ID24175A - Turunan-turunan imidazol yang mempunyai aktivitas penghambatan untuk farnesil transferase dan proses pembuatannya - Google Patents
Turunan-turunan imidazol yang mempunyai aktivitas penghambatan untuk farnesil transferase dan proses pembuatannyaInfo
- Publication number
- ID24175A ID24175A IDW20000933A ID20000933A ID24175A ID 24175 A ID24175 A ID 24175A ID W20000933 A IDW20000933 A ID W20000933A ID 20000933 A ID20000933 A ID 20000933A ID 24175 A ID24175 A ID 24175A
- Authority
- ID
- Indonesia
- Prior art keywords
- drivings
- imidazol
- making
- living activity
- farnesil
- Prior art date
Links
- RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical compound C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
- 102000004357 Transferases Human genes 0.000 title 1
- 108090000992 Transferases Proteins 0.000 title 1
- 229950008696 farnesil Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR19970063858 | 1997-11-28 | ||
| KR1019980011359A KR19990066679A (ko) | 1997-11-28 | 1998-03-31 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| KR1019980023698A KR20000002788A (ko) | 1998-06-23 | 1998-06-23 | 피라졸 구조를 갖는 파네실 전이효소 억제제 및그의 제조방법 |
| KR1019980024423A KR19990062439A (ko) | 1997-11-28 | 1998-06-26 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| KR19980031512 | 1998-08-03 | ||
| KR1019980046457A KR20000015758A (ko) | 1998-08-03 | 1998-10-30 | 피롤 구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID24175A true ID24175A (id) | 2000-07-13 |
Family
ID=27555104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDW20000933A ID24175A (id) | 1997-11-28 | 1998-11-25 | Turunan-turunan imidazol yang mempunyai aktivitas penghambatan untuk farnesil transferase dan proses pembuatannya |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6268363B1 (id) |
| EP (1) | EP1045846B1 (id) |
| JP (2) | JP3548118B2 (id) |
| CN (1) | CN1188407C (id) |
| AR (1) | AR017700A1 (id) |
| AT (1) | ATE239014T1 (id) |
| AU (1) | AU731272B2 (id) |
| BR (1) | BR9815423A (id) |
| CA (1) | CA2310629A1 (id) |
| DE (1) | DE69814167T2 (id) |
| ES (1) | ES2193590T3 (id) |
| HU (1) | HUP0004238A3 (id) |
| ID (1) | ID24175A (id) |
| IL (1) | IL135473A0 (id) |
| NZ (1) | NZ504013A (id) |
| PL (1) | PL340729A1 (id) |
| RU (1) | RU2179975C1 (id) |
| WO (1) | WO1999028315A1 (id) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2185307T3 (es) * | 1998-02-02 | 2003-04-16 | Lg Chemical Ltd | Inhibidores de la farnesil transferasa que tienen una estructura piperidinica y procedimiento para su preparacion. |
| JP2002543074A (ja) * | 1999-04-13 | 2002-12-17 | エルジー シーアイ リミテッド | ピロール構造を有するファネシル転移酵素阻害剤及びその製造方法 |
| KR100395300B1 (ko) * | 1999-08-11 | 2003-08-27 | 주식회사 엘지생명과학 | 피롤구조를 갖는 파네실 전이효소 억제제 및 그의 제조방법 |
| FR2796943A1 (fr) * | 1999-07-30 | 2001-02-02 | Aventis Pharma Sa | Derives de benzoxazinnes, leur procede de preparation et leur utilisation en therapeutique |
| KR20010063274A (ko) * | 1999-12-22 | 2001-07-09 | 성재갑 | 〔1-｛〔1-（1,3-벤조디옥솔-5-일메틸-1ｈ-이미다졸-5-일〕메틸｝-4-(1-나프틸)-1ｈ-피롤-3-일〕（4-메틸-1-피페라지닐）메타논의 약학적 조성물 |
| KR100412334B1 (ko) * | 2000-02-22 | 2003-12-31 | 주식회사 엘지생명과학 | 4-치환된-1ｈ-피롤-3-카복실산 에스테르의 새로운 제조방법 |
| WO2001074807A1 (en) * | 2000-03-30 | 2001-10-11 | Sagami Chemical Research Center | Indolylpyrrole derivatives and cell death inhibitors |
| EP1506189A1 (en) * | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
| US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| RU2311415C2 (ru) * | 2002-08-23 | 2007-11-27 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисерч | Синтез эпотилонов, их промежуточных продуктов, аналогов и их применения |
| JP4596916B2 (ja) * | 2002-09-05 | 2010-12-15 | メディミューン，エルエルシー | Ｃｄ２拮抗薬を投与することによりｔ細胞悪性腫瘍を予防または治療する方法 |
