novel fused, heteroatom-bridged pyrazole and imidazole derivatives and their use
UY33041A (en) 2009-11-27 2011-06-30 Bayer Schering Pharma Aktienegesellschaft PROCEDURE FOR THE PREPARATION OF {4,6-DIAMINO-2- [1- (2-FLUOROBENCIL) -1H-PIRAZOLO [3,4-B] PIRIDIN-3-IL] PIRIMIDIN-5-IL} CARBAMATO DE METTILO AND ITS PURIFICATION FOR USE AS A PHARMACEUTICAL ACTIVE PRINCIPLE
GB201004311D0 (en) 2010-03-15 2010-04-28 Proximagen Ltd New enzyme inhibitor compounds
WO2012003405A1 (en) 2010-06-30 2012-01-05 Ironwood Pharmaceuticals, Inc. Sgc stimulators
NZ609955A (en) 2010-11-09 2015-05-29 Ironwood Pharmaceuticals Inc Sgc stimulators
JP6005134B2 (en) * 2011-04-21 2016-10-12 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ Fluoroalkyl-substituted pyrazolopyridines and uses thereof
US9150574B2 (en) 2011-09-14 2015-10-06 Proximagen Limited Enzyme inhibitor compounds
CN104066731B (en) 2011-12-27 2016-06-15 铁木医药有限公司 2-Benzyl, 3-(pyrimidin-2-yl)-substituted pyrazoles useful as SGC stimulators
BR112014027952B1 (en) 2012-05-10 2022-06-21 Bayer Pharma Aktiengesellschaft Human monoclonal antibodies capable of binding to clotting factor xi, its use, pharmaceutical composition and drug comprising them, nucleic acid encoding it, as well as vector
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US20180169095A1 (en) 2015-05-06 2018-06-21 Bayer Pharma Aktiengesellschaft The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of digital ulcers (du) concomitant to systemic sclerosis (ssc)
CN113750102A (en) 2015-07-23 2021-12-07 拜耳制药股份公司 Stimulators and/or activators of soluble guanylate cyclase and uses thereof
JP2019502686A (en) 2015-12-14 2019-01-31 アイアンウッド ファーマシューティカルズ インコーポレイテッド Use of sGC stimulators to treat gastrointestinal sphincter dysfunction
WO2017121700A1 (en) * 2016-01-15 2017-07-20 Bayer Pharma Aktiengesellschaft 1,3-disubstituted 1h-pyrazolo[3,4-b]pyridine derivatives and use thereof as stimulators of soluble guanylate cyclase
WO2018069148A1 (en) 2016-10-11 2018-04-19 Bayer Pharma Aktiengesellschaft Combination containing sgc activators and mineralocorticoid receptor antagonists
JP7101688B2 (en) 2016-10-11 2022-07-15 バイエル・ファルマ・アクティエンゲゼルシャフト Combinations containing sGC stimulants and mineral corticoid receptor antagonists
US20190381039A1 (en) 2016-12-13 2019-12-19 Cyclerion Therapeutics, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS
JP7090639B2 (en) 2017-04-11 2022-06-24 サンシャイン・レイク・ファーマ・カンパニー・リミテッド Fluoride-substituted indazole compounds and their use
JP2021523201A (en) 2018-05-15 2021-09-02 バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 1,3-thiazole-2-yl-substituted benzamide for treating diseases associated with nerve fiber sensitization
JP7542518B2 (en) 2018-07-11 2024-08-30 ティセント セラピューティクス インコーポレーテッド Use of sGC stimulators for the treatment of mitochondrial disorders
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Also Published As

Publication number Publication date
NO992400D0 (en) 1999-05-19
AU729642B2 (en) 2001-02-08
BR9714363A (en) 2000-03-21
ES2214646T3 (en) 2004-09-16
MXPA99004826A (en) 2008-02-19
HUP0000562A2 (en) 2000-10-28
NO992400L (en) 1999-05-19
DE19649460A1 (en) 1998-05-28
ZA9710573B (en) 1998-06-10
SK67699A3 (en) 2000-02-14
CZ185099A3 (en) 1999-08-11
ATE259812T1 (en) 2004-03-15
PT944631E (en) 2004-06-30
NZ335890A (en) 2001-02-23
TR199901172T2 (en) 1999-08-23
IL129998A0 (en) 2000-02-29
JP2001505567A (en) 2001-04-24
AU5482398A (en) 1998-06-22
JP4422800B2 (en) 2010-02-24
HUP0000562A3 (en) 2001-12-28
EP0944631B1 (en) 2004-02-18
DK0944631T3 (en) 2004-06-07
DE59711321D1 (en) 2004-03-25
CA2272584C (en) 2007-10-16
CN1238773A (en) 1999-12-15
CN1122032C (en) 2003-09-24
JP2010013475A (en) 2010-01-21
WO1998023619A1 (en) 1998-06-04
TW403746B (en) 2000-09-01
HK1023119A1 (en) 2000-09-01
EE9900211A (en) 1999-12-15
EP0944631A1 (en) 1999-09-29
CA2272584A1 (en) 1998-06-04
AR010310A1 (en) 2000-06-07

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