IE33075L - Benzodiazepines - Google Patents
BenzodiazepinesInfo
- Publication number
- IE33075L IE33075L IE690630A IE63069A IE33075L IE 33075 L IE33075 L IE 33075L IE 690630 A IE690630 A IE 690630A IE 63069 A IE63069 A IE 63069A IE 33075 L IE33075 L IE 33075L
- Authority
- IE
- Ireland
- Prior art keywords
- added
- evapd
- stirred
- phh
- nh4oh
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
(A) Cpds. of the general formula (I) R = H or (2-7C) lower alkanoyl (B) Salts of I. Sedatives. 4.69N NaOEt/MeOH (0.9 ml) was added to III (1 g.) in DMF (15 ml), stirred 0.5 h., and ethylene oxide (0.45 g.) in DMF (5 ml) added. The mixture was stirred 2 h. at 25 deg., 1 h. at 60 deg., evapd. in vac., and succinic anhydride (1.5 g.) in PhMe (50 ml) added. After refluxing 3 h., the mixture was cooled in ice, basified (NH4OH) and sepd. The H2O phase was treated with 3N-NaOH (5 ml), stirred 30 mins., acidified (cHCl), and basified (NH4OH), extd. with CH2Cl2, washed with brine (50 ml), dried and evapd. The residue in PhH (15 ml) was filtered through SiO2 (50 g), eluted with PhH (200 ml) and EtOAc (250 ml), the EtOAc evapd., dissolved in EtOH (5 ml), and HCl-EtOH added, giving I-HCl (R=H), m.p.195-7 deg.
[FR2007969A1]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72735668A | 1968-05-07 | 1968-05-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33075L true IE33075L (en) | 1969-11-07 |
| IE33075B1 IE33075B1 (en) | 1974-03-06 |
Family
ID=24922333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE630/69A IE33075B1 (en) | 1968-05-07 | 1969-05-05 | Benzodiazepine derivatives and a process for the manufacture thereof |
Country Status (17)
| Country | Link |
|---|---|
| BE (1) | BE732557A (en) |
| BR (1) | BR6908524D0 (en) |
| CH (1) | CH512476A (en) |
| CS (1) | CS154270B2 (en) |
| DE (1) | DE1923250C3 (en) |
| DK (1) | DK120440B (en) |
| ES (1) | ES366840A1 (en) |
| FI (1) | FI49039C (en) |
| FR (1) | FR2007969A1 (en) |
| GB (1) | GB1192729A (en) |
| IE (1) | IE33075B1 (en) |
| IL (1) | IL32059A (en) |
| MY (1) | MY7100056A (en) |
| NL (1) | NL164557C (en) |
| NO (1) | NO122654B (en) |
| SE (1) | SE351646B (en) |
| YU (1) | YU33274B (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT224121B (en) * | 1959-12-10 | 1962-11-12 | Hoffmann La Roche | Process for the preparation of new 1,4-benzodiazepine derivatives |
| AT256114B (en) * | 1964-08-13 | 1967-08-10 | Hoffmann La Roche | Process for the preparation of new benzodiazepine derivatives |
-
1969
- 1969-04-22 IL IL32059A patent/IL32059A/en unknown
- 1969-04-23 CH CH614169A patent/CH512476A/en not_active IP Right Cessation
- 1969-04-30 DK DK239669AA patent/DK120440B/en not_active IP Right Cessation
- 1969-05-05 GB GB22779/69A patent/GB1192729A/en not_active Expired
- 1969-05-05 BR BR208524/69A patent/BR6908524D0/en unknown
- 1969-05-05 CS CS317969A patent/CS154270B2/cs unknown
- 1969-05-05 IE IE630/69A patent/IE33075B1/en unknown
- 1969-05-06 BE BE732557D patent/BE732557A/xx not_active IP Right Cessation
- 1969-05-06 ES ES366840A patent/ES366840A1/en not_active Expired
- 1969-05-06 FR FR6914419A patent/FR2007969A1/en not_active Withdrawn
- 1969-05-06 NO NO1864/69A patent/NO122654B/no unknown
- 1969-05-06 YU YU1104/69A patent/YU33274B/en unknown
- 1969-05-07 FI FI691348A patent/FI49039C/en active
- 1969-05-07 DE DE1923250A patent/DE1923250C3/en not_active Expired
- 1969-05-07 NL NL6906970.A patent/NL164557C/en not_active IP Right Cessation
- 1969-05-07 SE SE06467/69A patent/SE351646B/xx unknown
-
1971
- 1971-12-31 MY MY197156A patent/MY7100056A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1923250C3 (en) | 1981-04-02 |
| ES366840A1 (en) | 1971-04-01 |
| CH512476A (en) | 1971-09-15 |
| FR2007969A1 (en) | 1970-01-16 |
| IL32059A (en) | 1972-08-30 |
| NL164557C (en) | 1981-01-15 |
| IL32059A0 (en) | 1969-06-25 |
| FI49039B (en) | 1974-12-02 |
| NO122654B (en) | 1971-07-26 |
| NL164557B (en) | 1980-08-15 |
| DK120440B (en) | 1971-06-01 |
| BR6908524D0 (en) | 1973-01-04 |
| CS154270B2 (en) | 1974-03-29 |
| BE732557A (en) | 1969-11-06 |
| SE351646B (en) | 1972-12-04 |
| NL6906970A (en) | 1969-11-11 |
| MY7100056A (en) | 1971-12-31 |
| YU110469A (en) | 1976-03-31 |
| IE33075B1 (en) | 1974-03-06 |
| GB1192729A (en) | 1970-05-20 |
| YU33274B (en) | 1976-08-31 |
| DE1923250A1 (en) | 1969-11-20 |
| DE1923250B2 (en) | 1980-07-24 |
| FI49039C (en) | 1975-03-10 |
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