IE32778L - Nitrogen-containing heterocyclic derivatives - Google Patents
Nitrogen-containing heterocyclic derivativesInfo
- Publication number
- IE32778L IE32778L IE141268A IE141268A IE32778L IE 32778 L IE32778 L IE 32778L IE 141268 A IE141268 A IE 141268A IE 141268 A IE141268 A IE 141268A IE 32778 L IE32778 L IE 32778L
- Authority
- IE
- Ireland
- Prior art keywords
- alkoxy
- substituted
- optionally
- phenylalkylthio
- phenylalkylamino
- Prior art date
Links
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- -1 or Ph Chemical group 0.000 abstract 2
- 125000002071 phenylalkoxy group Chemical group 0.000 abstract 2
- 125000004660 phenylalkylthio group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000003444 anaesthetic effect Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000006266 etherification reaction Methods 0.000 abstract 1
- 150000002170 ethers Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1,235,684. Basic alcohols, ethers and esters. CENTRE DE RECHERCHES MARCEL MIDY. 15 Nov., 1968 [21 Nov., 1967], No. 52985/67. Heading C2C. Compounds of the general formula (Z=CH 2 CH 2 , CH=CH, CH 2 CH 2 CH 2 , CH 2 CH= CH; R=H, saturated or unsaturated C 1-8 aliphatic group, R 2 CO; R 2 =saturated or unsaturated C 1-6 aliphatic group, or Ph, phenylalkyl, PhOCH 2 , PhSCH 2 optionally ring- substituted by 1-3 substituents selected from Me, alkoxy, halogen; R 1 =Ph, PhO, phenylalkoxy, PhS, phenylalkylthio, PhNH, phenylalkylamino optionally ring - substituted by 1 or 2 substituents selected from NO 2 , NH 2 , halogen, alkyl, alkoxy and C 5-6 cycloalkyl, 2 - naphthyl, 1,2,3,4 - tetrahydro - 6 - naphthyl, C 5-6 cycloalkyl, alkoxy, alkylthio; n=0-2; provided that R 1 =PhO, phenylalkoxy, PhS, phenylalkylthio, PhNH, phenylalkylamino, optionally substituted, only when Z=CH 2 CH 2 or CH=CH) and their acid addition salts are prepared by the following reactions: optionally followed by etherification or esterification and/or salt formation. The preparation of the heterocyclic starting materials by standard methods is described. The above compounds have sympathicolytic, myolytic, psychotropically tranquillizing and analgesic and local anaesthetic activity and may be administered in the form of pharmaceutical preparations contaning them in association with a carrier.
[GB1235684A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB52985/67A GB1235684A (en) | 1967-11-21 | 1967-11-21 | Improvements in or relating to nitrogen-containing heterocyclic derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE32778L true IE32778L (en) | 1969-05-21 |
| IE32778B1 IE32778B1 (en) | 1973-11-28 |
Family
ID=10466156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE141268A IE32778B1 (en) | 1967-11-21 | 1968-11-21 | Improvements in or relating to nitrogen-containing heterocyclic derivatives |
Country Status (15)
| Country | Link |
|---|---|
| AT (1) | AT283340B (en) |
| BE (1) | BE724007A (en) |
| BR (1) | BR6804143D0 (en) |
| CH (1) | CH523881A (en) |
| CS (1) | CS153023B2 (en) |
| DE (1) | DE1809286B2 (en) |
| ES (1) | ES360460A1 (en) |
| FR (2) | FR1594756A (en) |
| GB (1) | GB1235684A (en) |
| IE (1) | IE32778B1 (en) |
| IN (1) | IN118661B (en) |
| LU (1) | LU57339A1 (en) |
| NL (1) | NL6816639A (en) |
| SE (1) | SE366546B (en) |
| SU (1) | SU363246A3 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5823399B2 (en) * | 1973-08-23 | 1983-05-14 | ウェルファイド株式会社 | Phenoxy Amino Probanol |
| JPS57136567A (en) * | 1981-02-17 | 1982-08-23 | Adeka Argus Chem Co Ltd | N-2-hydroxy-3-substituted piperidine compound |
-
1967
- 1967-11-21 GB GB52985/67A patent/GB1235684A/en not_active Expired
-
1968
- 1968-11-08 FR FR1594756D patent/FR1594756A/fr not_active Expired
- 1968-11-16 DE DE19681809286 patent/DE1809286B2/en active Granted
- 1968-11-18 LU LU57339D patent/LU57339A1/xx unknown
- 1968-11-18 BE BE724007D patent/BE724007A/xx unknown
- 1968-11-20 CH CH1729668A patent/CH523881A/en not_active IP Right Cessation
- 1968-11-20 IN IN118661A patent/IN118661B/en unknown
- 1968-11-20 ES ES360460A patent/ES360460A1/en not_active Expired
- 1968-11-20 BR BR20414368A patent/BR6804143D0/en unknown
- 1968-11-20 SE SE1577368A patent/SE366546B/xx unknown
- 1968-11-21 AT AT1132668A patent/AT283340B/en not_active IP Right Cessation
- 1968-11-21 IE IE141268A patent/IE32778B1/en unknown
- 1968-11-21 SU SU1284072A patent/SU363246A3/ru active
- 1968-11-21 NL NL6816639A patent/NL6816639A/xx unknown
- 1968-11-21 CS CS794668A patent/CS153023B2/cs unknown
-
1969
- 1969-02-10 FR FR183247A patent/FR8276M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1809286A1 (en) | 1969-08-14 |
| LU57339A1 (en) | 1969-02-26 |
| BR6804143D0 (en) | 1973-01-09 |
| CH523881A (en) | 1972-06-15 |
| CS153023B2 (en) | 1974-02-22 |
| FR8276M (en) | 1970-11-02 |
| NL6816639A (en) | 1969-05-23 |
| FR1594756A (en) | 1970-06-08 |
| IN118661B (en) | 1975-08-16 |
| SE366546B (en) | 1974-04-29 |
| DE1809286C3 (en) | 1975-04-03 |
| GB1235684A (en) | 1971-06-16 |
| SU363246A3 (en) | 1972-12-30 |
| ES360460A1 (en) | 1970-07-01 |
| BE724007A (en) | 1969-05-02 |
| IE32778B1 (en) | 1973-11-28 |
| AT283340B (en) | 1970-08-10 |
| DE1809286B2 (en) | 1974-08-01 |
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