ID853B - IMPROVEMENT OF THE FOSCARNET SYNTHESIS METHOD - Google Patents
IMPROVEMENT OF THE FOSCARNET SYNTHESIS METHODInfo
- Publication number
- ID853B ID853B IDP174892A ID921748A ID853B ID 853 B ID853 B ID 853B ID P174892 A IDP174892 A ID P174892A ID 921748 A ID921748 A ID 921748A ID 853 B ID853 B ID 853B
- Authority
- ID
- Indonesia
- Prior art keywords
- foscarnet
- improvement
- synthesis method
- heating
- reaction mixture
- Prior art date
Links
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 title abstract 4
- 229960005102 foscarnet Drugs 0.000 title abstract 2
- 238000001308 synthesis method Methods 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 6
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- NOJFJZZMRDSOLM-UHFFFAOYSA-N ethyl diethoxyphosphorylformate Chemical compound CCOC(=O)P(=O)(OCC)OCC NOJFJZZMRDSOLM-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- JTFHKOYORZAXSV-UHFFFAOYSA-K trisodium phosphonoformate hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[Na+].OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O.OP(O)(=O)C([O-])=O JTFHKOYORZAXSV-UHFFFAOYSA-K 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Health & Medical Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Catalysts (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Glass Compositions (AREA)
- Saccharide Compounds (AREA)
- Treating Waste Gases (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Steroid Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Abstract
The present invention relates to a method for the synthesis of foscarnet, i.e. trisodium phosphonoformate hexahydrate, comprising the steps of adding sodium hydroxide to water, heating the aqueous sodium hydroxide solution to 50 DEG C, adding triethyl phosphonoformate to said solution at 50 DEG C, heating the reaction mixture to reflux for about 1 hour, cooling of the reaction mixture and filtering-off of the product.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9005534A GB2241954A (en) | 1990-03-12 | 1990-03-12 | Preparation of trisodium phosphonoformate hexahydrate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ID853B true ID853B (en) | 1996-08-02 |
Family
ID=10672476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IDP174892A ID853B (en) | 1990-03-12 | 1992-01-27 | IMPROVEMENT OF THE FOSCARNET SYNTHESIS METHOD |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0479960B1 (en) |
| JP (1) | JP2568341B2 (en) |
| KR (1) | KR920701214A (en) |
| AT (1) | ATE129249T1 (en) |
| AU (1) | AU635413B2 (en) |
| BG (1) | BG61650B1 (en) |
| CA (1) | CA2053270C (en) |
| DE (2) | DE479960T1 (en) |
| DK (1) | DK0479960T3 (en) |
| ES (1) | ES2055681T3 (en) |
| FI (1) | FI101540B (en) |
| GB (1) | GB2241954A (en) |
| GR (2) | GR920300063T1 (en) |
| HK (1) | HK7297A (en) |
| HU (1) | HU212621B (en) |
| ID (1) | ID853B (en) |
| IE (1) | IE71021B1 (en) |
| IS (1) | IS1635B (en) |
| LT (1) | LT3585B (en) |
| LV (1) | LV10869B (en) |
| MY (1) | MY135300A (en) |
| NO (1) | NO179793C (en) |
| NZ (1) | NZ237386A (en) |
| PL (1) | PL166798B1 (en) |
| PT (1) | PT97009B (en) |
| RO (1) | RO111574B1 (en) |
| RU (1) | RU2043993C1 (en) |
| UA (1) | UA25900A1 (en) |
| WO (1) | WO1991013894A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3590579B2 (en) * | 2000-12-11 | 2004-11-17 | オーエスジー株式会社 | Diamond coated member and method of manufacturing the same |
| RU2228336C1 (en) * | 2002-12-23 | 2004-05-10 | Бондаренко Наталья Александровна | Method for preparing phosphonoformic acid trisodium salt hexahydrate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4018854A (en) * | 1973-07-23 | 1977-04-19 | E. I. Du Pont De Nemours And Company | Carboxyphosphonates |
| DD243500A1 (en) * | 1985-12-17 | 1987-03-04 | Univ Halle Wittenberg | PROCESS FOR PREPARING PHOSPHONO FORMATS |
| DE3607445A1 (en) * | 1986-03-07 | 1987-09-10 | Hoechst Ag | METHOD FOR PRODUCING ALKALI PHOSPHONO FORMATS |
| CS253848B1 (en) * | 1986-07-18 | 1987-12-17 | Viktor Zikan | Process for the production of triphosphoric acid tri-sodium salt hexahydrate |
-
1990
- 1990-03-12 GB GB9005534A patent/GB2241954A/en not_active Withdrawn
-
1991
- 1991-03-06 HU HU913521A patent/HU212621B/en unknown
- 1991-03-06 RO RO148727A patent/RO111574B1/en unknown
- 1991-03-06 ES ES91905856T patent/ES2055681T3/en not_active Expired - Lifetime
- 1991-03-06 KR KR1019910701581A patent/KR920701214A/en not_active Ceased
- 1991-03-06 AU AU74921/91A patent/AU635413B2/en not_active Expired
- 1991-03-06 DE DE199191905856T patent/DE479960T1/en active Pending
- 1991-03-06 EP EP91905856A patent/EP0479960B1/en not_active Expired - Lifetime
- 1991-03-06 JP JP3505894A patent/JP2568341B2/en not_active Expired - Lifetime
- 1991-03-06 CA CA002053270A patent/CA2053270C/en not_active Expired - Lifetime
- 1991-03-06 AT AT91905856T patent/ATE129249T1/en not_active IP Right Cessation
- 1991-03-06 UA UA5010100A patent/UA25900A1/en unknown
- 1991-03-06 PL PL91293014A patent/PL166798B1/en unknown
- 1991-03-06 DK DK91905856.0T patent/DK0479960T3/en active
- 1991-03-06 DE DE69113949T patent/DE69113949T2/en not_active Expired - Lifetime
- 1991-03-06 WO PCT/SE1991/000172 patent/WO1991013894A1/en not_active Ceased
- 1991-03-11 IE IE78891A patent/IE71021B1/en not_active IP Right Cessation
- 1991-03-11 IS IS3682A patent/IS1635B/en unknown
- 1991-03-11 NZ NZ237386A patent/NZ237386A/en unknown
- 1991-03-11 PT PT97009A patent/PT97009B/en not_active IP Right Cessation
- 1991-03-12 MY MYPI91000403A patent/MY135300A/en unknown
- 1991-11-01 NO NO914291A patent/NO179793C/en not_active IP Right Cessation
- 1991-11-11 FI FI915313A patent/FI101540B/en active
- 1991-11-11 RU SU915010100A patent/RU2043993C1/en active
- 1991-11-12 BG BG95452A patent/BG61650B1/en unknown
-
1992
- 1992-01-27 ID IDP174892A patent/ID853B/en unknown
- 1992-08-31 GR GR92300063T patent/GR920300063T1/en unknown
-
1993
- 1993-06-30 LV LVP-93-817A patent/LV10869B/en unknown
- 1993-12-30 LT LTIP1737A patent/LT3585B/en not_active IP Right Cessation
-
1995
- 1995-12-15 GR GR950403569T patent/GR3018439T3/en unknown
-
1997
- 1997-01-16 HK HK7297A patent/HK7297A/en not_active IP Right Cessation
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