IE33382L - Hexahydroazepines - Google Patents
HexahydroazepinesInfo
- Publication number
- IE33382L IE33382L IE691102A IE110269A IE33382L IE 33382 L IE33382 L IE 33382L IE 691102 A IE691102 A IE 691102A IE 110269 A IE110269 A IE 110269A IE 33382 L IE33382 L IE 33382L
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- analgesic
- alkanoyl
- hexahydroazepines
- azeoine
- Prior art date
Links
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical class C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 230000000202 analgesic effect Effects 0.000 abstract 3
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- -1 beta-benzoylethyl Chemical group 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Analgesic hexahydro 1H azeoine derivs.. N3A. And their acid addn. and quat. ammonium salts are new cpds. of formula (I): (where R1 = H, (1-6C) alkyl, PhCH2, or (2-6C) alkanoyl; R2 = (1-6C)alkyl; R3 = H, (1-6C) alkyl, (2-6C) alkenyl, (2-6C) alkynyl, cyclopropylmethyl (2-6C) alkanoyl, CO2 alkyl, CHO, phenacyl, phenethyl or beta-benzoylethyl, (Ph rings may be substd); n = 3 or 4; and m = 0 or 1; with the proviso that n + m = 4; R = H or (1-6C) alkyl if m = 0 or H if m = 1). Used as analgesic and analgesic antagonists in a dose of 10-200 mg./kg.
[FR2015812A1]
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3920168 | 1968-08-16 | ||
| GB4206068 | 1968-09-04 | ||
| GB4694/69A GB1285025A (en) | 1968-08-16 | 1969-01-28 | Hexahydroazepines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33382L true IE33382L (en) | 1970-02-16 |
| IE33382B1 IE33382B1 (en) | 1974-06-12 |
Family
ID=27254483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1102/69A IE33382B1 (en) | 1968-08-16 | 1969-08-06 | Hexahydroazepines |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS505197B1 (en) |
| AR (1) | AR194353A1 (en) |
| AT (1) | AT312611B (en) |
| BE (1) | BE737548A (en) |
| CH (3) | CH554865A (en) |
| DE (1) | DE1941534C3 (en) |
| DK (2) | DK141401B (en) |
| ES (1) | ES370497A1 (en) |
| FI (1) | FI51479C (en) |
| FR (1) | FR2015812A1 (en) |
| HU (1) | HU162512B (en) |
| IE (1) | IE33382B1 (en) |
| IL (1) | IL32801A (en) |
| IT (1) | IT1053698B (en) |
| NL (1) | NL164275C (en) |
| NO (2) | NO132046C (en) |
| SE (1) | SE366043B (en) |
| YU (2) | YU34124B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1319785A (en) * | 1970-02-06 | 1973-06-06 | Wyeth John & Brother Ltd | Hexahydroazepines |
| US3666752A (en) * | 1970-03-09 | 1972-05-30 | Bristol Myers Co | 4,4-diphenylhexahydroazepine compounds |
| DE2901180A1 (en) * | 1979-01-13 | 1980-07-24 | Basf Ag | HEXAHYDRO-1,4-OXAZEPINE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME |
| SE439186B (en) * | 1980-12-04 | 1985-06-03 | Olof Ohrnell | ELASTIC CLUTCH BETWEEN ONE INTERNAL AND EXTERNAL IN RELATION TO EACH CONCENTRIC ROW |
| DE3502667A1 (en) * | 1985-01-26 | 1986-07-31 | Klöckner-Humboldt-Deutz AG, 5000 Köln | Centrifugal oil filter for internal combustion engines |
| US20070078120A1 (en) * | 2003-10-21 | 2007-04-05 | Hitoshi Ban | Novel piperidine derivative |
