IE32038L - Penicillins - Google Patents
PenicillinsInfo
- Publication number
- IE32038L IE32038L IE42268A IE42268A IE32038L IE 32038 L IE32038 L IE 32038L IE 42268 A IE42268 A IE 42268A IE 42268 A IE42268 A IE 42268A IE 32038 L IE32038 L IE 32038L
- Authority
- IE
- Ireland
- Prior art keywords
- group
- phenyl
- salts
- penicillins
- aralkoxy
- Prior art date
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 4
- 150000002960 penicillins Chemical class 0.000 title abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 239000011734 sodium Substances 0.000 abstract 2
- 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- -1 aralkoxy Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910021538 borax Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229940049954 penicillin Drugs 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical class CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 235000010339 sodium tetraborate Nutrition 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1,197,973. Penicillins. BEECHAM GROUP Ltd. 18 April, 1968 [18 April, 1967], No. 17702/67. Addition to 1,004,670. Heading C2A. Penicillins of general Formula I and non-toxic salts thereof, wherein R is a phenyl, substituted phenyl, furyl or thienyl group, are prepared by chemically hydrolysing an intermediate penicillin of general Formula II or a non-toxic salt thereof, to remove group R<SP>2</SP>, where R<SP>2</SP> is a phenyl, substituted phenyl, naphthyl or substituted naphthyl group or the group -CHR<SP>11</SP>CXYZ wherein R<SP>11</SP> is H or an alkyl, phenyl, halogenomethyl or alkylsulphonyl group, X is halogen, NO 2 , alkoxy, aryloxy, aralkoxy, alkylsulphonyl, arylsulphonyl or aralkylsulphonyl and Y and Z are the same or different and each may be H, halogen, CH 3 , C 2 H 5 or when X is alkoxy or aralkoxy, Y and Z may together represent oxygen. Hydrolysis is by means of an aqueous or partly aqueous solution of pH 7 to 11À5 at 0-50‹ C., e.g. aqueous solution of NaHCO 3 , Na 2 HPO 4 or sodium borate. Alternatively, an organic base such as a water-miscible tertiary amine or quaternary ammonium hydroxide may be used. The preferred intermediates are those where R<SP>2</SP> is phenyl or 2,2,2-trichloroethyl. The salts may be inorganic e.g. sodium, potassium, calcium, aluminium or ammonium, or organic e.g. amine for example procaine salts. Specifications 1,004,670, 1,160,211 and 1,133,886 are referred to.
[GB1197973A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1770267A GB1197973A (en) | 1967-04-18 | 1967-04-18 | Penicillins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32038L true IE32038L (en) | 1968-10-18 |
| IE32038B1 IE32038B1 (en) | 1973-03-21 |
Family
ID=10099714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE42268A IE32038B1 (en) | 1967-04-18 | 1968-04-10 | Penicillins |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5118434B1 (en) |
| AT (1) | AT283591B (en) |
| BE (1) | BE713868A (en) |
| CH (1) | CH525237A (en) |
| DK (1) | DK132796C (en) |
| ES (1) | ES352849A1 (en) |
| FI (1) | FI51813C (en) |
| FR (1) | FR1560842A (en) |
| GB (1) | GB1197973A (en) |
| IE (1) | IE32038B1 (en) |
| NL (1) | NL6805524A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2635477A1 (en) * | 1975-08-20 | 1977-03-03 | Beecham Group Ltd | PROCESS FOR THE PRODUCTION OF SOLID, PRACTICALLY PURE SODIUM AND POTASSIUM SALT OF CLAVULANIC ACID |
| US4598074A (en) * | 1982-10-15 | 1986-07-01 | Beecham Group P.L.C. | β-lactam antibiotics |
-
1967
- 1967-04-18 GB GB1770267A patent/GB1197973A/en not_active Expired
-
1968
- 1968-04-10 IE IE42268A patent/IE32038B1/en unknown
- 1968-04-16 FR FR1560842D patent/FR1560842A/fr not_active Expired
- 1968-04-17 DK DK170368A patent/DK132796C/en active
- 1968-04-17 ES ES352849A patent/ES352849A1/en not_active Expired
- 1968-04-17 AT AT372468A patent/AT283591B/en not_active IP Right Cessation
- 1968-04-18 CH CH570868A patent/CH525237A/en not_active IP Right Cessation
- 1968-04-18 BE BE713868D patent/BE713868A/xx unknown
- 1968-04-18 JP JP2611868A patent/JPS5118434B1/ja active Pending
- 1968-04-18 FI FI107268A patent/FI51813C/en active
- 1968-04-18 NL NL6805524A patent/NL6805524A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES352849A1 (en) | 1969-08-01 |
| DK132796C (en) | 1976-07-12 |
| DE1770225A1 (en) | 1971-10-07 |
| GB1197973A (en) | 1970-07-08 |
| IE32038B1 (en) | 1973-03-21 |
| CH525237A (en) | 1972-07-15 |
| NL6805524A (en) | 1968-10-21 |
| BE713868A (en) | 1968-10-18 |
| DE1770225B2 (en) | 1976-03-25 |
| JPS5118434B1 (en) | 1976-06-09 |
| FI51813B (en) | 1976-12-31 |
| DK132796B (en) | 1976-02-09 |
| FI51813C (en) | 1977-04-12 |
| AT283591B (en) | 1970-08-10 |
| FR1560842A (en) | 1969-03-21 |
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