| US8034831B2 (en) | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| AU2003292218A1 (en) * | 2002-12-23 | 2004-07-14 | Sanofi-Aventis Deutschland Gmbh | PYRAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS |
| KR101224235B1 (ko) | 2003-04-11 | 2013-01-25 | 메디뮨 엘엘씨 | 재조합 ｉｌ９ 항체 및 그의 용도 |
| CN1819996B (zh) * | 2003-07-10 | 2010-10-27 | Osi制药公司 | 作为细胞色素p450抑制剂的亚萘基衍生物 |
| EP1660186B1 (en) | 2003-08-18 | 2013-12-25 | MedImmune, LLC | Humanization of antibodies |
| US7214825B2 (en) | 2003-10-17 | 2007-05-08 | Honeywell International Inc. | O-(3-chloropropenyl) hydroxylamine free base |
| US7183305B2 (en) | 2003-11-11 | 2007-02-27 | Allergan, Inc. | Process for the synthesis of imidazoles |
| US7880017B2 (en) | 2003-11-11 | 2011-02-01 | Allergan, Inc. | Process for the synthesis of imidazoles |
| CA2568742A1 (en) * | 2004-05-29 | 2005-12-08 | 7Tm Pharma A/S | Substituted thiazoleacetic as crth2 ligands |
| WO2006047639A2 (en) | 2004-10-27 | 2006-05-04 | Medimmune, Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
| EP1869192B1 (en) | 2005-03-18 | 2016-01-20 | MedImmune, LLC | Framework-shuffling of antibodies |
| KR20080025174A (ko) | 2005-06-23 | 2008-03-19 | 메디뮨 인코포레이티드 | 응집 및 단편화 프로파일이 최적화된 항체 제제 |
| EP2051977A2 (en) * | 2006-07-20 | 2009-04-29 | Amgen Inc. | SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1 |
| EP2484696B1 (en) | 2006-08-28 | 2017-08-16 | Kyowa Hakko Kirin Co., Ltd. | Antagonistic hLIGHT-specific human monoclonal antibodies |
| KR101540823B1 (ko) | 2007-03-30 | 2015-07-30 | 메디뮨 엘엘씨 | 항체 제제 |
| PE20090717A1 (es) | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| EP2215246B1 (en) | 2007-10-31 | 2015-01-07 | MedImmune, LLC | Protein scaffolds |
| EP2095819A1 (en) * | 2008-02-28 | 2009-09-02 | Maastricht University | N-benzyl imidazole derivatives and their use as aldosterone synthase inhibitors |
| US20120189633A1 (en) | 2011-01-26 | 2012-07-26 | Kolltan Pharmaceuticals, Inc. | Anti-kit antibodies and uses thereof |
| EP4063391A1 (en) | 2012-07-25 | 2022-09-28 | Celldex Therapeutics, Inc. | Anti-kit antibodies and uses thereof |
| SG11201502757QA (en) | 2012-10-09 | 2015-05-28 | Igenica Biotherapeutics Inc | Anti-c16orf54 antibodies and methods of use thereof |
| EP3003390B1 (en) | 2013-06-06 | 2021-07-07 | Pierre Fabre Médicament | Anti-c10orf54 antibodies and uses thereof |
| CN105764526B (zh) | 2013-08-26 | 2020-12-15 | 生物技术研发公司 | 编码抗唾液酸化路易斯a抗原的人抗体的核酸 |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| US9856324B2 (en) | 2014-06-04 | 2018-01-02 | MabVax Therapeutics, Inc. | Human monoclonal antibodies to ganglioside GD2 |
| KR102693806B1 (ko) | 2014-12-11 | 2024-08-09 | 피에르 파브르 메디카먼트 | 항-c10orf54 항체들 및 그들의 용도들 |
| PL3265123T3 (pl) | 2015-03-03 | 2023-03-13 | Kymab Limited | Przeciwciała, zastosowania i sposoby |
| KR102803158B1 (ko) | 2015-12-02 | 2025-05-08 | 주식회사 에스티큐브앤컴퍼니 | Btn1a1에 면역특이적으로 결합하는 항체와 분자 및 그의 치료 용도 |
| JP7227007B2 (ja) | 2015-12-02 | 2023-02-21 | ストサイエンシス， インコーポレイテッド | グリコシル化ｂｔｌａ（ｂ－及びｔ－リンパ球減弱因子）に特異的な抗体 |
| BR112019006448A2 (pt) | 2016-09-29 | 2019-06-25 | Bayer Cropscience Ag | novos derivados de 5-imidazol substituídos |
| WO2018083248A1 (en) | 2016-11-03 | 2018-05-11 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses & methods |
| CN111148762A (zh) | 2017-05-31 | 2020-05-12 | 斯特库伯株式会社 | 免疫特异性结合至btn1a1的抗体和分子及其治疗性用途 |
| CN111051346A (zh) | 2017-05-31 | 2020-04-21 | 斯特库伯株式会社 | 使用免疫特异性结合btn1a1的抗体和分子治疗癌症的方法 |
| JP2020522562A (ja) | 2017-06-06 | 2020-07-30 | ストキューブ アンド シーオー．， インコーポレイテッド | Ｂｔｎ１ａ１又はｂｔｎ１ａ１リガンドに結合する抗体及び分子を用いて癌を治療する方法 |
| US11707522B2 (en) | 2017-10-13 | 2023-07-25 | Boehringer Ingelheim International Gmbh | Human antibodies to Tn antigen |
| KR20250024129A (ko) | 2018-07-20 | 2025-02-18 | 피에르 파브르 메디카먼트 | Vista의 수용체 |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
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| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
