IE32021L - Benzothioxanthene derivatives. - Google Patents
Benzothioxanthene derivatives.Info
- Publication number
- IE32021L IE32021L IE680434A IE43468A IE32021L IE 32021 L IE32021 L IE 32021L IE 680434 A IE680434 A IE 680434A IE 43468 A IE43468 A IE 43468A IE 32021 L IE32021 L IE 32021L
- Authority
- IE
- Ireland
- Prior art keywords
- general formula
- benzothioxanthene
- derivative
- formula above
- reaction
- Prior art date
Links
- YEBQUUKDSJCPIX-UHFFFAOYSA-N 12h-benzo[a]thioxanthene Chemical class C1=CC=CC2=C3CC4=CC=CC=C4SC3=CC=C21 YEBQUUKDSJCPIX-UHFFFAOYSA-N 0.000 title abstract 8
- 238000006243 chemical reaction Methods 0.000 abstract 3
- NOKUQWYGRUGAAP-UHFFFAOYSA-N 12H-benzo[a]thioxanthen-1-ol Chemical class OC1=CC=CC=2C=CC=3SC=4C=CC=CC=4CC=3C=21 NOKUQWYGRUGAAP-UHFFFAOYSA-N 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 abstract 2
- 229910000043 hydrogen iodide Inorganic materials 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 abstract 2
- 239000011574 phosphorus Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000012024 dehydrating agents Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,191,384. Benzothioxanthene derivatives. MERCK & CO. Inc. 24 April, 1968 [27 April, 1967], No. 19394/68. Heading C2C. Novel benzothioxanthene derivatives of the general formulµ wherein B is a benzene ring fused in the [a] or [c] position, X is a chlorine or bromine atom attached to the left-hand ring and each R is a hydrogen atom or a C 1-6 alkyl group, and non- toxic acid addition salts thereof are prepared (a) by reaction of a hydroxybenzothioxanthene derivative of the general formula with phosphorus and hydrogen iodide; (b) by reaction of a benzothioxanthene derivative of the second general formula above with phosphorus and hydrogen iodide; (c) by catalytic hydrogenation of a benzothioxanthene derivative of the second general formula above, in each case producing a benzothioxanthene derivative of the first general formula above; or (d) by reaction of a hydroxy-benzothioxanthene derivative of the third general formula above with an acidic dehydrating agent to produce a benzothioxanthene derivative of the second general formula above; followed optionally by salification of the product. Pharmaceutical compositions having local anaesthetic activity comprise a non-toxic acid addition salt of a benzothioxanthene derivative of the first or second general formula above in sterile aqueous solution and may be administered by injection.
[GB1191384A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63412367A | 1967-04-27 | 1967-04-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32021L true IE32021L (en) | 1968-10-27 |
| IE32021B1 IE32021B1 (en) | 1973-03-21 |
Family
ID=24542527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE434/68A IE32021B1 (en) | 1967-04-27 | 1968-04-17 | Benzothioxanthene derivatives,their preparation and compositions containing them |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE714011A (en) |
| DE (1) | DE1768300A1 (en) |
| FR (2) | FR1589420A (en) |
| GB (2) | GB1191384A (en) |
| IE (1) | IE32021B1 (en) |
| IL (1) | IL29823A (en) |
| NL (1) | NL6805112A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4073912A (en) * | 1976-10-12 | 1978-02-14 | Smithkline Corporation | Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof |
| US4234643A (en) * | 1978-05-30 | 1980-11-18 | The Meyercord Co. | Tennis ball marking decalcomania |
-
1968
- 1968-04-10 NL NL6805112A patent/NL6805112A/xx unknown
- 1968-04-15 IL IL29823A patent/IL29823A/en unknown
- 1968-04-17 IE IE434/68A patent/IE32021B1/en unknown
- 1968-04-22 BE BE714011D patent/BE714011A/xx unknown
- 1968-04-24 GB GB09394/68A patent/GB1191384A/en not_active Expired
- 1968-04-24 GB GB51489/69A patent/GB1191385A/en not_active Expired
- 1968-04-26 FR FR1589420D patent/FR1589420A/fr not_active Expired
- 1968-04-26 DE DE19681768300 patent/DE1768300A1/en active Pending
- 1968-07-25 FR FR160546A patent/FR7942M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| IE32021B1 (en) | 1973-03-21 |
| IL29823A0 (en) | 1968-06-20 |
| IL29823A (en) | 1972-07-26 |
| FR7942M (en) | 1970-05-25 |
| GB1191385A (en) | 1970-05-13 |
| FR1589420A (en) | 1970-03-31 |
| BE714011A (en) | 1968-10-22 |
| GB1191384A (en) | 1970-05-13 |
| NL6805112A (en) | 1968-10-28 |
| DE1768300A1 (en) | 1971-11-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1294763A (en) | 3-oxo-2,3-dihydro-1,4-benzoxazine derivatives | |
| IE45624L (en) | (pyrazol-1-yl)-phenylacetic acids. | |
| IE34314B1 (en) | Dibenzodioxocine derivatives | |
| IE32021L (en) | Benzothioxanthene derivatives. | |
| GB1530074A (en) | Rho-acetamidophenol derivatives the preparation thereof and the use of such derivatives as therapeutic agents | |
| GB1374294A (en) | 2-amino-methylphenols | |
| GB1412932A (en) | Pharmaceutically active leurosine derivatives and preparation thereof | |
| GB1529251A (en) | 9,10-dihydroergopeptines | |
| GB1126860A (en) | Novel 4-substituted-7- and 8-chloroquinolines and a process for the preparation thereof | |
| GB1219387A (en) | Bicyclo[2.2.2]oct-2-ene-amino acid compounds | |
| GB1348259A (en) | Process for the preparation of 10-oxo-7,10-dihydro-1h-dioxino- 5,4-f-quinolyl-9-carboxylic acids | |
| GB1276719A (en) | Benzomorphan derivatives and their salts | |
| IE34139L (en) | 4-phenyl-butyric acid derivatives | |
| GB1254270A (en) | Benzoxazepine derivatives | |
| GB1410275A (en) | Phenoxycarboxylic acid derivatives their preparation and compositions containing them | |
| GB1211387A (en) | 0-benzylpiperidine derivative and a process for the preparation thereof | |
| GB1235409A (en) | Improvements in or relating to anticestode hydrazinoquinolines | |
| GB1171827A (en) | Improvements in or relating to Substituted Propanols and the Manufacture thereof | |
| GB1284516A (en) | Aminopropionyl derivatives of 2,3-diphenyl-cyclopropylamine | |
| GB1193521A (en) | Novel Esters of 1-Phenyl-1-Benzyl-2-Methyl-3-Dimethylaminopropanol, the preparation thereof and Compositions containing the same | |
| GB1154494A (en) | Novel N-Cycloalkyl-Azabicyclooctanes and Nonanes and Novel Intermediates and process for preparation | |
| GB1238288A (en) | ||
| GB1425911A (en) | Phenylacetic acid derivatives, process for their preparation and therapeutic composition containing same | |
| GB1471371A (en) | Cyclopenteno-b-pyridine derivative | |
| GB1310606A (en) | Adamantylcarboxamidophenylacetic acid derivatives their preparation and compositions containing them |