| WO2017121645A1 (en) * | 2016-01-15 | 2017-07-20 | Laboratorios Del Dr. Esteve, S.A. | 3-ethyl-3-phenylazepane derivatives having multimodal activity against pain |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2740779A (en) * | 1956-04-03 | Substituted azacycloalkanes |
-
1969
- 1969-08-06 IE IE1102/69A patent/IE33382B1/en unknown
- 1969-08-08 IL IL32801A patent/IL32801A/en unknown
- 1969-08-14 DE DE1941534A patent/DE1941534C3/en not_active Expired
- 1969-08-14 FR FR6928129A patent/FR2015812A1/en not_active Withdrawn
- 1969-08-14 BE BE737548D patent/BE737548A/xx not_active IP Right Cessation
- 1969-08-14 IT IT20967/69A patent/IT1053698B/en active
- 1969-08-14 ES ES370497A patent/ES370497A1/en not_active Expired
- 1969-08-15 NL NL6912483.A patent/NL164275C/en not_active IP Right Cessation
- 1969-08-15 NO NO3311/69A patent/NO132046C/no unknown
- 1969-08-15 SE SE11395/69A patent/SE366043B/xx unknown
- 1969-08-15 CH CH340773A patent/CH554865A/en not_active IP Right Cessation
- 1969-08-15 YU YU2102/69A patent/YU34124B/en unknown
- 1969-08-15 JP JP44064669A patent/JPS505197B1/ja active Pending
- 1969-08-15 FI FI692393A patent/FI51479C/en active
- 1969-08-15 CH CH1056472A patent/CH554864A/en not_active IP Right Cessation
- 1969-08-15 CH CH1241969A patent/CH536843A/en not_active IP Right Cessation
- 1969-08-15 DK DK439969AA patent/DK141401B/en not_active IP Right Cessation
- 1969-08-15 HU HUWI160A patent/HU162512B/hu unknown
- 1969-08-18 AT AT789269A patent/AT312611B/en not_active IP Right Cessation
-
1971
- 1971-07-09 DK DK340571A patent/DK150849C/en not_active IP Right Cessation
- 1971-11-30 AR AR239343A patent/AR194353A1/en active
-
1975
- 1975-02-11 NO NO750442A patent/NO142395C/en unknown
- 1975-10-27 YU YU02716/75A patent/YU39170B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1941534C3 (en) | 1980-07-24 |
| YU210269A (en) | 1978-06-30 |
| IE33382B1 (en) | 1974-06-12 |
| DE1941534A1 (en) | 1970-04-09 |
| IT1053698B (en) | 1981-10-10 |
| ES370497A1 (en) | 1972-04-16 |
| SE366043B (en) | 1974-04-08 |
| DK141401C (en) | 1980-09-08 |
| NO132046B (en) | 1975-06-02 |
| CH536843A (en) | 1973-05-15 |
| NO142395B (en) | 1980-05-05 |
| YU271675A (en) | 1982-02-28 |
| HU162512B (en) | 1973-02-28 |
| NO142395C (en) | 1980-08-13 |
| DK150849C (en) | 1988-02-01 |
| FR2015812A1 (en) | 1970-04-30 |
| NL164275B (en) | 1980-07-15 |
| CH554865A (en) | 1974-10-15 |
| JPS505197B1 (en) | 1975-02-28 |
| NL164275C (en) | 1980-12-15 |
| CH554864A (en) | 1974-10-15 |
| DE1941534B2 (en) | 1979-11-15 |
| NO132046C (en) | 1975-09-10 |
| NL6912483A (en) | 1970-02-18 |
| IL32801A (en) | 1973-06-29 |
| FI51479C (en) | 1977-01-10 |
| DK141401B (en) | 1980-03-10 |
| AT312611B (en) | 1974-01-10 |
| IL32801A0 (en) | 1969-11-12 |
| NO750442L (en) | 1970-02-17 |
| FI51479B (en) | 1976-09-30 |
| BE737548A (en) | 1970-02-16 |
| DK150849B (en) | 1987-07-06 |
| YU34124B (en) | 1978-12-31 |
| YU39170B (en) | 1984-08-31 |
| AR194353A1 (en) | 1973-07-13 |
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