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| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2026106912A1 (en) | 2024-11-12 | 2026-05-21 | Revolution Medicines, Inc. | Ras inhibitors |
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Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0300688A1 (en) | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
| US5681795A (en) * | 1994-03-02 | 1997-10-28 | Zeneca Limited | 3-benzoyl pyrrole and pyrazole herbicides |
| US5756528A (en) * | 1995-06-06 | 1998-05-26 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| EP0935462B1 (en) | 1996-03-29 | 2005-07-27 | Therakos, Inc. | Photopheresis treatment of leukocytes |
| JP2000507590A (ja) | 1996-04-03 | 2000-06-20 | メルク エンド カンパニー インコーポレーテッド | ファルネシル―タンパク質トランスフェラーゼ阻害剤 |
| EP0904076A1 (en) * | 1996-04-03 | 1999-03-31 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| AU717298B2 (en) * | 1996-04-03 | 2000-03-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| EP0891355A1 (en) | 1996-04-03 | 1999-01-20 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
| CA2249615A1 (en) * | 1996-04-03 | 1997-10-09 | Robert Gomez | Inhibitors of farnesyl-protein transferase |
-
1998
- 1998-11-25 ID IDW20000933A patent/ID24175A/id unknown
- 1998-11-25 BR BR9815423-0A patent/BR9815423A/pt not_active Application Discontinuation
- 1998-11-25 AT AT98959231T patent/ATE239014T1/de not_active IP Right Cessation
- 1998-11-25 WO PCT/KR1998/000377 patent/WO1999028315A1/en not_active Ceased
- 1998-11-25 JP JP2000523207A patent/JP3548118B2/ja not_active Expired - Fee Related
- 1998-11-25 HU HU0004238A patent/HUP0004238A3/hu unknown
- 1998-11-25 PL PL98340729A patent/PL340729A1/xx unknown
- 1998-11-25 AU AU15083/99A patent/AU731272B2/en not_active Ceased
- 1998-11-25 RU RU2000116633/04A patent/RU2179975C1/ru not_active IP Right Cessation
- 1998-11-25 IL IL13547398A patent/IL135473A0/xx unknown
- 1998-11-25 NZ NZ504013A patent/NZ504013A/en unknown
- 1998-11-25 US US09/554,646 patent/US6268363B1/en not_active Expired - Fee Related
- 1998-11-25 CN CNB988114976A patent/CN1188407C/zh not_active Expired - Fee Related
- 1998-11-25 CA CA002310629A patent/CA2310629A1/en not_active Abandoned
- 1998-11-25 EP EP98959231A patent/EP1045846B1/en not_active Expired - Lifetime
- 1998-11-25 DE DE69814167T patent/DE69814167T2/de not_active Expired - Fee Related
- 1998-11-25 ES ES98959231T patent/ES2193590T3/es not_active Expired - Lifetime
- 1998-11-30 AR ARP980106048A patent/AR017700A1/es not_active Application Discontinuation
-
2001
- 2001-03-20 US US09/813,437 patent/US6518429B2/en not_active Expired - Fee Related
- 2001-10-03 JP JP2001307368A patent/JP2002161092A/ja active Pending
- 2001-12-03 US US10/005,262 patent/US6472526B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2179975C1 (ru) | 2002-02-27 |
| AU1508399A (en) | 1999-06-16 |
| CN1279680A (zh) | 2001-01-10 |
| IL135473A0 (en) | 2001-05-20 |
| BR9815423A (pt) | 2000-10-17 |
| US6518429B2 (en) | 2003-02-11 |
| AR017700A1 (es) | 2001-09-12 |
| HUP0004238A2 (hu) | 2001-05-28 |
| EP1045846B1 (en) | 2003-05-02 |
| JP2001524550A (ja) | 2001-12-04 |
| US6472526B1 (en) | 2002-10-29 |
| WO1999028315A1 (en) | 1999-06-10 |
| ES2193590T3 (es) | 2003-11-01 |
| DE69814167D1 (de) | 2003-06-05 |
| DE69814167T2 (de) | 2004-02-26 |
| NZ504013A (en) | 2002-02-01 |
| HUP0004238A3 (en) | 2001-07-30 |
| US20020137769A1 (en) | 2002-09-26 |
| EP1045846A1 (en) | 2000-10-25 |
| US6268363B1 (en) | 2001-07-31 |
| AU731272B2 (en) | 2001-03-29 |
| CA2310629A1 (en) | 1999-06-10 |
| JP2002161092A (ja) | 2002-06-04 |
| PL340729A1 (en) | 2001-02-26 |
| JP3548118B2 (ja) | 2004-07-28 |
| RU2000116633A (ru) | 2004-02-20 |
| CN1188407C (zh) | 2005-02-09 |
| ATE239014T1 (de) | 2003-05-15 |
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